Aliases for MYL4 Gene
Aliases for MYL4 Gene
External Ids for MYL4 Gene
- HGNC: 7585
- Entrez Gene: 4635
- Ensembl: ENSG00000198336
- OMIM: 160770
- UniProtKB: P12829
Previous GeneCards Identifiers for MYL4 Gene
- GC17P044784
- GC17P047685
- GC17P045619
- GC17P045761
- GC17P042641
- GC17P045286
- GC17P040664
Summaries for MYL4 Gene
-
Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MYL4 Gene
MYL4 (Myosin Light Chain 4) is a Protein Coding gene. Diseases associated with MYL4 include Atrial Fibrillation, Familial, 18 and Familial Atrial Fibrillation. Among its related pathways are ERK Signaling and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. Gene Ontology (GO) annotations related to this gene include calcium ion binding and actin monomer binding. An important paralog of this gene is MYL3.
UniProtKB/Swiss-Prot for MYL4 Gene
-
Regulatory light chain of myosin. Does not bind calcium.
-
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.
Additional gene information for MYL4 Gene
- Monarch Initiative
- Search for MYL4 at DataMed
- Search for MYL4 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL4 Gene
Genomics for MYL4 Gene
GeneHancer (GH) Regulatory Elements for MYL4 Gene
Promoters and enhancers for MYL4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MYL4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MYL4 gene promoter:
-
- GATA-3
- RelA
- Zic3
- Zic1
- NF-kappaB
- NF-kappaB1
- NF-kappaB2
Regulatory Element Products
Genomic Locations for MYL4 Gene
Genomic Locations for MYL4 Gene
- chr17:47,200,446-47,227,697
- (GRCh38/hg38)
- Size:
- 27,252 bases
- Orientation:
- Plus strand
- chr17:45,277,812-45,301,045
- (GRCh37/hg19)
- Size:
- 23,234 bases
- Orientation:
- Plus strand
Genomic View for MYL4 Gene
Genes around MYL4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.32 by Entrez Gene
- 17q21.32 by HGNC
- 17q21.32 by Ensembl
MYL4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MYL4 Gene
Proteins for MYL4 Gene
-
Protein details for MYL4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P12829-MYL4_HUMAN
- Recommended name:
- Myosin light chain 4
- Protein Accession:
- P12829
- D3DXJ7
- P11783
Protein attributes for MYL4 Gene
- Size:
- 197 amino acids
- Molecular mass:
- 21565 Da
- Quaternary structure:
-
- Myosin is a hexamer of 2 heavy chains and 4 light chains.
Protein Expression for MYL4 Gene
Post-translational modifications for MYL4 Gene
Other Protein References for MYL4 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MYL4
- Novus Biologicals Antibodies for MYL4
-
Abcam antibodies for MYL4
- Invitrogen Antibodies for MYL4
- GeneTex MYL4 Antibody for MYL4
-
Boster Bio Antibodies for MYL4
-
Santa Cruz Biotechnology (SCBT) Antibodies for MYL4
Protein Products
-
OriGene Purified Proteins for MYL4
- Search Origene for MassSpec and Protein Over-expression Lysates for MYL4
- Origene Custom Protein Services for MYL4
- ProSpec Recombinant Proteins for MYL4
- Search GeneTex for Proteins for MYL4
-
Abcam proteins for MYL4
Assay Products
- antibodies-online: Search results for available MYL4 related products ranked by validation data
No data available for DME Specific Peptides for MYL4 Gene
Domains & Families for MYL4 Gene
Gene Families for MYL4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for MYL4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MYL4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for MYL4 Gene
Function for MYL4 Gene
Molecular function for MYL4 Gene
- UniProtKB/Swiss-Prot Function:
- Regulatory light chain of myosin. Does not bind calcium.
