Aliases for MYH15 Gene

Aliases for MYH15 Gene

  • Myosin Heavy Chain 15 2 3 4 5
  • Myosin, Heavy Polypeptide 15 2 3
  • Myosin-15 3 4
  • KIAA1000 2 4
  • MYH15 5

External Ids for MYH15 Gene

Previous GeneCards Identifiers for MYH15 Gene

  • GC03M109581
  • GC03M108108
  • GC03M105472

Summaries for MYH15 Gene

GeneCards Summary for MYH15 Gene

MYH15 (Myosin Heavy Chain 15) is a Protein Coding gene. Diseases associated with MYH15 include Deafness, Autosomal Recessive 102 and Heart Disease. Among its related pathways are Immune response CCR3 signaling in eosinophils and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. Gene Ontology (GO) annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYH6.

UniProtKB/Swiss-Prot Summary for MYH15 Gene

Tocris Summary for MYH15 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.

Gene Wiki entry for MYH15 Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYH15 Gene

Genomics for MYH15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MYH15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J108549 Enhancer 0.3 Ensembl 255.1 +0.3 262 1.2 NFE2 CEBPB MYH15 HSALNG0027906 CIP2A HHLA2
GH03J108406 Enhancer 1 Ensembl ENCODE 19.4 +142.1 142062 3.2 BCLAF1 ZNF580 YY1 REST TRIM22 FEZF1 HOMEZ CTCF FOXA2 ZNF610 MYH15 DZIP3 HHLA2 HSALNG0027900 lnc-CIP2A-3
GH03J108129 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 5 +417.0 417036 5 JUND BHLHE40 FEZF1 EP300 PRDM1 STAT3 SPI1 RFX1 ATF2 JUNB CD47 IFT57 MYH15 HSALNG0027888 HSALNG0027885 LINC01215
GH03J108820 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 5.3 -274.9 -274932 8.4 FEZF1 ZNF384 L3MBTL2 PKNOX1 CTBP1 POLR2A MNT HSALNG0027923 TRAT1 DZIP3 RETNLB MYH15 CIP2A HSALNG0027924 GUCA1C
GH03J108602 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 5.6 -53.9 -53915 2.4 RFX1 POLR2A CBX3 DZIP3 MYH15 CIP2A lnc-CIP2A-1 lnc-CIP2A-4 RETNLB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYH15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYH15

Top Transcription factor binding sites by QIAGEN in the MYH15 gene promoter:
  • HNF-1
  • HNF-1A
  • ISGF-3
  • MEF-2A
  • NF-1
  • NF-1/L
  • POU2F1
  • POU2F1a
  • S8
  • TBP

Genomic Locations for MYH15 Gene

Latest Assembly
chr3:108,380,368-108,549,462
(GRCh38/hg38)
Size:
169,095 bases
Orientation:
Minus strand

Previous Assembly
chr3:108,099,215-108,248,169
(GRCh37/hg19 by Entrez Gene)
Size:
148,955 bases
Orientation:
Minus strand

chr3:108,099,216-108,248,169
(GRCh37/hg19 by Ensembl)
Size:
148,954 bases
Orientation:
Minus strand

Genomic View for MYH15 Gene

Genes around MYH15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYH15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYH15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYH15 Gene

Proteins for MYH15 Gene

  • Protein details for MYH15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2K3-MYH15_HUMAN
    Recommended name:
    Myosin-15
    Protein Accession:
    Q9Y2K3

    Protein attributes for MYH15 Gene

    Size:
    1946 amino acids
    Molecular mass:
    224619 Da
    Quaternary structure:
    • Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
    SequenceCaution:
    • Sequence=BAA76844.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for MYH15 Gene

Post-translational modifications for MYH15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYH15 Gene

No data available for DME Specific Peptides for MYH15 Gene

Domains & Families for MYH15 Gene

Gene Families for MYH15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MYH15 Gene

InterPro:
Blocks:
  • IQ calmodulin-binding region
  • Myosin tail
  • Myosin N-terminal SH3-like domain

Suggested Antigen Peptide Sequences for MYH15 Gene

GenScript: Design optimal peptide antigens:
  • Myosin heavy chain 15 (MYH15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y2K3

UniProtKB/Swiss-Prot:

MYH15_HUMAN :
  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYH15: view

Function for MYH15 Gene

Molecular function for MYH15 Gene

UniProtKB/Swiss-Prot Function:
Muscle contraction.

Phenotypes From GWAS Catalog for MYH15 Gene

Gene Ontology (GO) - Molecular Function for MYH15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MYH15: view
genes like me logo Genes that share phenotypes with MYH15: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYH15

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYH15 Gene

Localization for MYH15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYH15 Gene

Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYH15 gene
Compartment Confidence
cytoskeleton 4
mitochondrion 3
nucleus 3
cytosol 3
plasma membrane 2
extracellular 2
endoplasmic reticulum 2
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MYH15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0016459 myosin complex IEA --
GO:0030016 myofibril IEA --
GO:0032982 myosin filament IEA --
genes like me logo Genes that share ontologies with MYH15: view

Pathways & Interactions for MYH15 Gene

PathCards logo

SuperPathways for MYH15 Gene

SuperPathway Contained pathways
1 Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
.49
.49
.42
.32
2 PAK Pathway
.56
.56
.36
3 Actin Nucleation by ARP-WASP Complex
.66
.35
4 RhoGDI Pathway
.33
.33
5 Vesicle-mediated transport
genes like me logo Genes that share pathways with MYH15: view

Pathways by source for MYH15 Gene

6 GeneGo (Thomson Reuters) pathways for MYH15 Gene
  • Cell adhesion Integrin-mediated cell adhesion and migration
  • Cell adhesion Tight junctions
  • Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
  • Development MAG-dependent inhibition of neurite outgrowth
  • Immune response CCR3 signaling in eosinophils
11 Qiagen pathways for MYH15 Gene
  • Actin Nucleation by ARP-WASP Complex
  • Antioxidant Action of Vitamin-C
  • Cellular Effects of Sildenafil
  • Epithelial Adherens Junctions
  • Epithelial Tight Junctions

Gene Ontology (GO) - Biological Process for MYH15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002074 extraocular skeletal muscle development IEA --
genes like me logo Genes that share ontologies with MYH15: view

No data available for SIGNOR curated interactions for MYH15 Gene

Drugs & Compounds for MYH15 Gene

(2) Drugs for MYH15 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(R)-(+)-Blebbistatin Pharma non-muscle myosin II ATPases inhibitor, cell-permeable, Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 0
BTS Pharma Selective inhibitor of skeletal muscle myosin II ATPase activity 0

(2) Additional Compounds for MYH15 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Blebbistatin
674289-55-5
(S)-(-)-Blebbistatin
856925-71-8

(4) Tocris Compounds for MYH15 Gene

Compound Action Cas Number
(+-)-Blebbistatin Selective inhibitor of myosin II ATPase activity 674289-55-5
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 1177356-70-5
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) 856925-71-8
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity 1576-37-0
genes like me logo Genes that share compounds with MYH15: view

Transcripts for MYH15 Gene

mRNA/cDNA for MYH15 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYH15

Alternative Splicing Database (ASD) splice patterns (SP) for MYH15 Gene

No ASD Table

Relevant External Links for MYH15 Gene

GeneLoc Exon Structure for
MYH15

Expression for MYH15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYH15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYH15 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.4).

Protein differential expression in normal tissues from HIPED for MYH15 Gene

This gene is overexpressed in Nasal epithelium (37.7) and Heart (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MYH15 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYH15

SOURCE GeneReport for Unigene cluster for MYH15 Gene:

Hs.731060

Evidence on tissue expression from TISSUES for MYH15 Gene

  • Nervous system(4.7)
  • Muscle(3.2)
  • Heart(2.7)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with MYH15: view

Primer products for research

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYH15 Gene

Orthologs for MYH15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYH15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MYH15 29 30
  • 99.43 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MYH15 29 30
  • 87.45 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MYH15 29 30
  • 86.04 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Myh15 29 16 30
  • 82.1 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Myh15 29
  • 81.03 (n)
Oppossum
(Monodelphis domestica)
Mammalia MYH15 30
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MYH15 30
  • 71 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MYH15 30
  • 64 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Mhc 30
  • 47 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea myo-5 30
  • 43 (a)
ManyToMany
unc-54 30
  • 43 (a)
ManyToMany
myo-3 30
  • 42 (a)
ManyToMany
myo-1 30
  • 41 (a)
ManyToMany
myo-6 30
  • 41 (a)
ManyToMany
myo-2 30
  • 41 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO1 30
  • 27 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 59 (a)
ManyToMany
-- 30
  • 58 (a)
ManyToMany
-- 30
  • 58 (a)
ManyToMany
-- 30
  • 58 (a)
ManyToMany
-- 30
  • 58 (a)
ManyToMany
-- 30
  • 58 (a)
ManyToMany
-- 30
  • 45 (a)
ManyToMany
Species where no ortholog for MYH15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for MYH15 Gene

ENSEMBL:
Gene Tree for MYH15 (if available)
TreeFam:
Gene Tree for MYH15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYH15: view image
Alliance of Genome Resources:
Additional Orthologs for MYH15

Paralogs for MYH15 Gene

(20) SIMAP similar genes for MYH15 Gene using alignment to 3 proteins:

  • MYH15_HUMAN
  • H9XFA0_HUMAN
  • L8E9Q8_HUMAN
genes like me logo Genes that share paralogs with MYH15: view

Variants for MYH15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYH15 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs1078456 Benign: not provided 108,410,739(-) C/Tp.Asp1467Asn
NM_014981.2(MYH15):c.4399G>A (p.Asp1467Asn)
MISSENSE
rs113330737 Benign: not provided 108,428,486(-) A/G
NM_014981.2(MYH15):c.3762+6T>C
INTRON
rs114502755 Benign: not provided 108,389,081(-) C/A
NM_014981.2(MYH15):c.5491-7G>T
INTRON
rs115721142 Benign: not provided 108,437,549(-) C/A
NM_014981.2(MYH15):c.3281+5G>T
INTRON
rs1332521067 Uncertain Significance: not provided 108,408,301(-) C/G
NM_014981.2(MYH15):c.4659G>C (p.Gln1553His)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MYH15 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MYH15 Gene

Variant ID Type Subtype PubMed ID
esv3304498 CNV mobile element insertion 20981092
esv3347514 CNV insertion 20981092
esv3398084 CNV insertion 20981092
nsv1006774 CNV loss 25217958
nsv1011158 CNV gain 25217958
nsv3937 CNV deletion 18451855
nsv478652 CNV novel sequence insertion 20440878
nsv526190 CNV gain 19592680
nsv829656 CNV loss 17160897
nsv829657 CNV gain 17160897
nsv829658 CNV gain 17160897

Variation tolerance for MYH15 Gene

Residual Variation Intolerance Score: 62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.51; 92.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYH15 Gene

Human Gene Mutation Database (HGMD)
MYH15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYH15
Leiden Open Variation Database (LOVD)
MYH15

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYH15 Gene

Disorders for MYH15 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MYH15 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
deafness, autosomal recessive 102
  • dfnb102
heart disease
  • congenital heart disease
cardiomyopathy, familial hypertrophic, 1
  • cmh1
- elite association - COSMIC cancer census association via MalaCards
Search MYH15 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MYH15

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MYH15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYH15 Gene

Publications for MYH15 Gene

  1. Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project. (PMID: 22443383) Oudot-Mellakh T … Morange PE (British journal of haematology 2012) 3 40
  2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 40
  3. Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry. (PMID: 19752551) Luke MM … Mannhalter C (Cerebrovascular diseases (Basel, Switzerland) 2009) 3 40
  4. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 40
  5. Five common gene variants identify elevated genetic risk for coronary heart disease. (PMID: 18073581) Bare LA … Boerwinkle E (Genetics in medicine : official journal of the American College of Medical Genetics 2007) 3 40

Products for MYH15 Gene

Sources for MYH15 Gene