Aliases for MYO15B Gene

Aliases for MYO15B Gene

  • Myosin XVB 2 3 5
  • Myosin XVB Pseudogene 2 3
  • MYO15BP 3 4
  • Unconventional Myosin XVBP Pseudogene 3
  • Unconventional Myosin-15B 4
  • Unconventional Myosin-XVB 4
  • Myosin XVBP 4
  • KIAA1783 4

External Ids for MYO15B Gene

Previous GeneCards Identifiers for MYO15B Gene

  • GC17P073562
  • GC17P076610
  • GC17P074048
  • GC17P074182
  • GC17P074214
  • GC17P071096
  • GC17P069007
  • GC17P073586

Summaries for MYO15B Gene

GeneCards Summary for MYO15B Gene

MYO15B (Myosin XVB) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for MYO15B Gene

Additional gene information for MYO15B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYO15B Gene

Genomics for MYO15B Gene

GeneHancer (GH) Regulatory Elements for MYO15B Gene

Promoters and enhancers for MYO15B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYO15B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MYO15B gene promoter:
  • AML1a
  • AREB6
  • c-Myc
  • E47
  • IRF-1
  • Lmo2
  • Max1
  • MyoD
  • PPAR-gamma1
  • TBP

Genomic Locations for MYO15B Gene

Genomic Locations for MYO15B Gene
chr17:75,588,058-75,626,849
(GRCh38/hg38)
Size:
38,792 bases
Orientation:
Plus strand
chr17:73,584,139-73,622,929
(GRCh37/hg19)
Size:
38,791 bases
Orientation:
Plus strand

Genomic View for MYO15B Gene

Genes around MYO15B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYO15B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYO15B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYO15B Gene

Proteins for MYO15B Gene

  • Protein details for MYO15B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JP2-MY15B_HUMAN
    Recommended name:
    Unconventional myosin-XVB
    Protein Accession:
    Q96JP2
    Secondary Accessions:
    • A0A0J9YVZ6

    Protein attributes for MYO15B Gene

    Size:
    1530 amino acids
    Molecular mass:
    167088 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47412.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MYO15B Gene

neXtProt entry for MYO15B Gene

Post-translational modifications for MYO15B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MYO15B Gene

Domains & Families for MYO15B Gene

Gene Families for MYO15B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for MYO15B Gene

GenScript: Design optimal peptide antigens:
  • Unconventional myosin-15B (MY15B_HUMAN)
  • cDNA: FLJ22686 fis, clone HSI10987 (Q9H614_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96JP2

UniProtKB/Swiss-Prot:

MY15B_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYO15B: view

Function for MYO15B Gene

Molecular function for MYO15B Gene

UniProtKB/Swiss-Prot Function:
Unknown, due to the absence of a functional motor domain.

Phenotypes From GWAS Catalog for MYO15B Gene

Gene Ontology (GO) - Molecular Function for MYO15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005515 protein binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYO15B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYO15B Gene

Localization for MYO15B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYO15B Gene

Cytoplasm.

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYO15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005903 brush border IEA --
GO:0016459 myosin complex IEA --
genes like me logo Genes that share ontologies with MYO15B: view

No data available for Subcellular locations from COMPARTMENTS for MYO15B Gene

Pathways & Interactions for MYO15B Gene

PathCards logo

SuperPathways for MYO15B Gene

No Data Available

Interacting Proteins for MYO15B Gene

Gene Ontology (GO) - Biological Process for MYO15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007605 sensory perception of sound IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MYO15B: view

No data available for Pathways by source and SIGNOR curated interactions for MYO15B Gene

Drugs & Compounds for MYO15B Gene

No Compound Related Data Available

Transcripts for MYO15B Gene

mRNA/cDNA for MYO15B Gene

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYO15B Gene

No ASD Table

Relevant External Links for MYO15B Gene

GeneLoc Exon Structure for
MYO15B
ECgene alternative splicing isoforms for
MYO15B

Expression for MYO15B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYO15B Gene

Protein differential expression in normal tissues from HIPED for MYO15B Gene

This gene is overexpressed in Fetal gut (58.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYO15B Gene



Protein tissue co-expression partners for MYO15B Gene

NURSA nuclear receptor signaling pathways regulating expression of MYO15B Gene:

MYO15B

SOURCE GeneReport for Unigene cluster for MYO15B Gene:

Hs.390817

mRNA Expression by UniProt/SwissProt for MYO15B Gene:

Q96JP2-MY15B_HUMAN
Tissue specificity: Detected in brain, stomach and kidney.

Evidence on tissue expression from TISSUES for MYO15B Gene

  • Nervous system(4.5)
  • Kidney(4.1)
  • Stomach(4)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with MYO15B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYO15B Gene

Orthologs for MYO15B Gene

This gene was present in the common ancestor of animals.

Orthologs for MYO15B Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Myo15b 33
  • 8 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYO15B 33
  • 7 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYO15B 33
OneToOne
dog
(Canis familiaris)
Mammalia MYO15B 33
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 5 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta d 33
  • 4 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hum-4 33
  • 2 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2003 33
  • 4 (a)
OneToMany
Species where no ortholog for MYO15B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MYO15B Gene

ENSEMBL:
Gene Tree for MYO15B (if available)
TreeFam:
Gene Tree for MYO15B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYO15B: view image

Paralogs for MYO15B Gene

(16) SIMAP similar genes for MYO15B Gene using alignment to 7 proteins:

  • MY15B_HUMAN
  • J3KTN4_HUMAN
  • J3QLB1_HUMAN
  • J3QLP5_HUMAN
  • J3QS75_HUMAN
  • J3QSF8_HUMAN
  • Q9H614_HUMAN
genes like me logo Genes that share paralogs with MYO15B: view

No data available for Paralogs for MYO15B Gene

Variants for MYO15B Gene

Sequence variations from dbSNP and Humsavar for MYO15B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000125398 -- 75,603,966(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000126605 -- 75,602,745(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000285813 -- 75,597,416(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000355611 -- 75,626,120(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, synonymous_variant
rs1000436977 -- 75,592,485(+) A/G 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MYO15B Gene

Variant ID Type Subtype PubMed ID
dgv373n27 CNV gain 19166990
nsv470603 CNV loss 18288195
nsv470604 CNV gain 18288195
nsv516133 CNV loss 19592680
nsv576027 CNV gain 21841781
nsv576030 CNV gain 21841781
nsv576031 CNV loss 21841781
nsv576032 CNV gain 21841781
nsv576033 CNV loss 21841781
nsv833543 CNV loss 17160897
nsv833544 CNV loss 17160897

Variation tolerance for MYO15B Gene

Gene Damage Index Score: 12.73; 94.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYO15B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYO15B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO15B Gene

Disorders for MYO15B Gene

Additional Disease Information for MYO15B

No disorders were found for MYO15B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYO15B Gene

Publications for MYO15B Gene

  1. Human myosin XVBP is a transcribed pseudogene. (PMID: 11964073) Boger ET … Friedman TB (Journal of muscle research and cell motility 2001) 3 4 23 56
  2. A millennial myosin census. (PMID: 11294886) Berg JS … Cheney RE (Molecular biology of the cell 2001) 2 3 4 56
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 56
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 56
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56

Products for MYO15B Gene

Sources for MYO15B Gene