- GENATLAS Biochemistry:
- myosin,light polypeptide 4,alkali,atrial,skeletal,embryonic,same as MLC1-A & MLC1-EMB
Phenotypes From GWAS Catalog for MYL4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003785 | actin monomer binding | IDA | 9180271 |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0032038 | myosin II heavy chain binding | NAS | 16675844 |
| GO:0051015 | actin filament binding | IMP | 9738905 |
Phenotypes for MYL4 Gene
- MGI mutant phenotypes for MYL4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MYL4:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Reduced mammosphere formation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased NF-kappaB reporter expression
- Decreased IL-8 secretion
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for MYL4 Gene
- MGI Knock Outs for MYL4:
-
- Myl4 Myl4<tm1a(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MYL4
-
CRISPR Products
-
OriGene CRISPR knockouts for MYL4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MYL4
- genomics-online: gRNA clones - Search results for 99 available MYL4 gene related products
- Overview of 99 available MYL4 gene related products
- Applied Biological Materials CRISPR for MYL4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MYL4
- GenScript: Design CRISPR guide RNA sequences for MYL4
miRNA for MYL4 Gene
- miRTarBase miRNAs that target MYL4
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MYL4
- Browse OriGene Inhibitory RNA Products For MYL4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYL4
- genomics-online: shRNA clones - Search results for 99 available MYL4 gene related products
- Overview of 99 available MYL4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MYL4
- VectorBuilder custom plasmid, inducible vectors for MYL4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MYL4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MYL4
- Applied Biological Materials Clones for MYL4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MYL4 Gene
Localization for MYL4 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| cytoskeleton | 4 |
| nucleus | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0016459 | myosin complex | IEA | -- |
| GO:0031672 | A band | IMP | 14985854 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL4 Gene
Pathways & Interactions for MYL4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 2 | Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases | ||
| 3 | PAK Pathway |
.56
|
|
| 4 | Actin Nucleation by ARP-WASP Complex |
.35
|
|
| 5 | RhoGDI Pathway |
.33
|
|
Pathways by source for MYL4 Gene
2 BioSystems pathways for MYL4 Gene
2 Reactome pathways for MYL4 Gene
3 KEGG pathways for MYL4 Gene
8 GeneGo (Thomson Reuters) pathways for MYL4 Gene
16 Qiagen pathways for MYL4 Gene
Interacting Proteins for MYL4 Gene
GPS-Prot Interaction Network for MYL4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002026 | regulation of the force of heart contraction | IMP | 16675844 |
| GO:0030049 | muscle filament sliding | TAS | -- |
| GO:0032781 | positive regulation of ATPase activity | IMP | 9738905 |
| GO:0060048 | cardiac muscle contraction | IMP | 14985854 |
No data available for SIGNOR curated interactions for MYL4 Gene
Drugs & Compounds for MYL4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Approved | Nutra | 0 | |||
| (R)-(+)-Blebbistatin | Pharma | non-muscle myosin II ATPases inhibitor, cell-permeable, Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) | 0 | |||
| BTS | Pharma | Selective inhibitor of skeletal muscle myosin II ATPase activity | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (+-)-Blebbistatin |
|
674289-55-5 |
|
|
||
| (S)-(-)-Blebbistatin |
|
856925-71-8 |
|
|
(4) Tocris Compounds for MYL4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| (+-)-Blebbistatin | Selective inhibitor of myosin II ATPase activity | 674289-55-5 |
| (R)-(+)-Blebbistatin | Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) | 1177356-70-5 |
| (S)-(-)-Blebbistatin | Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) | 856925-71-8 |
| BTS | Selective inhibitor of skeletal muscle myosin II ATPase activity | 1576-37-0 |
Transcripts for MYL4 Gene
mRNA/cDNA for MYL4 Gene
- (6) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (127) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000571981 920 bps (uc060gnf.1)
- ENST00000572316 850 bps (uc060gng.1)
- ENST00000570772 582 bps (uc060gnh.1)
- ENST00000576874 641 bps (uc060gni.1)
- ENST00000536623 650 bps (uc060gnj.1)
