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Aliases for MYL6B Gene

Aliases for MYL6B Gene

  • Myosin Light Chain 6B 2 3 4 5
  • Myosin, Light Polypeptide 6B, Alkali, Smooth Muscle And Non-Muscle 2 3
  • Myosin, Light Chain 6B, Alkali, Smooth Muscle And Non-Muscle 2 3
  • Smooth Muscle And Nonmuscle Myosin Light Chain Alkali 6B 3 4
  • Myosin Light Chain 1 Slow A 2 3
  • MLC1SA 3 4
  • Smooth Muscle And Non-Muscle Myosin Alkali Light Chain 6B 3
  • Myosin Light Chain 1, Slow-Twitch Muscle A Isoform 3
  • Myosin Light Chain 1 Slow-Twitch Muscle A Isoform 4
  • Myosin Alkali Light Chain 1 Slow A 3
  • MLC1sa 4

External Ids for MYL6B Gene

Previous GeneCards Identifiers for MYL6B Gene

  • GC12P054836
  • GC12P056546
  • GC12P053585

Summaries for MYL6B Gene

Entrez Gene Summary for MYL6B Gene

  • Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for MYL6B Gene

MYL6B (Myosin Light Chain 6B) is a Protein Coding gene. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and fMLP Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and structural constituent of muscle. An important paralog of this gene is MYL1.

UniProtKB/Swiss-Prot for MYL6B Gene

Gene Wiki entry for MYL6B Gene

Additional gene information for MYL6B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL6B Gene

Genomics for MYL6B Gene

GeneHancer (GH) Regulatory Elements for MYL6B Gene

Promoters and enhancers for MYL6B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J056150 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 600.7 +1.1 1062 4.9 SP1 ZNF652 ZFX SIX5 ZNF148 NKRF ZNF121 CEBPG GTF2F1 ZNF687 MYL6B PHC1P1 IKZF4 ENSG00000257740 PAN2 SMARCC2 ANKRD52 TMEM198B HSPD1P4 DNAJC14
GH12J056151 Enhancer 1 ENCODE dbSUPER 600.7 -1.5 -1514 0.2 NFIB ZSCAN21 NCOA3 SP7 PRDM1 ZNF331 ZNF221 ZNF300 ZEB2 ZNF629 MYL6B IKZF4 PHC1P1 ENSG00000257740 ANKRD52 SMARCC2 HSPD1P4 PAN2 NEMP1 TMEM198B
GH12J056124 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.1 -24.3 -24260 6.2 ZNF652 ZFX SP1 CC2D1A ELF3 CTCF MNT CBFA2T2 ZNF148 NKRF ENSG00000258317 ESYT1 BAZ2A NEMP1 SMARCC2 MYL6 RN7SL809P ZC3H10 ENSG00000258199 TMEM198B
GH12J056192 Enhancer 1.1 Ensembl ENCODE 18.8 +40.9 40932 1.2 CC2D1A CTCF MLLT1 NFRKB YY1 ZNF644 RAD21 KAT8 ZBTB8A ZNF600 GC12P056195 GC12P056196 MYL6B BAZ2A RNF41 NABP2 SLC39A5 MYL6 TRS-CGA4-1
GH12J056220 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 8.7 +70.6 70600 5.7 HDGF ZNF652 SP1 CC2D1A ZFX CTCF ELF3 MNT NKRF POLR2A NABP2 RNF41 NEMP1 BAZ2A PAN2 DNAJC14 ZBTB39 TMEM198B PHC1P1 ANKRD52
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYL6B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MYL6B gene promoter:
  • AREB6
  • ITF-2
  • MIF-1
  • Nkx2-5
  • Pax-2
  • Pax-2a
  • SRF
  • SRF (504 AA)
  • Tal-1beta
  • YY1

Genomic Locations for MYL6B Gene

Genomic Locations for MYL6B Gene
chr12:56,152,256-56,159,647
(GRCh38/hg38)
Size:
7,392 bases
Orientation:
Plus strand
chr12:56,546,040-56,553,431
(GRCh37/hg19)
Size:
7,392 bases
Orientation:
Plus strand

Genomic View for MYL6B Gene

Genes around MYL6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYL6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYL6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL6B Gene

Proteins for MYL6B Gene

  • Protein details for MYL6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14649-MYL6B_HUMAN
    Recommended name:
    Myosin light chain 6B
    Protein Accession:
    P14649

    Protein attributes for MYL6B Gene

    Size:
    208 amino acids
    Molecular mass:
    22764 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains.

    Three dimensional structures from OCA and Proteopedia for MYL6B Gene

neXtProt entry for MYL6B Gene

Post-translational modifications for MYL6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYL6B Gene

No data available for DME Specific Peptides for MYL6B Gene

Domains & Families for MYL6B Gene

Gene Families for MYL6B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MYL6B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYL6B Gene

GenScript: Design optimal peptide antigens:
  • Smooth muscle and nonmuscle myosin light chain alkali 6B (MYL6B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYL6B: view

No data available for UniProtKB/Swiss-Prot for MYL6B Gene

Function for MYL6B Gene

Molecular function for MYL6B Gene

UniProtKB/Swiss-Prot Function:
Regulatory light chain of myosin. Does not bind calcium.

