The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin... See more...

Aliases for MYBL2 Gene

Aliases for MYBL2 Gene

  • MYB Proto-Oncogene Like 2 2 3 5
  • BMYB 2 3 4
  • V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 2 2 3
  • Myb-Related Protein B 3 4
  • Myb-Like Protein 2 3 4
  • B-MYB 2 3
  • V-Myb Myeloblastosis Viral Oncogene Homolog-Like 2 3
  • MYBL2 5
  • B-Myb 4

External Ids for MYBL2 Gene

Previous GeneCards Identifiers for MYBL2 Gene

  • GC20P042024
  • GC20P042934
  • GC20P042981
  • GC20P041729
  • GC20P042295
  • GC20P039031

Summaries for MYBL2 Gene

Entrez Gene Summary for MYBL2 Gene

  • The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for MYBL2 Gene

MYBL2 (MYB Proto-Oncogene Like 2) is a Protein Coding gene. Among its related pathways are E2F transcription factor network and Cell cycle Cell cycle (generic schema). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is MYBL1.

UniProtKB/Swiss-Prot Summary for MYBL2 Gene

  • Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.

Gene Wiki entry for MYBL2 Gene

Additional gene information for MYBL2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYBL2 Gene

Genomics for MYBL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MYBL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J043656 Promoter/Enhancer 2 EPDnew FANTOM5 ENCODE CraniofacialAtlas 618.2 -9.3 -9340 2.8 BRCA1 HNRNPL CREB1 GATAD2A CTCF ATF7 ZNF629 PRDM10 TFE3 SIX5 MYBL2 NONHSAG031824.2 lnc-GTSF1L-10 IFT52 JPH2 SGK2 OSER1 SRSF6 L3MBTL1 lnc-IFT52-1-001
GH20J043665 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 631.2 +0.1 127 2.9 SP1 ATF7 PRDM10 ZNF629 ZNF692 POLR2A JUND LARP7 ZIC2 RBFOX2 MYBL2 IFT52 SRSF6 piR-31162-302 GTSF1L
GH20J043589 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 16.1 -76.2 -76218 2.4 CREB1 GATAD2A ATF7 PRDM10 REST ZNF629 RFX1 SIX5 LEF1 IKZF1 IFT52 ENSG00000282876 MYBL2 SRSF6 SGK2
GH20J043456 Promoter/Enhancer 2.6 UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas 11.8 -208.9 -208905 3.6 SP1 HNRNPL CREB1 GATAD2A REST ZNF629 TFE3 SOX13 NFKBIZ ZNF692 SRSF6 ENSG00000288000 piR-59928-084 IFT52 L3MBTL1 MYBL2 RF00026-644 RNU6-1251P
GH20J044206 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 +542.9 542870 6.1 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 REST ZNF629 TFE3 LEF1 OSER1 OSER1-DT SRSF6 FITM2 MYBL2 L3MBTL1 KCNK15 IFT52 CCN5 JPH2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYBL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYBL2

Top Transcription factor binding sites by QIAGEN in the MYBL2 gene promoter:
  • E2F
  • E2F-1
  • FOXO1
  • FOXO1a
  • Meis-1
  • Meis-1a
  • Meis-1b
  • p53
  • POU3F1
  • Sp1

Genomic Locations for MYBL2 Gene

Genomic Locations for MYBL2 Gene
chr20:43,667,019-43,716,496
(GRCh38/hg38)
Size:
49,478 bases
Orientation:
Plus strand
chr20:42,295,709-42,345,136
(GRCh37/hg19)
Size:
49,428 bases
Orientation:
Plus strand

Genomic View for MYBL2 Gene

Genes around MYBL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYBL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYBL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYBL2 Gene

Proteins for MYBL2 Gene

  • Protein details for MYBL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10244-MYBB_HUMAN
    Recommended name:
    Myb-related protein B
    Protein Accession:
    P10244
    Secondary Accessions:
    • B2RBS5
    • B7Z8D9
    • F8W6N6
    • Q53F07

    Protein attributes for MYBL2 Gene

    Size:
    700 amino acids
    Molecular mass:
    78764 Da
    Quaternary structure:
    • Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.

    Three dimensional structures from OCA and Proteopedia for MYBL2 Gene

    Alternative splice isoforms for MYBL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYBL2 Gene

Post-translational modifications for MYBL2 Gene

  • Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYBL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYBL2 Gene

Domains & Families for MYBL2 Gene

Gene Families for MYBL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MYBL2 Gene

InterPro:
Blocks:
  • Myb DNA-binding domain
ProtoNet:

Suggested Antigen Peptide Sequences for MYBL2 Gene

GenScript: Design optimal peptide antigens:
  • Myb-like protein 2 (MYBB_HUMAN)
genes like me logo Genes that share domains with MYBL2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MYBL2 Gene

Function for MYBL2 Gene

Molecular function for MYBL2 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.
GENATLAS Biochemistry:
avian myeloblastosis viral (v-myb) oncogene homolog-like 2

Phenotypes From GWAS Catalog for MYBL2 Gene

Gene Ontology (GO) - Molecular Function for MYBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10770937
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 10770937
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with MYBL2: view
genes like me logo Genes that share phenotypes with MYBL2: view

Animal Models for MYBL2 Gene

MGI Knock Outs for MYBL2:

Animal Model Products

CRISPR Products

Targeted motifs for MYBL2 Gene
HOMER Transcription Factor Regulatory Elements motif MYBL2
  • Consensus sequence: NHAACBGYYV Submotif: canonical Cell Type: Hela GEO ID: GSE27030

