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Aliases for MYL10 Gene

Aliases for MYL10 Gene

  • Myosin Light Chain 10 2 3 5
  • Precursor Lymphocyte-Specific Regulatory Light Chain 3 4
  • Myosin Light Chain 2, Lymphocyte-Specific 3 4
  • Myosin, Light Chain 10, Regulatory 2 3
  • MYLC2PL 3 4
  • PLRLC 3 4
  • Myosin Light Chain 2, Precursor Lymphocyte-Specific 3
  • Myosin Regulatory Light Chain 10 3

External Ids for MYL10 Gene

Previous GeneCards Identifiers for MYL10 Gene

  • GC07M101044
  • GC07M101256
  • GC07M095845

Summaries for MYL10 Gene

GeneCards Summary for MYL10 Gene

MYL10 (Myosin Light Chain 10) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Smooth Muscle Contraction. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is MYL2.

Additional gene information for MYL10 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYL10 Gene

Genomics for MYL10 Gene

GeneHancer (GH) Regulatory Elements for MYL10 Gene

Promoters and enhancers for MYL10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I101627 Enhancer 0.5 ENCODE 550.8 +0.7 705 2.3 ZNF121 ZFHX2 POLR2A EGR2 MYL10 POLR2J GC07P101590
GH07I101630 Enhancer 0.2 ENCODE 550.8 -1.5 -1520 0.1 MYL10 ENSG00000252824 FIS1 GC07M101683
GH07I101631 Enhancer 0.2 ENCODE 550.8 -1.6 -1612 0 MYL10 ENSG00000252824 GC07M101683
GH07I101624 Enhancer 0.6 ENCODE 0.8 +4.6 4638 0.9 ZNF335 ZFHX2 ZFP3 ZNF493 ZFP36 CTBP2 REST EGR2 ENSG00000239486 PRKRIP1 MYL10 GC07P101590
GH07I101602 Enhancer 1.2 FANTOM5 Ensembl ENCODE 0.3 +26.7 26695 0.4 ATF1 RB1 ARID4B ZNF48 RAD21 SLC30A9 ZNF213 ZNF143 RCOR1 ATF7 SH2B2 MOGAT3 GC07P101590 MYL10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MYL10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MYL10 gene promoter:

Genomic Locations for MYL10 Gene

Genomic Locations for MYL10 Gene
15,972 bases
Minus strand

Genomic View for MYL10 Gene

Genes around MYL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYL10 Gene

Proteins for MYL10 Gene

  • Protein details for MYL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myosin regulatory light chain 10
    Protein Accession:

    Protein attributes for MYL10 Gene

    226 amino acids
    Molecular mass:
    25308 Da
    Quaternary structure:
    • Myosin is a hexamer of 2 heavy chains and 4 light chains.
    • This chain binds calcium.

neXtProt entry for MYL10 Gene

Post-translational modifications for MYL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYL10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYL10 Gene

Domains & Families for MYL10 Gene

Gene Families for MYL10 Gene

Protein Domains for MYL10 Gene

Suggested Antigen Peptide Sequences for MYL10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYL10: view

No data available for UniProtKB/Swiss-Prot for MYL10 Gene

Function for MYL10 Gene

Phenotypes From GWAS Catalog for MYL10 Gene

Gene Ontology (GO) - Molecular Function for MYL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MYL10: view
genes like me logo Genes that share phenotypes with MYL10: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYL10 Gene

Localization for MYL10 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYL10 gene
Compartment Confidence
mitochondrion 5
cytosol 5
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MYL10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MYL10 Gene

Pathways & Interactions for MYL10 Gene

genes like me logo Genes that share pathways with MYL10: view

Pathways by source for MYL10 Gene

Gene Ontology (GO) - Biological Process for MYL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS --
genes like me logo Genes that share ontologies with MYL10: view

No data available for SIGNOR curated interactions for MYL10 Gene

Drugs & Compounds for MYL10 Gene

(1) Drugs for MYL10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with MYL10: view

Transcripts for MYL10 Gene

mRNA/cDNA for MYL10 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYL10 Gene

Myosin, light chain 10, regulatory:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYL10 Gene

No ASD Table

Relevant External Links for MYL10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYL10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYL10 Gene

mRNA differential expression in normal tissues according to GTEx for MYL10 Gene

This gene is overexpressed in Muscle - Skeletal (x22.9) and Pituitary (x14.4).

Protein differential expression in normal tissues from HIPED for MYL10 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYL10 Gene

Protein tissue co-expression partners for MYL10 Gene

NURSA nuclear receptor signaling pathways regulating expression of MYL10 Gene:


SOURCE GeneReport for Unigene cluster for MYL10 Gene:


Evidence on tissue expression from TISSUES for MYL10 Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with MYL10: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYL10 Gene

Orthologs for MYL10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYL10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MYL10 33 34
  • 99.26 (n)
(Bos Taurus)
Mammalia MYL10 33 34
  • 90.08 (n)
(Canis familiaris)
Mammalia MYL10 33 34
  • 89.76 (n)
(Mus musculus)
Mammalia Myl10 16 34 33
  • 88.44 (n)
(Monodelphis domestica)
Mammalia MYL10 34
  • 83 (a)
(Rattus norvegicus)
Mammalia Myl10 33
  • 79.44 (n)
(Ornithorhynchus anatinus)
Mammalia MYL10 34
  • 73 (a)
(Gallus gallus)
Aves MYL2 34
  • 85 (a)
MYL10 33
  • 77.03 (n)
(Anolis carolinensis)
Reptilia MYL10 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia myl10 33
  • 75.76 (n)
(Danio rerio)
Actinopterygii myl10 33 34
  • 75.61 (n)
idibd2025 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11077 34
  • 59 (a)
CSA.10194 34
  • 57 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2633 33
Species where no ortholog for MYL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYL10 Gene

Gene Tree for MYL10 (if available)
Gene Tree for MYL10 (if available)

Paralogs for MYL10 Gene

Paralogs for MYL10 Gene

(15) SIMAP similar genes for MYL10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MYL10: view

Variants for MYL10 Gene

Sequence variations from dbSNP and Humsavar for MYL10 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000192276 -- 101,626,330(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000304101 -- 101,614,663(-) G/A intron_variant
rs1000307995 -- 101,629,835(-) G/A upstream_transcript_variant
rs1000319216 -- 101,621,587(-) T/G intron_variant
rs1000445194 -- 101,630,019(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MYL10 Gene

Variant ID Type Subtype PubMed ID
nsv1161591 CNV deletion 26073780
nsv831078 CNV loss 17160897

Variation tolerance for MYL10 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYL10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYL10 Gene

Disorders for MYL10 Gene

Additional Disease Information for MYL10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MYL10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYL10 Gene

Publications for MYL10 Gene

  1. A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. (PMID: 1628631) Oltz EM … Alt FW (The EMBO journal 1992) 2 3 22 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. (PMID: 24528284) Ji Y … Weinshilboum RM (British journal of clinical pharmacology 2014) 3 58

Products for MYL10 Gene

Sources for MYL10 Gene

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