The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytopla... See more...

Aliases for MX2 Gene

Aliases for MX2 Gene

  • MX Dynamin Like GTPase 2 2 3 5
  • Interferon-Regulated Resistance GTP-Binding Protein MXB 2 3
  • Interferon-Induced GTP-Binding Protein Mx2 3 4
  • Second Interferon-Induced Protein P78 2 3
  • Myxovirus Resistance Protein 2 3 4
  • P78-Related Protein 3 4
  • MXB 2 3
  • Interferon-Regulated Resistance GTP-Binding Protein MxB 4
  • Myxovirus (Influenza) Resistance 2, Homolog Of Murine 2
  • Myxovirus (Influenza Virus) Resistance 2 (Mouse) 2
  • Myxovirus (Influenza Virus) Resistance 2 3
  • MX2 5

External Ids for MX2 Gene

Previous GeneCards Identifiers for MX2 Gene

  • GC21P039307
  • GC21P041654
  • GC21P041655
  • GC21P042734
  • GC21P028202

Summaries for MX2 Gene

Entrez Gene Summary for MX2 Gene

  • The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for MX2 Gene

MX2 (MX Dynamin Like GTPase 2) is a Protein Coding gene. Diseases associated with MX2 include Influenza and Myasthenic Syndrome, Congenital, 1A, Slow-Channel. Among its related pathways are Interferon gamma signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is MX1.

UniProtKB/Swiss-Prot Summary for MX2 Gene

  • Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.

Gene Wiki entry for MX2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MX2 Gene

Genomics for MX2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MX2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J041359 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 606.2 +0.2 160 5.7 HNRNPL CTCF REST POLR2A BACH1 LARP7 STAT3 SMAD5 TCF12 IKZF2 MX2 lnc-FAM3B-3 MX1 FAM3B piR-38351-289
GH21J041398 Promoter 0.3 EPDnew 611.9 +37.0 37008 0.1 MX2 MX1 piR-38351-289 lnc-MX1-4
GH21J041365 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas dbSUPER 25.2 +6.9 6923 5.8 CREB1 GATAD2A CTCF ZBTB33 RFX1 RCOR2 POLR2A BACH1 JUND LARP7 MX2 MX1 ENSG00000228318 FAM3B lnc-FAM3B-3 piR-38351-289
GH21J041496 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.1 +141.8 141849 14.6 REST ZIC2 SP1 EZH2 GTF2F1 SOX13 ZFX SP2 TCF7 CTCF TMPRSS2 MX2 ENSG00000207503 FAM3B ABCG1 lnc-RIPK4-5 lnc-RIPK4-6 MX1
GH21J041425 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 11.7 +64.6 64557 2.2 REST POLR2A BACH1 ZNF143 RBFOX2 SMAD5 SP1 TRIM22 EZH2 YY1 MX1 MX2 piR-38537-031 lnc-MX1-4 ENSG00000228318 TMPRSS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MX2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MX2

Top Transcription factor binding sites by QIAGEN in the MX2 gene promoter:
  • aMEF-2
  • AP-4
  • E47
  • ER-alpha
  • FOXI1
  • HFH-3
  • MEF-2
  • MEF-2A
  • Pax-2
  • Pax-2a

Genomic Locations for MX2 Gene

Genomic Locations for MX2 Gene
chr21:41,361,944-41,409,393
(GRCh38/hg38)
Size:
47,450 bases
Orientation:
Plus strand
chr21:42,733,870-42,781,317
(GRCh37/hg19)
Size:
47,448 bases
Orientation:
Plus strand

Genomic View for MX2 Gene

Genes around MX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MX2 Gene

Proteins for MX2 Gene

  • Protein details for MX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20592-MX2_HUMAN
    Recommended name:
    Interferon-induced GTP-binding protein Mx2
    Protein Accession:
    P20592
    Secondary Accessions:
    • B7Z5D3
    • D3DSI7

    Protein attributes for MX2 Gene

    Size:
    715 amino acids
    Molecular mass:
    82089 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MX2 Gene

    Alternative splice isoforms for MX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MX2 Gene

Post-translational modifications for MX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for MX2

No data available for DME Specific Peptides for MX2 Gene

Domains & Families for MX2 Gene

Gene Families for MX2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for MX2 Gene

Suggested Antigen Peptide Sequences for MX2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58681, highly similar to Interferon-induced GTP-binding protein Mx2 (B7Z5D3_HUMAN)
  • p78-related protein (MX2_HUMAN)
  • MX2 (Q75MY7_HUMAN)
  • MX2 (Q75MY8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P20592

UniProtKB/Swiss-Prot:

MX2_HUMAN :
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
genes like me logo Genes that share domains with MX2: view

Function for MX2 Gene

Molecular function for MX2 Gene

UniProtKB/Swiss-Prot Function:
Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.
UniProtKB/Swiss-Prot Induction:
By type I and type III interferons.
GENATLAS Biochemistry:
myxovirus (influenza) resistance 2,human murine MX equivalent

Phenotypes From GWAS Catalog for MX2 Gene

Gene Ontology (GO) - Molecular Function for MX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity TAS,IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IMP 15184662
GO:0008017 microtubule binding IBA 21873635
genes like me logo Genes that share ontologies with MX2: view
genes like me logo Genes that share phenotypes with MX2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MX2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MX2 Gene

Localization for MX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MX2 Gene

Cytoplasm. Nucleus. Nucleus, nuclear pore complex. Note=Localization to nuclear pores requires GTP-binding.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MX2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
cytoskeleton 4
mitochondrion 4
extracellular 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 2
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IBA 21873635
GO:0005643 nuclear pore IEA,IDA 15184662
GO:0005737 cytoplasm TAS,IBA 21873635
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with MX2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MX2 Gene

Pathways & Interactions for MX2 Gene

genes like me logo Genes that share pathways with MX2: view

Gene Ontology (GO) - Biological Process for MX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000266 mitochondrial fission IBA 21873635
GO:0002376 immune system process IEA --
GO:0003374 dynamin family protein polymerization involved in mitochondrial fission IBA 21873635
GO:0006952 defense response TAS 8798556
GO:0009615 response to virus IDA 24048477
genes like me logo Genes that share ontologies with MX2: view

No data available for SIGNOR curated interactions for MX2 Gene

Drugs & Compounds for MX2 Gene

No Compound Related Data Available

Transcripts for MX2 Gene

mRNA/cDNA for MX2 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MX2

Alternative Splicing Database (ASD) splice patterns (SP) for MX2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - - - - - - -
SP2:
SP3:
SP4:
SP5: - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: -
SP9:
SP10: - - - - - - - - -
SP11:
SP12:
SP13: - - - - - - - -
SP14: - - - -
SP15:
SP16:

ExUns: 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -

Relevant External Links for MX2 Gene

GeneLoc Exon Structure for
MX2

Expression for MX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MX2 Gene

This gene is overexpressed in Whole Blood (x19.2).

Protein differential expression in normal tissues from HIPED for MX2 Gene

This gene is overexpressed in Lymph node (20.3), Peripheral blood mononuclear cells (19.6), and Blymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MX2 Gene



Protein tissue co-expression partners for MX2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MX2

SOURCE GeneReport for Unigene cluster for MX2 Gene:

Hs.926

Evidence on tissue expression from TISSUES for MX2 Gene

  • Nervous system(4.8)
  • Blood(3.2)
  • Skin(3)
  • Spleen(2.9)
  • Lymph node(2.7)
  • Intestine(2.7)
  • Lung(2.5)
  • Eye(2.4)
  • Kidney(2.4)
  • Bone marrow(2.3)
  • Stomach(2.2)
  • Heart(2.2)
  • Muscle(2.2)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with MX2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MX2 Gene

Orthologs for MX2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MX2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MX2 30 31
  • 99.21 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MX2 30 31
  • 80.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MX2 30 31
  • 79.61 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 57 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves MX1 30
  • 54.53 (n)
MX 31
  • 45 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 54 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii mxe 30 31
  • 56.86 (n)
ManyToMany
mxc 31
  • 49 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta shi 31
  • 18 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea dyn-1 31
  • 21 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS1 31
  • 25 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 21 (a)
OneToMany
Species where no ortholog for MX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for MX2 Gene

ENSEMBL:
Gene Tree for MX2 (if available)
TreeFam:
Gene Tree for MX2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MX2: view image

Paralogs for MX2 Gene

Paralogs for MX2 Gene

(5) SIMAP similar genes for MX2 Gene using alignment to 8 proteins:

  • MX2_HUMAN
  • B7Z5D3_HUMAN
  • C9J9T4_HUMAN
  • C9JEL4_HUMAN
  • C9JS04_HUMAN
  • C9JZQ9_HUMAN
  • Q75MY7_HUMAN
  • Q75MY8_HUMAN
genes like me logo Genes that share paralogs with MX2: view

Variants for MX2 Gene

Additional dbSNP identifiers (rs#s) for MX2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MX2 Gene

Variant ID Type Subtype PubMed ID
dgv1273e212 CNV loss 25503493
dgv7834n54 CNV loss 21841781
esv3647060 CNV gain 21293372
esv3647061 CNV gain 21293372
esv3647062 CNV loss 21293372
nsv1057981 CNV loss 25217958
nsv1110761 CNV insertion 24896259
nsv1111229 CNV tandem duplication 24896259
nsv187364 CNV insertion 16902084
nsv473992 CNV novel sequence insertion 20440878
nsv528279 CNV gain 19592680
nsv834102 CNV loss 17160897

Variation tolerance for MX2 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MX2 Gene

Human Gene Mutation Database (HGMD)
MX2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MX2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MX2 Gene

Disorders for MX2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MX2 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MX2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MX2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MX2 Gene

Publications for MX2 Gene

  1. MX2 gene expression tends to be downregulated in subjects with HLA-DQB1*0602. (PMID: 18517045) Tanaka S … Honda M (Sleep 2008) 3 23 41
  2. Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope. (PMID: 8798556) Melén K … Julkunen I (The Journal of biological chemistry 1996) 2 3 23
  3. cDNA structures and regulation of two interferon-induced human Mx proteins. (PMID: 2481229) Aebi M … Staeheli P (Molecular and cellular biology 1989) 2 3 4
  4. Dynamins are forever: MxB inhibits HIV-1. (PMID: 24139395) Haller O (Cell host & microbe 2013) 3 4
  5. MX2 is an interferon-induced inhibitor of HIV-1 infection. (PMID: 24121441) Kane M … Bieniasz PD (Nature 2013) 3 4

Products for MX2 Gene

Sources for MX2 Gene