Aliases for MYBL2 Gene
Aliases for MYBL2 Gene
External Ids for MYBL2 Gene
- HGNC: 7548
- Entrez Gene: 4605
- Ensembl: ENSG00000101057
- OMIM: 601415
- UniProtKB: P10244
Previous GeneCards Identifiers for MYBL2 Gene
- GC20P042024
- GC20P042934
- GC20P042981
- GC20P041729
- GC20P042295
- GC20P039031
Summaries for MYBL2 Gene
-
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
GeneCards Summary for MYBL2 Gene
MYBL2 (MYB Proto-Oncogene Like 2) is a Protein Coding gene. Diseases associated with MYBL2 include Paraneoplastic Cerebellar Degeneration. Among its related pathways are Gene Expression and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is MYBL1.
UniProtKB/Swiss-Prot for MYBL2 Gene
-
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYBL2 Gene
Genomics for MYBL2 Gene
GeneHancer (GH) Regulatory Elements for MYBL2 Gene
Promoters and enhancers for MYBL2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH20I043666 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 571.5 | +0.2 | 196 | 2.1 | ARID4B SIN3A ZNF48 ZNF121 GLIS2 ZNF213 E2F8 KLF7 ATF7 RUNX3 | MYBL2 IFT52 SRSF6 OSER1 GC20M043632 | |
| GH20I043665 | Enhancer | 0.5 | ENCODE | 569.4 | -1.1 | -1103 | 0.5 | ZNF362 HDAC2 GFI1B KDM1A | MYBL2 GC20P043655 GC20M043632 | |
| GH20I043589 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 16.1 | -76.2 | -76219 | 2 | HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B | IFT52 ENSG00000282876 MYBL2 SRSF6 GC20P043584 RPL27AP | |
| GH20I043656 | Enhancer | 1.6 | FANTOM5 Ensembl ENCODE | 18.2 | -9.3 | -9340 | 2.8 | HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 | GC20P043655 IFT52 MYBL2 OSER1 SRSF6 SGK2 L3MBTL1 GC20M043632 | |
| GH20I043680 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 19.2 | +15.1 | 15085 | 2.8 | CTCF BACH1 EBF1 IRF4 ZKSCAN1 RELA POLR2A SCRT2 ZNF143 ATF7 | IFT52 MYBL2 GC20M043632 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MYBL2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MYBL2 Gene
Genomic Locations for MYBL2 Gene
- chr20:43,667,019-43,716,496
- (GRCh38/hg38)
- Size:
- 49,478 bases
- Orientation:
- Plus strand
- chr20:42,295,709-42,345,136
- (GRCh37/hg19)
Genomic View for MYBL2 Gene
Genes around MYBL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by Ensembl
- 20q13.12 by Entrez Gene
- 20q13.12 by HGNC
MYBL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MYBL2 Gene
Proteins for MYBL2 Gene
-
Protein details for MYBL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10244-MYBB_HUMAN
- Recommended name:
- Myb-related protein B
- Protein Accession:
- P10244
- B2RBS5
- B7Z8D9
- F8W6N6
- Q53F07
Protein attributes for MYBL2 Gene
- Size:
- 700 amino acids
- Molecular mass:
- 78764 Da
- Quaternary structure:
-
- Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.
Protein Expression for MYBL2 Gene
Post-translational modifications for MYBL2 Gene
- Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MYBL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MYBL2
- Novus Biologicals Antibodies for MYBL2
-
Abcam antibodies for MYBL2
- Invitrogen Antibodies for MYBL2
- GeneTex MYBL2 antibody for MYBL2
-
Santa Cruz Biotechnology (SCBT) Antibodies for MYBL2
Protein Products
-
OriGene Purified Proteins for MYBL2
- Search Origene for MassSpec and Protein Over-expression Lysates for MYBL2
- Origene Custom Protein Services for MYBL2
- Search GeneTex for Proteins for MYBL2
-
Abcam proteins for MYBL2
Assay Products
No data available for DME Specific Peptides for MYBL2 Gene
Domains & Families for MYBL2 Gene
Gene Families for MYBL2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for MYBL2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MYBL2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for MYBL2 Gene
Function for MYBL2 Gene
Molecular function for MYBL2 Gene
- GENATLAS Biochemistry:
- avian myeloblastosis viral (v-myb) oncogene homolog-like 2
- UniProtKB/Swiss-Prot Function:
- Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.
