Aliases for MYL12A Gene
- Myosin Light Chain 12A 2 3 5
- MRLC3 2 3 4
- MLCB 2 3 4
- Myosin, Light Polypeptide, Regulatory, Non-Sarcomeric (20kD) 2 3
- Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric 2 3
- Myosin Regulatory Light Chain 2, Nonsarcomeric 3 4
- Myosin Regulatory Light Chain MRLC3 3 4
- Epididymis Secretory Protein Li 24 3 4
This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]
GeneCards Summary for MYL12A Gene
MYL12A (Myosin Light Chain 12A) is a Protein Coding gene. Diseases associated with MYL12A include Cardiomyopathy, Familial Hypertrophic, 1 and Primary Cutaneous Amyloidosis. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include calcium ion binding and glutamate receptor binding. An important paralog of this gene is MYL12B.
UniProtKB/Swiss-Prot Summary for MYL12A Gene
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).