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Aliases for MYCBPAP Gene

Aliases for MYCBPAP Gene

  • MYCBP Associated Protein 2 3 5
  • AMY-1-Binding Protein 1 3 4
  • AMAM-1 3 4
  • AMAP-1 3 4
  • AMAP1 3 4
  • Testis Secretory Sperm-Binding Protein Li 214e 3
  • AMY1-Associating Protein 1 3
  • MYCBP-Associated Protein 3

External Ids for MYCBPAP Gene

Previous GeneCards Identifiers for MYCBPAP Gene

  • GC17P049061
  • GC17P045940
  • GC17P048585
  • GC17P043953

Summaries for MYCBPAP Gene

GeneCards Summary for MYCBPAP Gene

MYCBPAP (MYCBP Associated Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MYCBPAP Gene

  • May play a role in spermatogenesis. May be involved in synaptic processes (By similarity).

Additional gene information for MYCBPAP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYCBPAP Gene

Genomics for MYCBPAP Gene

GeneHancer (GH) Regulatory Elements for MYCBPAP Gene

Promoters and enhancers for MYCBPAP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J050507 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 675.4 +1.6 1644 5 HDGF PKNOX1 ATF1 SIN3A BATF IRF4 ZNF121 ZNF143 ATF7 RCOR1 MYCBPAP ENSG00000249451 EPN3 RSAD1 ACSF2 LOC105371824 SPATA20 CACNA1G CACNA1G-AS1 CHAD
GH17J050171 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 -315.9 -315862 42 CLOCK DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D COL1A1 SGCA ENSG00000262837 LUC7L3 FLJ45513 TMEM92-AS1 TMEM92 XYLT2 PPP1R9B ENSG00000253730
GH17J050262 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 -239.2 -239204 13.4 HDGF PKNOX1 SIN3A ZBTB7B ZNF143 ZNF263 MCM3 SP3 MXD4 REST TMEM92 MBTD1 ENSG00000262837 LUC7L3 FAM117A COL1A1 LOC105371824 MYCBPAP SPATA20 UTP18
GH17J050633 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.4 +130.6 130568 10.1 PKNOX1 FOXA2 MLX ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ABCC3 MBTD1 ENSG00000262837 CHAD ENSG00000249451 MYCBPAP CACNA1G CACNA1G-AS1 SPATA20 LOC105371824
GH17J050532 Enhancer 1.3 Ensembl ENCODE dbSUPER 21.9 +25.6 25632 3.8 ARID4B SIN3A GLI4 ZBTB7B GLIS2 ELK1 ZNF143 FOS SP3 ZNF592 EPN3 SPATA20 CACNA1G-AS1 MYCBPAP CACNA1G LOC105371824
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYCBPAP on UCSC Golden Path with GeneCards custom track

Genomic Locations for MYCBPAP Gene

Genomic Locations for MYCBPAP Gene
chr17:50,508,384-50,531,502
(GRCh38/hg38)
Size:
23,119 bases
Orientation:
Plus strand
chr17:48,585,745-48,608,862
(GRCh37/hg19)
Size:
23,118 bases
Orientation:
Plus strand

Genomic View for MYCBPAP Gene

Genes around MYCBPAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYCBPAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYCBPAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYCBPAP Gene

Proteins for MYCBPAP Gene

  • Protein details for MYCBPAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBZ2-MYBPP_HUMAN
    Recommended name:
    MYCBP-associated protein
    Protein Accession:
    Q8TBZ2
    Secondary Accessions:
    • A6NHJ3
    • Q8TDV8
    • Q9H0K0

    Protein attributes for MYCBPAP Gene

    Size:
    947 amino acids
    Molecular mass:
    108153 Da
    Quaternary structure:
    • Interacts with MYCBP.

neXtProt entry for MYCBPAP Gene

Post-translational modifications for MYCBPAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYCBPAP Gene

Domains & Families for MYCBPAP Gene

Gene Families for MYCBPAP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MYCBPAP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYCBPAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYCBPAP: view

No data available for UniProtKB/Swiss-Prot for MYCBPAP Gene

Function for MYCBPAP Gene

Molecular function for MYCBPAP Gene

UniProtKB/Swiss-Prot Function:
May play a role in spermatogenesis. May be involved in synaptic processes (By similarity).

