This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin an... See more...

Aliases for MYH10 Gene

Aliases for MYH10 Gene

  • Myosin Heavy Chain 10 2 3 4 5
  • Myosin, Heavy Polypeptide 10, Non-Muscle 2 3
  • Cellular Myosin Heavy Chain, Type B 3 4
  • Myosin-10 3 4
  • NMMHC-IIB 3 4
  • Myosin Heavy Chain, Nonmuscle Type B 3
  • Myosin, Heavy Chain 10, Non-Muscle 3
  • Myosin Heavy Chain, Non-Muscle IIb 4
  • Nonmuscle Myosin II Heavy Chain-B 3
  • Non-Muscle Myosin Heavy Chain IIb 4
  • Nonmuscle Myosin Heavy Chain IIB 3
  • Non-Muscle Myosin Heavy Chain B 4
  • NMMHC II-B 4
  • NMMHC-B 4
  • NMMHCB 3

External Ids for MYH10 Gene

Previous GeneCards Identifiers for MYH10 Gene

  • GC17M008754
  • GC17M009471
  • GC17M008320
  • GC17M008579
  • GC17M008580
  • GC17M008318

Summaries for MYH10 Gene

Entrez Gene Summary for MYH10 Gene

  • This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for MYH10 Gene

MYH10 (Myosin Heavy Chain 10) is a Protein Coding gene. Diseases associated with MYH10 include Congenital Ptosis and Coloboma, Ocular, Autosomal Dominant. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Immune response CCR3 signaling in eosinophils. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is MYH9.

UniProtKB/Swiss-Prot Summary for MYH10 Gene

  • Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.

Tocris Summary for MYH10 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis (ATPase enzyme activity), actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells, almost all eukaryotic cells are known to contain myosins.

Gene Wiki entry for MYH10 Gene

Additional gene information for MYH10 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYH10 Gene

Genomics for MYH10 Gene

GeneHancer (GH) Regulatory Elements for MYH10 Gene

Promoters and enhancers for MYH10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYH10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYH10

Top Transcription factor binding sites by QIAGEN in the MYH10 gene promoter:
  • FOXJ2
  • IRF-1
  • MyoD
  • Pax-4a
  • PPAR-alpha
  • Spz1
  • STAT5B

Genomic Locations for MYH10 Gene

Genomic Locations for MYH10 Gene
chr17:8,474,205-8,631,012
(GRCh38/hg38)
Size:
156,808 bases
Orientation:
Minus strand
chr17:8,377,523-8,534,079
(GRCh37/hg19)
Size:
156,557 bases
Orientation:
Minus strand

Genomic View for MYH10 Gene

Genes around MYH10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYH10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYH10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYH10 Gene

Proteins for MYH10 Gene

  • Protein details for MYH10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35580-MYH10_HUMAN
    Recommended name:
    Myosin-10
    Protein Accession:
    P35580
    Secondary Accessions:
    • B2RWP9
    • D3DTS1
    • F8VTL3
    • Q12989
    • Q149N3
    • Q149N4
    • Q16087
    • Q4LE45
    • Q6PK16
    • Q9BWG0

    Protein attributes for MYH10 Gene

    Size:
    1976 amino acids
    Molecular mass:
    228999 Da
    Quaternary structure:
    • Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6 (PubMed:16721066). Interacts with ECPAS (PubMed:20682791). Interacts with KIF26B (By similarity). Interacts with LARP6 (PubMed:20603131). Interacts with MCC (PubMed:22480440). Interacts with C9orf135 (PubMed:28345668).
    SequenceCaution:
    • Sequence=BAE06108.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MYH10 Gene

    Alternative splice isoforms for MYH10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYH10 Gene

Post-translational modifications for MYH10 Gene

  • Phosphorylated by ABL2.
  • Ubiquitination at Lys232, Lys817, Lys840, and Lys1800
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MYH10 Gene

Domains & Families for MYH10 Gene

Gene Families for MYH10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MYH10 Gene

Blocks:
  • Spectrin repeat
  • IQ calmodulin-binding region
  • Myosin tail
  • Myosin N-terminal SH3-like domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYH10 Gene

GenScript: Design optimal peptide antigens:
  • Nonmuscle myosin heavy chain 10 (A5XEH4_HUMAN)
  • MYH10 protein (B2RWP9_HUMAN)
  • Myosin, heavy polypeptide 10, non-muscle, isoform CRA_a (D3DTS1_HUMAN)
  • Non-muscle myosin heavy chain IIb (MYH10_HUMAN)
  • Myosin, heavy chain 10, non-muscle (Q149N4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35580

UniProtKB/Swiss-Prot:

MYH10_HUMAN :
  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Domain:
  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYH10: view

Function for MYH10 Gene

Molecular function for MYH10 Gene

UniProtKB/Swiss-Prot Function:
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.
GENATLAS Biochemistry:
myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 10,non muscle

