Aliases for MYCBP Gene
External Ids for MYCBP Gene
Previous GeneCards Identifiers for MYCBP Gene
The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for MYCBP Gene
MYCBP (MYC Binding Protein) is a Protein Coding gene. Diseases associated with MYCBP include Adult Liposarcoma and Colon Small Cell Carcinoma. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma and Notch Signaling Pathway (WikiPathways). Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is ENSG00000274944.
UniProtKB/Swiss-Prot Summary for MYCBP Gene
May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.