Aliases for MXD1 Gene
External Ids for MXD1 Gene
Previous HGNC Symbols for MXD1 Gene
Previous GeneCards Identifiers for MXD1 Gene
This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for MXD1 Gene
MXD1 (MAX Dimerization Protein 1) is a Protein Coding gene. Among its related pathways are Regulation of Telomerase and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is MXI1.
UniProtKB/Swiss-Prot for MXD1 Gene
Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. MAD thus antagonizes MYC transcriptional activity by competing for MAX.