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This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different is... See more...
Aliases for MYCN Gene
Aliases for MYCN Gene
External Ids for MYCN Gene
- HGNC: 7559
- Entrez Gene: 4613
- Ensembl: ENSG00000134323
- OMIM: 164840
- UniProtKB: P04198
Previous HGNC Symbols for MYCN Gene
- NMYC
Previous GeneCards Identifiers for MYCN Gene
- GC02P016084
- GC02P016102
- GC02P016032
- GC02P015998
- GC02P016080
- GC02P015942
- GC02P015943
- GC02P015953
- GC02P015954
- GC02P015952
- GC02P015950
- GC02P015944
- GC02P015945
- GC02P015946
- GC02P015947
- GC02P015948
Summaries for MYCN Gene
-
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
GeneCards Summary for MYCN Gene
MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYCN include Feingold Syndrome 1 and Retinoblastoma. Among its related pathways are Neuroscience and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity. An important paralog of this gene is MYC.
UniProtKB/Swiss-Prot Summary for MYCN Gene
-
Positively regulates the transcription of MYCNOS in neuroblastoma cells.
Additional gene information for MYCN Gene
- HGNC(7559)
- Entrez Gene(4613)
- Ensembl(ENSG00000134323)
- OMIM(164840)
- UniProtKB(P04198)
- Open Targets Platform(ENSG00000134323)
- Monarch Initiative
- Search for MYCN at DataMed
- Search for MYCN at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYCN Gene
Genomics for MYCN Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MYCN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MYCN on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYCN
- Top Transcription factor binding sites by QIAGEN in the MYCN gene promoter:
-
- Egr-3
- GR
- GR-alpha
- GR-beta
- HNF-4alpha1
- Nkx2-5
- p53
- Sp1
Genomic Locations for MYCN Gene
Genomic Locations for MYCN Gene
- chr2:15,940,550-15,947,007
- (GRCh38/hg38)
- Size:
- 6,458 bases
- Orientation:
- Plus strand
- chr2:16,080,683-16,087,129
- (GRCh37/hg19)
- Size:
- 6,447 bases
- Orientation:
- Plus strand
Genomic View for MYCN Gene
Genes around MYCN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p24.3 by HGNC
- 2p24.3 by Entrez Gene
- 2p24.3 by Ensembl
MYCN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MYCN Gene
Proteins for MYCN Gene
-
Protein details for MYCN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04198-MYCN_HUMAN
- Recommended name:
- N-myc proto-oncogene protein
- Protein Accession:
- P04198
- Q53XS5
- Q6LDT9
Protein attributes for MYCN Gene
- Size:
- 464 amino acids
- Molecular mass:
- 49561 Da
- Quaternary structure:
-
- Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1. Interacts with MYCNOS. Interacts with AURKA; interaction is phospho-independent and triggers AURKA activation; AURKA competes with FBXW7 for binding to unphosphorylated MYCN but not for binding to unphosphorylated MYCN (PubMed:27837025). Interacts with FBXW7; FBXW7 competes with AURKA for binding to unphosphorylated MYCN but not for binding to phosphorylated MYCN (PubMed:27837025).
- SequenceCaution:
-
- Sequence=AAA36371.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA68678.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for MYCN Gene
Post-translational modifications for MYCN Gene
- Phosphorylated by GSK3-beta which may promote its degradation (PubMed:24391509). Phosphorylated by AURKA (PubMed:27837025).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MYCN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ N Myc Antibody
- Novus Biologicals Antibodies for MYCN
-
Abcam antibodies for MYCN
- Invitrogen Antibodies for MYCN (AFLGC-MYCN)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MYCN
Protein Products
-
OriGene Purified Proteins for MYCN
- Search Origene for MassSpec and Protein Over-expression Lysates for MYCN
- Origene Custom Protein Services for MYCN
- antibodies-online: Show 7 available MYCN Proteins ranked by validation data
- Compare Top MYCN Proteins
-
Quality Products:
-
Abcam proteins for MYCN
Assay Products
- G Biosciences Immunotag™ N-myc proto-oncogene protein ELISA Kit
- antibodies-online: Show 8 available MYCN Elisa Kits ranked by validation data
- Compare Top MYCN Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for MYCN Gene
Domains & Families for MYCN Gene
Gene Families for MYCN Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for MYCN Gene
- InterPro:
- Blocks:
-
- Basic helix-loop-helix dimerization domain bHLH
- Myc proto-oncogene signature
- ProtoNet:
Suggested Antigen Peptide Sequences for MYCN Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ59229, highly similar to Homo sapiens v-myc myelocytomatosis viral related oncogene, neuroblastoma derived, mRNA (B4DRZ1_HUMAN)
- Class E basic helix-loop-helix protein 37 (MYCN_HUMAN)
- V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (Avian), isoform CRA_a (Q53XS5_HUMAN)
- N-myc protein (Q9UMQ5_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MYCN Gene
Function for MYCN Gene
Molecular function for MYCN Gene
- UniProtKB/Swiss-Prot Function:
- Positively regulates the transcription of MYCNOS in neuroblastoma cells.
- GENATLAS Biochemistry:
- avian myelocytomatosis viral (v-myc) oncogene homolog,neuroblastoma derived,amplified in retinoblastoma,neuroblastoma,small cell carcinoma of the lung,with poor prognosis
Phenotypes From GWAS Catalog for MYCN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 17327229 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 17327229 |
| GO:0003677 | DNA binding | TAS | 10597290 |
| GO:0003700 | DNA-binding transcription factor activity | IEA,TAS | 3796607 |
Phenotypes for MYCN Gene
- MGI mutant phenotypes for MYCN:
-
inferred from 12 alleles
- nervous system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- digestive/alimentary phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- hematopoietic system phenotype
- embryo phenotype
- craniofacial phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for MYCN:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Increased shRNA abundance (Z-score > 2)
- Increased IL-8 secretion
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Increased cell number in G2M, increased number of polyploid cells
Animal Models for MYCN Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MYCN - Select products 50% OFF >
- * MYCN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MYCN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MYCN
-
Santa Cruz Biotechnology (SCBT) CRISPR for MYCN
miRNA for MYCN Gene
- miRTarBase miRNAs that target MYCN
-
- hsa-miR-101-3p (MIRT000378)
- hsa-miR-34a-5p (MIRT000980)
- rno-miR-34a-5p (MIRT003704)
- mmu-let-7c-5p (MIRT004648)
- hsa-miR-29a-3p (MIRT006135)
- hsa-miR-34b-3p (MIRT006224)
- hsa-miR-34c-5p (MIRT006225)
- mmu-miR-30e-5p (MIRT013453)
- mmu-miR-181a-5p (MIRT014410)
- hsa-miR-202-3p (MIRT016613)
- hsa-miR-29c-3p (MIRT020415)
- hsa-miR-29b-3p (MIRT027239)
- hsa-miR-19b-3p (MIRT031210)
- hsa-miR-19a-3p (MIRT031308)
- hsa-let-7e-5p (MIRT032100)
- hsa-miR-126-5p (MIRT236107)
- hsa-miR-331-5p (MIRT236108)
- hsa-miR-4795-3p (MIRT236114)
- hsa-miR-6504-3p (MIRT236115)
- hsa-miR-6509-5p (MIRT236116)
- hsa-miR-767-5p (MIRT242904)
- hsa-miR-1252-5p (MIRT242905)
- hsa-miR-4503 (MIRT242906)
- hsa-miR-556-3p (MIRT535758)
- hsa-miR-582-5p (MIRT535759)
- hsa-miR-374c-3p (MIRT535760)
- hsa-miR-371a-5p (MIRT535761)
- hsa-miR-144-3p (MIRT535762)
- hsa-miR-4642 (MIRT535763)
- hsa-miR-6071 (MIRT535764)
- hsa-miR-6792-5p (MIRT535765)
- hsa-miR-891a-3p (MIRT535766)
- hsa-miR-3688-5p (MIRT535767)
- hsa-miR-1287-5p (MIRT535768)
- hsa-miR-3135b (MIRT535769)
- hsa-miR-3692-5p (MIRT535770)
- hsa-miR-93-3p (MIRT535771)
- hsa-miR-299-3p (MIRT535772)
- hsa-miR-4657 (MIRT535773)
- hsa-miR-4491 (MIRT535774)
- hsa-miR-4686 (MIRT535775)
- hsa-miR-449a (MIRT731559)
- hsa-miR-103a-3p (MIRT733041)
- hsa-miR-34b-5p (MIRT733042)
- hsa-miR-449b-5p (MIRT733043)
- mmu-miR-9-5p (MIRT734727)
- hsa-miR-375 (MIRT735188)
- hsa-miR-124-3p (MIRT735267)
Transcription Factor Targets for MYCN Gene
Targeted motifs for MYCN Gene
HOMER Transcription Factor Regulatory Elements motif MYCN
- Consensus sequence: GNCCACGTGG Submotif: canonical Cell Type: mES GEO ID: GSE11431
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MYCN
- Browse OriGene Inhibitory RNA Products For MYCN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYCN
Clone Products
- Applied Biological Materials (abm): Clones for MYCN - Select products 50% OFF >
- * MYCN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG207382
- MR207382
- MR207382L1
- MR207382L2
- MR207382L3
- MR207382L4
- RC201241
- RC201241L1
- RC201241L2
- RC201241L3
- RC201241L4
- RC235689
- RC236960
- RC238385
- RG201241
- RR206566
- RR206566L3
- RR206566L4
- MR207382L1V
- MR207382L2V
- MR207382L3V
- MR207382L4V
- RC201241L1V
- RC201241L2V
- RC201241L3V
- RC201241L4V
- RR206566L3V
- RR206566L4V
- RC402779
- RC402780
- RC402781
- RC402782
- RC402783
- RC402784
- RC402785
- RC402786
- RC402787
- RC402788
- RC402789
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MYCN
- Addgene plasmids for MYCN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MYCN
Cell Line Products
-
Horizon Cell Lines for MYCN
No data available for Enzyme Numbers (IUBMB) for MYCN Gene
Localization for MYCN Gene
Subcellular locations from UniProtKB/Swiss-Prot for MYCN Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Nucleoli (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | TAS | 3796607 |
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IEA,IDA | 10597290 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005730 | nucleolus | IDA | -- |
Pathways & Interactions for MYCN Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis and Autophagy | ||
| 2 | Neuroscience | ||
| 3 | Transcriptional misregulation in cancer | ||
| 4 | Notch Pathway | ||
| 5 | Pathways Affected in Adenoid Cystic Carcinoma | ||
Pathways by source for MYCN Gene
1 BioSystems pathway for MYCN Gene
1 KEGG pathway for MYCN Gene
1 Tocris pathway for MYCN Gene
2 Cell Signaling Technology pathways for MYCN Gene
Interacting Proteins for MYCN Gene
Selected Interacting proteins:
P04198-MYCN_HUMAN
ENSP00000281043
for MYCN Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MYCN
SIGNOR curated interactions for MYCN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 3796607 |
| GO:0010628 | positive regulation of gene expression | IDA | 23308108 |
| GO:0010629 | negative regulation of gene expression | IDA | 21796614 |
| GO:0045893 | positive regulation of transcription, DNA-templated | IMP | 24391509 |
Drugs & Compounds for MYCN Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| dinutuximab | Approved, Investigational | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for MYCN Gene
mRNA/cDNA for MYCN Gene
- 4 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000281043 2613 nts (view in UCSC)
- ENST00000638417 1693 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MYCN - Select products 50% OFF >
- * MYCN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MYCN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MYCN
-
Santa Cruz Biotechnology (SCBT) CRISPR for MYCN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MYCN
- Browse OriGene Inhibitory RNA Products For MYCN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYCN
Clone Products
- Applied Biological Materials (abm): Clones for MYCN - Select products 50% OFF >
- * MYCN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG207382
- MR207382
- MR207382L1
- MR207382L2
- MR207382L3
- MR207382L4
- RC201241
- RC201241L1
- RC201241L2
- RC201241L3
- RC201241L4
- RC235689
- RC236960
- RC238385
- RG201241
- RR206566
- RR206566L3
- RR206566L4
- MR207382L1V
- MR207382L2V
- MR207382L3V
- MR207382L4V
- RC201241L1V
- RC201241L2V
- RC201241L3V
- RC201241L4V
- RR206566L3V
- RR206566L4V
- RC402779
- RC402780
- RC402781
- RC402782
- RC402783
- RC402784
- RC402785
- RC402786
- RC402787
- RC402788
- RC402789
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MYCN
- Addgene plasmids for MYCN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MYCN
Relevant External Links for MYCN Gene
- GeneLoc Exon Structure for
- MYCN
Expression for MYCN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Blood (Hematopoietic System)
- Megakaryocyte-Erythroid Precursor Cells Hematopoietic Bone Marrow
- Hematopoietic Stem Cells Liver Bud
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
- Retina
-
Lung (Respiratory System)
- Distal Lung Epithelial Cells Terminal Sacs
- Distal Lung Progenitor Cells Lung Bud
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
- Gut Tube (Gastrointestinal Tract)
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
-
Epithelial Cells
- Distal Lung Epithelial Cells Terminal Sacs
-
Mesoderm (Gastrulation Derivatives)
- Septum Transversum Mesenchyme Cells Septum Transversum
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Bone (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Brain (Nervous System)
- Intermediate Mesoderm (Gastrulation Derivatives)
- Head Mesenchyme (Muscoskeletal System)
- Kidney (Urinary System)
- Epiblast (Early Embryonic Tissues)
This gene is overexpressed in Adipocyte (46.2) and Tlymphocyte (16.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MYCN Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYCN
SOURCE GeneReport for Unigene cluster for MYCN Gene:
Hs.25960mRNA Expression by UniProt/SwissProt for MYCN Gene:
P04198-MYCN_HUMAN
Tissue specificity:
Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level).
