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Aliases for MYH16 Gene

Aliases for MYH16 Gene

  • Myosin Heavy Chain 16 Pseudogene 2 3 4 5
  • Myosin, Heavy Polypeptide 16 2 3
  • Myosin Heavy Polypeptide 5 3 4
  • Myosin, Heavy Chain 16 2 3
  • Sarcomeric Myosin 2 3
  • MYH5 3 4
  • Myosin, Heavy Polypeptide 5 2
  • MYH16P 3
  • MHC20 3

External Ids for MYH16 Gene

Previous HGNC Symbols for MYH16 Gene

  • MYH5

Previous GeneCards Identifiers for MYH16 Gene

  • GC07U901194
  • GC07P098448
  • GC07P098516
  • GC07P098708
  • GC07P098870
  • GC07P093506

Summaries for MYH16 Gene

Entrez Gene Summary for MYH16 Gene

  • The MYH16 gene, encoding a sarcomeric myosin heavy chain expressed in nonhuman primate masticatory muscles, is inactivated in humans. Stedman et al. (2004) [PubMed 15042088] hypothesized that the decrement in masticatory muscle size caused by the inactivation of MYH16 removed an evolutionary constraint on encephalization in early man.[supplied by OMIM, Mar 2008]

GeneCards Summary for MYH16 Gene

MYH16 (Myosin Heavy Chain 16 Pseudogene) is a Pseudogene. Diseases associated with MYH16 include Myosin, Heavy Chain 16, Skeletal Muscle, Pseudogene. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Immune response CCR3 signaling in eosinophils.

UniProtKB/Swiss-Prot for MYH16 Gene

  • Has most probably lost the function in masticatory muscles contraction suspected for its homologs in dog (AC F1PT61) and apes.

Tocris Summary for MYH16 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.

Additional gene information for MYH16 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYH16 Gene

Genomics for MYH16 Gene

GeneHancer (GH) Regulatory Elements for MYH16 Gene

Promoters and enhancers for MYH16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I099223 Enhancer 1.4 Ensembl ENCODE dbSUPER 0.4 -13.9 -13885 1.9 PKNOX1 ATF1 ARNT YBX1 GTF3C2 TCF12 CBX5 ATF7 FOS TSHZ1 ZSCAN25 TRIM4 SMURF1 ZNF655 ZNF3 TRRAP PTCD1 LOC101927550 LOC100419643 ENSG00000242798
GH07I099272 Enhancer 1.1 Ensembl ENCODE 0.3 +35.0 35047 2.3 CLOCK ZNF121 ARID2 ZNF207 FOS ATF7 ZNF263 REST KAT8 SNIP1 ZSCAN25 ZNF655 TRIM4 PTCD1 LOC101927550 ZNF3 TRRAP LOC100419643 ZNF394 AP4M1
GH07I099266 Enhancer 0.9 Ensembl ENCODE 0.3 +29.1 29092 2.5 ELF3 SOX13 ZNF792 SAP130 ARID4B EBF1 RAD21 THRB ZSCAN9 RARA SMURF1 MYH16 GC07P099242 LOC105375421
GH07I099219 Enhancer 0.5 ENCODE 0.4 -19.3 -19296 0.2 SOX13 ZNF121 FOXA2 SP5 SMAD4 NR2F6 KPNA7 SMURF1 MYH16
GH07I099244 Enhancer 0.3 ENCODE 0.4 +6.3 6330 1 ATF2 GC07P099242 MYH16 LOC105375421
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MYH16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MYH16 gene promoter:

Genomic Locations for MYH16 Gene

Genomic Locations for MYH16 Gene
chr7:99,238,829-99,311,130
(GRCh38/hg38)
Size:
72,302 bases
Orientation:
Plus strand
chr7:98,836,417-98,908,753
(GRCh37/hg19)

Genomic View for MYH16 Gene

Genes around MYH16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYH16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYH16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYH16 Gene

Proteins for MYH16 Gene

  • Protein details for MYH16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6N6-MYH16_HUMAN
    Recommended name:
    Putative uncharacterized protein MYH16
    Protein Accession:
    Q9H6N6

    Protein attributes for MYH16 Gene

    Size:
    1097 amino acids
    Molecular mass:
    128290 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15219.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for MYH16 Gene

Post-translational modifications for MYH16 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MYH16 Gene

Domains & Families for MYH16 Gene

Gene Families for MYH16 Gene

Protein Domains for MYH16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYH16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6N6

UniProtKB/Swiss-Prot:

MYH16_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYH16: view

Function for MYH16 Gene

Molecular function for MYH16 Gene

UniProtKB/Swiss-Prot Function:
Has most probably lost the function in masticatory muscles contraction suspected for its homologs in dog (AC F1PT61) and apes.