Phenotypes From GWAS Catalog for MYBL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 10770937 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 10770937 |
| GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting | IBA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | TAS | 10770937 |
Phenotypes for MYBL2 Gene
- MGI mutant phenotypes for MYBL2:
- inferred from 8 alleles
- GenomeRNAi human phenotypes for MYBL2:
-
- Mitotic spindle defects
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Synthetic lethal with Ras
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased IL-8 secretion
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased cell migration
- Decreased homologous recombination repair frequency
- Increased cell number in S
- Weakly decreased NFAT1-GFP nuclear translocation
- Increased viability with MLN4924 (a NAE inhibitor)
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased cell migration
- Decreased viability
Animal Models for MYBL2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MYBL2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MYBL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MYBL2 gene
- Search ViGene Biosciences for MYBL2
CRISPR Products
-
OriGene CRISPR knockouts for MYBL2
- genomics-online: gRNA clones - Search results for 94 available MYBL2 gene related products
- Overview of 94 available MYBL2 gene related products
- Applied Biological Materials CRISPR for MYBL2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MYBL2
- GenScript: Design CRISPR guide RNA sequences for MYBL2
miRNA for MYBL2 Gene
- miRTarBase miRNAs that target MYBL2
-
- hsa-mir-30e-5p (MIRT006045)
- hsa-mir-149-3p (MIRT021213)
- hsa-mir-423-5p (MIRT038033)
- hsa-mir-505-3p (MIRT041019)
- hsa-mir-92a-3p (MIRT049701)
- hsa-mir-19b-3p (MIRT437542)
- hsa-mir-30d-5p (MIRT727122)
- hsa-mir-30c-5p (MIRT727123)
- hsa-mir-30b-5p (MIRT727124)
- hsa-mir-30a-5p (MIRT727125)
- hsa-mir-1343-5p (MIRT762579)
- hsa-mir-138-5p (MIRT762602)
- hsa-mir-185-3p (MIRT763170)
- hsa-mir-298 (MIRT764364)
- hsa-mir-3150a-3p (MIRT765028)
- hsa-mir-3175 (MIRT765241)
- hsa-mir-3184-5p (MIRT765279)
- hsa-mir-3622a-3p (MIRT766129)
- hsa-mir-3622b-3p (MIRT766149)
- hsa-mir-4324 (MIRT768620)
- hsa-mir-4456 (MIRT769203)
- hsa-mir-4492 (MIRT769720)
- hsa-mir-4498 (MIRT769754)
- hsa-mir-4667-5p (MIRT770841)
- hsa-mir-4693-3p (MIRT771126)
- hsa-mir-4700-5p (MIRT771300)
- hsa-mir-4728-5p (MIRT771718)
- hsa-mir-4763-3p (MIRT772019)
- hsa-mir-5001-5p (MIRT772919)
- hsa-mir-5007-5p (MIRT772950)
- hsa-mir-6085 (MIRT775475)
- hsa-mir-637 (MIRT776145)
- hsa-mir-6761-5p (MIRT778469)
- hsa-mir-6763-5p (MIRT778488)
- hsa-mir-6779-5p (MIRT778898)
- hsa-mir-6785-5p (MIRT779128)
- hsa-mir-6813-5p (MIRT779780)
- hsa-mir-6825-5p (MIRT779895)
- hsa-mir-6858-5p (MIRT780523)
- hsa-mir-6883-5p (MIRT780924)
- hsa-mir-7106-3p (MIRT781315)
- hsa-mir-7155-5p (MIRT781550)
- hsa-mir-762 (MIRT781793)
- hsa-mir-8089 (MIRT782443)
- hsa-mir-939-5p (MIRT782859)
Targeted motifs for MYBL2 Gene
HOMER Transcription Factor Regulatory Elements motif MYBL2
- Consensus sequence: NHAACBGYYV Submotif: canonical Cell Type: Hela GEO ID: GSE27030
miRNA Products
- Search ViGene Biosciences for MYBL2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MYBL2
- Browse OriGene Inhibitory RNA Products For MYBL2
