The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008] See more...

Aliases for MYDGF Gene

Aliases for MYDGF Gene

  • Myeloid Derived Growth Factor 2 3 5
  • Interleukin 27 Working Designation 2 3
  • Myeloid-Derived Growth Factor 3 4
  • C19orf10 3 4
  • Stromal Cell-Derived Growth Factor SF20 3
  • Chromosome 19 Open Reading Frame 10 2
  • UPF0556 Protein C19orf10 3
  • EUROIMAGE1875335 3
  • Interleukin-25 3
  • R33729_1 3
  • IL27w 3
  • IL25 3
  • SF20 3
  • IL27 3

External Ids for MYDGF Gene

Previous HGNC Symbols for MYDGF Gene

  • IL27
  • IL27w
  • C19orf10

Summaries for MYDGF Gene

Entrez Gene Summary for MYDGF Gene

  • The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYDGF Gene

MYDGF (Myeloid Derived Growth Factor) is a Protein Coding gene. Diseases associated with MYDGF include Myocardial Infarction and Somatization Disorder. Among its related pathways are Unfolded Protein Response (UPR) and Metabolism of proteins.

UniProtKB/Swiss-Prot Summary for MYDGF Gene

  • Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).

Additional gene information for MYDGF Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYDGF Gene

Genomics for MYDGF Gene

GeneHancer (GH) Regulatory Elements for MYDGF Gene

Promoters and enhancers for MYDGF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J004668 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 507.9 0.0 -24 2.9 NRF1 POLR2G USF1 SP1 GTF2E2 PHF8 FOS ZFX ZNF639 ZIC2 MYDGF lnc-DPP9-1 SNRPEP4 HDGFL2 SAFB DPP9-AS1
GH19J004690 Enhancer 1.1 Ensembl ENCODE dbSUPER 21 -23.8 -23798 8 ZBTB40 CTCF JUND FOS ZIC2 ZNF623 ZNF341 FOXA2 NR2F2 NFIC MYDGF DPP9 MIR7-3HG MIR7-3 FEM1A ENSG00000287884 LOC105372250
GH19J004122 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.9 +546.8 546802 2.8 HNRNPK EP300 TCF12 NRF1 POLR2G SP1 PHF8 CTCF ZFX ZNF639 MAP2K2 AB372675 CACTIN-AS1 DPP9-AS1 CACTIN APBA3 ENSG00000267030 ENSG00000269807 YJU2 DPP9
GH19J004340 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 9.9 +327.6 327560 4.3 ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 POLR2G USF1 SP1 NCOR1 STAP2 MPND ENSG00000267030 CACTIN-AS1 DPP9-AS1 APBA3 DAPK3 FSD1 TMIGD2 SHD
GH19J004644 Enhancer 0.9 Ensembl ENCODE 18.1 +22.6 22569 6.3 ZNF623 RBM25 CTCF NR2F2 KDM1A ZNF263 POLR2G MEF2B POLR2A BCOR MYDGF DPP9 TNFAIP8L1 lnc-TNFAIP8L1-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYDGF on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYDGF

Genomic Locations for MYDGF Gene

Genomic Locations for MYDGF Gene
chr19:4,641,374-4,670,403
(GRCh38/hg38)
Size:
29,030 bases
Orientation:
Minus strand
chr19:4,641,386-4,670,415
(GRCh37/hg19)
Size:
29,030 bases
Orientation:
Minus strand

Genomic View for MYDGF Gene

Genes around MYDGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYDGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYDGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYDGF Gene

Proteins for MYDGF Gene

  • Protein details for MYDGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969H8-MYDGF_HUMAN
    Recommended name:
    Myeloid-derived growth factor
    Protein Accession:
    Q969H8
    Secondary Accessions:
    • D6W628
    • O75256
    • O75272
    • Q9BTK7
    • Q9NP69

    Protein attributes for MYDGF Gene

    Size:
    173 amino acids
    Molecular mass:
    18795 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC27824.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC33800.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MYDGF Gene

Post-translational modifications for MYDGF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYDGF Gene

No data available for DME Specific Peptides for MYDGF Gene

Domains & Families for MYDGF Gene

Gene Families for MYDGF Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for MYDGF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYDGF Gene

GenScript: Design optimal peptide antigens:
  • Stromal cell-derived growth factor SF20 (CS010_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q969H8

UniProtKB/Swiss-Prot:

MYDGF_HUMAN :
  • Belongs to the MYDGF family.
Family:
  • Belongs to the MYDGF family.
genes like me logo Genes that share domains with MYDGF: view

Function for MYDGF Gene

Molecular function for MYDGF Gene

UniProtKB/Swiss-Prot Function:
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to myocardial infarction (MI).

Phenotypes From GWAS Catalog for MYDGF Gene

Gene Ontology (GO) - Molecular Function for MYDGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MYDGF: view
genes like me logo Genes that share phenotypes with MYDGF: view

Animal Models for MYDGF Gene

MGI Knock Outs for MYDGF:

Animal Model Products

  • Taconic Biosciences Mouse Models for MYDGF

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYDGF Gene

Localization for MYDGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYDGF Gene

Secreted. Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Golgi apparatus. Note=The C-terminal RTEL motif may provide retention in the endoplasmic reticulum. {ECO:0000269 PubMed:25581518, ECO:0000269 PubMed:29954947}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYDGF gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MYDGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,IDA 25581518
GO:0005783 endoplasmic reticulum IEA,IDA 29954947
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
genes like me logo Genes that share ontologies with MYDGF: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MYDGF Gene

Pathways & Interactions for MYDGF Gene

genes like me logo Genes that share pathways with MYDGF: view

Gene Ontology (GO) - Biological Process for MYDGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001934 positive regulation of protein phosphorylation IEA,ISS --
GO:0001938 positive regulation of endothelial cell proliferation IEA,IDA 25581518
GO:0006915 apoptotic process IEA --
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS,IEA --
genes like me logo Genes that share ontologies with MYDGF: view

No data available for SIGNOR curated interactions for MYDGF Gene

Drugs & Compounds for MYDGF Gene

(1) Drugs for MYDGF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MYDGF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MYDGF: view

Transcripts for MYDGF Gene

mRNA/cDNA for MYDGF Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYDGF Gene

No ASD Table

Relevant External Links for MYDGF Gene

GeneLoc Exon Structure for
MYDGF

Expression for MYDGF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYDGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MYDGF Gene

This gene is overexpressed in Oral epithelium (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYDGF Gene



Protein tissue co-expression partners for MYDGF Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYDGF

mRNA Expression by UniProt/SwissProt for MYDGF Gene:

Q969H8-MYDGF_HUMAN
Tissue specificity: Expressed in eosinophils (at protein level) (PubMed:29954947). Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502).

Evidence on tissue expression from TISSUES for MYDGF Gene

  • Skin(4.6)
  • Bone marrow(4.3)
  • Kidney(4.3)
  • Nervous system(3.5)
  • Lung(3.4)
  • Pancreas(2.9)
  • Blood(2.4)
  • Liver(2.3)
genes like me logo Genes that share expression patterns with MYDGF: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYDGF Gene

Orthologs for MYDGF Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYDGF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19ORF10 31
  • 100 (a)
OneToOne
C19H19orf10 30
  • 90.75 (n)
dog
(Canis familiaris)
Mammalia C19orf10 31
  • 90 (a)
OneToOne
C20H19orf10 30
  • 89.21 (n)
cow
(Bos Taurus)
Mammalia C7H19orf10 31 30
  • 88.44 (n)
OneToOne
mouse
(Mus musculus)
Mammalia D17Wsu104e 31 30
  • 84.04 (n)
OneToOne
Mydgf 17
rat
(Rattus norvegicus)
Mammalia LOC501282 30
  • 80 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C19orf10 31
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C19orf10 31
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves C28H19ORF10 31 30
  • 68.57 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c19orf10 30
  • 61.43 (n)
Str.16428 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.16799 30
zebrafish
(Danio rerio)
Actinopterygii zgc:92871 30
  • 61.44 (n)
C22H19orf10 (2 of 2) 31
  • 53 (a)
OneToMany
C22H19orf10 (1 of 2) 31
  • 53 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10031 30
Species where no ortholog for MYDGF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYDGF Gene

ENSEMBL:
Gene Tree for MYDGF (if available)
TreeFam:
Gene Tree for MYDGF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYDGF: view image

Paralogs for MYDGF Gene

No data available for Paralogs for MYDGF Gene

Variants for MYDGF Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYDGF Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs2270090 - p.Gly12Arg

Additional dbSNP identifiers (rs#s) for MYDGF Gene

Structural Variations from Database of Genomic Variants (DGV) for MYDGF Gene

Variant ID Type Subtype PubMed ID
esv2677201 CNV deletion 23128226
esv2718027 CNV deletion 23290073
esv2718030 CNV deletion 23290073
esv29521 CNV gain 19812545
esv3643508 CNV loss 21293372
nsv1062709 CNV loss 25217958
nsv1072849 CNV deletion 25765185
nsv428361 CNV loss 18775914
nsv578450 CNV gain 21841781
nsv578451 CNV loss 21841781
nsv833721 CNV loss 17160897
nsv953950 CNV deletion 24416366

Variation tolerance for MYDGF Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.84; 83.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYDGF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYDGF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYDGF Gene

Disorders for MYDGF Gene

MalaCards: The human disease database

(2) MalaCards diseases for MYDGF Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myocardial infarction
  • myocardial infarction, susceptibility to
somatization disorder
  • briquet's disorder
- elite association - COSMIC cancer census association via MalaCards
Search MYDGF in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MYDGF

genes like me logo Genes that share disorders with MYDGF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYDGF Gene

Publications for MYDGF Gene

  1. Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction. (PMID: 25581518) Korf-Klingebiel M … Wollert KC (Nature medicine 2015) 2 3 4 54
  2. The identification and characterization of a novel protein, c19orf10, in the synovium. (PMID: 17362502) Weiler T … Wilkins JA (Arthritis research & therapy 2007) 2 3 4 54
  3. Myeloid-derived growth factor is a resident endoplasmic reticulum protein. (PMID: 29954947) Bortnov V … Mosher DF (The Journal of biological chemistry 2018) 3 4 54
  4. Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma. (PMID: 21128247) Sunagozaka H … Kaneko S (International journal of cancer 2011) 2 3 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for MYDGF Gene

Sources for MYDGF Gene