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This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) is a Protein Coding gene. Diseases associated with MYD88 include Myd88 Deficiency and Macroglobulinemia, Waldenstrom 1. Among its related pathways are Antigen processing-Cross presentation and Bacterial infections in CF airways. Gene Ontology (GO) annotations related to this gene include identical protein binding and death receptor binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IEA | -- |
GO:0005121 | Toll binding | IEA | -- |
GO:0005123 | death receptor binding | TAS | 9374458 |
GO:0005149 | interleukin-1 receptor binding | IEA | -- |
GO:0005515 | protein binding | IEA,IPI | 10880445 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | 22155231 |
GO:0005737 | cytoplasm | IEA,IDA | 22155231 |
GO:0005829 | cytosol | IEA,TAS | -- |
GO:0005886 | plasma membrane | IEA,TAS | -- |
GO:0010008 | endosome membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated TLR4 signalling | ||
2 | Diseases associated with the TLR signaling cascade | ||
3 | Cytosolic sensors of pathogen-associated DNA | ||
4 | Toll-like Receptor Signaling Pathway |
.37
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5 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
Immune response IL-1 signaling pathway
.41
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
GO:0002238 | response to molecule of fungal origin | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | IEA,TAS | -- |
GO:0006909 | phagocytosis | IEA,IMP | 30883606 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
ST 2825 | Inhibitor of MyD88 dimerization | 894787-30-5 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||||||||||
SP7: | - | - | - | - | - | ||||||||||||||||||||||||
SP8: | - | ||||||||||||||||||||||||||||
SP9: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MYD88 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MYD88 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MYD88 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MYD88 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Myd88 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Myd88 30 |
|
||
Chicken (Gallus gallus) |
Aves | MYD88 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MYD88 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | myd88 30 |
|
||
Str.11893 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | myd88-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | myd88 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | MYD 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Myd88 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2481 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
639601 | Uncertain Significance: Myd88 deficiency | 38,138,813(+) | A/G | MISSENSE_VARIANT | |
653936 | Uncertain Significance: Myd88 deficiency | 38,141,149(+) | C/G | MISSENSE_VARIANT | |
660526 | Uncertain Significance: Myd88 deficiency | 38,138,912(+) | C/T | MISSENSE_VARIANT | |
709850 | Benign: Myd88 deficiency | 38,138,970(+) | C/G | SYNONYMOUS_VARIANT | |
719591 | Benign: Myd88 deficiency | 38,140,571(+) | T/C | MISSENSE_VARIANT,INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3359602 | CNV | duplication | 20981092 |
Disorder | Aliases | PubMed IDs |
---|---|---|
myd88 deficiency |
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|
macroglobulinemia, waldenstrom 1 |
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waldenstroem's macroglobulinemia |
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macroglobulinemia |
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central nervous system lymphoma |
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