Unigene Clusters for MYL4 Gene
- Myosin, light chain 4, alkali; atrial, embryonic:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MYL4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MYL4
- genomics-online: gRNA clones - Search results for 99 available MYL4 gene related products
- Overview of 99 available MYL4 gene related products
- Applied Biological Materials CRISPR for MYL4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MYL4
- GenScript: Design CRISPR guide RNA sequences for MYL4
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MYL4
- Browse OriGene Inhibitory RNA Products For MYL4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYL4
- genomics-online: shRNA clones - Search results for 99 available MYL4 gene related products
- Overview of 99 available MYL4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MYL4
- VectorBuilder custom plasmid, inducible vectors for MYL4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MYL4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MYL4
- Applied Biological Materials Clones for MYL4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||
| SP7: | - |
Expression for MYL4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Heart Tube Cells Heart Tube
- Primitive Heart Tube Cells Primitive Heart Tube
- Cardiomyocytes Right Ventricle
- Cardiomyocytes Left Atrium
- Cardiac Fibroblasts Myocardium
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Autopod
- Zeugopod
- Bone (Muscoskeletal System)
- NULL (Uncategorized)
-
Skeletal Muscle (Muscoskeletal System)
- Multinuclear Myocyte Extraocular Muscles
-
Blood (Hematopoietic System)
- Erythroblasts Hematopoietic Bone Marrow
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Gut Tube (Gastrointestinal Tract)
- Neural Crest (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
- Endoderm (Gastrulation Derivatives)
-
Spleen (Hematopoietic System)
-
Lung (Respiratory System)
-
Dermis (Integumentary System)
mRNA differential expression in normal tissues according to GTEx for MYL4 Gene
This gene is overexpressed in Heart - Atrial Appendage (x49.6).
This gene is overexpressed in Fetal heart (39.6), Prostate (15.3), and Heart (9.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYL4 Gene
NURSA nuclear receptor signaling pathways regulating expression of MYL4 Gene:
MYL4SOURCE GeneReport for Unigene cluster for MYL4 Gene:
Hs.463300Evidence on tissue expression from TISSUES for MYL4 Gene
- Muscle(4.7)
- Blood(4.1)
- Pancreas(4)
- Spleen(4)
- Heart(3.4)
Primer Products
-
OriGene qPCR primer pairs and template standards for MYL4
-
OriGene qPCR primer pairs for MYL4
- genomics-online: primer clones - Search results for 99 available MYL4 gene related products
- Overview of 99 available MYL4 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYL4 Gene
Orthologs for MYL4 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MYL4 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MYL4 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MYL4 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MYL4 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Myl4 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Myl4 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MYL4 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MYL4 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MYL4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | myl4 33 |
|
||
| Str.7898 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | cmlc1 34 |
|
OneToMany | |
| myl4 34 33 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7231 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Mlc-c 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | mlc-5 34 |
|
ManyToMany | |
| mlc-6 34 |
|
ManyToMany | |||
| T12D8.6 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MLC1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.211 34 |
|
ManyToMany | |
| CSA.6288 34 |
|
ManyToMany | |||
| CSA.6678 34 |
|
ManyToMany | |||
| CSA.4806 34 |
|
ManyToMany |
- Species where no ortholog for MYL4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for MYL4 Gene
- ENSEMBL:
- Gene Tree for MYL4 (if available)
- TreeFam:
- Gene Tree for MYL4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MYL4: view image
Paralogs for MYL4 Gene
(11) SIMAP similar genes for MYL4 Gene using alignment to 6 proteins:
- MYL4_HUMAN
- I3L1K6_HUMAN
- I3L1R3_HUMAN
- I3L3U1_HUMAN
- I3L4B1_HUMAN
- I3L532_HUMAN
Variants for MYL4 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs114024716 | benign, Atrial fibrillation, familial, 18 | 47,221,678(+) | G/A | intron_variant | |
