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Aliases for MYO15B Gene
Aliases for MYO15B Gene
External Ids for MYO15B Gene
- HGNC: 14083
- Entrez Gene: 80022
- Ensembl: ENSG00000266714
- UniProtKB: Q96JP2
Previous GeneCards Identifiers for MYO15B Gene
- GC17P073562
- GC17P076610
- GC17P074048
- GC17P074182
- GC17P074214
- GC17P071096
- GC17P069007
- GC17P073586
Summaries for MYO15B Gene
GeneCards Summary for MYO15B Gene
MYO15B (Myosin XVB) is a Protein Coding gene.
UniProtKB/Swiss-Prot Summary for MYO15B Gene
-
Unknown, due to the absence of a functional motor domain.
Additional gene information for MYO15B Gene
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYO15B Gene
Genomics for MYO15B Gene
GeneHancer (GH) Regulatory Elements for MYO15B Gene
Promoters and enhancers for MYO15B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MYO15B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MYO15B gene promoter:
-
- AML1a
- AREB6
- c-Myc
- E47
- IRF-1
- Lmo2
- Max1
- MyoD
- PPAR-gamma1
- TBP
Genomic Locations for MYO15B Gene
Genomic Locations for MYO15B Gene
- chr17:75,588,058-75,626,849
- (GRCh38/hg38)
- Size:
- 38,792 bases
- Orientation:
- Plus strand
- chr17:73,584,139-73,622,929
- (GRCh37/hg19)
- Size:
- 38,791 bases
- Orientation:
- Plus strand
Genomic View for MYO15B Gene
Genes around MYO15B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
MYO15B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MYO15B Gene
Proteins for MYO15B Gene
-
Protein details for MYO15B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96JP2-MY15B_HUMAN
- Recommended name:
- Unconventional myosin-XVB
- Protein Accession:
- Q96JP2
- A0A0J9YVZ6
Protein attributes for MYO15B Gene
- Size:
- 1530 amino acids
- Molecular mass:
- 167088 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB47412.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for MYO15B Gene
Post-translational modifications for MYO15B Gene
No Post-translational modifications
Other Protein References for MYO15B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_016880615.1
- XP_016880625.1
- XP_016880613.1
- XP_016880623.1
- NP_001296171.1
- XP_016880614.1
- XP_016880624.1
- XP_016880632.1
- XP_016880612.1
- XP_016880622.1
- XP_016880631.1
- XP_016880611.1
- XP_016880621.1
- XP_024306720.1
- XP_016880619.1
- XP_016880629.1
- XP_016880609.1
- XP_016880630.1
- XP_016880610.1
- XP_016880620.1
- XP_016880617.1
- XP_016880627.1
- XP_016880618.1
- XP_016880628.1
- XP_016880616.1
- XP_016880626.1
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MYO15B
- Origene Custom Protein Services for MYO15B
No data available for DME Specific Peptides for MYO15B Gene
Domains & Families for MYO15B Gene
Gene Families for MYO15B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MYO15B Gene
Suggested Antigen Peptide Sequences for MYO15B Gene
- GenScript: Design optimal peptide antigens:
-
- Unconventional myosin-15B (MY15B_HUMAN)
- cDNA: FLJ22686 fis, clone HSI10987 (Q9H614_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96JP2UniProtKB/Swiss-Prot:
MY15B_HUMAN :- Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
- Family:
-
- Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Function for MYO15B Gene
Molecular function for MYO15B Gene
- UniProtKB/Swiss-Prot Function:
- Unknown, due to the absence of a functional motor domain.
Phenotypes From GWAS Catalog for MYO15B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0003774 | motor activity | IEA | -- |
| GO:0003779 | actin binding | IEA | -- |
| GO:0005515 | protein binding | IEA | -- |
| GO:0005524 | ATP binding | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Browse CRISPR knockouts for MYO15B
- genomics-online: gRNA clones - Search results for available MYO15B gene related products
- Applied Biological Materials (abm): CRISPR Clones for MYO15B - Select products 50% OFF >
- * MYO15B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MYO15B CRISPR applications: KO, Activation, Repression, and more - Browse All
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MYO15B
- Browse OriGene Inhibitory RNA Products For MYO15B
- genomics-online: shRNA clones - Search results for available MYO15B gene related products
Clone Products
- genomics-online: cdna clones - Search results for available MYO15B gene related products
- orf clones - Search results for available MYO15B gene related products
- Applied Biological Materials (abm): Clones for MYO15B - Select products 50% OFF >
- * MYO15B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MYO15B tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYO15B Gene
Localization for MYO15B Gene
Subcellular locations from UniProtKB/Swiss-Prot for MYO15B Gene
- Cytoplasm.
