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Aliases for MYNN Gene

Aliases for MYNN Gene

  • Myoneurin 2 3 3 5
  • Zinc Finger And BTB Domain-Containing Protein 31 3 4
  • ZBTB31 3 4
  • OSZF 3 4
  • Zinc Finger Protein With BTB/POZ Domain 3
  • SBBIZ1 3
  • ZNF902 3

External Ids for MYNN Gene

Previous GeneCards Identifiers for MYNN Gene

  • GC03P166758
  • GC03P170539
  • GC03P170892
  • GC03P170812
  • GC03P170973
  • GC03P169490
  • GC03P166860

Summaries for MYNN Gene

Entrez Gene Summary for MYNN Gene

  • This gene encodes a member of the BTB/POZ and zinc finger domain-containing protein family that are involved in the control of gene expression. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 14. [provided by RefSeq, Jun 2010]

GeneCards Summary for MYNN Gene

MYNN (Myoneurin) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZBTB49.

Additional gene information for MYNN Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYNN Gene

Genomics for MYNN Gene

GeneHancer (GH) Regulatory Elements for MYNN Gene

Promoters and enhancers for MYNN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J169771 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 706.1 +3.4 3431 3.4 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MYNN TRV-AAC1-1 PIR36992 PHC3 SEC62-AS1 PRKCI CLDN11 LRRC34 ENSG00000270096 ENSG00000269889
GH03J169768 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 684.9 -0.1 -134 1.4 PKNOX1 SIN3A DMAP1 GLI4 ZNF2 ZBTB7B BRCA1 ZNF48 YY1 GTF3C2 MYNN ACTRT3 ENSG00000269889 SEC62-AS1 PHC3 LRRC34 GC03M169768 GC03M169659
GH03J169657 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 73.1 -106.0 -105981 12.4 PKNOX1 FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B MECOM MYNN PHC3 SEC62-AS1 ENSG00000270096 PRKCI ENSG00000239628 RPL22P1 SLC7A14 ACTRT3
GH03J169762 Promoter/Enhancer 1.8 Ensembl ENCODE 58.1 -5.2 -5230 3.1 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B ENSG00000277925 TERC GC03M169769 GC03M169768 GC03M169767 MYNN SEC62-AS1 PHC3 ENSG00000239628 PRKCI
GH03J170221 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 28.9 +453.7 453652 3.4 HDGF PKNOX1 CLOCK ARNT NEUROD1 SIN3A ZNF2 ZBTB7B YY1 SLC30A9 PRKCI ENSG00000270096 MYNN SEC62-AS1 ENSG00000239628 PHC3 RPL22P1 GPR160 RPL22L1 SLC7A14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYNN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MYNN gene promoter:
  • Sp1
  • p53
  • Arnt
  • GATA-1
  • AREB6
  • AML1a
  • LyF-1
  • NF-kappaB1
  • HOXA9

Genomic Locations for MYNN Gene

Genomic Locations for MYNN Gene
20,068 bases
Plus strand
16,886 bases
Plus strand

Genomic View for MYNN Gene

Genes around MYNN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYNN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYNN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYNN Gene

Proteins for MYNN Gene

  • Protein details for MYNN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R6C9
    • Q6QHA6
    • Q6QHA7
    • Q6R3G1
    • Q6R3G2
    • Q6R4A0
    • Q7Z716
    • Q7Z717
    • Q86Z11
    • Q86Z12
    • Q9NS01
    • Q9UIW8

    Protein attributes for MYNN Gene

    610 amino acids
    Molecular mass:
    68682 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MYNN Gene

    Alternative splice isoforms for MYNN Gene


neXtProt entry for MYNN Gene

Post-translational modifications for MYNN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYNN Gene

Domains & Families for MYNN Gene

Gene Families for MYNN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MYNN Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with MYNN: view

Function for MYNN Gene

Phenotypes From GWAS Catalog for MYNN Gene

Gene Ontology (GO) - Molecular Function for MYNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 10873615
GO:0005515 protein binding IEA --
GO:0008270 zinc ion binding TAS 10873615
genes like me logo Genes that share ontologies with MYNN: view
genes like me logo Genes that share phenotypes with MYNN: view

Animal Model Products

miRNA for MYNN Gene

miRTarBase miRNAs that target MYNN

Clone Products

  • Addgene plasmids for MYNN

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYNN Gene

Localization for MYNN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYNN Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYNN gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with MYNN: view

