Aliases for MYC Gene
- MYC Proto-Oncogene, BHLH Transcription Factor 2 3 5
- V-Myc Avian Myelocytomatosis Viral Oncogene Homolog 2 3
- Class E Basic Helix-Loop-Helix Protein 39 3 4
- Transcription Factor P64 3 4
- Proto-Oncogene C-Myc 3 4
- BHLHe39 3 4
- Myc-Related Translation/Localization Regulatory Factor 3
- Avian Myelocytomatosis Viral Oncogene Homolog 3
External Ids for MYC Gene
Previous GeneCards Identifiers for MYC Gene
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
GeneCards Summary for MYC Gene
MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement. Among its related pathways are ERK Signaling and p38 MAPK Signaling Pathway (WikiPathways). Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is MYCN.
UniProtKB/Swiss-Prot for MYC Gene
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5-CAC[GA]TG-3. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000).