Aliases for MYD88 Gene
External Ids for MYD88 Gene
Previous GeneCards Identifiers for MYD88 Gene
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
GeneCards Summary for MYD88 Gene
MYD88 (Myeloid Differentiation Primary Response 88) is a Protein Coding gene. Diseases associated with MYD88 include Myd88 Deficiency and Waldenstrom Macroglobulinemia. Among its related pathways are Activated TLR4 signalling and Bacterial infections in CF airways. Gene Ontology (GO) annotations related to this gene include identical protein binding and death receptor binding.
UniProtKB/Swiss-Prot for MYD88 Gene
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).