Aliases for MYB Gene
External Ids for MYB Gene
Previous GeneCards Identifiers for MYB Gene
This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
GeneCards Summary for MYB Gene
MYB (MYB Proto-Oncogene, Transcription Factor) is a Protein Coding gene. Diseases associated with MYB include Angiocentric Glioma and Acute Basophilic Leukemia. Among its related pathways are Notch-mediated HES/HEY network and Pathways Affected in Adenoid Cystic Carcinoma. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is MYBL1.
UniProtKB/Swiss-Prot Summary for MYB Gene
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.