Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYL7 Gene

Aliases for MYL7 Gene

  • Myosin Light Chain 7 2 3 5
  • Myosin, Light Polypeptide 7, Regulatory 2 3
  • Myosin, Light Chain 7, Regulatory 2 3
  • Myosin Regulatory Light Chain 7 3 4
  • Myosin Light Chain 2a 3 4
  • MLC-2a 3 4
  • MYLC2A 3 4
  • MLC2a 3 4
  • MYL2A 3 4
  • Myosin Regulatory Light Chain 2, Atrial Isoform 3

External Ids for MYL7 Gene

Previous GeneCards Identifiers for MYL7 Gene

  • GC00U912966
  • GC07M043919
  • GC07M043951
  • GC07M044144
  • GC07M044178
  • GC07M044063

Summaries for MYL7 Gene

GeneCards Summary for MYL7 Gene

MYL7 (Myosin Light Chain 7) is a Protein Coding gene. Diseases associated with MYL7 include Familial Atrial Fibrillation. Among its related pathways are ERK Signaling and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is MYL5.

Tocris Summary for MYL7 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.

Gene Wiki entry for MYL7 Gene

Additional gene information for MYL7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL7 Gene

Genomics for MYL7 Gene

GeneHancer (GH) Regulatory Elements for MYL7 Gene

Promoters and enhancers for MYL7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J044146 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 650.7 -4.2 -4179 0.2 ZNF263 SUZ12 MAX ZBTB33 EZH2 MYL7 DDX56 SNHG15 TMED4 POLM SNORA5C LOC105375258 GCK
GH07J044141 Promoter 0.5 EPDnew 650.7 +0.0 39 0.1 MYL7 RNA5SP230
GH07J044196 Enhancer 0.7 ENCODE 12.4 -55.2 -55169 0.2 CTCF IRF3 RAD21 RFX5 CC2D1A ARID2 SMC3 ZNF143 RCOR1 CREM GCK MYL7 POLD2 RNA5SP230 POLM AEBP1 LOC105375257
GH07J044162 Enhancer 0.7 ENCODE 12.2 -21.0 -21029 0.2 FOXA2 MAX CEBPG RAD21 YY1 EGR1 HNF4G RXRA CEBPB REST MYL7 RNA5SP230 POLD2 AEBP1 POLM ENSG00000239775 PGAM2 LOC105375257 LOC105375258 GCK
GH07J044163 Enhancer 0.7 ENCODE 12.2 -22.1 -22135 1.9 FOXA2 MAX RAD21 YY1 EGR1 HNF4G ZNF687 RXRA REST MNT MYL7 RNA5SP230 POLD2 AEBP1 ENSG00000239775 PGAM2 POLM URGCP LOC105375257 LOC105375258
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYL7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MYL7 gene promoter:
  • COUP-TF1
  • COUP
  • COUP-TF
  • HNF-4alpha2
  • HNF-4alpha1

Genomic Locations for MYL7 Gene

Genomic Locations for MYL7 Gene
chr7:44,138,864-44,141,388
(GRCh38/hg38)
Size:
2,525 bases
Orientation:
Minus strand
chr7:44,178,463-44,180,931
(GRCh37/hg19)
Size:
2,469 bases
Orientation:
Minus strand

Genomic View for MYL7 Gene

Genes around MYL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL7 Gene

Proteins for MYL7 Gene

  • Protein details for MYL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01449-MLRA_HUMAN
    Recommended name:
    Myosin regulatory light chain 2, atrial isoform
    Protein Accession:
    Q01449
    Secondary Accessions:
    • B2R4L3

    Protein attributes for MYL7 Gene

    Size:
    175 amino acids
    Molecular mass:
    19448 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains.
    Miscellaneous:
    • This chain binds calcium.

neXtProt entry for MYL7 Gene

Post-translational modifications for MYL7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYL7 Gene

Domains & Families for MYL7 Gene

Gene Families for MYL7 Gene

Protein Domains for MYL7 Gene

Suggested Antigen Peptide Sequences for MYL7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYL7: view

No data available for UniProtKB/Swiss-Prot for MYL7 Gene

Function for MYL7 Gene

Gene Ontology (GO) - Molecular Function for MYL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MYL7: view
genes like me logo Genes that share phenotypes with MYL7: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYL7 Gene

Localization for MYL7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYL7 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
mitochondrion 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MYL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016459 myosin complex NAS 1429676
GO:0031672 A band IDA 15621049
GO:0043197 dendritic spine IEA --
genes like me logo Genes that share ontologies with MYL7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MYL7 Gene

Pathways & Interactions for MYL7 Gene

genes like me logo Genes that share pathways with MYL7: view

Gene Ontology (GO) - Biological Process for MYL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS --
genes like me logo Genes that share ontologies with MYL7: view