- genomics-online: shRNA clones - Search results for 94 available MYBL2 gene related products
- Overview of 94 available MYBL2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MYBL2 gene
Clone Products
- Sino Biological Human cDNA Clone for MYBL2
- VectorBuilder custom plasmid, inducible vectors for MYBL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MYBL2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MYBL2
- Applied Biological Materials Clones for MYBL2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for MYBL2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MYBL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MYBL2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for MYBL2 Gene
Localization for MYBL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MYBL2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0031523 | Myb complex | IEA | -- |
Pathways & Interactions for MYBL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of PLK1 Activity at G2/M Transition |
.49
|
|
| 2 | Cell Cycle, Mitotic |
.83
|
|
| 3 | Gene Expression |
.48
|
|
| 4 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | ||
| 5 | Cellular senescence (KEGG) | ||
Pathways by source for MYBL2 Gene
3 BioSystems pathways for MYBL2 Gene
11 Reactome pathways for MYBL2 Gene
2 KEGG pathways for MYBL2 Gene
Interacting Proteins for MYBL2 Gene
Selected Interacting proteins:
ENSP00000217026
P10244-MYBB_HUMAN
for MYBL2 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS | -- |
| GO:0006366 | transcription by RNA polymerase II | IEA | -- |
| GO:0030154 | cell differentiation | IBA | -- |
Transcripts for MYBL2 Gene
mRNA/cDNA for MYBL2 Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (367) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MYBL2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MYBL2
- genomics-online: gRNA clones - Search results for 94 available MYBL2 gene related products
- Overview of 94 available MYBL2 gene related products
- Applied Biological Materials CRISPR for MYBL2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MYBL2
- GenScript: Design CRISPR guide RNA sequences for MYBL2
miRNA Products
- Search ViGene Biosciences for MYBL2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MYBL2
- Browse OriGene Inhibitory RNA Products For MYBL2
- genomics-online: shRNA clones - Search results for 94 available MYBL2 gene related products
- Overview of 94 available MYBL2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MYBL2 gene
Clone Products
- Sino Biological Human cDNA Clone for MYBL2
- VectorBuilder custom plasmid, inducible vectors for MYBL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MYBL2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MYBL2
- Applied Biological Materials Clones for MYBL2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 16b | · | 16c | ^ | 17a | · | 17b |
|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | - | ||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: | |||||||
| SP8: | |||||||
| SP9: | |||||||
| SP10: | - | ||||||
| SP11: | |||||||
| SP12: | |||||||
| SP13: |
Expression for MYBL2 Gene
mRNA differential expression in normal tissues according to GTEx for MYBL2 Gene
This gene is overexpressed in Spleen (x6.2), Testis (x4.4), and Whole Blood (x4.1).
