Aliases for MXD3 Gene
Aliases for MXD3 Gene
External Ids for MXD3 Gene
- HGNC: 14008
- Entrez Gene: 83463
- Ensembl: ENSG00000213347
- OMIM: 609450
- UniProtKB: Q9BW11
Previous GeneCards Identifiers for MXD3 Gene
- GC05M177575
- GC05M176668
- GC05M176713
- GC05M176715
- GC05M176665
- GC05M176666
- GC05M176732
- GC05M171653
- GC05M176733
- GC05M176744
- GC05M177302
- GC05M177304
- GC05M177311
- GC05M177319
- GC05M177326
Summaries for MXD3 Gene
-
This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
GeneCards Summary for MXD3 Gene
MXD3 (MAX Dimerization Protein 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein dimerization activity. An important paralog of this gene is MXD1.
UniProtKB/Swiss-Prot for MXD3 Gene
-
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MXD3 Gene
Genomics for MXD3 Gene
GeneHancer (GH) Regulatory Elements for MXD3 Gene
Promoters and enhancers for MXD3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MXD3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MXD3 gene promoter:
-
- ARP-1
- Gfi-1
- HEN1
- HOXA9
- NRSF form 1
- NRSF form 2
- HOXA9B
- Meis-1
- Meis-1b
- deltaCREB
Regulatory Element Products
Genomic Locations for MXD3 Gene
Genomic Locations for MXD3 Gene
- chr5:177,301,461-177,312,757
- (GRCh38/hg38)
- Size:
- 11,297 bases
- Orientation:
- Minus strand
- chr5:176,728,462-176,739,758
- (GRCh37/hg19)
- Size:
- 11,297 bases
- Orientation:
- Minus strand
Genomic View for MXD3 Gene
Genes around MXD3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q35.3 by Entrez Gene
- 5q35.3 by HGNC
- 5q35.3 by Ensembl
MXD3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MXD3 Gene
Proteins for MXD3 Gene
-
Protein details for MXD3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BW11-MAD3_HUMAN
- Recommended name:
- Max dimerization protein 3
- Protein Accession:
- Q9BW11
- B4E0J1
- Q53HK1
- Q7Z4Y0
- Q8NDJ7
- Q96ME3
Protein attributes for MXD3 Gene
- Size:
- 206 amino acids
- Molecular mass:
- 23477 Da
- Quaternary structure:
-
- Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17 (By similarity).
Post-translational modifications for MXD3 Gene
Other Protein References for MXD3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MXD3
- Novus Biologicals Antibodies for MXD3
-
Abcam antibodies for MXD3
- Invitrogen Antibodies for MXD3 (AFLGC-MXD3)
- GeneTex MXD3 Antibody for MXD3
Protein Products
-
OriGene Purified Proteins for MXD3
- Search Origene for MassSpec and Protein Over-expression Lysates for MXD3
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- ProSpec Recombinant Proteins for MXD3
- Search GeneTex for Proteins for MXD3
-
Abcam proteins for MXD3
Assay Products
- antibodies-online: Search results for available MXD3 related products ranked by validation data
No data available for DME Specific Peptides for MXD3 Gene
Domains & Families for MXD3 Gene
Gene Families for MXD3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for MXD3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MXD3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for MXD3 Gene
Function for MXD3 Gene
Molecular function for MXD3 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).
