Aliases for MYH16 Gene
External Ids for MYH16 Gene
Previous HGNC Symbols for MYH16 Gene
Previous GeneCards Identifiers for MYH16 Gene
The MYH16 gene, encoding a sarcomeric myosin heavy chain expressed in nonhuman primate masticatory muscles, is inactivated in humans. Stedman et al. (2004) [PubMed 15042088] hypothesized that the decrement in masticatory muscle size caused by the inactivation of MYH16 removed an evolutionary constraint on encephalization in early man.[supplied by OMIM, Mar 2008]
GeneCards Summary for MYH16 Gene
MYH16 (Myosin Heavy Chain 16 Pseudogene) is a Pseudogene. Diseases associated with MYH16 include Myosin, Heavy Chain 16, Skeletal Muscle, Pseudogene. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Immune response CCR3 signaling in eosinophils.
UniProtKB/Swiss-Prot for MYH16 Gene
Has most probably lost the function in masticatory muscles contraction suspected for its homologs in dog (AC F1PT61) and apes.
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.