Phenotypes From GWAS Catalog for MYH10 Gene

Gene Ontology (GO) - Molecular Function for MYH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000146 microfilament motor activity IDA 15845534
GO:0000166 nucleotide binding IEA --
GO:0003774 motor activity IEA --
GO:0003779 actin binding NAS 7782316
GO:0005515 protein binding IEA,IPI 7542763
genes like me logo Genes that share ontologies with MYH10: view
genes like me logo Genes that share phenotypes with MYH10: view

Animal Models for MYH10 Gene

MGI Knock Outs for MYH10:

Clone Products

  • Addgene plasmids for MYH10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYH10 Gene

Localization for MYH10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYH10 Gene

Cell projection, lamellipodium. Note=Colocalizes with MCC at the leading edge of migrating cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYH10 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
mitochondrion 3
extracellular 2
nucleus 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (4)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MYH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 7699007
GO:0005634 nucleus HDA 21630459
GO:0005737 cytoplasm IDA 7699007
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MYH10: view

Pathways & Interactions for MYH10 Gene

PathCards logo

SuperPathways for MYH10 Gene

SuperPathway Contained pathways
1 Semaphorin interactions
2 Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
.49
.49
.42
.32
3 PAK Pathway
.56
.56
.36
4 Regulation of actin cytoskeleton
5 Actin Nucleation by ARP-WASP Complex
.66
.35
genes like me logo Genes that share pathways with MYH10: view

Pathways by source for MYH10 Gene

6 GeneGo (Thomson Reuters) pathways for MYH10 Gene
  • Cell adhesion Integrin-mediated cell adhesion and migration
  • Cell adhesion Tight junctions
  • Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
  • Development MAG-dependent inhibition of neurite outgrowth
  • Immune response CCR3 signaling in eosinophils
11 Qiagen pathways for MYH10 Gene
  • Actin Nucleation by ARP-WASP Complex
  • Antioxidant Action of Vitamin-C
  • Cellular Effects of Sildenafil
  • Epithelial Adherens Junctions
  • Epithelial Tight Junctions
1 Cell Signaling Technology pathway for MYH10 Gene

SIGNOR curated interactions for MYH10 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MYH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IDA 15774463
GO:0001701 in utero embryonic development IEA --
GO:0001764 neuron migration IEA --
GO:0001778 plasma membrane repair IEA --
GO:0003279 cardiac septum development IEA --
genes like me logo Genes that share ontologies with MYH10: view

Drugs & Compounds for MYH10 Gene

(4) Drugs for MYH10 Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(R)-(+)-Blebbistatin Pharma non-muscle myosin II ATPases inhibitor, cell-permeable, Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 0
BTS Pharma Selective inhibitor of skeletal muscle myosin II ATPase activity 0

(3) Additional Compounds for MYH10 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-Blebbistatin
674289-55-5
(S)-(-)-Blebbistatin
856925-71-8

(4) Tocris Compounds for MYH10 Gene

Compound Action Cas Number
(+-)-Blebbistatin Selective inhibitor of myosin II ATPase activity 674289-55-5
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (+-)-blebbistatin (Cat. No. 1760) 1177356-70-5
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (+-)-blebbistatin (Cat. No. 1760) 856925-71-8
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity 1576-37-0
genes like me logo Genes that share compounds with MYH10: view

Transcripts for MYH10 Gene

mRNA/cDNA for MYH10 Gene

4 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for MYH10

Alternative Splicing Database (ASD) splice patterns (SP) for MYH10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2:
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: - -
SP11:
SP12:
SP13:

ExUns: 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MYH10 Gene

GeneLoc Exon Structure for
MYH10

Expression for MYH10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYH10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYH10 Gene

This gene is overexpressed in Artery - Aorta (x15.0), Artery - Coronary (x6.6), and Artery - Tibial (x4.0).

Protein differential expression in normal tissues from HIPED for MYH10 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYH10 Gene



Protein tissue co-expression partners for MYH10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYH10

SOURCE GeneReport for Unigene cluster for MYH10 Gene:

Hs.16355

mRNA Expression by UniProt/SwissProt for MYH10 Gene:

P35580-MYH10_HUMAN
Tissue specificity: Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum.

Evidence on tissue expression from TISSUES for MYH10 Gene

  • Nervous system(4.8)
  • Liver(4.7)
  • Eye(4.5)
  • Muscle(4.5)
  • Lung(4.1)
  • Gall bladder(3.8)
  • Heart(3.7)
  • Intestine(3.4)
  • Kidney(3)
  • Pancreas(2.9)
  • Blood(2.7)
  • Adrenal gland(2.5)
genes like me logo Genes that share expression patterns with MYH10: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MYH10 Gene

Orthologs for MYH10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYH10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYH10 31 30
  • 99.58 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYH10 31
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYH10 31 30
  • 90.77 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MYH10 31 30
  • 90.35 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Myh10 17 31 30
  • 89.57 (n)
rat
(Rattus norvegicus)
Mammalia Myh10 30
  • 89.29 (n)
chicken
(Gallus gallus)
Aves MYH10 31 30
  • 83.09 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYH10 31
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493774 30
  • 71.03 (n)
Str.20258 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.833 30
zebrafish
(Danio rerio)
Actinopterygii myh10 31 30
  • 78.6 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007523 30
  • 62.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta zip 31 32 30
  • 61.45 (n)
OneToMany
CG3493 32
  • 22 (a)
worm
(Caenorhabditis elegans)
Secernentea nmy-1 31 30
  • 57.21 (n)
ManyToMany
nmy-2 31
  • 44 (a)
ManyToMany
hcp-1 32
  • 20 (a)
hcp-2 32
  • 19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MYO1 33 31
  • 30 (a)
Species where no ortholog for MYH10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYH10 Gene

ENSEMBL:
Gene Tree for MYH10 (if available)
TreeFam:
Gene Tree for MYH10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYH10: view image

Paralogs for MYH10 Gene

(38) SIMAP similar genes for MYH10 Gene using alignment to 8 proteins:

  • MYH10_HUMAN
  • A5XEH4_HUMAN
  • B2RWP9_HUMAN
  • D3DTS1_HUMAN
  • E7ERA5_HUMAN
  • F8W6L6_HUMAN
  • G1UI33_HUMAN
  • Q9BWG0_HUMAN
genes like me logo Genes that share paralogs with MYH10: view

Variants for MYH10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYH10 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
625873 Pathogenic: Hypertelorism; Wide nose; Epicanthus inversus; Congenital ocular coloboma; Abnormal facial shape; Congenital ptosis; Midface retrusion 8,492,463(-) C/G MISSENSE_VARIANT
710457 Benign: not provided 8,481,351(-) C/T SYNONYMOUS_VARIANT
712206 Benign: not provided 8,475,843(-) G/A SYNONYMOUS_VARIANT
715691 Benign: not provided 8,521,185(-) T/C SYNONYMOUS_VARIANT
717057 Likely Benign: not provided 8,530,689(-) A/AC INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MYH10 Gene

Structural Variations from Database of Genomic Variants (DGV) for MYH10 Gene

Variant ID Type Subtype PubMed ID
dgv1414n106 CNV deletion 24896259
dgv174e215 CNV deletion 23714750
esv1105639 CNV deletion 17803354
esv2112361 CNV deletion 18987734
esv2715614 CNV deletion 23290073
esv2715615 CNV deletion 23290073
esv2715616 CNV deletion 23290073
nsv1071332 CNV deletion 25765185
nsv111760 CNV deletion 16902084
nsv111869 CNV deletion 16902084
nsv1127535 CNV deletion 24896259
nsv471981 CNV novel sequence insertion 20440878
nsv478579 CNV novel sequence insertion 20440878
nsv510433 OTHER sequence alteration 20534489
nsv510434 OTHER sequence alteration 20534489
nsv960404 CNV duplication 23825009

Variation tolerance for MYH10 Gene

Residual Variation Intolerance Score: 0.373% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYH10 Gene

Human Gene Mutation Database (HGMD)
MYH10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYH10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYH10 Gene

Disorders for MYH10 Gene

MalaCards: The human disease database

(11) MalaCards diseases for MYH10 Gene - From: ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
congenital ptosis
coloboma, ocular, autosomal dominant
  • coloboma, uveoretinal
coloboma of macula
  • agenesis of macula
hypertelorism
lymphangioleiomyomatosis
  • lam
- elite association - COSMIC cancer census association via MalaCards
Search MYH10 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MYH10_HUMAN
  • Note=Associated with severe intellectual disability, microcephaly, and feeding difficulties as well as cerebral atrophy. {ECO:0000269 PubMed:25003005, ECO:0000269 PubMed:25356899}.

Additional Disease Information for MYH10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MYH10: view

No data available for Genatlas for MYH10 Gene

Publications for MYH10 Gene

  1. Neuronal cell expression of inserted isoforms of vertebrate nonmuscle myosin heavy chain II-B. (PMID: 7782316) Itoh K … Adelstein RS (The Journal of biological chemistry 1995) 3 4 23 54
  2. Cloning of the cDNA encoding human nonmuscle myosin heavy chain-B and analysis of human tissues with isoform-specific antibodies. (PMID: 7499478) Phillips CL … Adelstein RS (Journal of muscle research and cell motility 1995) 3 4 23 54
  3. Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes. (PMID: 1860190) Simons M … Weir L (Circulation research 1991) 2 3 4 54
  4. A human de novo mutation in MYH10 phenocopies the loss of function mutation in mice. (PMID: 25003005) Tuzovic L … Chung WK (Rare diseases (Austin, Tex.) 2013) 3 4 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54

Products for MYH10 Gene

Sources for MYH10 Gene