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This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-t... See more...
Aliases for MYD88 Gene
Aliases for MYD88 Gene
External Ids for MYD88 Gene
- HGNC: 7562
- NCBI Entrez Gene: 4615
- Ensembl: ENSG00000172936
- OMIM®: 602170
- UniProtKB/Swiss-Prot: Q99836
Previous GeneCards Identifiers for MYD88 Gene
- GC03P037467
- GC03M038006
- GC03P037993
- GC03P038140
- GC03P038155
Summaries for MYD88 Gene
-
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
GeneCards Summary for MYD88 Gene
MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) is a Protein Coding gene. Diseases associated with MYD88 include Immunodeficiency 68 and Macroglobulinemia, Waldenstrom 1. Among its related pathways are IL-1 signaling pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include identical protein binding and death receptor binding.
UniProtKB/Swiss-Prot Summary for MYD88 Gene
-
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).
Additional gene information for MYD88 Gene
- HGNC (7562)
- NCBI Entrez Gene (4615)
- Ensembl (ENSG00000172936)
- OMIM® (602170)
- UniProtKB/Swiss-Prot (Q99836)
- Open Targets Platform(ENSG00000172936)
- Monarch Initiative
- Search for MYD88 at DataMed
- Search for MYD88 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYD88 Gene
Genomics for MYD88 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MYD88 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MYD88 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYD88
- Top Transcription factor binding sites by QIAGEN in the MYD88 gene promoter:
-
- AP-1
- ATF-2
- c-Fos
- c-Jun
- IRF-1
- STAT3
Genomic Locations for MYD88 Gene
Latest Assembly
- chr3:38,138,478-38,143,022
- (GRCh38/hg38)
- Size:
- 4,545 bases
- Orientation:
- Plus strand
Previous Assembly
- chr3:38,180,152-38,184,513
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 4,362 bases
- Orientation:
- Plus strand
- chr3:38,179,969-38,184,513
- (GRCh37/hg19 by Ensembl)
- Size:
- 4,545 bases
- Orientation:
- Plus strand
Genomic View for MYD88 Gene
Genes around MYD88 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p22.2 by HGNC
- 3p22.2 by Entrez Gene
- 3p22.2 by Ensembl
MYD88 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MYD88 Gene
Proteins for MYD88 Gene
-
Protein details for MYD88 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99836-MYD88_HUMAN
- Recommended name:
- Myeloid differentiation primary response protein MyD88
- Protein Accession:
- Q99836
- B4DKH8
- B4DKU4
- B4DQ60
- B4DQ72
- J3KPU4
- J3KQ87
- J3KQJ6
- P78397
- Q53XS7
Protein attributes for MYD88 Gene
- Size:
- 296 amino acids
- Molecular mass:
- 33233 Da
- Quaternary structure:
-
- Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, TLR5, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1, IKBKE and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with PIK3AP1. Interacts (via TIR domain) with DHX9 (via H2A and OB-fold regions); this interaction is direct (PubMed:20696886). Interacts with OTUD4 deubiquitinase; the interaction is direct (PubMed:29395066).
- (Microbial infection) In case of infection, interacts with uropathogenic E.coli protein TcpC; suppressing Toll-like receptor (TLR)-mediated cytokine production.
- (Microbial infection) In case of infection, interacts with uropathogenic E.faecalis protein TcpF; suppressing Toll-like receptor (TLR)-mediated cytokine production.
- SequenceCaution:
-
- Sequence=BAG60822.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAG60834.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=EAW64521.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for MYD88 Gene
Protein Expression for MYD88 Gene
Post-translational modifications for MYD88 Gene
- Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88.
-
Ubiquitination at Lys95, Lys119, Lys231, and Lys282
- NX_Q99836 (NX_Q99836-1)
- Modification sites at PhosphoSitePlus
Other Protein References for MYD88 Gene
Antibodies for research
- LifeSpan BioSciences MYD88 Antibody and MYD88 Monoclonal Antibody
- NSJ Bioreagents MyD88 Antibody
- BioLegend MyD88 Antibody
-
Custom Antibody ServicesOriGene Antibodies for MYD88
- AP02277SU-N
- AP02277SU-S
- AP07327PU-N
- AP08396PU-N
- AP18123PU-N
- AP20639PU-N
- CF502104
- CF502116
- CF502117
- CF502118
- DDX1400P-100
- DDX1401P-100
- SP1273P
- SP1274P
- TA302999
- TA305998
- TA305999
- TA319687
- TA324013
- TA326877
- TA336449
- TA337031
- TA337167
- TA354406
- TA502104
- TA502104S
- TA502116
- TA502116S
- TA502117
- TA502117S
- TA502118
- TA502118S
- Novus Biologicals Antibodies for MYD88
-
Abcam antibodies for MYD88
- Invitrogen Antibodies for MYD88 (AFLGC-MYD88)
- antibodies-online: Show 65 available MYD88 Antibodies ranked by validation data
- Compare Top MYD88 Antibodies
-
Recommended
- 218 WB Antibodies (anti-human)
- 13 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 122 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 FACS Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 72 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for MYD88
- myeloid differentiation primary response gene (88) [2125]
- myeloid differentiation primary response gene (88) [2127]
- myeloid differentiation primary response 88 [45-095]
- myeloid differentiation primary response gene (88) [33-054]
- myeloid differentiation primary response 88 [49-221]
- myeloid differentiation primary response gene (88) [PM-4673]
-
Santa Cruz Biotechnology (SCBT) Antibodies for MYD88
- Sino Biological Antibodies for MYD88
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for MYD88
- Origene Custom Protein Services for MYD88
- ProSpec Recombinant Proteins for MYD88
-
ProSci Proteins for MYD88
-
Abcam proteins for MYD88
Assay products for research
- RayBiotech Custom Human MyD88 ELISA
-
Custom Assay ServicesOriGene ELISA Kits for MYD88
- antibodies-online: Show 59 available MYD88 Elisa Kits ranked by validation data
- Compare Top MYD88 Elisa Kits
-
Quality Products:
- ABIN1116076
- ABIN414798
- ABIN366188
- ABIN1672854
- ABIN1029341
- ABIN5521131
- ABIN2708338
- ABIN6719682
- ABIN5668650
- ABIN5592366
- ABIN425033
- ABIN367678
- ABIN5521132
- ABIN4993591
- ABIN1571379
- ABIN5592367
- ABIN5657046
- ABIN2536876
- ABIN4971332
- ABIN2949668
- ABIN432286
- ABIN5521133
- ABIN1571380
- ABIN5657047
- ABIN4971330
- ABIN2536877
- ABIN4971333
- ABIN6205822
- ABIN2044005
- ABIN1143513
- ABIN1564417
- ABIN6205815
- ABIN1143510
-
Boster Bio ELISA Kits for MYD88
No data available for DME Specific Peptides for MYD88 Gene
Domains & Families for MYD88 Gene
Gene Families for MYD88 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for MYD88 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MYD88 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ59950, highly similar to Myeloid differentiation primary response protein MyD88 (B4DQ60_HUMAN)
- cDNA FLJ59951, highly similar to Myeloid differentiation primary response protein MyD88 (B4DQ72_HUMAN)
- Myeloid differentiation primary response protein MyD88 (MYD88_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q99836UniProtKB/Swiss-Prot:
MYD88_HUMAN :- The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.
- Domain:
-
- The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.
Function for MYD88 Gene
Molecular function for MYD88 Gene
- UniProtKB/Swiss-Prot Function:
- Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).
- GENATLAS Biochemistry:
- myeloid differentiation primary response gene,88,binding the cytoplasmic tail of TLR proteins leading to their activation,initiating an intracellular signaling pathway to NFKB and its target genes
Phenotypes From GWAS Catalog for MYD88 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IEA | -- |
| GO:0005121 | Toll binding | IEA | -- |
| GO:0005123 | death receptor binding | TAS | 9374458 |
| GO:0005149 | interleukin-1 receptor binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 10880445 |
Phenotypes for MYD88 Gene
- MGI mutant phenotypes for MYD88:
-
inferred from 14 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- renal/urinary system phenotype
- liver/biliary system phenotype
- hematopoietic system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for MYD88:
-
- no effect
- Negative genetic interaction between MUS81-/- and MUS81+/+
- shRNA abundance <= 50%
- Reduced mammosphere formation
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Two nuclei (binuclear)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Models for MYD88 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for MYD88
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MYD88 - Starting at $85 >
- * MYD88 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MYD88
-
Santa Cruz Biotechnology (SCBT) CRISPR for MYD88
miRNA for MYD88 Gene
- miRTarBase miRNAs that target MYD88
-
- hsa-miR-203a-3p (MIRT007368)
- hsa-miR-155-5p (MIRT020533)
- hsa-miR-21-5p (MIRT054356)
- mmu-miR-489-3p (MIRT054725)
- hsa-miR-6817-3p (MIRT237424)
- mmu-miR-124-3p (MIRT437501)
- hsa-miR-149-5p (MIRT438020)
- mmu-miR-150-5p (MIRT438429)
- mmu-miR-31-5p (MIRT438430)
- hsa-miR-384 (MIRT527503)
- hsa-miR-3685 (MIRT527504)
- hsa-miR-155-3p (MIRT527505)
- hsa-miR-6715b-3p (MIRT527506)
- hsa-miR-5690 (MIRT527507)
- mmu-miR-203-3p (MIRT734953)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MYD88
- Browse OriGene Inhibitory RNA Products For MYD88
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYD88
Clone products for research
- Applied Biological Materials (abm): Clones for MYD88 - Starting at $45 >
- * MYD88 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG227105
- MR227105
- MR227105L3
- MR227105L4
- RC202253
- RC202253L1
- RC202253L2
- RC202253L3
- RC202253L4
- RC229151
- RC229612
- RC229612L3
- RC229612L4
- RC229682
- RC229682L3
- RC229682L4
- RC229790
- RC229790L3
- RC229790L4
- RC229873
- RC229873L1
- RC229873L2
- RC229873L3
- RC229873L4
- RG202253
- RG229151
- RG229612
- RG229682
- RG229790
- RG229873
- RR202145
- RR202145L3
- RR202145L4
- MR227105L3V
- MR227105L4V
- RC202253L1V
- RC202253L2V
- RC202253L3V
- RC202253L4V
- RC229612L3V
- RC229612L4V
- RC229682L3V
- RC229682L4V
- RC229790L3V
- RC229790L4V
- RC229873L1V
- RC229873L2V
- RC229873L3V
- RC229873L4V
- RR202145L3V
- RR202145L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MYD88
- Addgene plasmids for MYD88
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MYD88
Cell Lines for research
-
Horizon Cell Lines for MYD88
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MYD88 Gene
Localization for MYD88 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MYD88 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| endosome | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| extracellular | 4 |
| mitochondrion | 3 |
| lysosome | 3 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| golgi apparatus | 2 |
- Cytosol (3)
- Mitochondria (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 22155231 |
| GO:0005737 | cytoplasm | IDA | 22155231 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0010008 | endosome membrane | TAS | -- |
Pathways & Interactions for MYD88 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Diseases associated with the TLR signaling cascade | ||
