Aliases for MYADML2 Gene

Aliases for MYADML2 Gene

  • Myeloid Associated Differentiation Marker Like 2 2 3 5
  • Myeloid-Associated Differentiation Marker-Like Protein 2 3 4

External Ids for MYADML2 Gene

Previous GeneCards Identifiers for MYADML2 Gene

  • GC17M077490
  • GC17M079897
  • GC17M075298

Summaries for MYADML2 Gene

GeneCards Summary for MYADML2 Gene

MYADML2 (Myeloid Associated Differentiation Marker Like 2) is a Protein Coding gene. An important paralog of this gene is MYADM.

Additional gene information for MYADML2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYADML2 Gene

Genomics for MYADML2 Gene

GeneHancer (GH) Regulatory Elements for MYADML2 Gene

Promoters and enhancers for MYADML2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J081938 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 770.5 +6.0 6032 5.6 ZNF652 SP7 ZIC2 POLR2A ZFHX2 ZNF335 ZNF223 SIN3A ZBTB33 KDM1A MYADML2 ENSG00000235296 PYCR1 TBCD ARL16 WDR45B ENSG00000263731 TSPAN10 ENSG00000262877 GCGR
GH17J081948 Enhancer 0.4 Ensembl 761.3 -1.0 -967 0.8 ZNF121 NFIC SSRP1 NFIA MYADML2 piR-57134-054 ASPSCR1 MG828546
GH17J081908 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 13.3 +36.1 36074 6 SP1 CTCF LCORL MLX RBPJ SMARCE1 POLR2A NR2F1 NR2F6 MIXL1 PCYT2 CEP131 MAFG ENSG00000235296 PYCR1 MYADML2 HGS GCGR lnc-SIRT7-2 lnc-SIRT7-1
GH17J081958 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 13.7 -13.2 -13168 3.2 ZNF24 ZBTB40 CTCF NR2F6 HCFC1 ELF1 L3MBTL2 RAD21 MNT ZNF148 NOTUM ENSG00000260563 ENSG00000262652 ARL2BPP9 SLC38A10 TEPSIN CHMP6 ENSG00000262049 HGS MYADML2
GH17J082011 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 12 -66.9 -66859 4.6 MLX RBPJ NR2F6 RERE ELF3 POLR2A TFE3 HNF1A SP5 GLIS2 CENPX CEP131 DCXR ASPSCR1 MYADML2 ENSG00000235296 PYCR1 MAFG SIRT7 PCYT2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYADML2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MYADML2 gene promoter:
  • ATF-2
  • c-Jun
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • p53

Genomic Locations for MYADML2 Gene

Genomic Locations for MYADML2 Gene
chr17:81,939,645-81,947,233
(GRCh38/hg38)
Size:
7,589 bases
Orientation:
Minus strand
chr17:79,897,521-79,905,109
(GRCh37/hg19)
Size:
7,589 bases
Orientation:
Minus strand

Genomic View for MYADML2 Gene

Genes around MYADML2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYADML2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYADML2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYADML2 Gene

Proteins for MYADML2 Gene

  • Protein details for MYADML2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NDP7-MADL2_HUMAN
    Recommended name:
    Myeloid-associated differentiation marker-like protein 2
    Protein Accession:
    A6NDP7

    Protein attributes for MYADML2 Gene

    Size:
    307 amino acids
    Molecular mass:
    32967 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MYADML2 Gene

Post-translational modifications for MYADML2 Gene

No Post-translational modifications

Other Protein References for MYADML2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MYADML2 Gene

Domains & Families for MYADML2 Gene

Gene Families for MYADML2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MYADML2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MYADML2 Gene

GenScript: Design optimal peptide antigens:
  • Myeloid-associated differentiation marker-like protein 2 (MADL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NDP7

UniProtKB/Swiss-Prot:

MADL2_HUMAN :
  • Belongs to the MAL family.
Family:
  • Belongs to the MAL family.
genes like me logo Genes that share domains with MYADML2: view

Function for MYADML2 Gene

Phenotypes From GWAS Catalog for MYADML2 Gene

Phenotypes for MYADML2 Gene

genes like me logo Genes that share phenotypes with MYADML2: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MYADML2 Gene