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYBL2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for MYBL2 Gene

Localization for MYBL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYBL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYBL2 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MYBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0031523 Myb complex IEA --
genes like me logo Genes that share ontologies with MYBL2: view

Pathways & Interactions for MYBL2 Gene

genes like me logo Genes that share pathways with MYBL2: view

Pathways by source for MYBL2 Gene

SIGNOR curated interactions for MYBL2 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for MYBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0006357 regulation of transcription by RNA polymerase II TAS --
GO:0043525 positive regulation of neuron apoptotic process IEA --
GO:0045893 positive regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with MYBL2: view

Drugs & Compounds for MYBL2 Gene

(4) Drugs for MYBL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for MYBL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MYBL2: view

Transcripts for MYBL2 Gene

mRNA/cDNA for MYBL2 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYBL2

Alternative Splicing Database (ASD) splice patterns (SP) for MYBL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a ·
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - - - -
SP6: - - - -
SP7: - - -
SP8: -
SP9: - - -
SP10: -
SP11: - - -
SP12:
SP13:

ExUns: 16b · 16c ^ 17a · 17b
SP1: -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:

Relevant External Links for MYBL2 Gene

GeneLoc Exon Structure for
MYBL2

Expression for MYBL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYBL2 Gene

mRNA differential expression in normal tissues according to GTEx for MYBL2 Gene

This gene is overexpressed in Spleen (x6.2), Testis (x4.4), and Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for MYBL2 Gene

This gene is overexpressed in Lymph node (29.9), Plasma (23.4), and Heart (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYBL2 Gene



Protein tissue co-expression partners for MYBL2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYBL2

SOURCE GeneReport for Unigene cluster for MYBL2 Gene:

Hs.179718

Evidence on tissue expression from TISSUES for MYBL2 Gene

  • Nervous system(4.7)
  • Eye(4.3)
  • Intestine(3.6)
  • Skin(3)
  • Lung(2.9)
  • Lymph node(2.7)
  • Bone marrow(2.6)
  • Pancreas(2.3)
  • Muscle(2.3)
  • Blood(2.2)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with MYBL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYBL2 Gene

Orthologs for MYBL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYBL2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MYBL2 30 31
  • 96.71 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MYBL2 30 31
  • 88.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MYBL2 30 31
  • 87.48 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mybl2 30
  • 85.1 (n)
Mouse
(Mus musculus)
Mammalia Mybl2 30 17 31
  • 84.24 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MYBL2 31
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 56 (a)
OneToMany
-- 31
  • 46 (a)
OneToMany
Chicken
(Gallus gallus)
Aves MYBL2 30 31
  • 72.57 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MYBL2 31
  • 66 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mybl2 30
  • 63.11 (n)
Str.10235 30
African clawed frog
(Xenopus laevis)
Amphibia myb1 30
Zebrafish
(Danio rerio)
Actinopterygii mybl2 30 31
  • 74.96 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Myb 31 32
  • 28 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BAS1 31
  • 15 (a)
OneToMany
Species where no ortholog for MYBL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MYBL2 Gene

ENSEMBL:
Gene Tree for MYBL2 (if available)
TreeFam:
Gene Tree for MYBL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYBL2: view image

Paralogs for MYBL2 Gene

Paralogs for MYBL2 Gene

(4) SIMAP similar genes for MYBL2 Gene using alignment to 2 proteins:

  • MYBB_HUMAN
  • F8W6N6_HUMAN

Pseudogenes.org Pseudogenes for MYBL2 Gene

genes like me logo Genes that share paralogs with MYBL2: view

Variants for MYBL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYBL2 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
713738 Benign: not provided 43,702,560(+) A/G MISSENSE_VARIANT
717597 Benign: not provided 43,692,228(+) G/A MISSENSE_VARIANT
777577 Benign: not provided 43,713,065(+) G/A MISSENSE_VARIANT
778894 Benign: not provided 43,681,786(+) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
781902 Benign: not provided 43,699,784(+) G/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for MYBL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MYBL2 Gene

Variant ID Type Subtype PubMed ID
esv2606313 CNV insertion 19546169
esv2854458 CNV duplication 24192839
esv3302967 CNV tandem duplication 20981092
esv3645886 CNV gain 21293372
esv3645889 CNV gain 21293372
esv3645890 CNV loss 21293372
nsv1057847 CNV loss 25217958
nsv1114218 CNV deletion 24896259
nsv1117285 CNV tandem duplication 24896259
nsv1127838 CNV deletion 24896259
nsv1131592 CNV deletion 24896259
nsv1139761 CNV duplication 24896259
nsv180297 CNV deletion 16902084
nsv3385 CNV deletion 18451855

Variation tolerance for MYBL2 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.02; 80.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYBL2 Gene

Human Gene Mutation Database (HGMD)
MYBL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYBL2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYBL2 Gene

Disorders for MYBL2 Gene

Additional Disease Information for MYBL2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for MYBL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYBL2 Gene

Publications for MYBL2 Gene

  1. Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb. (PMID: 10095772) Bartsch O … Ferrari S (European journal of biochemistry 1999) 3 4 23
  2. The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties. (PMID: 9840932) Saville MK … Watson RJ (Oncogene 1998) 3 4 23
  3. Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q 13.1. (PMID: 8812502) Noben-Trauth K … Klempnauer KH (Genomics 1996) 2 3 23
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 41
  5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 41

Products for MYBL2 Gene

Sources for MYBL2 Gene