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The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin... See more...
Aliases for MYBL2 Gene
Aliases for MYBL2 Gene
External Ids for MYBL2 Gene
- HGNC: 7548
- NCBI Entrez Gene: 4605
- Ensembl: ENSG00000101057
- OMIM®: 601415
- UniProtKB/Swiss-Prot: P10244
Previous GeneCards Identifiers for MYBL2 Gene
- GC20P042024
- GC20P042934
- GC20P042981
- GC20P041729
- GC20P042295
- GC20P039031
Summaries for MYBL2 Gene
-
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
GeneCards Summary for MYBL2 Gene
MYBL2 (MYB Proto-Oncogene Like 2) is a Protein Coding gene. Among its related pathways are Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is MYBL1.
UniProtKB/Swiss-Prot Summary for MYBL2 Gene
-
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.
Additional gene information for MYBL2 Gene
- HGNC (7548)
- NCBI Entrez Gene (4605)
- Ensembl (ENSG00000101057)
- OMIM® (601415)
- UniProtKB/Swiss-Prot (P10244)
- Open Targets Platform(ENSG00000101057)
- Alliance of Genome Resources
- Search for MYBL2 at DataMed
- Search for MYBL2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYBL2 Gene
Genomics for MYBL2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MYBL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MYBL2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYBL2
- Top Transcription factor binding sites by QIAGEN in the MYBL2 gene promoter:
-
- E2F
- E2F-1
- FOXO1
- FOXO1a
- Meis-1
- Meis-1a
- Meis-1b
- p53
- POU3F1
- Sp1
Genomic Locations for MYBL2 Gene
Latest Assembly
- chr20:43,667,019-43,716,495
- (GRCh38/hg38)
- Size:
- 49,477 bases
- Orientation:
- Plus strand
Previous Assembly
- chr20:42,295,754-42,345,122
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 49,369 bases
- Orientation:
- Plus strand
Genomic View for MYBL2 Gene
Genes around MYBL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by HGNC
- 20q13.12 by Entrez Gene
- 20q13.12 by Ensembl
MYBL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MYBL2 Gene
Proteins for MYBL2 Gene
-
Protein details for MYBL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10244-MYBB_HUMAN
- Recommended name:
- Myb-related protein B
- Protein Accession:
- P10244
- B2RBS5
- B7Z8D9
- F8W6N6
- Q53F07
Protein attributes for MYBL2 Gene
- Size:
- 700 amino acids
- Molecular mass:
- 78764 Da
- Quaternary structure:
-
- Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.
Protein Expression for MYBL2 Gene
Post-translational modifications for MYBL2 Gene
- Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MYBL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences MYBL2 Antibody
- G Biosciences Immunotag™ MYBL2 Antibody
- NSJ Bioreagents MYBL2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for MYBL2
- Novus Biologicals Antibodies for MYBL2
-
Abcam antibodies for MYBL2
- Invitrogen Antibodies for MYBL2 (AFLGC-Mybl2)
- antibodies-online: Show 26 available MYBL2 Antibodies ranked by validation data
- Compare Top MYBL2 Antibodies
-
Recommended
- 57 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 47 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 73 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
-
Boster Bio Antibodies for MYBL2
-
Santa Cruz Biotechnology (SCBT) Antibodies for MYBL2
- Sino Biological Antibodies for MYBL2
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for MYBL2
- Origene Custom Protein Services for MYBL2
-
Abcam proteins for MYBL2
Assay products for research
- antibodies-online: Show 5 available MYBL2 Elisa Kits ranked by validation data
- Compare Top MYBL2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for MYBL2 Gene
Domains & Families for MYBL2 Gene
Gene Families for MYBL2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for MYBL2 Gene
- InterPro:
- Blocks:
-
- Myb DNA-binding domain
Suggested Antigen Peptide Sequences for MYBL2 Gene
- GenScript: Design optimal peptide antigens:
-
- Myb-like protein 2 (MYBB_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MYBL2 Gene
Function for MYBL2 Gene
Molecular function for MYBL2 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.
- GENATLAS Biochemistry:
- avian myeloblastosis viral (v-myb) oncogene homolog-like 2
Phenotypes From GWAS Catalog for MYBL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 10770937 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IBA | 21873635 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 10770937 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 17159899 |
Phenotypes for MYBL2 Gene
- MGI mutant phenotypes for MYBL2:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for MYBL2:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 25%
- shRNA abundance <= 50%
- no effect
- Decreased viability
- Increased viability with MLN4924 (a NAE inhibitor)
- Increased IL-8 secretion
- Synthetic lethal with Ras
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Moderately decreased NFAT1-GFP nuclear translocation
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased viability in colon lineage
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased homologous recombination repair frequency
- Increased cell number in G2M, increased nuclei size in G2M
- Mitotic spindle defects
- Increased cell migration
Animal Models for MYBL2 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MYBL2 - Starting at $85 >
- * MYBL2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MYBL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MYBL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MYBL2
miRNA for MYBL2 Gene
- miRTarBase miRNAs that target MYBL2
-
- hsa-miR-30e-5p (MIRT006045)
- hsa-miR-149-3p (MIRT021213)
- hsa-miR-423-5p (MIRT038033)
- hsa-miR-505-3p (MIRT041019)
- hsa-miR-92a-3p (MIRT049701)
- hsa-miR-19b-3p (MIRT437542)
- hsa-miR-30d-5p (MIRT727122)
- hsa-miR-30c-5p (MIRT727123)
- hsa-miR-30b-5p (MIRT727124)
- hsa-miR-30a-5p (MIRT727125)
- hsa-miR-1343-5p (MIRT762579)
- hsa-miR-138-5p (MIRT762602)
- hsa-miR-185-3p (MIRT763170)
- hsa-miR-298 (MIRT764364)
- hsa-miR-3150a-3p (MIRT765028)
- hsa-miR-3175 (MIRT765241)
- hsa-miR-3184-5p (MIRT765279)
- hsa-miR-3622a-3p (MIRT766129)
- hsa-miR-3622b-3p (MIRT766149)
- hsa-miR-4324 (MIRT768620)
- hsa-miR-4456 (MIRT769203)
- hsa-miR-4492 (MIRT769720)
- hsa-miR-4498 (MIRT769754)
- hsa-miR-4667-5p (MIRT770841)
- hsa-miR-4693-3p (MIRT771126)
- hsa-miR-4700-5p (MIRT771300)
- hsa-miR-4728-5p (MIRT771718)
- hsa-miR-4763-3p (MIRT772019)
- hsa-miR-5001-5p (MIRT772919)
- hsa-miR-5007-5p (MIRT772950)
- hsa-miR-6085 (MIRT775475)
- hsa-miR-637 (MIRT776145)
- hsa-miR-6761-5p (MIRT778469)
- hsa-miR-6763-5p (MIRT778488)
- hsa-miR-6779-5p (MIRT778898)
- hsa-miR-6785-5p (MIRT779128)
- hsa-miR-6813-5p (MIRT779780)
- hsa-miR-6825-5p (MIRT779895)
- hsa-miR-6858-5p (MIRT780523)
- hsa-miR-6883-5p (MIRT780924)
- hsa-miR-7106-3p (MIRT781315)
- hsa-miR-7155-5p (MIRT781550)
- hsa-miR-762 (MIRT781793)
- hsa-miR-8089 (MIRT782443)
- hsa-miR-939-5p (MIRT782859)
Targeted motifs for MYBL2 Gene
HOMER Transcription Factor Regulatory Elements motif MYBL2
- Consensus sequence: NHAACBGYYV Submotif: canonical Cell Type: Hela GEO ID: GSE27030
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MYBL2
- Browse OriGene Inhibitory RNA Products For MYBL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYBL2
Clone products for research
- Applied Biological Materials (abm): Clones for MYBL2 - Starting at $45 >
- * MYBL2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for MYBL2
- Addgene plasmids for MYBL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MYBL2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for MYBL2 Gene
Localization for MYBL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MYBL2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0031523 | Myb complex | IEA | -- |
Pathways & Interactions for MYBL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of PLK1 Activity at G2/M Transition |
.49
|
|
| 2 | Cell Cycle, Mitotic |
.83
|
|
| 3 | Gene Expression |
.48
|
|
| 4 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | ||
| 5 | Cellular senescence (KEGG) | ||
Pathways by source for MYBL2 Gene
3 BioSystems pathways for MYBL2 Gene
11 Reactome pathways for MYBL2 Gene
1 KEGG pathway for MYBL2 Gene
Interacting Proteins for MYBL2 Gene
Selected Interacting proteins:
P10244-MYBB_HUMAN
ENSP00000217026
for MYBL2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MYBL2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000278 | mitotic cell cycle | IBA | 21873635 |
| GO:0006355 | regulation of transcription, DNA-templated | IBA | 21873635 |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS | -- |
| GO:0043525 | positive regulation of neuron apoptotic process | IEA | -- |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA | 10770937 |
Transcripts for MYBL2 Gene
mRNA/cDNA for MYBL2 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000217026 2668 nts (view in UCSC)
- ENST00000396863 2704 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MYBL2 - Starting at $85 >
- * MYBL2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MYBL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MYBL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MYBL2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MYBL2
- Browse OriGene Inhibitory RNA Products For MYBL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYBL2
Clone products for research
- Applied Biological Materials (abm): Clones for MYBL2 - Starting at $45 >
- * MYBL2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for MYBL2
- Addgene plasmids for MYBL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MYBL2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 16b | · | 16c | ^ | 17a | · | 17b |
|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | - | ||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: | |||||||
| SP8: | |||||||
| SP9: | |||||||
| SP10: | - | ||||||
| SP11: | |||||||
| SP12: | |||||||
| SP13: |
Relevant External Links for MYBL2 Gene
- GeneLoc Exon Structure for
- MYBL2
Expression for MYBL2 Gene
mRNA differential expression in normal tissues according to GTEx for MYBL2 Gene
This gene is overexpressed in Spleen (x6.2), Testis (x4.4), and Whole Blood (x4.1).
