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Aliases for MYO15B Gene
Aliases for MYO15B Gene
External Ids for MYO15B Gene
- HGNC: 14083
- NCBI Entrez Gene: 80022
- Ensembl: ENSG00000266714
- UniProtKB/Swiss-Prot: Q96JP2
Previous GeneCards Identifiers for MYO15B Gene
- GC17P073562
- GC17P076610
- GC17P074048
- GC17P074182
- GC17P074214
- GC17P071096
- GC17P069007
- GC17P073586
Summaries for MYO15B Gene
GeneCards Summary for MYO15B Gene
MYO15B (Myosin XVB) is a Protein Coding gene.
UniProtKB/Swiss-Prot Summary for MYO15B Gene
-
Unknown, due to the absence of a functional motor domain.
Additional gene information for MYO15B Gene
- HGNC (14083)
- NCBI Entrez Gene (80022)
- Ensembl (ENSG00000266714)
- UniProtKB/Swiss-Prot (Q96JP2)
- Open Targets Platform(ENSG00000266714)
- Search for MYO15B at DataMed
- Search for MYO15B at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYO15B Gene
Genomics for MYO15B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MYO15B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MYO15B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYO15B
- Top Transcription factor binding sites by QIAGEN in the MYO15B gene promoter:
-
- AML1a
- AREB6
- c-Myc
- E47
- IRF-1
- Lmo2
- Max1
- MyoD
- PPAR-gamma1
- TBP
Genomic Locations for MYO15B Gene
Latest Assembly
- chr17:75,587,545-75,626,851
- (GRCh38/hg38)
- Size:
- 39,307 bases
- Orientation:
- Plus strand
Previous Assembly
- chr17:73,584,139-73,622,929
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 38,791 bases
- Orientation:
- Plus strand
- chr17:73,584,139-73,622,929
- (GRCh37/hg19 by Ensembl)
- Size:
- 38,791 bases
- Orientation:
- Plus strand
Genomic View for MYO15B Gene
Genes around MYO15B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
MYO15B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MYO15B Gene
Proteins for MYO15B Gene
-
Protein details for MYO15B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96JP2-MY15B_HUMAN
- Recommended name:
- Unconventional myosin-XVB
- Protein Accession:
- Q96JP2
- A0A0J9YVZ6
Protein attributes for MYO15B Gene
- Size:
- 1530 amino acids
- Molecular mass:
- 167088 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB47412.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for MYO15B Gene
Post-translational modifications for MYO15B Gene
No Post-translational modifications
Other Protein References for MYO15B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_016880609.1
- XP_016880610.1
- XP_016880611.1
- XP_016880612.1
- XP_016880613.1
- XP_016880614.1
- XP_016880615.1
- XP_016880616.1
- XP_016880617.1
- XP_016880618.1
- XP_016880619.1
- XP_016880620.1
- XP_016880621.1
- XP_016880622.1
- XP_016880623.1
- XP_016880624.1
- XP_016880625.1
- XP_016880626.1
- XP_016880627.1
- XP_016880628.1
- XP_016880629.1
- XP_016880630.1
- XP_016880631.1
- XP_016880632.1
- XP_024306720.1
- NP_001296171.1
Antibodies for research
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MYO15B
- Origene Custom Protein Services for MYO15B
Assay products for research
No data available for DME Specific Peptides for MYO15B Gene
Domains & Families for MYO15B Gene
Gene Families for MYO15B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MYO15B Gene
Suggested Antigen Peptide Sequences for MYO15B Gene
- GenScript: Design optimal peptide antigens:
-
- Unconventional myosin-15B (MY15B_HUMAN)
- cDNA: FLJ22686 fis, clone HSI10987 (Q9H614_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96JP2UniProtKB/Swiss-Prot:
MY15B_HUMAN :- Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
- Family:
-
- Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Function for MYO15B Gene
Molecular function for MYO15B Gene
- UniProtKB/Swiss-Prot Function:
- Unknown, due to the absence of a functional motor domain.
Phenotypes From GWAS Catalog for MYO15B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003674 | molecular_function | ND | -- |
| GO:0003774 | motor activity | IEA | -- |
| GO:0003779 | actin binding | IEA | -- |
| GO:0005515 | protein binding | IEA | -- |
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MYO15B - Starting at $85 >
- * MYO15B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MYO15B
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MYO15B
- Browse OriGene Inhibitory RNA Products For MYO15B
Clone products for research
- Applied Biological Materials (abm): Clones for MYO15B - Starting at $45 >
- * MYO15B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYO15B Gene
Localization for MYO15B Gene
Subcellular locations from UniProtKB/Swiss-Prot for MYO15B Gene
- Cytoplasm.