Phenotypes From GWAS Catalog for MXD3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IEA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for MXD3 Gene
- MGI mutant phenotypes for MXD3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MXD3:
-
- Increased HPV18 LCR reporter activity
- Decreased viability ratio
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased Nanog expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased IL-8 secretion
- Increased transferrin (TF) endocytosis
Animal Models for MXD3 Gene
- MGI Knock Outs for MXD3:
-
- Mxd3 Mxd3<tm1Rne>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MXD3
-
CRISPR Products
-
OriGene CRISPR knockouts for MXD3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MXD3
- genomics-online: gRNA clones - Search results for available MXD3 gene related products
- Applied Biological Materials CRISPR for MXD3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MXD3
- GenScript: Design CRISPR guide RNA sequences for MXD3
miRNA for MXD3 Gene
- miRTarBase miRNAs that target MXD3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MXD3
- Browse OriGene Inhibitory RNA Products For MXD3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MXD3
- genomics-online: shRNA clones - Search results for available MXD3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MXD3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MXD3
- genomics-online: cdna clones - Search results for available MXD3 gene related products
- orf clones - Search results for available MXD3 gene related products
- Applied Biological Materials Clones for MXD3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
- ESI BIO PureStem ES-210, Ecto-ntu Progenitor for MXD3
-
Horizon Cell Lines for MXD3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MXD3 Gene
Localization for MXD3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MXD3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 2 |
- Nucleoli (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0090575 | RNA polymerase II transcription factor complex | IEA | -- |
Pathways & Interactions for MXD3 Gene
No Data Available
Interacting Proteins for MXD3 Gene
Selected Interacting proteins:
Q9BW11-MAD3_HUMAN
ENSP00000401867
for MXD3 Gene via
UniProtKB
IID
STRING
GPS-Prot Interaction Network for MXD3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0045892 | negative regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for MXD3 Gene
Transcripts for MXD3 Gene
mRNA/cDNA for MXD3 Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (709) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000503473 2279 bps (uc063kcf.1)
- ENST00000509339 579 bps (uc063kcj.1)
- ENST00000427908 2269 bps (uc010jkk.3)
- ENST00000423571 1534 bps (uc003mga.4)
- ENST00000439742 1483 bps (uc003mgb.3)
Unigene Clusters for MXD3 Gene
- MAX dimerization protein 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MXD3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MXD3
- genomics-online: gRNA clones - Search results for available MXD3 gene related products
- Applied Biological Materials CRISPR for MXD3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MXD3
- GenScript: Design CRISPR guide RNA sequences for MXD3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MXD3
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MXD3
- genomics-online: shRNA clones - Search results for available MXD3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MXD3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MXD3
- genomics-online: cdna clones - Search results for available MXD3 gene related products
- orf clones - Search results for available MXD3 gene related products
- Applied Biological Materials Clones for MXD3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MXD3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for MXD3 Gene
This gene is overexpressed in Whole Blood (x4.7).
NURSA nuclear receptor signaling pathways regulating expression of MXD3 Gene:
MXD3SOURCE GeneReport for Unigene cluster for MXD3 Gene:
Hs.743332Evidence on tissue expression from TISSUES for MXD3 Gene
- Lung(4.1)
Primer Products
-
OriGene qPCR primer pairs for MXD3
-
OriGene qPCR primer pairs and template standards for MXD3
- genomics-online: primer clones - Search results for available MXD3 gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MXD3 Gene
Orthologs for MXD3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | MXD3 34 33 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | MXD3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MXD3 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mxd3 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mxd3 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MXD3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MXD3 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MXD3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mxd3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mxd3 34 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | mdl-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2549 34 |
|
OneToMany |
- Species where no ortholog for MXD3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for MXD3 Gene
- ENSEMBL:
- Gene Tree for MXD3 (if available)
- TreeFam:
- Gene Tree for MXD3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MXD3: view image
Paralogs for MXD3 Gene
Variants for MXD3 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000246353 | -- | 177,312,479(-) | C/T | upstream_transcript_variant | |
| rs1000480379 | -- | 177,311,708(-) | G/C | intron_variant | |
| rs1000526900 | -- | 177,313,943(-) | T/G | upstream_transcript_variant | |
| rs1000584174 | -- | 177,312,159(-) | C/G | 5_prime_UTR_variant | |
| rs1001044130 | -- | 177,308,321(-) | T/A | intron_variant |
Residual Variation Intolerance Score:
58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.49;
29.01% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MXD3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MXD3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MXD3 Gene
Disorders for MXD3 Gene
Additional Disease Information for MXD3
No disorders were found for MXD3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MXD3 Gene
Publications for MXD3 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? (PMID: 10918583) Meroni G … Reymond A (Oncogene 2000) 3 22 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Novel targeted therapy for neuroblastoma: silencing the MXD3 gene using siRNA. (PMID: 28419087) Duong C … Satake N (Pediatric research 2017) 3 58
Products for MXD3 Gene
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- Custom Antibody ServicesOriGene Antibodies for MXD3
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- OriGene Purified Proteins for MXD3
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- antibodies-online: Search results for 10 available MXD3 Proteins ranked by validation data
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- Quality Products:
- GeneTex MXD3 Antibody for MXD3
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- Horizon Cell Lines for MXD3
- genomics-online: cdna clones - Search results for available MXD3 gene related products
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Sources for MXD3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt