Aliases for MYCN Gene
External Ids for MYCN Gene
Previous HGNC Symbols for MYCN Gene
Previous GeneCards Identifiers for MYCN Gene
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
GeneCards Summary for MYCN Gene
MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYCN include Feingold Syndrome 1 and Neuroblastoma. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity. An important paralog of this gene is MYC.
UniProtKB/Swiss-Prot Summary for MYCN Gene
Positively regulates the transcription of MYCNOS in neuroblastoma cells.