| rs143234546 | benign, Atrial fibrillation, familial, 18 | 47,213,813(+) | C/T | coding_sequence_variant, synonymous_variant | |
| rs144870368 | likely-benign, Atrial fibrillation, familial, 18 | 47,219,907(+) | T/C | coding_sequence_variant, missense_variant | |
| rs146859926 | benign, Atrial fibrillation, familial, 18 | 47,222,376(+) | G/A | intron_variant | |
| rs150593274 | likely-benign, Atrial fibrillation, familial, 18 | 47,221,773(+) | C/A/T | coding_sequence_variant, missense_variant, synonymous_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1146669 | OTHER | inversion | 26484159 |
Residual Variation Intolerance Score:
66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.63;
31.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MYL4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL4 Gene
Disorders for MYL4 Gene
(4) MalaCards diseases for MYL4 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| atrial fibrillation, familial, 18 |
|
|
| familial atrial fibrillation |
|
|
| atrial fibrillation |
|
|
| aortic valve disease 2 |
|
Search MYL4 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MYL4_HUMAN- Atrial fibrillation, familial, 18 (ATFB18) [MIM:617280]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO:0000269 PubMed:27066836}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for MYL4
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for MYL4 Gene
Publications for MYL4 Gene
- Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones. (PMID: 3417683) Kurabayashi M … Yazaki Y (The Journal of biological chemistry 1988) 2 3 4 58
- A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. (PMID: 27066836) Orr N … Gollob MH (Nature communications 2016) 3 4 58
- Human atrial myosin light chain 1 expression attenuates heart failure. (PMID: 16106982) Abdelaziz AI … Morano I (Advances in experimental medicine and biology 2005) 3 22 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Functional characterization of the human atrial essential myosin light chain (hALC-1) in a transgenic rat model. (PMID: 14985854) Abdelaziz AI … Morano I (Journal of molecular medicine (Berlin, Germany) 2004) 3 22 58
Products for MYL4 Gene
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MYL4
- Sino Biological Human cDNA Clone for MYL4
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MYL4
- Novus Biologicals proteins and lysates for MYL4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MYL4
- Abcam proteins for MYL4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for MYL4
- ESI BIO PureStem Z11, Meso Progenitor for MYL4
- Cyagen custom Knockout/knockin (KOKI) mouse models for MYL4
- VectorBuilder custom plasmid, inducible vectors for MYL4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MYL4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 79 available MYL4 Antibodies ranked by validation data
- Compare Top MYL4 Antibodies
- antibodies-online: Search results for available MYL4 related products ranked by validation data
- antibodies-online: Search results for 12 available MYL4 Proteins ranked by validation data
- Compare Top MYL4 Proteins
- GeneTex MYL4 Antibody for MYL4
- Search GeneTex for Proteins for MYL4
- Santa Cruz Biotechnology (SCBT) Antibodies for MYL4
- Search Santa Cruz Biotechnology (SCBT) for MYL4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MYL4
- Horizon Cell Lines for MYL4
- genomics-online: cdna clones - Search results for 99 available MYL4 gene related products
- Overview of 99 available MYL4 gene related products
- orf clones - Search results for 99 available MYL4 gene related products
- Overview of 99 available MYL4 gene related products
- genomics-online: gRNA clones - Search results for 99 available MYL4 gene related products
- Overview of 99 available MYL4 gene related products
- genomics-online: primer clones - Search results for 99 available MYL4 gene related products
- Overview of 99 available MYL4 gene related products
- genomics-online: shRNA clones - Search results for 99 available MYL4 gene related products
- Overview of 99 available MYL4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MYL4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MYL4
- GeneCopoeia miRNA 3'UTR Target clone products for MYL4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYL4
- Boster Bio Antibodies for MYL4
- Browse Boster Bio ELISA Kits
Sources for MYL4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt