MVP Gene (Protein Coding)

Major Vault Protein

GC16P030010
GIFtS:
41
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug r... See more...

Aliases for MVP Gene

Aliases for MVP Gene

  • Major Vault Protein 2 3 4 5
  • Lung Resistance-Related Protein 2 3 4
  • LRP 3 4
  • Testicular Secretory Protein Li 30 3
  • VAULT1 3

External Ids for MVP Gene

Previous GeneCards Identifiers for MVP Gene

  • GC16M029301
  • GC16P030151
  • GC16P029826
  • GC16P029869
  • GC16P029739
  • GC16P029831
  • GC16P027492
  • GC16P029832
  • GC16P029840
  • GC16P029863
  • GC16P029979
  • GC16P029995
  • GC16P029878
  • GC16P029888
  • GC16P029898
  • GC16P029907
  • GC16P029922
  • GC16P029931
  • GC16P029948
  • GC16P029965

Summaries for MVP Gene

Entrez Gene Summary for MVP Gene

  • This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for MVP Gene

MVP (Major Vault Protein) is a Protein Coding gene. Diseases associated with MVP include Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis and Lung Cancer. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein phosphatase binding.

UniProtKB/Swiss-Prot Summary for MVP Gene

  • Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Gene Wiki entry for MVP Gene

Additional gene information for MVP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MVP Gene

Genomics for MVP Gene

GeneHancer (GH) Regulatory Elements for MVP Gene

Promoters and enhancers for MVP Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH16J029819 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 758.3 +2.5 2520 7.5 SIN3A POLR2A USF2 FOS ZNF362 RELA RAD21 MNT ZNF652 CTCF MVP ENSG00000238045 ENSG00000261766 SH2B1 ZNF785 DOC2A TAOK2 TMEM219 HIRIP3 INO80E
GH16J029828 Promoter/Enhancer 1.1 EPDnew ENCODE 750.4 +9.6 9636 3.4 MLX USF2 NR2F6 ZNF362 MNT SP1 TFE3 SP5 ZNF384 ZNF644 MVP CDIPTOSP CDIPT C16orf92 TLCD3B DOC2A TMEM219 HIRIP3 INO80E C16orf54
GH16J029803 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 51.7 -9.7 -9652 14.9 PPP1R10 E2F8 ZNF785 SIN3A ZNF24 SP1 ZBTB40 CTCF SIX5 ZBTB6 PRRT2 MAZ ENSG00000280893 piR-45320 piR-53734 piR-50884 piR-51020 PAGR1 SRCAP ATXN2L
GH16J030089 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 34.5 +273.6 273616 9.2 ZNF785 ZNF24 ZBTB40 CTCF SIX5 ZBTB6 MLX RBPJ SMARCE1 POLR2A YPEL3 TBX6 lnc-PPP4C-2 SRCAP INO80E SETD1A BCL7C SMG1P2 SMG1P5 MVP
GH16J030063 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 27.9 +246.5 246481 7.8 ZNF785 SIN3A ZNF24 SP1 ZBTB40 CTCF SREBF1 FOXA1 MLX RBPJ piR-38178 ALDOA SMG1P5 SRCAP SETD1A NPIPB12 SMG1P2 RNF40 FBRS INO80E
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MVP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MVP gene promoter:
  • AP-1
  • ATF-2
  • c-Myb
  • p53

Genomic Locations for MVP Gene

Genomic Locations for MVP Gene
chr16:29,820,394-29,848,039
(GRCh38/hg38)
Size:
27,646 bases
Orientation:
Plus strand
chr16:29,831,715-29,859,360
(GRCh37/hg19)
Size:
27,646 bases
Orientation:
Plus strand

Genomic View for MVP Gene

Genes around MVP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MVP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MVP Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MVP Gene

Proteins for MVP Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MVP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14764-MVP_HUMAN
    Recommended name:
    Major vault protein
    Protein Accession:
    Q14764
    Secondary Accessions:
    • Q96BG4
    • Q9BPW6
    • Q9BQT1
    • Q9UBD1

    Protein attributes for MVP Gene

    Size:
    893 amino acids
    Molecular mass:
    99327 Da
    Quaternary structure:
    • The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540.

    Three dimensional structures from OCA and Proteopedia for MVP Gene

neXtProt entry for MVP Gene

Protein Expression for MVP Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MVP Gene

Other Protein References for MVP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MVP

No data available for DME Specific Peptides for MVP Gene

Domains & Families for MVP Gene

Gene Families for MVP Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transporters

Protein Domains for MVP Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MVP Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54179 (B4DVL1_HUMAN)
  • Lung resistance-related protein (MVP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14764

UniProtKB/Swiss-Prot:

MVP_HUMAN :
  • MVP 3 mediates interaction with PTEN.
Domain:
  • MVP 3 mediates interaction with PTEN.
  • MVP 4 mediates interaction with PARP4.
genes like me logo Genes that share domains with MVP: view

Function for MVP Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MVP Gene

UniProtKB/Swiss-Prot Function:
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFNG/IFN-gamma.
GENATLAS Biochemistry:
major vault protein,110kDa,highly expressed in epithelial cells with secretory and excretory functions,overexpressed in acute myeloid leukemia resistant to chemotherapy

Phenotypes From GWAS Catalog for MVP Gene

Gene Ontology (GO) - Molecular Function for MVP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15133037
GO:0019901 protein kinase binding IPI 16441665
GO:0019903 protein phosphatase binding IDA 15133037
GO:0042802 identical protein binding IPI 21988832
genes like me logo Genes that share ontologies with MVP: view
genes like me logo Genes that share phenotypes with MVP: view

Animal Models for MVP Gene

MGI Knock Outs for MVP:
  • Mvp Mvp<tm1Wie>

Animal Model Products

CRISPR Products

miRNA for MVP Gene

miRTarBase miRNAs that target MVP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MVP

Clone Products

  • Addgene plasmids for MVP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MVP Gene

Localization for MVP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MVP Gene

Cytoplasm. Nucleus, nuclear pore complex. Cytoplasm, perinuclear region. Note=5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MVP gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MVP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IBA,IDA 15133037
GO:0005643 nuclear pore IEA --
GO:0005737 cytoplasm IDA,IBA 16441665
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MVP: view

Pathways & Interactions for MVP Gene

PathCards logo

SuperPathways for MVP Gene

genes like me logo Genes that share pathways with MVP: view

Pathways by source for MVP Gene

Gene Ontology (GO) - Biological Process for MVP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0023057 negative regulation of signaling IDA 16441665
GO:0031953 negative regulation of protein autophosphorylation IDA 16441665
GO:0038127 ERBB signaling pathway IDA 15133037
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with MVP: view

No data available for SIGNOR curated interactions for MVP Gene

Drugs & Compounds for MVP Gene

Products:

  1. Drug

(31) Drugs for MVP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(13) Additional Compounds for MVP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MVP: view

Transcripts for MVP Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MVP Gene

(4) REFSEQ mRNAs :
(24) Additional mRNA sequences :
(667) Selected AceView cDNA sequences:
(19) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MVP

Clone Products

  • Addgene plasmids for MVP

Alternative Splicing Database (ASD) splice patterns (SP) for MVP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - - - - - - - - - - - -
SP9:
SP10:
SP11: - - - - - - -
SP12:
SP13: - -
SP14: - -
SP15: - - -
SP16: -
SP17:

ExUns: 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21
SP1: -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8: - -
SP9: -
SP10: - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for MVP Gene

GeneLoc Exon Structure for
MVP
ECgene alternative splicing isoforms for
MVP

Expression for MVP Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MVP Gene

mRNA expression in normal human tissues for MVP Gene
mRNA expression by GTEx for MVP GenemRNA expression by BioGPS for MVP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MVP Gene

This gene is overexpressed in Whole Blood (x5.7).

Protein differential expression in normal tissues from HIPED for MVP Gene

This gene is overexpressed in Bone marrow stromal cell (32.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MVP Gene



Protein tissue co-expression partners for MVP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MVP Gene:

MVP

SOURCE GeneReport for Unigene cluster for MVP Gene:

Hs.632177

mRNA Expression by UniProt/SwissProt for MVP Gene:

Q14764-MVP_HUMAN
Tissue specificity: Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.

Evidence on tissue expression from TISSUES for MVP Gene

  • Liver(4.5)
  • Eye(4.4)
  • Nervous system(4.4)
  • Kidney(4.1)
  • Intestine(4)
  • Skin(3.9)
  • Lung(3.5)
  • Spleen(3.1)
  • Gall bladder(2.4)
  • Blood(2.3)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with MVP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MVP Gene

Orthologs for MVP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MVP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MVP 33
  • 100 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia LRP 33
  • 91 (a)
 OneToOne
MVP 32
  • 87.98 (n)
cow
(Bos Taurus)
 Mammalia MVP 33 32
  • 87.15 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mvp 17 33 32
  • 86.62 (n)
rat
(Rattus norvegicus)
 Mammalia Mvp 32
  • 86.35 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia MVP 33
  • 81 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia MVP 33
  • 79 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MVP 33 32
  • 70.31 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia MVP 33
  • 72 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia mvp 32
  • 71.07 (n)
Str.15344 32
African clawed frog
(Xenopus laevis)
 Amphibia MGC68839 32
zebrafish
(Danio rerio)
 Actinopterygii mvp 33 32 32
  • 68.55 (n)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.11019 32
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 69 (a)
 OneToOne
Cin.6610 32
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.6610 32
Species where no ortholog for MVP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MVP Gene

ENSEMBL:
Gene Tree for MVP (if available)
TreeFam:
Gene Tree for MVP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MVP: view image

Paralogs for MVP Gene

No data available for Paralogs for MVP Gene

Variants for MVP Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MVP Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000028521 -- 29,833,498(+) G/A intron_variant
rs1000170079 -- 29,845,451(+) C/T intron_variant
rs1000197357 -- 29,823,680(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000534770 -- 29,839,612(+) A/G intron_variant
rs1000551883 -- 29,822,991(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MVP Gene

Variant ID Type Subtype PubMed ID
esv33498 CNV gain 17666407
esv3638373 CNV loss 21293372
nsv518568 CNV gain 19592680
nsv827611 CNV gain 20364138
nsv833186 CNV loss 17160897

Variation tolerance for MVP Gene

Residual Variation Intolerance Score: 8.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MVP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MVP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MVP Gene

Disorders for MVP Gene

MalaCards: The human disease database

(8) MalaCards diseases for MVP Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MVP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MVP

Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MVP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MVP Gene

Publications for MVP Gene

  1. Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling. (PMID: 16441665) Kim E … Suh PG (The FEBS journal 2006) 3 4 23 56
  2. The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals. (PMID: 16418217) Steiner E … Berger W (Journal of cell science 2006) 3 4 23 56
  3. The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. (PMID: 15133037) Kolli S … Bennett AM (The Journal of biological chemistry 2004) 3 4 23 56
  4. PTEN associates with the vault particles in HeLa cells. (PMID: 12177006) Yu Z … Shen SH (The Journal of biological chemistry 2002) 3 4 23 56
  5. The drug resistance-related protein LRP is the human major vault protein. (PMID: 7585126) Scheffer GL … Scheper RJ (Nature medicine 1995) 2 3 4 56

ExternalLinks

View latest publications for MVP gene in Mastermind

Products for MVP Gene

  • Addgene plasmids for MVP

Sources for MVP Gene