Localization for MYADML2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYADML2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYADML2 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MYADML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21325632
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MYADML2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MYADML2 Gene

Pathways & Interactions for MYADML2 Gene

PathCards logo

SuperPathways for MYADML2 Gene

No Data Available

Interacting Proteins for MYADML2 Gene

Gene Ontology (GO) - Biological Process for MYADML2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MYADML2 Gene

Drugs & Compounds for MYADML2 Gene

No Compound Related Data Available

Transcripts for MYADML2 Gene

mRNA/cDNA for MYADML2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(644) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYADML2 Gene

No ASD Table

Relevant External Links for MYADML2 Gene

GeneLoc Exon Structure for
MYADML2
ECgene alternative splicing isoforms for
MYADML2

Expression for MYADML2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYADML2 Gene

mRNA differential expression in normal tissues according to GTEx for MYADML2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.3), Brain - Caudate (basal ganglia) (x4.8), Heart - Left Ventricle (x4.7), Brain - Frontal Cortex (BA9) (x4.5), Brain - Cortex (x4.4), and Muscle - Skeletal (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of MYADML2 Gene:

MYADML2

SOURCE GeneReport for Unigene cluster for MYADML2 Gene:

Hs.729645

Evidence on tissue expression from TISSUES for MYADML2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with MYADML2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MYADML2 Gene

Orthologs for MYADML2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYADML2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYADML2 32
  • 98.7 (n)
dog
(Canis familiaris)
Mammalia MYADML2 33 32
  • 88.17 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MYADML2 33 32
  • 87.4 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myadml2 32
  • 84.8 (n)
mouse
(Mus musculus)
Mammalia Myadml2 17 33 32
  • 83.71 (n)
oppossum
(Monodelphis domestica)
Mammalia MYADML2 33
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYADML2 32
  • 73.09 (n)
lizard
(Anolis carolinensis)
Reptilia MYADML2 33
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myadml2 32
  • 63.42 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC570494 32
  • 65.78 (n)
MYADML2 33
  • 62 (a)
OneToOne
Species where no ortholog for MYADML2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYADML2 Gene

ENSEMBL:
Gene Tree for MYADML2 (if available)
TreeFam:
Gene Tree for MYADML2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYADML2: view image

Paralogs for MYADML2 Gene

Paralogs for MYADML2 Gene

(2) SIMAP similar genes for MYADML2 Gene using alignment to 1 proteins:

  • MADL2_HUMAN
genes like me logo Genes that share paralogs with MYADML2: view

Variants for MYADML2 Gene

Sequence variations from dbSNP and Humsavar for MYADML2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1555624118 uncertain-significance, not provided 81,940,862(-) C/A coding_sequence_variant, missense_variant
rs1000947527 -- 81,939,763(-) C/A/G 3_prime_UTR_variant
rs1001333915 -- 81,940,187(-) G/A 3_prime_UTR_variant
rs1001357101 -- 81,940,405(-) T/G 3_prime_UTR_variant
rs1001604948 -- 81,944,235(-) TCTCT/TCT intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MYADML2 Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv2338985 CNV deletion 18987734
esv2658619 CNV deletion 23128226
esv2716464 CNV deletion 23290073
esv2716465 CNV deletion 23290073
esv29964 CNV loss 17803354
esv32874 CNV loss 17666407
esv3641409 CNV loss 21293372
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv833569 CNV loss 17160897
nsv833571 CNV loss 17160897
nsv952392 CNV deletion 24416366

Variation tolerance for MYADML2 Gene

Gene Damage Index Score: 4.28; 62.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYADML2 Gene

Human Gene Mutation Database (HGMD)
MYADML2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYADML2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYADML2 Gene

Disorders for MYADML2 Gene

Additional Disease Information for MYADML2

No disorders were found for MYADML2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYADML2 Gene

Publications for MYADML2 Gene

  1. MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration. (PMID: 21325632) Aranda JF … Alonso MA (Molecular biology of the cell 2011) 3 56
  2. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) König R … Chanda SK (Cell 2008) 3 56
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56

Products for MYADML2 Gene

Sources for MYADML2 Gene