Evidence on tissue expression from TISSUES for MYCN Gene
- Nervous system(4.9)
- Eye(3.2)
- Bone marrow(2.8)
- Kidney(2.7)
- Liver(2.7)
- Adrenal gland(2.6)
- Blood(2.6)
- Skin(2.5)
- Lung(2.4)
- Intestine(2.4)
- Lymph node(2.2)
- Heart(2.2)
- Muscle(2.2)
- Bone(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MYCN Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cheek
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- head
- jaw
- larynx
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- skull
- vocal cord
Thorax:
- chest wall
- clavicle
- esophagus
- heart
- lung
- rib
- rib cage
- scapula
- sternum
- trachea
Abdomen:
- adrenal gland
- biliary tract
- duodenum
- intestine
- kidney
- large intestine
- liver
- pancreas
- small intestine
- spleen
- stomach
Pelvis:
- pelvis
- placenta
- uterus
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- peripheral nervous system
- red blood cell
- skin
- spinal column
- spinal cord
- sweat gland
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for MYCN
-
OriGene qPCR primer pairs and template standards for MYCN
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for MYCN Gene
Orthologs for MYCN Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MYCN 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MYCN 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MYCN 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mycn 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mycn 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MYCN 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MYCN 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MYCN 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mycn 30 |
|
||
| Str.16732 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | mycn-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mycn 30 31 |
|
OneToOne | |
| wufb57a02 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | dm 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for MYCN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MYCN Gene
- ENSEMBL:
- Gene Tree for MYCN (if available)
- TreeFam:
- Gene Tree for MYCN (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MYCN: view image
Paralogs for MYCN Gene
Variants for MYCN Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYCN Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 642491 | Uncertain Significance: not provided | 15,942,320(+) | G/C | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
| 669345 | Likely Benign: not provided | 15,941,967(+) | C/T | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
| 695119 | Pathogenic: Feingold syndrome 1 | 15,945,804(+) | A/AAG | FRAMESHIFT_VARIANT,THREE_PRIME_UTR_VARIANT | |
| 695120 | Benign: Feingold syndrome 1 | 15,940,650(+) | C/T | NONSENSE,FIVE_PRIME_UTR_VARIANT | |
| 702007 | Likely Benign: not provided | 15,945,764(+) | G/A | SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1102e212 | CNV | loss | 25503493 |
Residual Variation Intolerance Score:
14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.84;
17.56% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MYCN Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYCN Gene
Disorders for MYCN Gene
(76) MalaCards diseases for MYCN Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| feingold syndrome 1 |
|
|
| retinoblastoma |
|
|
| neuroblastoma |
|
|
| childhood medulloblastoma |
|
|
| cerebral primitive neuroectodermal tumor |
|
Search MYCN in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MYCN_HUMAN- Note=Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses. {ECO:0000269 PubMed:2834684}.
- Feingold syndrome 1 (FGLDS1) [MIM:164280]: A syndrome characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability, mental retardation, and limb malformations. Hand and foot abnormalities may include hypoplastic thumbs, clinodactyly of second and fifth fingers, syndactyly (characteristically between second and third and fourth and fifth toes), and shortened or absent middle phalanges. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described. {ECO:0000269 PubMed:15821734, ECO:0000269 PubMed:16906565}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for MYCN
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for MYCN Gene
Publications for MYCN Gene
- Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II. (PMID: 1425701) Hagiwara T … Taya Y (European journal of biochemistry 1992) 3 4 23
- Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors. (PMID: 27837025) Richards MW … Bayliss R (Proceedings of the National Academy of Sciences of the United States of America 2016) 3 4
- NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas. (PMID: 24391509) Suenaga Y … Nakagawara A (PLoS genetics 2014) 3 4
- Transcriptional repression of SKP2 is impaired in MYCN-amplified neuroblastoma. (PMID: 20424123) Muth D … Westermann F (Cancer research 2010) 3 23
- Nitric oxide control of MYCN expression and multi drug resistance genes in tumours of neural origin. (PMID: 20236072) Porro A … Perini G (Current pharmaceutical design 2010) 3 23
ExternalLinks
Products for MYCN Gene
- Custom Antibody ServicesOriGene Antibodies for MYCN
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MYCN
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for MYCN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYCN
Sources for MYCN Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
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- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
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- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
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- (109) Disease Ontology
- (110) Genetics Home Reference
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- (112) MedlinePlus
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- (115) NCBI Bookshelf
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- (124) Horizon
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- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
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- (143) Applied Biosystems
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- (152) DiseaseEnhancer
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- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
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- (175) Open Targets Platform
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- (177) snoDB
- (178) MirGeneDB