| 3 | Cytosolic sensors of pathogen-associated DNA | ||
| 4 | Toll-like Receptor Signaling Pathway |
.37
.31
|
|
| 5 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
Immune response IL-1 signaling pathway
.41
|
|
Pathways by source for MYD88 Gene
2 Sino Biological pathways for MYD88 Gene
12 BioSystems pathways for MYD88 Gene
47 Reactome pathways for MYD88 Gene
24 KEGG pathways for MYD88 Gene
10 GeneGo (Thomson Reuters) pathways for MYD88 Gene
- Bacterial infections in CF airways
- Cytokine production by Th17 cells in CF
- Cytokine production by Th17 cells in CF (Mouse model)
- IL-1 beta-dependent CFTR expression
- Immune response Bacterial infections in normal airways
4 R&D Systems pathways for MYD88 Gene
12 Qiagen pathways for MYD88 Gene
- 14-3-3 Induced Apoptosis
- IL-1 Pathway
- iNOS Signaling
- NF-KappaB (p50-p65) Pathway
- NF-KappaB Family Pathway
1 Cell Signaling Technology pathway for MYD88 Gene
1 GeneTex pathway for MYD88 Gene
Interacting Proteins for MYD88 Gene
Selected Interacting proteins:
Q99836-MYD88_HUMAN
ENSP00000401399
for MYD88 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MYD88
SIGNOR curated interactions for MYD88 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
| GO:0002238 | response to molecule of fungal origin | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | -- |
| GO:0006909 | phagocytosis | IMP | 30883606 |
Drugs & Compounds for MYD88 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for MYD88 Gene
| Compound | Action | Cas Number |
|---|---|---|
| ST 2825 | Inhibitor of MyD88 dimerization | 894787-30-5 |
Drug products for research
- ApexBio compounds for MYD88
Transcripts for MYD88 Gene
mRNA/cDNA for MYD88 Gene
- 9 REFSEQ mRNAs :
- 20 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000396334 2850 nts (view in UCSC)
- ENST00000416282 2725 nts (view in UCSC)
- ENST00000417037 2638 nts (view in UCSC)
- ENST00000421516 2691 nts (view in UCSC)
- ENST00000460295 1088 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MYD88 - Starting at $85 >
- * MYD88 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MYD88
-
Santa Cruz Biotechnology (SCBT) CRISPR for MYD88
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MYD88
- Browse OriGene Inhibitory RNA Products For MYD88
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYD88
Clone products for research
- Applied Biological Materials (abm): Clones for MYD88 - Starting at $45 >
- * MYD88 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG227105
- MR227105
- MR227105L3
- MR227105L4
- RC202253
- RC202253L1
- RC202253L2
- RC202253L3
- RC202253L4
- RC229151
- RC229612
- RC229612L3
- RC229612L4
- RC229682
- RC229682L3
- RC229682L4
- RC229790
- RC229790L3
- RC229790L4
- RC229873
- RC229873L1
- RC229873L2
- RC229873L3
- RC229873L4
- RG202253
- RG229151
- RG229612
- RG229682
- RG229790
- RG229873
- RR202145
- RR202145L3
- RR202145L4
- MR227105L3V
- MR227105L4V
- RC202253L1V
- RC202253L2V
- RC202253L3V
- RC202253L4V
- RC229612L3V
- RC229612L4V
- RC229682L3V
- RC229682L4V
- RC229790L3V
- RC229790L4V
- RC229873L1V
- RC229873L2V
- RC229873L3V
- RC229873L4V
- RR202145L3V
- RR202145L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MYD88
- Addgene plasmids for MYD88
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MYD88
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||
| SP7: | - | - | - | - | - | ||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||
| SP9: |
Relevant External Links for MYD88 Gene
- GeneLoc Exon Structure for
- MYD88
Expression for MYD88 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Secondary Spermatocyte Seminiferous Tubules
-
Gonad
- Secondary Spermatocyte Seminiferous Tubules
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for MYD88 Gene
This gene is overexpressed in Whole Blood (x17.2).
This gene is overexpressed in Monocytes (13.1), Peripheral blood mononuclear cells (10.3), and Lymph node (8.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYD88 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYD88
SOURCE GeneReport for Unigene cluster for MYD88 Gene:
Hs.82116mRNA Expression by UniProt/SwissProt for MYD88 Gene:
Q99836-MYD88_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for MYD88 Gene
- Blood(4.9)
- Spleen(4.8)
- Lymph node(4.7)
- Pancreas(4.5)
- Nervous system(4.4)
- Intestine(3.8)
- Lung(3.6)
- Liver(3.5)
- Kidney(3.4)
- Bone marrow(3.4)
- Heart(3.4)
- Skin(3.2)
- Stomach(3.2)
- Muscle(3)
- Eye(2.3)
- Adrenal gland(2.2)
- Bone(2.1)
- Thyroid gland(2.1)
- Gall bladder(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MYD88 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- respiratory
- skeleton
Regions:
Head and neck:
- brain
- ear
- head
- mouth
- sinus
- skull
Thorax:
- lung
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- white blood cell
Primer products for research
-
OriGene qPCR primer pairs for MYD88
-
OriGene qPCR primer pairs and template standards for MYD88
Gene Expression Assays for research
Orthologs for MYD88 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MYD88 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MYD88 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MYD88 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MYD88 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Myd88 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Myd88 30 |
|
||
| Chicken (Gallus gallus) |
Aves | MYD88 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MYD88 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | myd88 30 |
|
||
| Str.11893 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | myd88-A 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | myd88 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | MYD 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Myd88 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2481 31 |
|
OneToOne |
- Species where no ortholog for MYD88 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MYD88 Gene
- ENSEMBL:
- Gene Tree for MYD88 (if available)
- TreeFam:
- Gene Tree for MYD88 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MYD88: view image
Paralogs for MYD88 Gene
No data available for Paralogs for MYD88 Gene
Variants for MYD88 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYD88 Gene
| SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 838237 | Uncertain Significance: Myd88 deficiency | 38,140,403(+) |
G/A NM_002468.5(MYD88):c.479G>A (p.Arg160His) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON | |
| 846019 | Uncertain Significance: Myd88 deficiency | 38,139,969(+) |
C/A NM_002468.5(MYD88):c.434C>A (p.Ala145Glu) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON | |
| 953721 | Uncertain Significance: Myd88 deficiency | 38,139,993(+) |
C/A NM_002468.5(MYD88):c.458C>A (p.Pro153His) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON | |
| 958926 | Uncertain Significance: Myd88 deficiency | 38,138,671(+) |
G/A NM_002468.5(MYD88):c.-30G>A |
FIVE_PRIME_UTR | |
| 961630 | Uncertain Significance: Myd88 deficiency | 38,138,693(+) |
C/G NM_002468.5(MYD88):c.-8C>G |
FIVE_PRIME_UTR |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3359602 | CNV | duplication | 20981092 |
Residual Variation Intolerance Score:
30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.85;
17.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MYD88 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYD88 Gene
Disorders for MYD88 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency 68 |
|
|
| macroglobulinemia, waldenstrom 1 |
|
|
| waldenstroem's macroglobulinemia |
|
|
| macroglobulinemia |
|
|
| central nervous system lymphoma |
|
|
Search MYD88 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MYD88_HUMAN- Immunodeficiency 68 (IMD68) [MIM:612260]: An autosomal recessive primary immunodeficiency characterized by life-threatening, often recurrent, pyogenic bacterial infections, including invasive pneumococcal disease, beginning in infancy or early childhood. {ECO:0000269 PubMed:18669862, ECO:0000269 PubMed:19506249, ECO:0000269 PubMed:21057262, ECO:0000269 PubMed:24316379}. Note=The disease is caused by variants affecting the gene represented in this entry.
- Note=Defects in MYD88 are frequently found in many hematological malignancies, such as activated B-cell type diffuse large B-cell lymphoma (ABC-DLBCL), Waldenstroem macroglobulinemia, cutaneous diffuse large B cell lymphoma (CBCL) and primary central nervous system lymphoma (PCNSL). {ECO:0000269 PubMed:21179087, ECO:0000269 PubMed:22931316}.
Additional Disease Information for MYD88
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for MYD88 Gene
Publications for MYD88 Gene
- MYD88 L265P somatic mutation in Waldenström's macroglobulinemia. (PMID: 22931316) Treon SP ā¦ Hunter ZR (The New England journal of medicine 2012) 3 4 74
- Oncogenically active MYD88 mutations in human lymphoma. (PMID: 21179087) Ngo VN ā¦ Staudt LM (Nature 2011) 3 4 74
- Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins. (PMID: 19265123) Dai P ā¦ Chen X (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 4 23
- Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling. (PMID: 19506249) Ohnishi H ā¦ Shirakawa M (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 23
- Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE. (PMID: 19254290) Tewfik MA ā¦ Desrosiers M (Allergy 2009) 3 23 41
ExternalLinks
Products for MYD88 Gene
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- 122 WB Antibodies (anti-mouse)
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- myeloid differentiation primary response gene (88) [2125]
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Sources for MYD88 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23)