Phenotypes From GWAS Catalog for MYCBPAP Gene

Gene Ontology (GO) - Molecular Function for MYCBPAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12151104
genes like me logo Genes that share ontologies with MYCBPAP: view
genes like me logo Genes that share phenotypes with MYCBPAP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYCBPAP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYCBPAP Gene

Localization for MYCBPAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYCBPAP Gene

Cytoplasm. Membrane. Note=Colocalizes with MYCBP in the cytoplasm. {ECO:0000250 UniProtKB:Q69CM7, ECO:0000269 PubMed:12151104}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYCBPAP gene
Compartment Confidence
mitochondrion 2
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYCBPAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 12151104
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MYCBPAP: view

Pathways & Interactions for MYCBPAP Gene

SuperPathways for MYCBPAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYCBPAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 chemical synaptic transmission ISS --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEP 12151104
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with MYCBPAP: view

No data available for Pathways by source and SIGNOR curated interactions for MYCBPAP Gene

Drugs & Compounds for MYCBPAP Gene

No Compound Related Data Available

Transcripts for MYCBPAP Gene

Unigene Clusters for MYCBPAP Gene

MYCBP associated protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYCBPAP

Alternative Splicing Database (ASD) splice patterns (SP) for MYCBPAP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - - -
SP2:
SP3:
SP4: -
SP5:

ExUns: 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for MYCBPAP Gene

GeneLoc Exon Structure for
MYCBPAP
ECgene alternative splicing isoforms for
MYCBPAP

Expression for MYCBPAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYCBPAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYCBPAP Gene

This gene is overexpressed in Testis (x33.2).

Protein differential expression in normal tissues from HIPED for MYCBPAP Gene

This gene is overexpressed in Stomach (28.8), Esophagus (14.5), Breast (12.3), and Frontal cortex (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MYCBPAP Gene



NURSA nuclear receptor signaling pathways regulating expression of MYCBPAP Gene:

MYCBPAP

SOURCE GeneReport for Unigene cluster for MYCBPAP Gene:

Hs.398196

mRNA Expression by UniProt/SwissProt for MYCBPAP Gene:

Q8TBZ2-MYBPP_HUMAN
Tissue specificity: Expressed specifically in testis.
genes like me logo Genes that share expression patterns with MYCBPAP: view

No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYCBPAP Gene

Orthologs for MYCBPAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYCBPAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYCBPAP 34 33
  • 99.61 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MYCBPAP 34 33
  • 84.36 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MYCBPAP 34 33
  • 83.3 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mycbpap 16 34 33
  • 77.31 (n)
rat
(Rattus norvegicus)
Mammalia Mycbpap 33
  • 75.56 (n)
oppossum
(Monodelphis domestica)
Mammalia MYCBPAP 34
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYCBPAP 34
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYCBPAP 34 33
  • 56.18 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYCBPAP 34
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mycbpap 33
  • 54.73 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101882572 33
  • 51.49 (n)
mycbpap 34
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToMany
-- 34
  • 30 (a)
OneToMany
Species where no ortholog for MYCBPAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYCBPAP Gene

ENSEMBL:
Gene Tree for MYCBPAP (if available)
TreeFam:
Gene Tree for MYCBPAP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYCBPAP: view image

Paralogs for MYCBPAP Gene

(3) SIMAP similar genes for MYCBPAP Gene using alignment to 9 proteins:

  • MYBPP_HUMAN
  • C9JXR6_HUMAN
  • C9JZX1_HUMAN
  • H0Y7R1_HUMAN
  • H7C0Z8_HUMAN
  • I3L2I8_HUMAN
  • K7EJ23_HUMAN
  • K7EJV4_HUMAN
  • K7EKR6_HUMAN
genes like me logo Genes that share paralogs with MYCBPAP: view

No data available for Paralogs for MYCBPAP Gene

Variants for MYCBPAP Gene

Sequence variations from dbSNP and Humsavar for MYCBPAP Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000079395 -- 50,521,814(+) T/C intron_variant
rs1000169888 -- 50,507,073(+) A/G upstream_transcript_variant
rs1000289527 -- 50,523,488(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000390833 -- 50,512,141(+) C/G intron_variant
rs1000626905 -- 50,522,101(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MYCBPAP Gene

Variant ID Type Subtype PubMed ID
nsv111976 CNV deletion 16902084
nsv2082 CNV insertion 18451855
nsv833477 CNV loss 17160897

Variation tolerance for MYCBPAP Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.99; 87.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYCBPAP Gene

Human Gene Mutation Database (HGMD)
MYCBPAP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYCBPAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYCBPAP Gene

Disorders for MYCBPAP Gene

Additional Disease Information for MYCBPAP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MYCBPAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYCBPAP Gene

Publications for MYCBPAP Gene

  1. AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis. (PMID: 12151104) Yukitake H … Ariga H (Biochimica et biophysica acta 2002) 2 3 4 22 58
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox CS … Borecki IB (PLoS genetics 2012) 3 58
  5. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PMID: 21085059) Israni A … DeKAF Investigators (Transplantation 2010) 44 58

Products for MYCBPAP Gene

Sources for MYCBPAP Gene

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