MYNN Gene (Protein Coding)

Myoneurin

GC03P169773
GIFtS:
39
This gene encodes a member of the BTB/POZ and zinc finger domain-containing protein family that are involved in the control of gene expression. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 14. [provided by RefSeq, Jun 2010] See more...

Aliases for MYNN Gene

Aliases for MYNN Gene

  • Myoneurin 2 3 4 5
  • Zinc Finger And BTB Domain-Containing Protein 31 3 4
  • ZBTB31 3 4
  • OSZF 3 4
  • Zinc Finger Protein With BTB/POZ Domain 3
  • SBBIZ1 3
  • ZNF902 3

External Ids for MYNN Gene

Previous GeneCards Identifiers for MYNN Gene

  • GC03P166758
  • GC03P170539
  • GC03P170892
  • GC03P170812
  • GC03P170973
  • GC03P169490
  • GC03P166860

Summaries for MYNN Gene

Entrez Gene Summary for MYNN Gene

  • This gene encodes a member of the BTB/POZ and zinc finger domain-containing protein family that are involved in the control of gene expression. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 14. [provided by RefSeq, Jun 2010]

GeneCards Summary for MYNN Gene

MYNN (Myoneurin) is a Protein Coding gene. Diseases associated with MYNN include Cogan-Reese Syndrome. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZBTB17.

Additional gene information for MYNN Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYNN Gene

Genomics for MYNN Gene

GeneHancer (GH) Regulatory Elements for MYNN Gene

Promoters and enhancers for MYNN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYNN on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYNN

Top Transcription factor binding sites by QIAGEN in the MYNN gene promoter:
  • AML1a
  • AREB6
  • Arnt
  • GATA-1
  • HOXA9
  • LyF-1
  • NF-kappaB1
  • p53
  • Sp1

Genomic Locations for MYNN Gene

Genomic Locations for MYNN Gene
chr3:169,769,649-169,789,716
(GRCh38/hg38)
Size:
20,068 bases
Orientation:
Plus strand
chr3:169,490,619-169,507,504
(GRCh37/hg19)
Size:
16,886 bases
Orientation:
Plus strand

Genomic View for MYNN Gene

Genes around MYNN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYNN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYNN Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MYNN Gene

Proteins for MYNN Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MYNN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPC7-MYNN_HUMAN
    Recommended name:
    Myoneurin
    Protein Accession:
    Q9NPC7
    Secondary Accessions:
    • B2R6C9
    • Q6QHA6
    • Q6QHA7
    • Q6R3G1
    • Q6R3G2
    • Q6R4A0
    • Q7Z716
    • Q7Z717
    • Q86Z11
    • Q86Z12
    • Q9NS01
    • Q9UIW8

    Protein attributes for MYNN Gene

    Size:
    610 amino acids
    Molecular mass:
    68682 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MYNN Gene

    Alternative splice isoforms for MYNN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYNN Gene

Protein Expression for MYNN Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MYNN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYNN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYNN Gene

Domains & Families for MYNN Gene

Gene Families for MYNN Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MYNN Gene

Blocks:
  • BTB/POZ domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYNN Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92895, Homo sapiens myoneurin (MYNN), mRNA (B2R6C9_HUMAN)
  • Zinc finger and BTB domain-containing protein 31 (MYNN_HUMAN)
  • MYNN protein (Q05CW1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NPC7

UniProtKB/Swiss-Prot:

MYNN_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with MYNN: view

Function for MYNN Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MYNN Gene

Gene Ontology (GO) - Molecular Function for MYNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity TAS 10873615
GO:0005515 protein binding IEA --
GO:0008270 zinc ion binding TAS 10873615
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MYNN: view
genes like me logo Genes that share phenotypes with MYNN: view

Animal Model Products

CRISPR Products

miRNA for MYNN Gene

miRTarBase miRNAs that target MYNN

Clone Products

  • Addgene plasmids for MYNN

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYNN Gene

Localization for MYNN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYNN Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYNN gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MYNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with MYNN: view

Pathways & Interactions for MYNN Gene

PathCards logo

SuperPathways for MYNN Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated TAS 10873615
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:1990830 cellular response to leukemia inhibitory factor IEA --
genes like me logo Genes that share ontologies with MYNN: view

No data available for Pathways by source and SIGNOR curated interactions for MYNN Gene

Drugs & Compounds for MYNN Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MYNN Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MYNN Gene

3 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for MYNN

Alternative Splicing Database (ASD) splice patterns (SP) for MYNN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d ·
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5:
SP6: - - -
SP7: - - -
SP8: - - -
SP9: - -
SP10:
SP11: - - - - -
SP12: - -

ExUns: 12e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for MYNN Gene

GeneLoc Exon Structure for
MYNN

Expression for MYNN Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYNN Gene

mRNA expression in normal human tissues for MYNN Gene
mRNA expression by GTEx for MYNN GenemRNA expression by BioGPS for MYNN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYNN Gene



Protein tissue co-expression partners for MYNN Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYNN

SOURCE GeneReport for Unigene cluster for MYNN Gene:

Hs.507025

mRNA Expression by UniProt/SwissProt for MYNN Gene:

Q9NPC7-MYNN_HUMAN
Tissue specificity: Mainly expressed in the neuromuscular system. Located in and around synaptic myonuclei in adult muscle. Expression is dysregulated after nerve injury. Also found in the testis, ovary and placenta.

Evidence on tissue expression from TISSUES for MYNN Gene

  • Nervous system(4.6)
  • Lung(4.2)
  • Lymph node(4.2)
  • Spleen(4.2)
  • Blood(4)
genes like me logo Genes that share expression patterns with MYNN: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYNN Gene

Orthologs for MYNN Gene

This gene was present in the common ancestor of animals.

Orthologs for MYNN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MYNN 31 30
  • 99.67 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia MYNN 31 30
  • 94.37 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia MYNN 31 30
  • 92.25 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mynn 17 31 30
  • 87.92 (n)
rat
(Rattus norvegicus)
 Mammalia Mynn 30
  • 86.97 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia MYNN 31
  • 83 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia MYNN 31
  • 82 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MYNN 31 30
  • 77.21 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia MYNN 31
  • 80 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100492148 30
  • 66.33 (n)
zebrafish
(Danio rerio)
 Actinopterygii mynn 31
  • 29 (a)
 OneToOne
-- 30
fruit fly
(Drosophila melanogaster)
 Insecta CG1602 32
  • 36 (a)
rgr 32
  • 35 (a)
Species where no ortholog for MYNN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYNN Gene

ENSEMBL:
Gene Tree for MYNN (if available)
TreeFam:
Gene Tree for MYNN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYNN: view image

Paralogs for MYNN Gene

Paralogs for MYNN Gene

(378) SIMAP similar genes for MYNN Gene using alignment to 3 proteins:

  • MYNN_HUMAN
  • Q05CW1_HUMAN
  • R4GMT1_HUMAN

Pseudogenes.org Pseudogenes for MYNN Gene

genes like me logo Genes that share paralogs with MYNN: view

Variants for MYNN Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYNN Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs10936599 Association: Chronic osteomyelitis 169,774,313(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for MYNN Gene

Structural Variations from Database of Genomic Variants (DGV) for MYNN Gene

Variant ID Type Subtype PubMed ID
esv2422204 CNV deletion 17116639
nsv7356 OTHER inversion 18451855

Variation tolerance for MYNN Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYNN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYNN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYNN Gene

Disorders for MYNN Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYNN Gene - From: DISEASES

Disorder Aliases PubMed IDs
cogan-reese syndrome
- elite association - COSMIC cancer census association via MalaCards
Search MYNN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MYNN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MYNN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYNN Gene

Publications for MYNN Gene

  1. Myoneurin, a novel member of the BTB/POZ-zinc finger family highly expressed in human muscle. (PMID: 10873615) Alliel PM … Périn JP (Biochemical and biophysical research communications 2000) 2 3 4 23 54
  2. Neuromuscular expression of the BTB/POZ and zinc finger protein myoneurin. (PMID: 14694499) Cifuentes-Diaz C … Alliel PM (Muscle & nerve 2004) 3 4 23 54
  3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 41 54
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 41 54
  5. Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois PC … van Heel DA (Nature genetics 2010) 3 41 54

ExternalLinks

View latest publications for MYNN gene in Mastermind

Products for MYNN Gene

  • Addgene plasmids for MYNN

Sources for MYNN Gene