Aliases for MYCL Gene

Aliases for MYCL Gene

  • MYCL Proto-Oncogene, BHLH Transcription Factor 2 3 5
  • BHLHe38 2 3 4
  • LMYC 2 3 4
  • Class E Basic Helix-Loop-Helix Protein 38 3 4
  • Myc-Related Gene From Lung Cancer 2 3
  • Protein L-Myc-1 3 4
  • Protein L-Myc 3 4
  • MYCL1 3 4
  • V-Myc Avian Myelocytomatosis Viral Oncogene Homolog 1, Lung Carcinoma Derived 2
  • V-Myc Avian Myelocytomatosis Viral Oncogene Lung Carcinoma Derived Homolog 3
  • V-Myc Myelocytomatosis Viral Oncogene Homolog 1, Lung Carcinoma Derived 3
  • V-Myc Myelocytomatosis Viral Oncogene Homolog 4
  • L-Myc-1 Proto-Oncogene 3
  • L-Myc Protein 2
  • Oncogene Lmyc 2
  • BHLHE38 4
  • L-Myc 3
  • MYCL 5

External Ids for MYCL Gene

Previous HGNC Symbols for MYCL Gene

  • MYCL1

Previous GeneCards Identifiers for MYCL Gene

  • GC01M040362

Summaries for MYCL Gene

CIViC Summary for MYCL Gene

GeneCards Summary for MYCL Gene

MYCL (MYCL Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYCL include Apocrine Adenosis Of Breast and Lower Lip Cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity. An important paralog of this gene is MYCN.

Gene Wiki entry for MYCL Gene

Additional gene information for MYCL Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYCL Gene

Genomics for MYCL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MYCL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYCL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYCL

Genomic Locations for MYCL Gene

Genomic Locations for MYCL Gene
chr1:39,895,426-39,902,256
(GRCh38/hg38)
Size:
6,831 bases
Orientation:
Minus strand
chr1:40,361,096-40,367,928
(GRCh37/hg19)
Size:
6,833 bases
Orientation:
Minus strand

Genomic View for MYCL Gene

Genes around MYCL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYCL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYCL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYCL Gene

Proteins for MYCL Gene

  • Protein details for MYCL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12524-MYCL_HUMAN
    Recommended name:
    Protein L-Myc
    Protein Accession:
    P12524
    Secondary Accessions:
    • A2A2C9
    • B4DJH2
    • Q14897
    • Q5QPL0
    • Q5QPL1
    • Q9NUE9

    Protein attributes for MYCL Gene

    Size:
    364 amino acids
    Molecular mass:
    40327 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.
    SequenceCaution:
    • Sequence=AAH11864.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA30248.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MYCL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYCL Gene

Post-translational modifications for MYCL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYCL Gene

No data available for DME Specific Peptides for MYCL Gene

Domains & Families for MYCL Gene

Gene Families for MYCL Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MYCL Gene

InterPro:
Blocks:
  • Basic helix-loop-helix dimerization domain bHLH
  • Myc proto-oncogene signature
ProtoNet:

Suggested Antigen Peptide Sequences for MYCL Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60597, highly similar to L-myc-1 proto-oncogene protein (B4DJH2_HUMAN)
  • Class E basic helix-loop-helix protein 38 (MYCL1_HUMAN)
  • L-myc protein (Q86YL9_HUMAN)
genes like me logo Genes that share domains with MYCL: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MYCL Gene

Function for MYCL Gene

Phenotypes From GWAS Catalog for MYCL Gene

Gene Ontology (GO) - Molecular Function for MYCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding TAS 10597290
GO:0003700 DNA-binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with MYCL: view
genes like me logo Genes that share phenotypes with MYCL: view

Animal Models for MYCL Gene

MGI Knock Outs for MYCL:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYCL

Clone Products

  • Addgene plasmids for MYCL

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYCL Gene

Localization for MYCL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYCL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYCL gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0042025 host cell nucleus IEA --
genes like me logo Genes that share ontologies with MYCL: view

Pathways & Interactions for MYCL Gene

PathCards logo

SuperPathways for MYCL Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045607 regulation of inner ear auditory receptor cell differentiation IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with MYCL: view