Pathways & Interactions for MYNN Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA,TAS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:1990830 cellular response to leukemia inhibitory factor IEA --
genes like me logo Genes that share ontologies with MYNN: view

No data available for Pathways by source and SIGNOR curated interactions for MYNN Gene

Drugs & Compounds for MYNN Gene

No Compound Related Data Available

Transcripts for MYNN Gene

Unigene Clusters for MYNN Gene

Representative Sequences:

Clone Products

  • Addgene plasmids for MYNN

Alternative Splicing Database (ASD) splice patterns (SP) for MYNN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d ·
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP6: - - -
SP7: - - -
SP8: - - -
SP9: - -
SP11: - - - - -
SP12: - -

ExUns: 12e

Relevant External Links for MYNN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYNN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYNN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYNN Gene

Protein tissue co-expression partners for MYNN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYNN Gene:


SOURCE GeneReport for Unigene cluster for MYNN Gene:


mRNA Expression by UniProt/SwissProt for MYNN Gene:

Tissue specificity: Mainly expressed in the neuromuscular system. Located in and around synaptic myonuclei in adult muscle. Expression is dysregulated after nerve injury. Also found in the testis, ovary and placenta.

Evidence on tissue expression from TISSUES for MYNN Gene

  • Nervous system(4.6)
  • Lung(4.2)
  • Lymph node(4.2)
  • Spleen(4.2)
  • Blood(4)
genes like me logo Genes that share expression patterns with MYNN: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYNN Gene

Orthologs for MYNN Gene

This gene was present in the common ancestor of animals.

Orthologs for MYNN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MYNN 34 33
  • 99.67 (n)
(Canis familiaris)
Mammalia MYNN 34 33
  • 94.37 (n)
(Bos Taurus)
Mammalia MYNN 34 33
  • 92.25 (n)
(Mus musculus)
Mammalia Mynn 16 34 33
  • 87.92 (n)
(Rattus norvegicus)
Mammalia Mynn 33
  • 86.97 (n)
(Ornithorhynchus anatinus)
Mammalia MYNN 34
  • 83 (a)
(Monodelphis domestica)
Mammalia MYNN 34
  • 82 (a)
(Gallus gallus)
Aves MYNN 34 33
  • 77.21 (n)
(Anolis carolinensis)
Reptilia MYNN 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492148 33
  • 66.33 (n)
(Danio rerio)
Actinopterygii mynn 34
  • 29 (a)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta CG1602 35
  • 36 (a)
rgr 35
  • 35 (a)
Species where no ortholog for MYNN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYNN Gene

Gene Tree for MYNN (if available)
Gene Tree for MYNN (if available)
Evolutionary constrained regions (ECRs) for MYNN: view image

Paralogs for MYNN Gene

Paralogs for MYNN Gene

(378) SIMAP similar genes for MYNN Gene using alignment to 3 proteins:

  • Q05CW1_HUMAN
  • R4GMT1_HUMAN Pseudogenes for MYNN Gene

genes like me logo Genes that share paralogs with MYNN: view

Variants for MYNN Gene

Sequence variations from dbSNP and Humsavar for MYNN Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs10936599 association, Chronic osteomyelitis 169,774,313(+) C/T 5_prime_UTR_variant, coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1000107656 -- 169,781,869(+) A/G intron_variant
rs1000135495 -- 169,778,972(+) A/C 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000176719 -- 169,789,834(+) A/G downstream_transcript_variant
rs1000184827 -- 169,775,623(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MYNN Gene

Variant ID Type Subtype PubMed ID
esv2422204 CNV deletion 17116639
nsv7356 OTHER inversion 18451855

Variation tolerance for MYNN Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYNN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYNN Gene

Disorders for MYNN Gene

Additional Disease Information for MYNN

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MYNN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYNN Gene

Publications for MYNN Gene

  1. Myoneurin, a novel member of the BTB/POZ-zinc finger family highly expressed in human muscle. (PMID: 10873615) Alliel PM … Périn JP (Biochemical and biophysical research communications 2000) 2 3 4 22 58
  2. Neuromuscular expression of the BTB/POZ and zinc finger protein myoneurin. (PMID: 14694499) Cifuentes-Diaz C … Alliel PM (Muscle & nerve 2004) 3 4 22 58
  3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 44 58
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  5. Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois PC … van Heel DA (Nature genetics 2010) 3 44 58

Products for MYNN Gene

  • Addgene plasmids for MYNN

Sources for MYNN Gene

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