Aliases for MYH14 Gene
External Ids for MYH14 Gene
Previous HGNC Symbols for MYH14 Gene
Previous GeneCards Identifiers for MYH14 Gene
This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for MYH14 Gene
MYH14 (Myosin Heavy Chain 14) is a Protein Coding gene. Diseases associated with MYH14 include Peripheral Neuropathy, Myopathy, Hoarseness, And Hearing Loss and Deafness, Autosomal Dominant 4A. Among its related pathways are Tight junction and Developmental Biology. Gene Ontology (GO) annotations related to this gene include calmodulin binding and motor activity. An important paralog of this gene is MYH10.
UniProtKB/Swiss-Prot Summary for MYH14 Gene
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.