Gene Ontology (GO) - Molecular Function for MYH16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
genes like me logo Genes that share ontologies with MYH16: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYH16 Gene

Localization for MYH16 Gene

Gene Ontology (GO) - Cellular Components for MYH16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016459 myosin complex IEA --
genes like me logo Genes that share ontologies with MYH16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MYH16 Gene

Drugs & Compounds for MYH16 Gene

(2) Drugs for MYH16 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(R)-(+)-Blebbistatin Pharma non-muscle myosin II ATPases inhibitor, cell-permeable, Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 0
BTS Pharma Selective inhibitor of skeletal muscle myosin II ATPase activity 0

(2) Additional Compounds for MYH16 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Blebbistatin
674289-55-5
(S)-(-)-Blebbistatin
856925-71-8

(4) Tocris Compounds for MYH16 Gene

Compound Action Cas Number
(+-)-Blebbistatin Selective inhibitor of myosin II ATPase activity 674289-55-5
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 1177356-70-5
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) 856925-71-8
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity 1576-37-0
genes like me logo Genes that share compounds with MYH16: view

Transcripts for MYH16 Gene

mRNA/cDNA for MYH16 Gene

(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MYH16 Gene

No ASD Table

Relevant External Links for MYH16 Gene

GeneLoc Exon Structure for
MYH16
ECgene alternative splicing isoforms for
MYH16

Expression for MYH16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYH16 Gene

mRNA differential expression in normal tissues according to GTEx for MYH16 Gene

This gene is overexpressed in Testis (x24.2).

NURSA nuclear receptor signaling pathways regulating expression of MYH16 Gene:

MYH16

SOURCE GeneReport for Unigene cluster for MYH16 Gene:

Hs.621401

mRNA Expression by UniProt/SwissProt for MYH16 Gene:

Q9H6N6-MYH16_HUMAN
Tissue specificity: Specifically expressed in muscles of the head including temporalis and tensor veli palatini.
genes like me logo Genes that share expression patterns with MYH16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYH16 Gene

Orthologs for MYH16 Gene

Evolution for MYH16 Gene

ENSEMBL:
Gene Tree for MYH16 (if available)
TreeFam:
Gene Tree for MYH16 (if available)

No data available for Orthologs for MYH16 Gene

Paralogs for MYH16 Gene

(14) SIMAP similar genes for MYH16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MYH16: view

No data available for Paralogs for MYH16 Gene

Variants for MYH16 Gene

Sequence variations from dbSNP and Humsavar for MYH16 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000064394 -- 99,280,210(+) T/A intron_variant
rs1000119389 -- 99,273,267(+) C/A upstream_transcript_variant
rs1000255920 -- 99,273,391(+) C/T non_coding_transcript_variant
rs1000305937 -- 99,287,244(+) A/G intron_variant
rs1000480329 -- 99,279,144(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MYH16 Gene

Variant ID Type Subtype PubMed ID
nsv831068 CNV loss 17160897
esv3614275 CNV loss 21293372
esv3572019 CNV loss 25503493
esv2661738 CNV deletion 23128226

Additional Variant Information for MYH16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYH16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MYH16 Gene

Disorders for MYH16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYH16 Gene - From: OMIM

Disorder Aliases PubMed IDs
myosin, heavy chain 16, skeletal muscle, pseudogene
  • myh16
- elite association - COSMIC cancer census association via MalaCards
Search MYH16 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MYH16

genes like me logo Genes that share disorders with MYH16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYH16 Gene

Publications for MYH16 Gene

  1. Comparative analyses reveal a complex history of molecular evolution for human MYH16. (PMID: 15470226) Perry GH … Stone AC (Molecular biology and evolution 2005) 3 22 58
  2. Evolution of sarcomeric myosin heavy chain genes: evidence from fish. (PMID: 15014174) McGuigan K … Postlethwait JH (Molecular biology and evolution 2004) 2 3 58
  3. Myosin gene mutation correlates with anatomical changes in the human lineage. (PMID: 15042088) Stedman HH … Mitchell MA (Nature 2004) 3 4 58
  4. Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family. (PMID: 11919279) Desjardins PR … Stedman HH (Molecular biology and evolution 2002) 2 3 58
  5. Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. (PMID: 24550385) Abu-Odeh M … Aqeilan RI (The Journal of biological chemistry 2014) 3 58

Products for MYH16 Gene

Sources for MYH16 Gene

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