No data available for SIGNOR curated interactions for MYL7 Gene

Drugs & Compounds for MYL7 Gene

(4) Drugs for MYL7 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
(R)-(+)-Blebbistatin Pharma non-muscle myosin II ATPases inhibitor, cell-permeable, Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 0
BTS Pharma Selective inhibitor of skeletal muscle myosin II ATPase activity 0
(±)-Blebbistatin Pharma non-muscle myosin II ATPases inhibitor, cell-permeable 0

(2) Additional Compounds for MYL7 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Blebbistatin
674289-55-5
(S)-(-)-Blebbistatin
856925-71-8

(4) Tocris Compounds for MYL7 Gene

Compound Action Cas Number
(+-)-Blebbistatin Selective inhibitor of myosin II ATPase activity 674289-55-5
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 1177356-70-5
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) 856925-71-8
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity 1576-37-0
genes like me logo Genes that share compounds with MYL7: view

Transcripts for MYL7 Gene

mRNA/cDNA for MYL7 Gene

Unigene Clusters for MYL7 Gene

Myosin, light chain 7, regulatory:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYL7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - - -
SP7: -
SP8: -

Relevant External Links for MYL7 Gene

GeneLoc Exon Structure for
MYL7
ECgene alternative splicing isoforms for
MYL7

Expression for MYL7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYL7 Gene

This gene is overexpressed in Heart - Atrial Appendage (x47.1) and Heart - Left Ventricle (x5.5).

Protein differential expression in normal tissues from HIPED for MYL7 Gene

This gene is overexpressed in Fetal heart (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MYL7 Gene



Protein tissue co-expression partners for MYL7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MYL7 Gene:

MYL7

SOURCE GeneReport for Unigene cluster for MYL7 Gene:

Hs.75636

mRNA Expression by UniProt/SwissProt for MYL7 Gene:

Q01449-MLRA_HUMAN
Tissue specificity: Predominantly expressed in adult atrial muscle.

Evidence on tissue expression from TISSUES for MYL7 Gene

  • Heart(5)
  • Pancreas(4.1)
  • Muscle(3.9)
genes like me logo Genes that share expression patterns with MYL7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MYL7 Gene

Orthologs for MYL7 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYL7 34 33
  • 99.43 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MYL7 34
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYL7 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYL7 34 33
  • 91.05 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myl7 33
  • 89.64 (n)
mouse
(Mus musculus)
Mammalia Myl7 16 34 33
  • 88.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYL7 34
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mylc2a-prov 33
zebrafish
(Danio rerio)
Actinopterygii myl7 34 33
  • 72.94 (n)
OneToOne
mylc2a 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9036 33
fruit fly
(Drosophila melanogaster)
Insecta Mlc2 34
  • 31 (a)
OneToMany
CG33098 34
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mlc-1 34
  • 42 (a)
OneToMany
mlc-2 34
  • 42 (a)
OneToMany
Species where no ortholog for MYL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MYL7 Gene

ENSEMBL:
Gene Tree for MYL7 (if available)
TreeFam:
Gene Tree for MYL7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYL7: view image

Paralogs for MYL7 Gene

Paralogs for MYL7 Gene

(12) SIMAP similar genes for MYL7 Gene using alignment to 8 proteins:

  • MLRA_HUMAN
  • C9JEG4_HUMAN
  • F8WD94_HUMAN
  • H7BZE4_HUMAN
  • H7C1B1_HUMAN
  • H7C243_HUMAN
  • H7C3E3_HUMAN
  • H7C482_HUMAN
genes like me logo Genes that share paralogs with MYL7: view

Variants for MYL7 Gene

Sequence variations from dbSNP and Humsavar for MYL7 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000570025 -- 44,139,921(-) G/A intron_variant
rs1000627529 -- 44,140,847(-) G/C coding_sequence_variant, intron_variant, missense_variant
rs1001330505 -- 44,138,773(-) G/A/T downstream_transcript_variant
rs1002572636 -- 44,142,591(-) A/T upstream_transcript_variant
rs1002800652 -- 44,142,421(-) T/C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MYL7 Gene

Variant ID Type Subtype PubMed ID
nsv428165 CNV gain 18775914
nsv470210 CNV loss 18288195
nsv8082 CNV gain 18304495
nsv830983 CNV loss 17160897
nsv951637 CNV deletion 24416366

Variation tolerance for MYL7 Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYL7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYL7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL7 Gene

Disorders for MYL7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYL7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
familial atrial fibrillation
  • atrial fibrillation, familial, 1
- elite association - COSMIC cancer census association via MalaCards
Search MYL7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MYL7

genes like me logo Genes that share disorders with MYL7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYL7 Gene

Publications for MYL7 Gene

  1. Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. (PMID: 8207020) Kubalak SW … Chien KR (The Journal of biological chemistry 1994) 2 3 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development. (PMID: 1429676) Hailstones D … Gunning P (The Journal of biological chemistry 1992) 3 4 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells. (PMID: 19794400) Zhong Y … Toborek M (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010) 3 58

Products for MYL7 Gene

Sources for MYL7 Gene

Content
Loading form....