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005903 | brush border | IEA | -- |
| GO:0016459 | myosin complex | IEA | -- |
No data available for Subcellular locations from COMPARTMENTS for MYO15B Gene
Pathways & Interactions for MYO15B Gene
Interacting Proteins for MYO15B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007605 | sensory perception of sound | IEA | -- |
| GO:0008150 | biological_process | ND | -- |
No data available for Pathways by source and SIGNOR curated interactions for MYO15B Gene
Transcripts for MYO15B Gene
mRNA/cDNA for MYO15B Gene
- (2) REFSEQ mRNAs :
- (21) Additional mRNA sequences :
- (186) Selected AceView cDNA sequences:
- (36) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000584516 5709 bps (ENST00000584516.5)
- ENST00000619501 7167 bps (ENST00000619501.4)
- ENST00000621743 8646 bps (ENST00000621743.4)
- ENST00000610510 9195 bps (ENST00000610510.4)
- ENST00000645453 9704 bps (ENST00000645453.1)
CRISPR Products
- Browse CRISPR knockouts for MYO15B
- genomics-online: gRNA clones - Search results for available MYO15B gene related products
- Applied Biological Materials (abm): CRISPR Clones for MYO15B - Select products 50% OFF >
- * MYO15B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MYO15B CRISPR applications: KO, Activation, Repression, and more - Browse All
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MYO15B
- Browse OriGene Inhibitory RNA Products For MYO15B
- genomics-online: shRNA clones - Search results for available MYO15B gene related products
Clone Products
- genomics-online: cdna clones - Search results for available MYO15B gene related products
- orf clones - Search results for available MYO15B gene related products
- Applied Biological Materials (abm): Clones for MYO15B - Select products 50% OFF >
- * MYO15B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MYO15B tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for MYO15B Gene
This gene is overexpressed in Fetal gut (58.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYO15B Gene
NURSA nuclear receptor signaling pathways regulating expression of MYO15B Gene:
MYO15BSOURCE GeneReport for Unigene cluster for MYO15B Gene:
Hs.390817mRNA Expression by UniProt/SwissProt for MYO15B Gene:
Q96JP2-MY15B_HUMAN
Tissue specificity:
Detected in brain, stomach and kidney.
Evidence on tissue expression from TISSUES for MYO15B Gene
- Nervous system(4.5)
- Kidney(4.1)
- Stomach(4)
- Intestine(2.2)
Primer Products
-
OriGene qPCR primer pairs for MYO15B
- genomics-online: primer clones - Search results for available MYO15B gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYO15B Gene
Orthologs for MYO15B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| mouse (Mus musculus) |
Mammalia | Myo15b 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MYO15B 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MYO15B 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MYO15B 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
ManyToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | d 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | hum-4 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2003 33 |
|
OneToMany |
- Species where no ortholog for MYO15B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Evolution for MYO15B Gene
- ENSEMBL:
- Gene Tree for MYO15B (if available)
- TreeFam:
- Gene Tree for MYO15B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MYO15B: view image
Paralogs for MYO15B Gene
(16) SIMAP similar genes for MYO15B Gene using alignment to 7 proteins:
- MY15B_HUMAN
- J3KTN4_HUMAN
- J3QLB1_HUMAN
- J3QLP5_HUMAN
- J3QS75_HUMAN
- J3QSF8_HUMAN
- Q9H614_HUMAN
No data available for Paralogs for MYO15B Gene
Variants for MYO15B Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000125398 | -- | 75,603,966(+) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000126605 | -- | 75,602,745(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000285813 | -- | 75,597,416(+) | C/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000355611 | -- | 75,626,120(+) | G/A | coding_sequence_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, synonymous_variant | |
| rs1000436977 | -- | 75,592,485(+) | A/G | 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv373n27 | CNV | gain | 19166990 |
| nsv470603 | CNV | loss | 18288195 |
| nsv470604 | CNV | gain | 18288195 |
| nsv516133 | CNV | loss | 19592680 |
| nsv576027 | CNV | gain | 21841781 |
| nsv576030 | CNV | gain | 21841781 |
| nsv576031 | CNV | loss | 21841781 |
| nsv576032 | CNV | gain | 21841781 |
| nsv576033 | CNV | loss | 21841781 |
| nsv833543 | CNV | loss | 17160897 |
| nsv833544 | CNV | loss | 17160897 |
Gene Damage Index Score:
12.73;
94.66% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MYO15B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MYO15B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO15B Gene
Disorders for MYO15B Gene
Additional Disease Information for MYO15B
No disorders were found for MYO15B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYO15B Gene
Publications for MYO15B Gene
- Human myosin XVBP is a transcribed pseudogene. (PMID: 11964073) Boger ET … Friedman TB (Journal of muscle research and cell motility 2001) 3 4 23 56
- A millennial myosin census. (PMID: 11294886) Berg JS … Cheney RE (Molecular biology of the cell 2001) 2 3 4 56
- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 56
- E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 56
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56
ExternalLinks
Products for MYO15B Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MYO15B
- Origene Custom Protein Services for MYO15B
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MYO15B
- Browse OriGene Inhibitory RNA Products For MYO15B
- OriGene qPCR primer pairs for MYO15B
- Browse CRISPR knockouts for MYO15B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MYO15B
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
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- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- antibodies-online: Search results for available MYO15B related products ranked by validation data
- antibodies-online: Search results for available MYO15B related products ranked by validation data
- antibodies-online: Search results for available MYO15B related products ranked by validation data
- genomics-online: cdna clones - Search results for available MYO15B gene related products
- orf clones - Search results for available MYO15B gene related products
- genomics-online: gRNA clones - Search results for available MYO15B gene related products
- genomics-online: primer clones - Search results for available MYO15B gene related products
- genomics-online: shRNA clones - Search results for available MYO15B gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MYO15B
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Sources for MYO15B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource