Aliases for MYEOV Gene

Aliases for MYEOV Gene

  • Myeloma Overexpressed 2 3 5
  • OCIM 2 3 4
  • Myeloma Overexpressed (In A Subset Of T(11;14) Positive Multiple Myelomas) 2 3
  • Myeloma-Overexpressed Gene Protein 3 4
  • Oncogene In Multiple Myeloma 3 4
  • Myeloma Overexpressed Gene (In A Subset Of T(11;14) Positive Multiple Myelomas) 3
  • MYEOV 5

External Ids for MYEOV Gene

Previous GeneCards Identifiers for MYEOV Gene

  • GC11P071586
  • GC11P070758
  • GC11P069311
  • GC11P068836
  • GC11P068818
  • GC11P069061
  • GC11P065407

Summaries for MYEOV Gene

GeneCards Summary for MYEOV Gene

MYEOV (Myeloma Overexpressed) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYEOV Gene

Genomics for MYEOV Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around MYEOV on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYEOV

Top Transcription factor binding sites by QIAGEN in the MYEOV gene promoter:
  • AhR
  • AML1a
  • Arnt
  • FAC1
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2
  • RFX1
  • SRY

Genomic Locations for MYEOV Gene

Latest Assembly
chr11:69,294,151-69,367,726
(GRCh38/hg38)
Size:
73,576 bases
Orientation:
Plus strand

Previous Assembly
chr11:69,061,622-69,064,754
(GRCh37/hg19 by Entrez Gene)
Size:
3,133 bases
Orientation:
Plus strand

chr11:69,061,605-69,182,494
(GRCh37/hg19 by Ensembl)
Size:
120,890 bases
Orientation:
Plus strand

Genomic View for MYEOV Gene

Genes around MYEOV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYEOV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYEOV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYEOV Gene

Proteins for MYEOV Gene

  • Protein details for MYEOV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EZ4-MYEOV_HUMAN
    Recommended name:
    Myeloma-overexpressed gene protein
    Protein Accession:
    Q96EZ4
    Secondary Accessions:
    • Q9UGN6
    • Q9UGN7

    Protein attributes for MYEOV Gene

    Size:
    313 amino acids
    Molecular mass:
    33556 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB65726.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for MYEOV Gene

Post-translational modifications for MYEOV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYEOV Gene

Domains & Families for MYEOV Gene

Gene Families for MYEOV Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MYEOV Gene

GenScript: Design optimal peptide antigens:
  • Oncogene in multiple myeloma (MYEOV_HUMAN)
genes like me logo Genes that share domains with MYEOV: view

No data available for Protein Domains , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MYEOV Gene

Function for MYEOV Gene

Phenotypes From GWAS Catalog for MYEOV Gene

Gene Ontology (GO) - Molecular Function for MYEOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with MYEOV: view
genes like me logo Genes that share phenotypes with MYEOV: view

miRNA for MYEOV Gene

miRTarBase miRNAs that target MYEOV

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYEOV

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYEOV Gene

Localization for MYEOV Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYEOV gene
Compartment Confidence
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 0
cytosol 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MYEOV Gene

Pathways & Interactions for MYEOV Gene

PathCards logo

SuperPathways for MYEOV Gene

No Data Available

Interacting Proteins for MYEOV Gene

Gene Ontology (GO) - Biological Process for MYEOV Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MYEOV Gene

Drugs & Compounds for MYEOV Gene

No Compound Related Data Available

Transcripts for MYEOV Gene

mRNA/cDNA for MYEOV Gene

6 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYEOV

Alternative Splicing Database (ASD) splice patterns (SP) for MYEOV Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - - - - - - - -
SP6: - -
SP7: - - - - -
SP8:
SP9: - - -

Relevant External Links for MYEOV Gene

GeneLoc Exon Structure for
MYEOV

Expression for MYEOV Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYEOV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYEOV Gene

This gene is overexpressed in Esophagus - Mucosa (x11.8), Adipose - Subcutaneous (x7.0), Skin - Sun Exposed (Lower leg) (x5.5), Vagina (x4.5), Breast - Mammary Tissue (x4.2), and Skin - Not Sun Exposed (Suprapubic) (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYEOV

SOURCE GeneReport for Unigene cluster for MYEOV Gene:

Hs.523848

Evidence on tissue expression from TISSUES for MYEOV Gene

  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with MYEOV: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYEOV Gene

Orthologs for MYEOV Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MYEOV Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MYEOV 29 30
  • 98.32 (n)
OneToOne
Species where no ortholog for MYEOV was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MYEOV Gene

ENSEMBL:
Gene Tree for MYEOV (if available)
TreeFam:
Gene Tree for MYEOV (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYEOV: view image
Alliance of Genome Resources:
Additional Orthologs for MYEOV

Paralogs for MYEOV Gene

No data available for Paralogs for MYEOV Gene

Variants for MYEOV Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYEOV Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs552116583 Benign: not provided 69,296,256(+) TG/T
NM_001293291.2(MYEOV):c.813del (p.Trp272fs)
FRAMESHIFT
rs11228610 -- p.Gly271Arg
rs11539762 -- p.Arg198Gln
rs12274095 -- p.Pro284Thr
rs7103126 -- p.Val159Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MYEOV Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for MYEOV Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.92; 87.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYEOV Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYEOV
Leiden Open Variation Database (LOVD)
MYEOV

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYEOV Gene

Disorders for MYEOV Gene

Additional Disease Information for MYEOV

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MYEOV Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYEOV Gene

Publications for MYEOV Gene

  1. Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32). (PMID: 10753852) Janssen JW … Schuuring E (Blood 2000) 2 3 4 22
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. MYEOV, a gene at 11q13, is coamplified with CCND1, but epigenetically inactivated in a subset of esophageal squamous cell carcinomas. (PMID: 12202983) Janssen JW … Inazawa J (Journal of human genetics 2002) 3 22
  4. High expression of MYEOV reflects poor prognosis in non-small cell lung cancer. (PMID: 33278551) Zhang R … Ma A (Gene 2021) 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for MYEOV Gene

Sources for MYEOV Gene