Aliases for MYLK3 Gene
External Ids for MYLK3 Gene
Previous GeneCards Identifiers for MYLK3 Gene
Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]
GeneCards Summary for MYLK3 Gene
MYLK3 (Myosin Light Chain Kinase 3) is a Protein Coding gene. Diseases associated with MYLK3 include Hypoplastic Right Heart Syndrome and Dilated Cardiomyopathy. Among its related pathways are Focal Adhesion and Apelin signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MYLK2.
UniProtKB/Swiss-Prot Summary for MYLK3 Gene
Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity).
Myosin Light Chain Kinases (MLCKs) are a group of protein serine/threonine kinases that are currently divided into two subtypes. MLCK1 is found in smooth muscle and phosphorylates myosin II regulatory light chains at Ser19. MLCK2 is located in the striated muscle.