Aliases for MYADM Gene

Aliases for MYADM Gene

  • Myeloid Associated Differentiation Marker 2 3 5
  • Myeloid-Associated Differentiation Marker 3 4
  • Myeloid Upregulated Protein 3
  • Protein SB135 4
  • SB135 3
  • MYADM 5

External Ids for MYADM Gene

Previous GeneCards Identifiers for MYADM Gene

  • GC00U990550
  • GC19P059062
  • GC19P054369
  • GC19P050688
  • GC19P053866
  • GC19P053996
  • GC19P054027
  • GC19P054048
  • GC19P054122
  • GC19P053867
  • GC19P053897
  • GC19P053923
  • GC19P053952
  • GC19P053974
  • GC19P053975
  • GC19P053978
  • GC19P054635
  • GC19P055578

Summaries for MYADM Gene

GeneCards Summary for MYADM Gene

MYADM (Myeloid Associated Differentiation Marker) is a Protein Coding gene. An important paralog of this gene is MYADML2.

Gene Wiki entry for MYADM Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MYADM Gene

Genomics for MYADM Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MYADM Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MYADM on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MYADM

Top Transcription factor binding sites by QIAGEN in the MYADM gene promoter:
  • CREB
  • deltaCREB
  • TBP

Genomic Locations for MYADM Gene

Latest Assembly
chr19:53,864,763-53,876,435
(GRCh38/hg38)
Size:
11,673 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,368,882-54,379,689
(GRCh37/hg19 by Entrez Gene)
Size:
10,808 bases
Orientation:
Plus strand

chr19:54,369,477-54,379,691
(GRCh37/hg19 by Ensembl)
Size:
10,215 bases
Orientation:
Plus strand

Genomic View for MYADM Gene

Genes around MYADM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYADM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYADM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYADM Gene

Proteins for MYADM Gene

  • Protein details for MYADM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S97-MYADM_HUMAN
    Recommended name:
    Myeloid-associated differentiation marker
    Protein Accession:
    Q96S97
    Secondary Accessions:
    • B2RE58
    • Q542Z1
    • Q7Z507
    • Q8N9R4
    • Q96CS6
    • Q96SK9

    Protein attributes for MYADM Gene

    Size:
    322 amino acids
    Molecular mass:
    35274 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP97182.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAB55302.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MYADM Gene

Post-translational modifications for MYADM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MYADM Gene

Domains & Families for MYADM Gene

Gene Families for MYADM Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for MYADM Gene

InterPro:
Blocks:
  • Marvel

Suggested Antigen Peptide Sequences for MYADM Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53753, highly similar to Myeloid-associated differentiation marker (B4DG42_HUMAN)
  • Protein SB135 (MYADM_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96S97

UniProtKB/Swiss-Prot:

MYADM_HUMAN :
  • Belongs to the MAL family.
Family:
  • Belongs to the MAL family.
genes like me logo Genes that share domains with MYADM: view

Function for MYADM Gene

Phenotypes From GWAS Catalog for MYADM Gene

Gene Ontology (GO) - Molecular Function for MYADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with MYADM: view
genes like me logo Genes that share phenotypes with MYADM: view

Animal Models for research

  • Taconic Biosciences Mouse Models for MYADM

miRNA for MYADM Gene

miRTarBase miRNAs that target MYADM

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYADM

Clone products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MYADM Gene

Localization for MYADM Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYADM Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYADM gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 2
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MYADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 21325632
GO:0005886 plasma membrane IBA,IMP 21325632
GO:0005911 cell-cell junction IBA,IDA 23264465
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MYADM: view

Pathways & Interactions for MYADM Gene

PathCards logo

SuperPathways for MYADM Gene

No Data Available

Gene Ontology (GO) - Biological Process for MYADM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IMP 23264465
GO:0010629 negative regulation of gene expression IMP 23264465
GO:0010810 NOT regulation of cell-substrate adhesion IMP 21325632
GO:0030335 positive regulation of cell migration IMP 21325632
GO:0030837 negative regulation of actin filament polymerization IMP 23264465
genes like me logo Genes that share ontologies with MYADM: view

No data available for Pathways by source and SIGNOR curated interactions for MYADM Gene

Drugs & Compounds for MYADM Gene

No Compound Related Data Available

Transcripts for MYADM Gene

mRNA/cDNA for MYADM Gene

12 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MYADM

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for MYADM Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP8: - -
SP9:

Relevant External Links for MYADM Gene

GeneLoc Exon Structure for
MYADM

Expression for MYADM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MYADM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYADM Gene

This gene is overexpressed in Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for MYADM Gene

This gene is overexpressed in Nasal epithelium (20.0) and Colon muscle (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MYADM Gene



Protein tissue co-expression partners for MYADM Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MYADM

SOURCE GeneReport for Unigene cluster for MYADM Gene:

Hs.380906

mRNA Expression by UniProt/SwissProt for MYADM Gene:

Q96S97-MYADM_HUMAN
Tissue specificity: Widely expressed. Not detected in thymus.

