Aliases for MYL10 Gene

Aliases for MYL10 Gene

  • Myosin Light Chain 10 2 3 5
  • MYLC2PL 2 3 4
  • PLRLC 2 3 4
  • Precursor Lymphocyte-Specific Regulatory Light Chain 3 4
  • Myosin Light Chain 2, Lymphocyte-Specific 3 4
  • Myosin, Light Chain 10, Regulatory 2 3
  • Myosin Regulatory Light Chain 10 3 4
  • Myosin Light Chain 2, Precursor Lymphocyte-Specific 3
  • MGC3479 2
  • MYL10 5

External Ids for MYL10 Gene

Previous GeneCards Identifiers for MYL10 Gene

  • GC07M101044
  • GC07M101256
  • GC07M095845

Summaries for MYL10 Gene

GeneCards Summary for MYL10 Gene

MYL10 (Myosin Light Chain 10) is a Protein Coding gene. Diseases associated with MYL10 include Primary Cutaneous Amyloidosis and Myopathy, Centronuclear, 2. Among its related pathways are Cardiac conduction and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is MYL2.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYL10 Gene

Genomics for MYL10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MYL10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J101630 Enhancer 0.6 Ensembl ENCODE 250.7 -1.7 -1705 2.4 SCRT1 NR2C1 RFX1 NR2F2 SCRT2 MYL10 piR-41141-032 CUX1 ENSG00000252824 POLR2J AP1S1 FIS1 RF00017-5985 L13304-033
GH07J101627 Enhancer 0.4 ENCODE 250.7 +0.7 705 2.3 EGR2 ZFHX2 ZNF121 MYL10 piR-41141-032 POLR2J RF00017-5984 L13304-033 COL26A1
GH07J101624 Enhancer 1 Ensembl ENCODE CraniofacialAtlas 0.7 +3.7 3736 2.9 ZNF513 SMAD4 RARA YY1 TAF1 EGR1 NR2F6 ZFP36 ZFP3 RAD21 POLR2J AP1S1 MYL10 RF00017-5984 L13304-033 COL26A1
GH07J101602 Enhancer 1.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas 0.3 +26.5 26495 1.2 MYC ZNF654 ZNF10 ZBTB10 CTCF REST TRIM22 BHLHE40 ZNF341 SMAD4 SH2B2 MOGAT3 RF00017-5984 MYL10 L13304-033 COL26A1 RF00017-5977
GH07J101632 Enhancer 0.5 ENCODE 0.7 -4.4 -4376 1.7 YY1 CREB1 TRIM28 CBX3 KDM1A RF00017-5985 POLR2J MYL10 piR-41141-032 L13304-033 CUX1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYL10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYL10

Top Transcription factor binding sites by QIAGEN in the MYL10 gene promoter:
  • AML1a
  • Cdc5
  • HSF2
  • NF-1
  • Pax-4a
  • POU3F2
  • RSRFC4
  • S8
  • Spz1
  • TBP

Genomic Locations for MYL10 Gene

Latest Assembly
15,967 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
15,967 bases
Minus strand

(GRCh37/hg19 by Ensembl)
15,972 bases
Minus strand

Genomic View for MYL10 Gene

Genes around MYL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL10 Gene

Proteins for MYL10 Gene

  • Protein details for MYL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myosin regulatory light chain 10
    Protein Accession:

    Protein attributes for MYL10 Gene

    226 amino acids
    Molecular mass:
    25308 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains.
    • This chain binds calcium.

neXtProt entry for MYL10 Gene

Post-translational modifications for MYL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYL10 Gene

No data available for DME Specific Peptides for MYL10 Gene

Domains & Families for MYL10 Gene

Gene Families for MYL10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MYL10 Gene

Suggested Antigen Peptide Sequences for MYL10 Gene

GenScript: Design optimal peptide antigens:
  • Precursor lymphocyte-specific regulatory light chain (MYL10_HUMAN)
genes like me logo Genes that share domains with MYL10: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MYL10 Gene

Function for MYL10 Gene

Phenotypes From GWAS Catalog for MYL10 Gene

Gene Ontology (GO) - Molecular Function for MYL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 32296183
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MYL10: view
genes like me logo Genes that share phenotypes with MYL10: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYL10

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYL10 Gene

Localization for MYL10 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYL10 gene
Compartment Confidence
mitochondrion 5
cytosol 4
cytoskeleton 3
plasma membrane 2
extracellular 2
nucleus 2
endoplasmic reticulum 2
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MYL10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL10 Gene

Pathways & Interactions for MYL10 Gene

genes like me logo Genes that share pathways with MYL10: view

Pathways by source for MYL10 Gene

Gene Ontology (GO) - Biological Process for MYL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS --
genes like me logo Genes that share ontologies with MYL10: view

No data available for SIGNOR curated interactions for MYL10 Gene

Drugs & Compounds for MYL10 Gene

(1) Drugs for MYL10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6959
genes like me logo Genes that share compounds with MYL10: view

Transcripts for MYL10 Gene

mRNA/cDNA for MYL10 Gene

1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYL10

Alternative Splicing Database (ASD) splice patterns (SP) for MYL10 Gene

No ASD Table

Relevant External Links for MYL10 Gene

GeneLoc Exon Structure for

Expression for MYL10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYL10 Gene

mRNA differential expression in normal tissues according to GTEx for MYL10 Gene

This gene is overexpressed in Muscle - Skeletal (x22.9) and Pituitary (x14.4).

Protein differential expression in normal tissues from HIPED for MYL10 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MYL10 Gene

Protein tissue co-expression partners for MYL10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYL10

SOURCE GeneReport for Unigene cluster for MYL10 Gene:


Evidence on tissue expression from TISSUES for MYL10 Gene

  • Skin(4.3)
  • Muscle(2.9)
  • Heart(2.5)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with MYL10: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYL10 Gene

Orthologs for MYL10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYL10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MYL10 29 30
  • 99.26 (n)
(Bos Taurus)
Mammalia MYL10 29 30
  • 90.08 (n)
(Canis familiaris)
Mammalia MYL10 29 30
  • 89.76 (n)
(Mus musculus)
Mammalia Myl10 29 16 30
  • 88.44 (n)
(Monodelphis domestica)
Mammalia MYL10 30
  • 83 (a)
(Rattus norvegicus)
Mammalia Myl10 29
  • 79.44 (n)
(Ornithorhynchus anatinus)
Mammalia MYL10 30
  • 73 (a)
(Gallus gallus)
Aves MYL2 30
  • 85 (a)
MYL10 29
  • 77.03 (n)
(Anolis carolinensis)
Reptilia MYL10 30
  • 80 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia myl10 29
  • 75.76 (n)
(Danio rerio)
Actinopterygii myl10 29 30
  • 75.61 (n)
idibd2025 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11077 30
  • 59 (a)
CSA.10194 30
  • 57 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.2633 29
Species where no ortholog for MYL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MYL10 Gene

Gene Tree for MYL10 (if available)
Gene Tree for MYL10 (if available)
Evolutionary constrained regions (ECRs) for MYL10: view image
Alliance of Genome Resources:
Additional Orthologs for MYL10

Paralogs for MYL10 Gene

Paralogs for MYL10 Gene

(15) SIMAP similar genes for MYL10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MYL10: view

Variants for MYL10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYL10 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs141873317 Not Provided: not provided 101,613,679(-) G/A
NM_138403.5(MYL10):c.565C>T (p.Arg189Cys)
rs12216595 -- p.Met46Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MYL10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MYL10 Gene

Variant ID Type Subtype PubMed ID
nsv1161591 CNV deletion 26073780
nsv831078 CNV loss 17160897

Variation tolerance for MYL10 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYL10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL10 Gene

Disorders for MYL10 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MYL10 Gene - From: COP

Disorder Aliases PubMed IDs
primary cutaneous amyloidosis
  • familial primary localized cutaneous amyloidosis
myopathy, centronuclear, 2
  • cnm2
cardiomyopathy, familial hypertrophic, 1
  • cmh1
- elite association - COSMIC cancer census association via MalaCards
Search MYL10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MYL10

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MYL10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYL10 Gene

Publications for MYL10 Gene

  1. A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. (PMID: 1628631) Oltz EM … Alt FW (The EMBO journal 1992) 2 3 22
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 40
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for MYL10 Gene

Sources for MYL10 Gene