Aliases for MXD3 Gene
External Ids for MXD3 Gene
Previous GeneCards Identifiers for MXD3 Gene
This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
GeneCards Summary for MXD3 Gene
MXD3 (MAX Dimerization Protein 3) is a Protein Coding gene. Diseases associated with MXD3 include Myxosarcoma and Perianal Hematoma. Gene Ontology (GO) annotations related to this gene include protein dimerization activity. An important paralog of this gene is MXD1.
UniProtKB/Swiss-Prot Summary for MXD3 Gene
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).