Evidence on tissue expression from TISSUES for MYADM Gene

  • Nervous system(4.8)
  • Bone marrow(4.5)
  • Thyroid gland(4.3)
  • Blood(3.5)
  • Pancreas(3.5)
  • Lung(3.1)
  • Kidney(2.8)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with MYADM: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MYADM Gene

Orthologs for MYADM Gene

This gene was present in the common ancestor of chordates.

Orthologs for MYADM Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MYADM 29 30
  • 99.28 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 92 (a)
OneToMany
-- 30
  • 92 (a)
OneToMany
LOC100855913 29
  • 87.16 (n)
Cow
(Bos Taurus)
Mammalia MYADM 29 30
  • 86.44 (n)
OneToMany
-- 30
  • 69 (a)
OneToMany
-- 30
  • 64 (a)
OneToMany
-- 30
  • 59 (a)
OneToMany
-- 30
  • 58 (a)
OneToMany
-- 30
  • 56 (a)
OneToMany
-- 30
  • 56 (a)
OneToMany
-- 30
  • 54 (a)
OneToMany
-- 30
  • 54 (a)
OneToMany
-- 30
  • 52 (a)
OneToMany
-- 30
  • 52 (a)
OneToMany
-- 30
  • 52 (a)
OneToMany
-- 30
  • 52 (a)
OneToMany
-- 30
  • 46 (a)
OneToMany
-- 30
  • 41 (a)
OneToMany
-- 30
  • 37 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Myadm 29
  • 80.79 (n)
Mouse
(Mus musculus)
Mammalia Myadm 29 16 30
  • 80.24 (n)
OneToOne
Chicken
(Gallus gallus)
Aves -- 30
  • 42 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia MYADM 30
  • 58 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia myadm 29
  • 59.42 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29941 29
Zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-67a8.2 29
  • 59.37 (n)
MYADM (2 of 2) 30
  • 53 (a)
OneToMany
MYADM (1 of 2) 30
  • 49 (a)
OneToMany
-- 29
Species where no ortholog for MYADM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MYADM Gene

ENSEMBL:
Gene Tree for MYADM (if available)
TreeFam:
Gene Tree for MYADM (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MYADM: view image
Alliance of Genome Resources:
Additional Orthologs for MYADM

Paralogs for MYADM Gene

Paralogs for MYADM Gene

(2) SIMAP similar genes for MYADM Gene using alignment to 5 proteins:

  • MYADM_HUMAN
  • C9J5M0_HUMAN
  • C9JC07_HUMAN
  • C9JJV6_HUMAN
  • C9JZL8_HUMAN

Pseudogenes.org Pseudogenes for MYADM Gene

genes like me logo Genes that share paralogs with MYADM: view

Variants for MYADM Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MYADM Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MYADM Gene

Variant ID Type Subtype PubMed ID
esv24957 CNV loss 19812545
esv2663412 CNV deletion 23128226
esv2718812 CNV deletion 23290073
esv2718842 CNV deletion 23290073
esv2718843 CNV deletion 23290073
esv3644776 CNV loss 21293372
nsv1064558 CNV gain 25217958
nsv833876 CNV loss 17160897
nsv953610 CNV deletion 24416366

Variation tolerance for MYADM Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MYADM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYADM
Leiden Open Variation Database (LOVD)
MYADM

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MYADM Gene

Disorders for MYADM Gene

Additional Disease Information for MYADM

No disorders were found for MYADM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MYADM Gene

Publications for MYADM Gene

  1. Cloning of human myeloid-associated differentiation marker (MYADM) gene whose expression was up-regulated in NB4 cells induced by all-trans retinoic acid. (PMID: 12075932) Cui W … Zhao S (Molecular biology reports 2001) 2 3 4 22
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4

Products for MYADM Gene

Sources for MYADM Gene