Phenotypes From GWAS Catalog for MYL6B Gene

Gene Ontology (GO) - Molecular Function for MYL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity TAS 2304459
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15510214
GO:0008307 structural constituent of muscle TAS 2304459
genes like me logo Genes that share ontologies with MYL6B: view
genes like me logo Genes that share phenotypes with MYL6B: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for MYL6B - Now 50% OFF >
  • * MYL6B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * MYL6B tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYL6B Gene

Localization for MYL6B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYL6B gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005859 muscle myosin complex TAS 2458299
GO:0016459 myosin complex TAS 2304459
GO:0016461 unconventional myosin complex TAS 2304459
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with MYL6B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL6B Gene

Pathways & Interactions for MYL6B Gene

genes like me logo Genes that share pathways with MYL6B: view

SIGNOR curated interactions for MYL6B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MYL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 2304459
GO:0007519 skeletal muscle tissue development TAS 2304459
GO:0030049 muscle filament sliding TAS 2304459
genes like me logo Genes that share ontologies with MYL6B: view

Drugs & Compounds for MYL6B Gene

(2) Drugs for MYL6B Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7611
4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID Experimental Pharma Target 0
genes like me logo Genes that share compounds with MYL6B: view

Transcripts for MYL6B Gene

mRNA/cDNA for MYL6B Gene

Unigene Clusters for MYL6B Gene

Myosin, light chain 6B, alkali, smooth muscle and non-muscle:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for MYL6B - Now 50% OFF >
  • * MYL6B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * MYL6B tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for MYL6B Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8
SP1: - - -
SP2: -
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for MYL6B Gene

GeneLoc Exon Structure for
MYL6B
ECgene alternative splicing isoforms for
MYL6B

Expression for MYL6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYL6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYL6B Gene

This gene is overexpressed in Muscle - Skeletal (x9.1).

Protein differential expression in normal tissues from HIPED for MYL6B Gene

This gene is overexpressed in Neutrophil (12.6), Nasal epithelium (8.3), Blymphocyte (7.8), Esophagus (6.5), and Cervix (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYL6B Gene



NURSA nuclear receptor signaling pathways regulating expression of MYL6B Gene:

MYL6B

SOURCE GeneReport for Unigene cluster for MYL6B Gene:

Hs.632731

Evidence on tissue expression from TISSUES for MYL6B Gene

  • Muscle(4.4)
  • Nervous system(4.4)
  • Blood(2)
genes like me logo Genes that share expression patterns with MYL6B: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYL6B Gene

Orthologs for MYL6B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYL6B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYL6B 35 34
  • 99.52 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Myl6b 17 35 34
  • 88.57 (n)
dog
(Canis familiaris)
Mammalia MYL6B 35 34
  • 86.22 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1560334 34
  • 86.15 (n)
cow
(Bos Taurus)
Mammalia MYL6B 35 34
  • 84.78 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYL6B 35
  • 74 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii myl6 35
  • 66 (a)
ManyToMany
zgc:153867 35
  • 61 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Mlc-c 35
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mlc-5 35
  • 47 (a)
ManyToMany
mlc-6 35
  • 45 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MLC1 35
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.211 35
  • 53 (a)
ManyToMany
CSA.6678 35
  • 44 (a)
ManyToMany
CSA.4806 35
  • 44 (a)
ManyToMany
CSA.6288 35
  • 44 (a)
ManyToMany
Species where no ortholog for MYL6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MYL6B Gene

ENSEMBL:
Gene Tree for MYL6B (if available)
TreeFam:
Gene Tree for MYL6B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYL6B: view image

Paralogs for MYL6B Gene

Paralogs for MYL6B Gene

(11) SIMAP similar genes for MYL6B Gene using alignment to 3 proteins:

  • MYL6B_HUMAN
  • F8VSA2_HUMAN
  • F8W1I5_HUMAN

Pseudogenes.org Pseudogenes for MYL6B Gene

genes like me logo Genes that share paralogs with MYL6B: view

Variants for MYL6B Gene

Sequence variations from dbSNP and Humsavar for MYL6B Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000265933 -- 56,156,421(+) A/G intron_variant
rs1000893926 -- 56,151,448(+) C/A upstream_transcript_variant
rs1001177739 -- 56,156,252(+) G/A intron_variant
rs1001371958 -- 56,154,167(+) G/C/T intron_variant
rs1001775884 -- 56,156,048(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MYL6B Gene

Variant ID Type Subtype PubMed ID
dgv2648n54 CNV loss 21841781
nsv1051961 CNV gain 25217958
nsv559013 CNV loss 21841781

Variation tolerance for MYL6B Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYL6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYL6B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL6B Gene

Disorders for MYL6B Gene

Additional Disease Information for MYL6B

No disorders were found for MYL6B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYL6B Gene

Publications for MYL6B Gene

  1. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PMID: 2304459) Hailstones DL … Gunning PW (Molecular and cellular biology 1990) 2 3 4 23 58
  2. A novel isoform of myosin alkali light chain isolated from human muscle cells. (PMID: 2602161) Zimmermann K … Starzinski-Powitz A (Nucleic acids research 1989) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease. (PMID: 28902428) Brady GF … Omary MB (Hepatology (Baltimore, Md.) 2018) 3 58
  5. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3 58

Products for MYL6B Gene

Sources for MYL6B Gene

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