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005903 | brush border | IEA | -- |
| GO:0016459 | myosin complex | IEA | -- |
No data available for Subcellular locations from COMPARTMENTS for MYO15B Gene
Pathways & Interactions for MYO15B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
No data available for Pathways by source and SIGNOR curated interactions for MYO15B Gene
Transcripts for MYO15B Gene
mRNA/cDNA for MYO15B Gene
- 2 REFSEQ mRNAs :
- 21 NCBI additional mRNA sequence :
- 36 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000577296 494 nts (view in UCSC)
- ENST00000577342 643 nts (view in UCSC)
- ENST00000577613 564 nts (view in UCSC)
- ENST00000577785 565 nts (view in UCSC)
- ENST00000577948 816 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MYO15B - Starting at $85 >
- * MYO15B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MYO15B
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MYO15B
- Browse OriGene Inhibitory RNA Products For MYO15B
Clone products for research
- Applied Biological Materials (abm): Clones for MYO15B - Starting at $45 >
- * MYO15B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MYO15B Gene
- GeneLoc Exon Structure for
- MYO15B
Expression for MYO15B Gene
This gene is overexpressed in Fetal gut (58.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYO15B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYO15B
SOURCE GeneReport for Unigene cluster for MYO15B Gene:
Hs.390817mRNA Expression by UniProt/SwissProt for MYO15B Gene:
Q96JP2-MY15B_HUMAN
Tissue specificity:
Detected in brain, stomach and kidney.
Primer products for research
-
OriGene qPCR primer pairs for MYO15B
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYO15B Gene
Orthologs for MYO15B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Mouse (Mus musculus) |
Mammalia | Myo15b 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MYO15B 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MYO15B 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MYO15B 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | d 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | hum-4 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2003 31 |
|
OneToMany |
- Species where no ortholog for MYO15B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Zebrafish (Danio rerio)
Evolution for MYO15B Gene
- ENSEMBL:
- Gene Tree for MYO15B (if available)
- TreeFam:
- Gene Tree for MYO15B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MYO15B: view image
Paralogs for MYO15B Gene
(16) SIMAP similar genes for MYO15B Gene using alignment to 7 proteins:
- MY15B_HUMAN
- J3KTN4_HUMAN
- J3QLB1_HUMAN
- J3QLP5_HUMAN
- J3QS75_HUMAN
- J3QSF8_HUMAN
- Q9H614_HUMAN
No data available for Paralogs for MYO15B Gene
Variants for MYO15B Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYO15B Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs3803728 | - |
p.Arg547Trp |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv373n27 | CNV | gain | 19166990 |
| nsv470603 | CNV | loss | 18288195 |
| nsv470604 | CNV | gain | 18288195 |
| nsv516133 | CNV | loss | 19592680 |
| nsv576027 | CNV | gain | 21841781 |
| nsv576030 | CNV | gain | 21841781 |
| nsv576031 | CNV | loss | 21841781 |
| nsv576032 | CNV | gain | 21841781 |
| nsv576033 | CNV | loss | 21841781 |
| nsv833543 | CNV | loss | 17160897 |
| nsv833544 | CNV | loss | 17160897 |
Gene Damage Index Score:
12.73;
94.66% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MYO15B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MYO15B
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYO15B Gene
Disorders for MYO15B Gene
Additional Disease Information for MYO15B
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for MYO15B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYO15B Gene
Publications for MYO15B Gene
- A millennial myosin census. (PMID: 11294886) Berg JS … Cheney RE (Molecular biology of the cell 2001) 2 3 4
- Human myosin XVBP is a transcribed pseudogene. (PMID: 11964073) Boger ET … Friedman TB (Journal of muscle research and cell motility 2001) 3 4 23
- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
ExternalLinks
Products for MYO15B Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MYO15B
- Origene Custom Protein Services for MYO15B
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MYO15B
- Browse OriGene Inhibitory RNA Products For MYO15B
- OriGene qPCR primer pairs for MYO15B
- OriGene CRISPR knockouts for MYO15B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MYO15B
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- VectorBuilder Custom and pre-made DNA vectors for MYO15B (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MYO15B (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MYO15B (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MYO15B CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MYO15B
- antibodies-online: Search results for available MYO15B related products ranked by validation data
- antibodies-online: Search results for available MYO15B related products ranked by validation data
- antibodies-online: Search results for available MYO15B related products ranked by validation data
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MYO15B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MYO15B
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MYO15B
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MYO15B
Sources for MYO15B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB