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Aliases for MYCBP Gene

Aliases for MYCBP Gene

  • MYC Binding Protein 2 3 5
  • C-Myc Binding Protein 2 3
  • Associate Of Myc-1 2 3
  • AMY-1 3 4
  • C-Myc-Binding Protein 3
  • Associate Of Myc 1 4
  • AMY1 4

External Ids for MYCBP Gene

Previous GeneCards Identifiers for MYCBP Gene

  • GC01M039252
  • GC01M038336
  • GC01M038792
  • GC01M038741
  • GC01M038997
  • GC01M039101
  • GC01M039328
  • GC01M037446

Summaries for MYCBP Gene

Entrez Gene Summary for MYCBP Gene

  • The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for MYCBP Gene

MYCBP (MYC Binding Protein) is a Protein Coding gene. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma and Notch signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is ENSG00000274944.

UniProtKB/Swiss-Prot for MYCBP Gene

  • May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.

Gene Wiki entry for MYCBP Gene

Additional gene information for MYCBP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYCBP Gene

Genomics for MYCBP Gene

GeneHancer (GH) Regulatory Elements for MYCBP Gene

Promoters and enhancers for MYCBP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J038872 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 673.2 +0.8 837 2.3 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF416 MYCBP ENSG00000273637 SF3A3 PPIE LOC101929516 INPP5B SNORA55 PPIEL AKIRIN1 PABPC4
GH01J037988 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 54.4 +884.3 884318 2.4 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SF3A3 GC01P037993 RNU6-510P C1orf109 GNL2 MYCBP FTH1P1 INPP5B FHL3 RSPO1
GH01J039025 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 36.4 -152.5 -152461 2.4 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 SLC30A9 NDUFS5 PPIE MYCBP TRIT1 LOC101929516 AKIRIN1 SNORA55 PPIEL GJA9 RRAGC
GH01J037994 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.3 +872.8 872767 13.7 HDGF SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 E2F8 FHL3 SF3A3 SNIP1 MYCBP C1orf109 FTH1P1 GNL2 MEAF6 UTP11 MTF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYCBP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MYCBP gene promoter:
  • AP-2gamma
  • AP-2beta
  • AP-2alphaA
  • AP-2alpha
  • C/EBPalpha
  • SRF
  • SRF (504 AA)
  • HFH-1
  • NF-AT
  • NF-AT1

Genomic Locations for MYCBP Gene

Genomic Locations for MYCBP Gene
11,616 bases
Minus strand
19,128 bases
Minus strand

Genomic View for MYCBP Gene

Genes around MYCBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYCBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYCBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYCBP Gene

Proteins for MYCBP Gene

  • Protein details for MYCBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    c-Myc-binding protein
    Protein Accession:
    Secondary Accessions:
    • B2R4N0
    • Q5TA64
    • Q96HE2

    Protein attributes for MYCBP Gene

    103 amino acids
    Molecular mass:
    11967 Da
    Quaternary structure:
    • Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84. Interacts with MYCBPAP.

    Three dimensional structures from OCA and Proteopedia for MYCBP Gene

neXtProt entry for MYCBP Gene

Post-translational modifications for MYCBP Gene

  • Ubiquitination at Lys20 and isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for MYCBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYCBP Gene

Domains & Families for MYCBP Gene

Gene Families for MYCBP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MYCBP Gene


Suggested Antigen Peptide Sequences for MYCBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AMY1 family.
  • Belongs to the AMY1 family.
genes like me logo Genes that share domains with MYCBP: view

Function for MYCBP Gene

Molecular function for MYCBP Gene

UniProtKB/Swiss-Prot Function:
May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.
GENATLAS Biochemistry:
c-myc binding protein,mostly expressed in the cytoplasm,translocating into the nucleus of c-myc (MYC) expression,stimulating the activation of the E-box regulated transcription by MYC/MAX

Phenotypes From GWAS Catalog for MYCBP Gene

Gene Ontology (GO) - Molecular Function for MYCBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 9797456
GO:0005515 protein binding IPI 12151104
genes like me logo Genes that share ontologies with MYCBP: view
genes like me logo Genes that share phenotypes with MYCBP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYCBP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYCBP Gene

Localization for MYCBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYCBP Gene

Cytoplasm. Nucleus. Mitochondrion. Note=Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYCBP gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MYCBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9797456
GO:0005737 cytoplasm IEA,IDA 9797456
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with MYCBP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MYCBP Gene

Pathways & Interactions for MYCBP Gene

genes like me logo Genes that share pathways with MYCBP: view

Pathways by source for MYCBP Gene

Gene Ontology (GO) - Biological Process for MYCBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 9797456
GO:0007283 spermatogenesis IEP 12151104
genes like me logo Genes that share ontologies with MYCBP: view

No data available for SIGNOR curated interactions for MYCBP Gene

Drugs & Compounds for MYCBP Gene

No Compound Related Data Available

Transcripts for MYCBP Gene

mRNA/cDNA for MYCBP Gene

(1) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(538) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYCBP Gene

C-myc binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYCBP

Alternative Splicing Database (ASD) splice patterns (SP) for MYCBP Gene

No ASD Table

Relevant External Links for MYCBP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYCBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYCBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MYCBP Gene

This gene is overexpressed in Lavage (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYCBP Gene

Protein tissue co-expression partners for MYCBP Gene

NURSA nuclear receptor signaling pathways regulating expression of MYCBP Gene:


SOURCE GeneReport for Unigene cluster for MYCBP Gene:


mRNA Expression by UniProt/SwissProt for MYCBP Gene:

Tissue specificity: Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung.

Evidence on tissue expression from TISSUES for MYCBP Gene

  • Blood(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with MYCBP: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYCBP Gene

Orthologs for MYCBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYCBP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MYCBP 34 33
  • 100 (n)
(Bos Taurus)
Mammalia MYCBP 34 33
  • 97.09 (n)
(Canis familiaris)
Mammalia MYCBP 34 33
  • 96.76 (n)
(Mus musculus)
Mammalia Mycbp 16 34 33
  • 95.15 (n)
(Rattus norvegicus)
Mammalia Mycbp 33
  • 94.17 (n)
(Ornithorhynchus anatinus)
Mammalia MYCBP 34
  • 92 (a)
(Gallus gallus)
Aves MYCBP 34 33
  • 81.55 (n)
(Anolis carolinensis)
Reptilia MYCBP 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mycbp 33
  • 72.49 (n)
Str.10099 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6491 33
(Danio rerio)
Actinopterygii mycbp 34 33
  • 61.76 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4055 33
sea squirt
(Ciona savignyi)
Ascidiacea Cin.4517 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4517 33
Species where no ortholog for MYCBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYCBP Gene

Gene Tree for MYCBP (if available)
Gene Tree for MYCBP (if available)
Evolutionary constrained regions (ECRs) for MYCBP: view image

Paralogs for MYCBP Gene

Paralogs for MYCBP Gene Pseudogenes for MYCBP Gene

genes like me logo Genes that share paralogs with MYCBP: view

Variants for MYCBP Gene

Sequence variations from dbSNP and Humsavar for MYCBP Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000003932 -- 38,867,170(-) G/A intron_variant
rs1000060196 -- 38,864,286(-) G/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000657994 -- 38,862,595(-) A/G 3_prime_UTR_variant, non_coding_transcript_variant
rs1001491394 -- 38,863,936(-) G/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1001546920 -- 38,866,694(-) C/T intron_variant

Variation tolerance for MYCBP Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYCBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYCBP Gene

Disorders for MYCBP Gene

Additional Disease Information for MYCBP

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MYCBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYCBP Gene

Publications for MYCBP Gene

  1. AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC. (PMID: 9797456) Taira T … Ariga H (Genes to cells : devoted to molecular & cellular mechanisms 1998) 2 3 4 22 58
  2. AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis. (PMID: 12151104) Yukitake H … Ariga H (Biochimica et biophysica acta 2002) 3 4 22 58
  3. AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase. (PMID: 11483602) Furusawa M … Ariga H (The Journal of biological chemistry 2001) 3 4 22 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for MYCBP Gene

Sources for MYCBP Gene

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