No data available for Pathways by source and SIGNOR curated interactions for MYCL Gene

Drugs & Compounds for MYCL Gene

(1) Drugs for MYCL Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MYCL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MYCL: view

Transcripts for MYCL Gene

mRNA/cDNA for MYCL Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYCL

Clone Products

  • Addgene plasmids for MYCL

Alternative Splicing Database (ASD) splice patterns (SP) for MYCL Gene

No ASD Table

Relevant External Links for MYCL Gene

GeneLoc Exon Structure for
MYCL

Expression for MYCL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYCL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYCL Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x9.8), Skin - Not Sun Exposed (Suprapubic) (x7.9), Pancreas (x5.9), Bladder (x5.3), and Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for MYCL Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MYCL Gene



Protein tissue co-expression partners for MYCL Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYCL

Evidence on tissue expression from TISSUES for MYCL Gene

  • Nervous system(4.4)
  • Skin(2.9)
  • Pancreas(2.6)
  • Blood(2.4)
  • Intestine(2.3)
  • Lymph node(2.2)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with MYCL: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYCL Gene

Orthologs for MYCL Gene

This gene was present in the common ancestor of animals.

Orthologs for MYCL Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MYCL1 30
  • 99.43 (n)
MYCL 31
  • 91 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia MYCL 30
  • 90.59 (n)
MYCL1 31
  • 90 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia MYCL 30 31
  • 90.27 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mycl 30 17 31
  • 86.26 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mycl 30
  • 85.81 (n)
Oppossum
(Monodelphis domestica)
Mammalia MYCL 31
  • 53 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MYCL1 30
  • 65.89 (n)
MYCL 31
  • 55 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MYCL 31
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mycl 30
  • 57.11 (n)
Zebrafish
(Danio rerio)
Actinopterygii myclb 30 31
  • 59.19 (n)
OneToMany
mycla 31
  • 38 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta dm 31
  • 9 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 9 (a)
OneToMany
Species where no ortholog for MYCL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MYCL Gene

ENSEMBL:
Gene Tree for MYCL (if available)
TreeFam:
Gene Tree for MYCL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYCL: view image

Paralogs for MYCL Gene

Paralogs for MYCL Gene

(1) SIMAP similar genes for MYCL Gene using alignment to 3 proteins:

  • MYCL_HUMAN
  • E9PQS5_HUMAN
  • U5GXR9_HUMAN

Pseudogenes.org Pseudogenes for MYCL Gene

genes like me logo Genes that share paralogs with MYCL: view

Variants for MYCL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYCL Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
811452 Uncertain Significance: not specified 39,901,853(-) G/C MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT
rs3134614 - p.Thr362Ser

Additional dbSNP identifiers (rs#s) for MYCL Gene

Structural Variations from Database of Genomic Variants (DGV) for MYCL Gene

Variant ID Type Subtype PubMed ID
esv2666580 CNV deletion 23128226
esv2758933 CNV loss 17122850
nsv472423 CNV novel sequence insertion 20440878

Variation tolerance for MYCL Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYCL Gene

Human Gene Mutation Database (HGMD)
MYCL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYCL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYCL Gene

Disorders for MYCL Gene

MalaCards: The human disease database

(7) MalaCards diseases for MYCL Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
apocrine adenosis of breast
  • apocrine adenosis of the breast
lower lip cancer
lung cancer
  • adenocarcinoma of lung
non-proliferative fibrocystic change of the breast
  • non-proliferative fibrocystic change
merkel cell carcinoma
  • trabecular adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search MYCL in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with MYCL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYCL Gene

Publications for MYCL Gene

  1. Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc. (PMID: 19020549) Paulson KG … Nghiem P (The Journal of investigative dermatology 2009) 3 23
  2. L-myc polymorphism in head and neck nonmelanoma skin and lower lip cancers. (PMID: 18645122) Gözü A … Isbir T (Archives of otolaryngology--head & neck surgery 2008) 3 23
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas. (PMID: 12707044) Wu R … Cho KR (The American journal of pathology 2003) 3 23

Products for MYCL Gene

Sources for MYCL Gene