This gene is overexpressed in Lymph node (29.9), Plasma (23.4), and Heart (15.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYBL2 Gene
NURSA nuclear receptor signaling pathways regulating expression of MYBL2 Gene:
MYBL2SOURCE GeneReport for Unigene cluster for MYBL2 Gene:
Hs.179718Evidence on tissue expression from TISSUES for MYBL2 Gene
- Nervous system(4.6)
- Eye(4.1)
- Intestine(3.1)
- Lung(2.3)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs for MYBL2
-
OriGene qPCR primer pairs and template standards for MYBL2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYBL2 Gene
Orthologs for MYBL2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MYBL2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MYBL2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MYBL2 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mybl2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Mybl2 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MYBL2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | MYBL2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MYBL2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mybl2 33 |
|
||
| Str.10235 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | myb1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mybl2 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Myb 35 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | BAS1 34 |
|
OneToMany |
- Species where no ortholog for MYBL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MYBL2 Gene
(4) SIMAP similar genes for MYBL2 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for MYBL2 Gene
Variants for MYBL2 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000040800 | -- | 43,665,272(+) | C/T | upstream_transcript_variant | |
| rs1000072888 | -- | 43,670,875(+) | A/G | intron_variant | |
| rs1000073365 | -- | 43,693,485(+) | C/A | intron_variant | |
| rs1000128444 | -- | 43,670,489(+) | A/T | intron_variant | |
| rs1000135141 | -- | 43,709,898(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2606313 | CNV | insertion | 19546169 |
| esv2854458 | CNV | duplication | 24192839 |
| esv3302967 | CNV | tandem duplication | 20981092 |
| esv3645886 | CNV | gain | 21293372 |
| esv3645889 | CNV | gain | 21293372 |
| esv3645890 | CNV | loss | 21293372 |
| nsv1057847 | CNV | loss | 25217958 |
| nsv1114218 | CNV | deletion | 24896259 |
| nsv1117285 | CNV | tandem duplication | 24896259 |
| nsv1127838 | CNV | deletion | 24896259 |
| nsv1131592 | CNV | deletion | 24896259 |
| nsv1139761 | CNV | duplication | 24896259 |
| nsv180297 | CNV | deletion | 16902084 |
| nsv3385 | CNV | deletion | 18451855 |
Residual Variation Intolerance Score:
43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.02;
80.14% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MYBL2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYBL2 Gene
Disorders for MYBL2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| paraneoplastic cerebellar degeneration |
|
|
Search MYBL2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MYBL2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MYBL2 Gene
Publications for MYBL2 Gene
- Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb. (PMID: 10095772) Bartsch O … Ferrari S (European journal of biochemistry 1999) 3 4 22 58
- The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties. (PMID: 9840932) Saville MK … Watson RJ (Oncogene 1998) 3 4 22 58
- Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q 13.1. (PMID: 8812502) Noben-Trauth K … Klempnauer KH (Genomics 1996) 2 3 22 58
- Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
- Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 44 58
Products for MYBL2 Gene
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- Custom Antibody ServicesOriGene Antibodies for MYBL2
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- Cyagen custom Knockout/knockin (KOKI) mouse models for MYBL2
- VectorBuilder custom plasmid, inducible vectors for MYBL2
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MYBL2
- antibodies-online: Search results for 109 available MYBL2 Antibodies ranked by validation data
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- GeneTex MYBL2 antibody for MYBL2
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- ViGene Biosciences adenoviral particle packaged cDNA for MYBL2 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for MYBL2 gene
- Search ViGene Biosciences for MYBL2
- Santa Cruz Biotechnology (SCBT) Antibodies for MYBL2
- Search Santa Cruz Biotechnology (SCBT) for MYBL2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MYBL2
- genomics-online: cdna clones - Search results for 94 available MYBL2 gene related products
- Overview of 94 available MYBL2 gene related products
- orf clones - Search results for 94 available MYBL2 gene related products
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- genomics-online: gRNA clones - Search results for 94 available MYBL2 gene related products
- Overview of 94 available MYBL2 gene related products
- genomics-online: primer clones - Search results for 94 available MYBL2 gene related products
- Overview of 94 available MYBL2 gene related products
- genomics-online: shRNA clones - Search results for 94 available MYBL2 gene related products
- Overview of 94 available MYBL2 gene related products
Sources for MYBL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
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- (110) ClinicalTrials
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- (114) diseasecard
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- (135) Horizon
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- (150) Human Protein Atlas
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- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
