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The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytopla... See more...
Aliases for MX2 Gene
Aliases for MX2 Gene
External Ids for MX2 Gene
- HGNC: 7533
- Entrez Gene: 4600
- Ensembl: ENSG00000183486
- OMIM: 147890
- UniProtKB: P20592
Previous GeneCards Identifiers for MX2 Gene
- GC21P039307
- GC21P041654
- GC21P041655
- GC21P042734
- GC21P028202
Summaries for MX2 Gene
-
The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]
GeneCards Summary for MX2 Gene
MX2 (MX Dynamin Like GTPase 2) is a Protein Coding gene. Diseases associated with MX2 include Influenza and Myasthenic Syndrome, Congenital, 1A, Slow-Channel. Among its related pathways are Interferon gamma signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is MX1.
UniProtKB/Swiss-Prot Summary for MX2 Gene
-
Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.
Additional gene information for MX2 Gene
- HGNC(7533)
- Entrez Gene(4600)
- Ensembl(ENSG00000183486)
- OMIM(147890)
- UniProtKB(P20592)
- Open Targets Platform(ENSG00000183486)
- Monarch Initiative
- Search for MX2 at DataMed
- Search for MX2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MX2 Gene
Genomics for MX2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MX2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MX2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MX2
- Top Transcription factor binding sites by QIAGEN in the MX2 gene promoter:
-
- aMEF-2
- AP-4
- E47
- ER-alpha
- FOXI1
- HFH-3
- MEF-2
- MEF-2A
- Pax-2
- Pax-2a
Genomic Locations for MX2 Gene
Genomic Locations for MX2 Gene
- chr21:41,361,944-41,409,393
- (GRCh38/hg38)
- Size:
- 47,450 bases
- Orientation:
- Plus strand
- chr21:42,733,870-42,781,317
- (GRCh37/hg19)
- Size:
- 47,448 bases
- Orientation:
- Plus strand
Genomic View for MX2 Gene
Genes around MX2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.3 by HGNC
- 21q22.3 by Entrez Gene
- 21q22.3 by Ensembl
MX2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MX2 Gene
Proteins for MX2 Gene
-
Protein details for MX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P20592-MX2_HUMAN
- Recommended name:
- Interferon-induced GTP-binding protein Mx2
- Protein Accession:
- P20592
- B7Z5D3
- D3DSI7
Protein attributes for MX2 Gene
- Size:
- 715 amino acids
- Molecular mass:
- 82089 Da
- Quaternary structure:
- No Data Available
Protein Expression for MX2 Gene
Post-translational modifications for MX2 Gene
Other Protein References for MX2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ MX2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for MX2
- Novus Biologicals Antibodies for MX2
-
Abcam antibodies for MX2
- Invitrogen Antibodies for MX2 (AFLGC-MX2)
-
Biorbyt antibodies for MX2
-
Santa Cruz Biotechnology (SCBT) Antibodies for MX2
- Sino Biological Antibodies for MX2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MX2
- Origene Custom Protein Services for MX2
- ProSpec Recombinant Proteins for MX2
- antibodies-online: Show 8 available MX2 Proteins ranked by validation data
- Compare Top MX2 Proteins
-
Quality Products:
-
Abcam proteins for MX2
Assay Products
- antibodies-online: Show 7 available MX2 Elisa Kits ranked by validation data
- Compare Top MX2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for MX2 Gene
Domains & Families for MX2 Gene
Gene Families for MX2 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transporters
Protein Domains for MX2 Gene
- InterPro:
- Blocks:
-
- Dynamin
- ProtoNet:
Suggested Antigen Peptide Sequences for MX2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58681, highly similar to Interferon-induced GTP-binding protein Mx2 (B7Z5D3_HUMAN)
- p78-related protein (MX2_HUMAN)
- MX2 (Q75MY7_HUMAN)
- MX2 (Q75MY8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P20592UniProtKB/Swiss-Prot:
MX2_HUMAN :- Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
- Family:
-
- Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
Function for MX2 Gene
Molecular function for MX2 Gene
- UniProtKB/Swiss-Prot Function:
- Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.
- UniProtKB/Swiss-Prot Induction:
- By type I and type III interferons.
- GENATLAS Biochemistry:
- myxovirus (influenza) resistance 2,human murine MX equivalent
Phenotypes From GWAS Catalog for MX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003924 | GTPase activity | TAS,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0005525 | GTP binding | IMP | 15184662 |
| GO:0008017 | microtubule binding | IBA | 21873635 |
Phenotypes for MX2 Gene
- GenomeRNAi human phenotypes for MX2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Increased gamma-H2AX phosphorylation
- Decreased cilium length after serum starvation
- Increased transferrin (TF) endocytosis
- Increased ionizing radiation sensitivity
- Inconclusive
- Decreased viability after ionizing radiation
- Decreased cilium length
- Increased Hepatitis C virus replication
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MX2 - Select products 50% OFF >
- * MX2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MX2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MX2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MX2
miRNA for MX2 Gene
- miRTarBase miRNAs that target MX2
-
- hsa-miR-146a-5p (MIRT021267)
- hsa-miR-6833-3p (MIRT628753)
- hsa-miR-4768-5p (MIRT628754)
- hsa-miR-297 (MIRT628755)
- hsa-miR-6873-3p (MIRT628756)
- hsa-miR-2117 (MIRT628757)
- hsa-miR-223-5p (MIRT628758)
- hsa-miR-567 (MIRT628759)
- hsa-miR-4670-3p (MIRT628760)
- hsa-miR-6817-3p (MIRT628761)
- hsa-miR-7110-3p (MIRT628762)
- hsa-miR-148a-5p (MIRT628763)
- hsa-miR-3611 (MIRT633708)
- hsa-miR-511-3p (MIRT710678)
- hsa-miR-506-5p (MIRT787035)
- hsa-miR-574-5p (MIRT787870)
- hsa-miR-630 (MIRT788161)
- hsa-miR-6867-5p (MIRT789210)
- hsa-miR-892c-5p (MIRT789929)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MX2
- Browse OriGene Inhibitory RNA Products For MX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MX2
Clone Products
- Applied Biological Materials (abm): Clones for MX2 - Select products 50% OFF >
- * MX2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MX2
Cell Line Products
-
Horizon Cell Lines for MX2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MX2 Gene
Localization for MX2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MX2 Gene
- Cytoplasm. Nucleus. Nucleus, nuclear pore complex. Note=Localization to nuclear pores requires GTP-binding.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| cytoskeleton | 4 |
| mitochondrion | 4 |
| extracellular | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS,IBA | 21873635 |
| GO:0005643 | nuclear pore | IEA,IDA | 15184662 |
| GO:0005737 | cytoplasm | TAS,IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MX2 Gene
Pathways & Interactions for MX2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of the SLBP independent Mature mRNA | ||
| 2 | Cytokine Signaling in Immune system | ||
| 3 | Innate Immune System |
.61
|
|
| 4 | Immune response IFN alpha/beta signaling pathway | ||
| 5 | Interferon gamma signaling | ||
Pathways by source for MX2 Gene
6 Reactome pathways for MX2 Gene
Interacting Proteins for MX2 Gene
Selected Interacting proteins:
P20592-MX2_HUMAN
ENSP00000333657
for MX2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for MX2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000266 | mitochondrial fission | IBA | 21873635 |
| GO:0002376 | immune system process | IEA | -- |
| GO:0003374 | dynamin family protein polymerization involved in mitochondrial fission | IBA | 21873635 |
| GO:0006952 | defense response | TAS | 8798556 |
| GO:0009615 | response to virus | IDA | 24048477 |
No data available for SIGNOR curated interactions for MX2 Gene
Transcripts for MX2 Gene
mRNA/cDNA for MX2 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000330714 3408 nts (view in UCSC)
- ENST00000398632 2211 nts (view in UCSC)
- ENST00000416447 843 nts (view in UCSC)
- ENST00000418103 604 nts (view in UCSC)
- ENST00000435611 618 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MX2 - Select products 50% OFF >
- * MX2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MX2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MX2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MX2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MX2
- Browse OriGene Inhibitory RNA Products For MX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MX2
Clone Products
- Applied Biological Materials (abm): Clones for MX2 - Select products 50% OFF >
- * MX2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MX2
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | · | 9f | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: |
| ExUns: | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | · | 20c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||||
| SP16: | - |
Relevant External Links for MX2 Gene
- GeneLoc Exon Structure for
- MX2
Expression for MX2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for MX2 Gene
This gene is overexpressed in Whole Blood (x19.2).
This gene is overexpressed in Lymph node (20.3), Peripheral blood mononuclear cells (19.6), and Blymphocyte (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MX2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MX2
SOURCE GeneReport for Unigene cluster for MX2 Gene:
Hs.926Evidence on tissue expression from TISSUES for MX2 Gene
- Nervous system(4.8)
- Blood(3.2)
- Skin(3)
- Spleen(2.9)
- Lymph node(2.7)
- Intestine(2.7)
- Lung(2.5)
- Eye(2.4)
- Kidney(2.4)
- Bone marrow(2.3)
- Stomach(2.2)
- Heart(2.2)
- Muscle(2.2)
- Liver(2.1)
Primer Products
-
OriGene qPCR primer pairs for MX2
-
OriGene qPCR primer pairs and template standards for MX2
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MX2 Gene
Orthologs for MX2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MX2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MX2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MX2 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Chicken (Gallus gallus) |
Aves | MX1 30 |
|
||
| MX 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Zebrafish (Danio rerio) |
Actinopterygii | mxe 30 31 |
|
ManyToMany | |
| mxc 31 |
|
ManyToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | shi 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | dyn-1 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for MX2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for MX2 Gene
- ENSEMBL:
- Gene Tree for MX2 (if available)
- TreeFam:
- Gene Tree for MX2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MX2: view image
Paralogs for MX2 Gene
Variants for MX2 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1273e212 | CNV | loss | 25503493 |
| dgv7834n54 | CNV | loss | 21841781 |
| esv3647060 | CNV | gain | 21293372 |
| esv3647061 | CNV | gain | 21293372 |
| esv3647062 | CNV | loss | 21293372 |
| nsv1057981 | CNV | loss | 25217958 |
| nsv1110761 | CNV | insertion | 24896259 |
| nsv1111229 | CNV | tandem duplication | 24896259 |
| nsv187364 | CNV | insertion | 16902084 |
| nsv473992 | CNV | novel sequence insertion | 20440878 |
| nsv528279 | CNV | gain | 19592680 |
| nsv834102 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.10;
38.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MX2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MX2 Gene
Disorders for MX2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| influenza |
|
|
| myasthenic syndrome, congenital, 1a, slow-channel |
|
|
| microphthalmia with limb anomalies |
|
|
| hantavirus hemorrhagic fever with renal syndrome |
|
|
Search MX2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MX2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MX2 Gene
Publications for MX2 Gene
- MX2 gene expression tends to be downregulated in subjects with HLA-DQB1*0602. (PMID: 18517045) Tanaka S … Honda M (Sleep 2008) 3 23 41
- Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope. (PMID: 8798556) Melén K … Julkunen I (The Journal of biological chemistry 1996) 2 3 23
- cDNA structures and regulation of two interferon-induced human Mx proteins. (PMID: 2481229) Aebi M … Staeheli P (Molecular and cellular biology 1989) 2 3 4
- Dynamins are forever: MxB inhibits HIV-1. (PMID: 24139395) Haller O (Cell host & microbe 2013) 3 4
- MX2 is an interferon-induced inhibitor of HIV-1 infection. (PMID: 24121441) Kane M … Bieniasz PD (Nature 2013) 3 4
ExternalLinks
Products for MX2 Gene
- Custom Antibody ServicesOriGene Antibodies for MX2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for MX2
- Origene Custom Protein Services for MX2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MX2
- Browse OriGene Inhibitory RNA Products For MX2
- OriGene qPCR primer pairs for MX2
- OriGene qPCR primer pairs and template standards for MX2
- OriGene CRISPR knockouts for MX2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MX2
- Sino Biological Human cDNA Clone for MX2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for MX2
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MX2
- Novus Biologicals proteins and lysates for MX2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MX2
- Abcam proteins for MX2
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- Browse Primary Antibodies
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
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- VectorBuilder Custom and pre-made DNA vectors for MX2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MX2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MX2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MX2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MX2
- antibodies-online: Show 4 available MX2 Antibodies ranked by validation data
- Compare Top MX2 Antibodies
- antibodies-online: Show 7 available MX2 Elisa Kits ranked by validation data
- Compare Top MX2 Elisa Kits
- Quality Products:
- antibodies-online: Show 8 available MX2 Proteins ranked by validation data
- Compare Top MX2 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for MX2
- Search Santa Cruz Biotechnology (SCBT) for MX2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MX2
- Horizon Cell Lines for MX2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MX2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MX2
- Biorbyt antibodies for MX2
Sources for MX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB