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Aliases for MYBL1 Gene

Aliases for MYBL1 Gene

  • MYB Proto-Oncogene Like 1 2 3 5
  • V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 1 2 3
  • Myb-Like Protein 1 3 4
  • AMYB 3 4
  • Myb-Related Protein A 3
  • A-MYB 3
  • A-Myb 4

External Ids for MYBL1 Gene

Previous GeneCards Identifiers for MYBL1 Gene

  • GC08M067414
  • GC08M067197
  • GC08M067524
  • GC08M067526
  • GC08M067636
  • GC08M067474
  • GC08M062964

Summaries for MYBL1 Gene

GeneCards Summary for MYBL1 Gene

MYBL1 (MYB Proto-Oncogene Like 1) is a Protein Coding gene. Diseases associated with MYBL1 include Burkitt Lymphoma and Cutaneous Adenocystic Carcinoma. Among its related pathways are Preimplantation Embryo and IL4-mediated signaling events. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is MYB.

UniProtKB/Swiss-Prot for MYBL1 Gene

  • Transcription factor that specifically recognizes the sequence 5-YAAC[GT]G-3 (PubMed:8058310, PubMed:7987850). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity).

Additional gene information for MYBL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYBL1 Gene

Genomics for MYBL1 Gene

GeneHancer (GH) Regulatory Elements for MYBL1 Gene

Promoters and enhancers for MYBL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J066605 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 658.8 +3.9 3870 8.8 PKNOX1 ARNT ARID4B SIN3A YY1 SLC30A9 POLR2B ZNF213 ZNF143 SP3 MYBL1 ARFGEF1 C8orf44 ADHFE1 RRS1 RRS1-AS1 VXN VCPIP1 LOC105375884 GC08M066613
GH08J066663 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.6 -52.0 -51951 6.1 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 C8orf44 SGK3 VCPIP1 C8orf44-SGK3 ARFGEF1 MYBL1 VXN ENSG00000201365
GH08J066516 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11 +92.0 92026 12.3 PKNOX1 CLOCK FOXA2 NEUROD1 SIN3A ZNF213 FOS RUNX3 DEK JUNB RNU6-1324P MYBL1 VXN GC08M066613
GH08J066493 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 10.7 +120.0 120022 1.6 MEIS2 PKNOX1 SAP130 L3MBTL2 MZF1 GABPA SMARCA4 IKZF1 GABPB1 NR2C1 VXN MYBL1 RNU6-1324P LOC100131770
GH08J066511 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +101.1 101089 3.3 PKNOX1 NEUROD1 MZF1 NFXL1 RAD21 ZNF143 RCOR1 DEK HCFC1 GATAD2B MYBL1 VXN MCMDC2 RNU6-1324P GC08M066613
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYBL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MYBL1 gene promoter:
  • LyF-1
  • POU2F1a
  • POU2F1
  • FOXD3
  • GATA-6
  • Meis-1b
  • HOXA9B
  • HOXA9

Genomic Locations for MYBL1 Gene

Genomic Locations for MYBL1 Gene
chr8:66,562,175-66,614,247
(GRCh38/hg38)
Size:
52,073 bases
Orientation:
Minus strand
chr8:67,474,410-67,526,482
(GRCh37/hg19)
Size:
52,073 bases
Orientation:
Minus strand

Genomic View for MYBL1 Gene

Genes around MYBL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYBL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYBL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYBL1 Gene

Proteins for MYBL1 Gene

  • Protein details for MYBL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10243-MYBA_HUMAN
    Recommended name:
    Myb-related protein A
    Protein Accession:
    P10243
    Secondary Accessions:
    • E7EW29
    • Q495F9

    Protein attributes for MYBL1 Gene

    Size:
    752 amino acids
    Molecular mass:
    85887 Da
    Quaternary structure:
    • Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.

    Alternative splice isoforms for MYBL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYBL1 Gene

Post-translational modifications for MYBL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYBL1 Gene

Domains & Families for MYBL1 Gene

Gene Families for MYBL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MYBL1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYBL1: view

No data available for UniProtKB/Swiss-Prot for MYBL1 Gene

Function for MYBL1 Gene

Molecular function for MYBL1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that specifically recognizes the sequence 5-YAAC[GT]G-3 (PubMed:8058310, PubMed:7987850). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity).
GENATLAS Biochemistry:
avian myeloblastosis viral (v-myb) oncogene homolog-like 1

Phenotypes From GWAS Catalog for MYBL1 Gene

Gene Ontology (GO) - Molecular Function for MYBL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 7987850
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 7987850
GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting IBA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with MYBL1: view
genes like me logo Genes that share phenotypes with MYBL1: view

Animal Models for MYBL1 Gene

MGI Knock Outs for MYBL1:

Animal Model Products

miRNA for MYBL1 Gene

miRTarBase miRNAs that target MYBL1
Targeted motifs for MYBL1 Gene
HOMER Transcription Factor Regulatory Elements motif MYBL1
  • Consensus sequence: TGGCAGTTGG Submotif: canonical Cell Type: Testes GEO ID: GSE44588

