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The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
MYBL2 (MYB Proto-Oncogene Like 2) is a Protein Coding gene. Among its related pathways are E2F transcription factor network and Cell cycle Cell cycle (generic schema). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is MYBL1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IBA | 21873635 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 10770937 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 10770937 |
GO:0003677 | DNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0031523 | Myb complex | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of PLK1 Activity at G2/M Transition |
.50
|
|
2 | Cell Cycle, Mitotic |
.83
|
|
3 | Gene Expression |
.48
|
|
4 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | ||
5 | Cellular senescence (KEGG) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000278 | mitotic cell cycle | IBA | 21873635 |
GO:0006355 | regulation of transcription, DNA-templated | IBA | 21873635 |
GO:0006357 | regulation of transcription by RNA polymerase II | TAS | -- |
GO:0043525 | positive regulation of neuron apoptotic process | IEA | -- |
GO:0045893 | positive regulation of transcription, DNA-templated | IBA | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
ExUns: | 16b | · | 16c | ^ | 17a | · | 17b |
---|---|---|---|---|---|---|---|
SP1: | - | ||||||
SP2: | |||||||
SP3: | |||||||
SP4: | - | ||||||
SP5: | |||||||
SP6: | |||||||
SP7: | |||||||
SP8: | |||||||
SP9: | |||||||
SP10: | - | ||||||
SP11: | |||||||
SP12: | |||||||
SP13: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MYBL2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MYBL2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MYBL2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mybl2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mybl2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MYBL2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | MYBL2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MYBL2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mybl2 30 |
|
||
Str.10235 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | myb1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mybl2 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Myb 31 32 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | BAS1 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
713738 | Benign: not provided | 43,702,560(+) | A/G | MISSENSE_VARIANT | |
717597 | Benign: not provided | 43,692,228(+) | G/A | MISSENSE_VARIANT | |
777577 | Benign: not provided | 43,713,065(+) | G/A | MISSENSE_VARIANT | |
778894 | Benign: not provided | 43,681,786(+) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
781902 | Benign: not provided | 43,699,784(+) | G/T | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2606313 | CNV | insertion | 19546169 |
esv2854458 | CNV | duplication | 24192839 |
esv3302967 | CNV | tandem duplication | 20981092 |
esv3645886 | CNV | gain | 21293372 |
esv3645889 | CNV | gain | 21293372 |
esv3645890 | CNV | loss | 21293372 |
nsv1057847 | CNV | loss | 25217958 |
nsv1114218 | CNV | deletion | 24896259 |
nsv1117285 | CNV | tandem duplication | 24896259 |
nsv1127838 | CNV | deletion | 24896259 |
nsv1131592 | CNV | deletion | 24896259 |
nsv1139761 | CNV | duplication | 24896259 |
nsv180297 | CNV | deletion | 16902084 |
nsv3385 | CNV | deletion | 18451855 |
No disorders were found for MYBL2 Gene.