Aliases for MYCT1 Gene

Aliases for MYCT1 Gene

  • MYC Target 1 2 3 5
  • MTLC 2 3 4
  • Myc Target In Myeloid Cells Protein 1 3 4
  • Myc Target Protein 1 3 4
  • Myc Target In Myeloid Cells 1 3
  • FLJ21269 2
  • MYCT1 5
  • MTMC1 4

External Ids for MYCT1 Gene

Previous GeneCards Identifiers for MYCT1 Gene

  • GC06P153050
  • GC06P153111
  • GC06P153061
  • GC06P153062
  • GC06P153019
  • GC06P150582

Summaries for MYCT1 Gene

GeneCards Summary for MYCT1 Gene

MYCT1 (MYC Target 1) is a Protein Coding gene. Diseases associated with MYCT1 include Hepatocellular Carcinoma. Among its related pathways are Validated targets of C-MYC transcriptional activation.

UniProtKB/Swiss-Prot Summary for MYCT1 Gene

  • May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYCT1 Gene

Genomics for MYCT1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MYCT1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J152694 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 250.7 +1.1 1110 8.2 ZNF654 RAD21 JUND BHLHE40 REST SP1 TAF1 CTCF EP300 NR2F2 MYCT1 VIP HSPD1P16
GH06J152681 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 250.4 -16.0 -15995 3.4 ZNF366 SPI1 ZNF512 piR-38716-134 MYCT1 SYNE1 VIP LOC105378061 lnc-MYCT1-1
GH06J152746 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 0.3 +48.5 48453 0.7 JUND CEBPA CEBPB EP300 FOXA2 SMAD4 SAP130 RFX5 FOSL2 FOXP1 VIP HSALNG0054405 MYCT1
GH06J152643 Enhancer 0.8 Ensembl ENCODE 0.2 -54.9 -54875 0.8 ZNF654 ZNF10 CTCF ZNF217 RAD21 SMC3 YY1 TEAD3 MIER2 TRIM28 piR-50443-331 SYNE1 lnc-MYCT1-1 MYCT1
GH06J152750 Promoter 0.7 EPDnew 0.2 +52.9 52883 0.1 REST SIN3A YY1 MBD1 EHMT2 MIER2 ZNF143 CREB1 DNMT3B VIP HSALNG0054405 MYCT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYCT1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYCT1

Top Transcription factor binding sites by QIAGEN in the MYCT1 gene promoter:
  • Evi-1
  • FAC1
  • GR
  • GR-alpha
  • Hlf
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • S8

Genomic Locations for MYCT1 Gene

Latest Assembly
chr6:152,697,895-152,747,175
(GRCh38/hg38)
Size:
49,281 bases
Orientation:
Plus strand

Previous Assembly
chr6:153,019,030-153,049,320
(GRCh37/hg19 by Entrez Gene)
Size:
30,291 bases
Orientation:
Plus strand

chr6:153,019,030-153,045,702
(GRCh37/hg19 by Ensembl)
Size:
26,673 bases
Orientation:
Plus strand

Genomic View for MYCT1 Gene

Genes around MYCT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYCT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYCT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYCT1 Gene

Proteins for MYCT1 Gene

  • Protein details for MYCT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N699-MYCT1_HUMAN
    Recommended name:
    Myc target protein 1
    Protein Accession:
    Q8N699
    Secondary Accessions:
    • Q8N396
    • Q8TBE8
    • Q9H763

    Protein attributes for MYCT1 Gene

    Size:
    235 amino acids
    Molecular mass:
    26593 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MYCT1 Gene

Post-translational modifications for MYCT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYCT1 Gene

Domains & Families for MYCT1 Gene

Gene Families for MYCT1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MYCT1 Gene

InterPro:

Suggested Antigen Peptide Sequences for MYCT1 Gene

GenScript: Design optimal peptide antigens:
  • Myc target 1 transcript variant 1 (D6Q1S4_HUMAN)
  • Myc target in myeloid cells protein 1 (MYCT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N699

UniProtKB/Swiss-Prot:

MYCT1_HUMAN :
  • Belongs to the MYCT1 family.
Family:
  • Belongs to the MYCT1 family.
genes like me logo Genes that share domains with MYCT1: view

Function for MYCT1 Gene

Molecular function for MYCT1 Gene

UniProtKB/Swiss-Prot Function:
May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity).

Phenotypes From GWAS Catalog for MYCT1 Gene

genes like me logo Genes that share phenotypes with MYCT1: view

miRNA for MYCT1 Gene

miRTarBase miRNAs that target MYCT1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYCT1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYCT1 Gene

Localization for MYCT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYCT1 Gene

Nucleus. Note=Expressed in nuclei of hepatocellular carcinoma cell line BEL-7402 cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYCT1 gene
Compartment Confidence
nucleus 4
plasma membrane 3
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MYCT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with MYCT1: view

Pathways & Interactions for MYCT1 Gene

genes like me logo Genes that share pathways with MYCT1: view

Pathways by source for MYCT1 Gene

1 BioSystems pathway for MYCT1 Gene

Interacting Proteins for MYCT1 Gene

Selected Interacting proteins: Q8N699-MYCT1_HUMAN for MYCT1 Gene via IID

Symbol External ID(s) Details
FANCD2

SIGNOR curated interactions for MYCT1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MYCT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061484 hematopoietic stem cell homeostasis IEA --
genes like me logo Genes that share ontologies with MYCT1: view

Drugs & Compounds for MYCT1 Gene

No Compound Related Data Available

Transcripts for MYCT1 Gene

mRNA/cDNA for MYCT1 Gene

4 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYCT1

Alternative Splicing Database (ASD) splice patterns (SP) for MYCT1 Gene

No ASD Table

Relevant External Links for MYCT1 Gene

GeneLoc Exon Structure for
MYCT1

Expression for MYCT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYCT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYCT1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x4.1).

Protein differential expression in normal tissues from HIPED for MYCT1 Gene

This gene is overexpressed in Platelet (29.1), Peripheral blood mononuclear cells (24.5), and Placenta (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MYCT1 Gene



Protein tissue co-expression partners for MYCT1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYCT1

SOURCE GeneReport for Unigene cluster for MYCT1 Gene:

Hs.18160

mRNA Expression by UniProt/SwissProt for MYCT1 Gene:

Q8N699-MYCT1_HUMAN
Tissue specificity: Down-regulated in gastric cancer tissues.

Evidence on tissue expression from TISSUES for MYCT1 Gene

  • Intestine(4.2)
  • Nervous system(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with MYCT1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MYCT1 Gene

Orthologs for MYCT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYCT1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MYCT1 29 30
  • 99.43 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MYCT1 29 30
  • 86.84 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MYCT1 29 30
  • 86.32 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MYCT1 30
  • 86 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Myct1 29
  • 85.92 (n)
Mouse
(Mus musculus)
Mammalia Myct1 29 16 30
  • 84.85 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MYCT1 30
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MYCT1 29 30
  • 69.53 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MYCT1 30
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia myct1 29
  • 65.07 (n)
Zebrafish
(Danio rerio)
Actinopterygii myct1 29 30
  • 49.1 (n)
OneToMany
MYCT1 (2 of 2) 30
  • 29 (a)
OneToMany
Species where no ortholog for MYCT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MYCT1 Gene

ENSEMBL:
Gene Tree for MYCT1 (if available)
TreeFam:
Gene Tree for MYCT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYCT1: view image
Alliance of Genome Resources:
Additional Orthologs for MYCT1

Paralogs for MYCT1 Gene

No data available for Paralogs for MYCT1 Gene

Variants for MYCT1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYCT1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs17710008 -- p.Gly119Ser
rs17852097 -- p.Arg127Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MYCT1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MYCT1 Gene

Variant ID Type Subtype PubMed ID
dgv3414n106 CNV deletion 24896259
esv2228317 CNV deletion 18987734
esv2463453 CNV deletion 19546169
esv2660075 CNV deletion 23128226
esv2732910 CNV deletion 23290073
esv3540661 CNV deletion 23714750
esv4043 CNV loss 18987735
esv8713 CNV loss 19470904
nsv1074022 CNV deletion 25765185
nsv1117675 CNV deletion 24896259
nsv1145108 CNV deletion 24896259
nsv1153425 CNV deletion 26484159
nsv348864 CNV deletion 16902084
nsv499526 CNV loss 21111241
nsv508435 CNV deletion 20534489
nsv511919 CNV loss 21212237
nsv5546 CNV deletion 18451855
nsv955815 CNV deletion 24416366
nsv970179 CNV duplication 23825009

Variation tolerance for MYCT1 Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.63; 82.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYCT1 Gene

Human Gene Mutation Database (HGMD)
MYCT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYCT1
Leiden Open Variation Database (LOVD)
MYCT1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYCT1 Gene

Disorders for MYCT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MYCT1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search MYCT1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MYCT1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MYCT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYCT1 Gene

Publications for MYCT1 Gene

  1. Transmembrane domain is crucial to the subcellular localization and function of Myc target 1. (PMID: 26710964) Wu S … Chu L (Journal of cellular and molecular medicine 2016) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. [Cloning and characterization of MTLC, a novel gene in 6q25]. (PMID: 12673574) Qiu G … Sun K (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2003) 3 4
  4. Expression of MTLC gene in gastric carcinoma. (PMID: 14562369) Qiu GB … Sun KL (World journal of gastroenterology 2003) 3 4
  5. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. (PMID: 31391242) Nowak M … Sommer T (Journal of cell science 2019) 3

Products for MYCT1 Gene

Sources for MYCT1 Gene