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for MYBL1 Gene

Localization for MYBL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYBL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYBL1 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MYBL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS,IBA 8058310
genes like me logo Genes that share ontologies with MYBL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MYBL1 Gene

Pathways & Interactions for MYBL1 Gene

genes like me logo Genes that share pathways with MYBL1: view

Gene Ontology (GO) - Biological Process for MYBL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0006366 transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with MYBL1: view

No data available for SIGNOR curated interactions for MYBL1 Gene

Drugs & Compounds for MYBL1 Gene

(1) Drugs for MYBL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MYBL1: view

Transcripts for MYBL1 Gene

Unigene Clusters for MYBL1 Gene

V-myb myeloblastosis viral oncogene homolog (avian)-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYBL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1:
SP2: -

Relevant External Links for MYBL1 Gene

GeneLoc Exon Structure for
MYBL1
ECgene alternative splicing isoforms for
MYBL1

Expression for MYBL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYBL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYBL1 Gene

This gene is overexpressed in Artery - Tibial (x6.3) and Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for MYBL1 Gene

This gene is overexpressed in Cerebrospinal fluid (50.5) and Monocytes (17.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MYBL1 Gene



Protein tissue co-expression partners for MYBL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MYBL1 Gene:

MYBL1

SOURCE GeneReport for Unigene cluster for MYBL1 Gene:

Hs.445898

mRNA Expression by UniProt/SwissProt for MYBL1 Gene:

P10243-MYBA_HUMAN
Tissue specificity: Expressed in a variety of lymphoid and solid tumor lines cultured in vitro.

Evidence on tissue expression from TISSUES for MYBL1 Gene

  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with MYBL1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MYBL1 Gene

Orthologs for MYBL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYBL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYBL1 34 33
  • 99.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MYBL1 34 33
  • 94.05 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MYBL1 34 33
  • 93.4 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYBL1 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mybl1 16 34 33
  • 90.95 (n)
rat
(Rattus norvegicus)
Mammalia Mybl1 33
  • 90.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYBL1 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYBL1 34 33
  • 78.78 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYBL1 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mybl1 33
  • 67.14 (n)
African clawed frog
(Xenopus laevis)
Amphibia xamyb 33
zebrafish
(Danio rerio)
Actinopterygii mybl1 34 33
  • 58.09 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Myb 34
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BAS1 34
  • 14 (a)
OneToMany
Species where no ortholog for MYBL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYBL1 Gene

ENSEMBL:
Gene Tree for MYBL1 (if available)
TreeFam:
Gene Tree for MYBL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYBL1: view image

Paralogs for MYBL1 Gene

Paralogs for MYBL1 Gene

(3) SIMAP similar genes for MYBL1 Gene using alignment to 3 proteins:

  • MYBA_HUMAN
  • E7EWZ1_HUMAN
  • Q495G0_HUMAN
genes like me logo Genes that share paralogs with MYBL1: view

Variants for MYBL1 Gene

Sequence variations from dbSNP and Humsavar for MYBL1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000015223 -- 66,592,126(-) C/T intron_variant
rs1000049764 -- 66,575,886(-) A/G intron_variant
rs1000091248 -- 66,610,861(-) C/T intron_variant
rs1000210720 -- 66,613,414(-) T/C upstream_transcript_variant
rs1000223409 -- 66,569,219(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MYBL1 Gene

Variant ID Type Subtype PubMed ID
esv3617488 CNV gain 21293372
esv994614 CNV loss 20482838
nsv831346 CNV loss 17160897

Variation tolerance for MYBL1 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYBL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYBL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYBL1 Gene

Disorders for MYBL1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MYBL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
burkitt lymphoma
  • bl
cutaneous adenocystic carcinoma
  • adenoid cystic carcinoma of the skin
adenoid cystic carcinoma
  • salivary gland adenoid cystic carcinoma
breast adenoid cystic carcinoma
  • adenoid cystic carcinoma of breast
lacrimal gland adenocarcinoma
  • adenocarcinoma of lacrimal gland
- elite association - COSMIC cancer census association via MalaCards
Search MYBL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MYBL1

genes like me logo Genes that share disorders with MYBL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYBL1 Gene

Publications for MYBL1 Gene

  1. DNA binding and transactivation activity of A-myb, a c-myb-related gene. (PMID: 7987850) Ma XP … Calabretta B (Cancer research 1994) 3 4 22 58
  2. The human A-myb protein is a strong activator of transcription. (PMID: 8058310) Golay J … Introna M (Oncogene 1994) 3 4 22 58
  3. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PMID: 17531812) Litovchick L … DeCaprio JA (Molecular cell 2007) 3 4 58
  4. The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. (PMID: 16055500) Kurahashi T … Ishii S (Molecular biology of the cell 2005) 3 22 58
  5. Nucleolin, a novel partner for the Myb transcription factor family that regulates their activity. (PMID: 10660576) Ying GG … Golay J (The Journal of biological chemistry 2000) 3 22 58

Products for MYBL1 Gene

Sources for MYBL1 Gene

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