This gene is overexpressed in Lymph node (29.9), Plasma (23.4), and Heart (15.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYBL2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYBL2
SOURCE GeneReport for Unigene cluster for MYBL2 Gene:
Hs.179718Evidence on tissue expression from TISSUES for MYBL2 Gene
- Nervous system(4.7)
- Eye(4.3)
- Intestine(3.5)
- Skin(2.9)
- Lung(2.7)
- Lymph node(2.6)
- Bone marrow(2.5)
- Pancreas(2.3)
- Muscle(2.2)
- Blood(2)
Primer products for research
-
OriGene qPCR primer pairs for MYBL2
-
OriGene qPCR primer pairs and template standards for MYBL2
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYBL2 Gene
Orthologs for MYBL2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MYBL2 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MYBL2 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MYBL2 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mybl2 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mybl2 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MYBL2 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | MYBL2 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MYBL2 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mybl2 29 |
|
||
| Str.10235 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | myb1 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mybl2 29 30 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Myb 30 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | BAS1 30 |
|
OneToMany |
- Species where no ortholog for MYBL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MYBL2 Gene
- ENSEMBL:
- Gene Tree for MYBL2 (if available)
- TreeFam:
- Gene Tree for MYBL2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MYBL2: view image
- Alliance of Genome Resources:
- Additional Orthologs for MYBL2
Paralogs for MYBL2 Gene
Variants for MYBL2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYBL2 Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs138968603 | Benign: not provided | 43,699,784(+) |
G/T NM_002466.4(MYBL2):c.691G>T (p.Val231Phe) |
MISSENSE | |
| rs2227937 | Benign: not provided | 43,681,786(+) |
C/T NM_002466.4(MYBL2):c.117C>T (p.Asp39=) |
SYNONYMOUS_VARIANT,INTRON | |
| rs6017146 | Benign: not provided | 43,702,560(+) |
A/Gp.Asn341Ser NM_002466.4(MYBL2):c.1022A>G (p.Asn341Ser) |
MISSENSE | |
| rs7660 | Benign: not provided | 43,713,065(+) |
G/Ap.Val595Met NM_002466.4(MYBL2):c.1783G>A (p.Val595Met) |
MISSENSE | |
| rs79958576 | Benign: not provided | 43,692,228(+) |
G/A NM_002466.4(MYBL2):c.572G>A (p.Ser191Asn) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2606313 | CNV | insertion | 19546169 |
| esv2854458 | CNV | duplication | 24192839 |
| esv3302967 | CNV | tandem duplication | 20981092 |
| esv3645886 | CNV | gain | 21293372 |
| esv3645889 | CNV | gain | 21293372 |
| esv3645890 | CNV | loss | 21293372 |
| nsv1057847 | CNV | loss | 25217958 |
| nsv1114218 | CNV | deletion | 24896259 |
| nsv1117285 | CNV | tandem duplication | 24896259 |
| nsv1127838 | CNV | deletion | 24896259 |
| nsv1131592 | CNV | deletion | 24896259 |
| nsv1139761 | CNV | duplication | 24896259 |
| nsv180297 | CNV | deletion | 16902084 |
| nsv3385 | CNV | deletion | 18451855 |
Residual Variation Intolerance Score:
43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.02;
80.14% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MYBL2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYBL2 Gene
Disorders for MYBL2 Gene
Additional Disease Information for MYBL2
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for MYBL2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYBL2 Gene
Publications for MYBL2 Gene
- Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb. (PMID: 10095772) Bartsch O … Ferrari S (European journal of biochemistry 1999) 3 4 22
- The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties. (PMID: 9840932) Saville MK … Watson RJ (Oncogene 1998) 3 4 22
- Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q 13.1. (PMID: 8812502) Noben-Trauth K … Klempnauer KH (Genomics 1996) 2 3 22
- Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 40
- Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 40
ExternalLinks
Products for MYBL2 Gene
- Custom Antibody ServicesOriGene Antibodies for MYBL2
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- Addgene plasmids for MYBL2
- antibodies-online: Show 26 available MYBL2 Antibodies ranked by validation data
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- 57 WB Antibodies (anti-rat)
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- 73 WB Antibodies (anti-human)
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- 3 IP Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- antibodies-online: Show 5 available MYBL2 Elisa Kits ranked by validation data
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- antibodies-online: Show 6 available MYBL2 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for MYBL2
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- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MYBL2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MYBL2
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- Boster Bio Antibodies for MYBL2
Sources for MYBL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
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- (43) Atlas
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- (62) Proteopedia
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- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
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- (78) MaxQB
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