This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug r... See more...

Aliases for MVP Gene

Aliases for MVP Gene

  • Major Vault Protein 2 3 4 5
  • Lung Resistance-Related Protein 2 3 4
  • LRP 3 4
  • Testicular Secretory Protein Li 30 3
  • VAULT1 3

External Ids for MVP Gene

Previous GeneCards Identifiers for MVP Gene

  • GC16M029301
  • GC16P030151
  • GC16P029826
  • GC16P029869
  • GC16P029739
  • GC16P029831
  • GC16P027492
  • GC16P029832
  • GC16P029840
  • GC16P029863
  • GC16P029979
  • GC16P029995
  • GC16P030010
  • GC16P029878
  • GC16P029888
  • GC16P029898
  • GC16P029907
  • GC16P029922
  • GC16P029931
  • GC16P029948
  • GC16P029965

Summaries for MVP Gene

Entrez Gene Summary for MVP Gene

  • This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for MVP Gene

MVP (Major Vault Protein) is a Protein Coding gene. Diseases associated with MVP include Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis and Lung Cancer. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein phosphatase binding.

UniProtKB/Swiss-Prot Summary for MVP Gene

  • Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Gene Wiki entry for MVP Gene

Additional gene information for MVP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MVP Gene

Genomics for MVP Gene

GeneHancer (GH) Regulatory Elements for MVP Gene

Promoters and enhancers for MVP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MVP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MVP

Top Transcription factor binding sites by QIAGEN in the MVP gene promoter:
  • AP-1
  • ATF-2
  • c-Myb
  • p53

Genomic Locations for MVP Gene

Genomic Locations for MVP Gene
chr16:29,820,394-29,848,039
(GRCh38/hg38)
Size:
27,646 bases
Orientation:
Plus strand
chr16:29,831,715-29,859,360
(GRCh37/hg19)
Size:
27,646 bases
Orientation:
Plus strand

Genomic View for MVP Gene

Genes around MVP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MVP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MVP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MVP Gene

Proteins for MVP Gene

  • Protein details for MVP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14764-MVP_HUMAN
    Recommended name:
    Major vault protein
    Protein Accession:
    Q14764
    Secondary Accessions:
    • Q96BG4
    • Q9BPW6
    • Q9BQT1
    • Q9UBD1

    Protein attributes for MVP Gene

    Size:
    893 amino acids
    Molecular mass:
    99327 Da
    Quaternary structure:
    • The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1. May interact with ZNF540.

    Three dimensional structures from OCA and Proteopedia for MVP Gene

neXtProt entry for MVP Gene

Post-translational modifications for MVP Gene

No data available for DME Specific Peptides for MVP Gene

Domains & Families for MVP Gene

Gene Families for MVP Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transporters

Protein Domains for MVP Gene

Blocks:
  • Major vault protein, N-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MVP Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54179 (B4DVL1_HUMAN)
  • Lung resistance-related protein (MVP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14764

UniProtKB/Swiss-Prot:

MVP_HUMAN :
  • MVP 3 mediates interaction with PTEN.
Domain:
  • MVP 3 mediates interaction with PTEN.
  • MVP 4 mediates interaction with PARP4.
genes like me logo Genes that share domains with MVP: view

Function for MVP Gene

Molecular function for MVP Gene

UniProtKB/Swiss-Prot Function:
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFNG/IFN-gamma.
GENATLAS Biochemistry:
major vault protein,110kDa,highly expressed in epithelial cells with secretory and excretory functions,overexpressed in acute myeloid leukemia resistant to chemotherapy

Phenotypes From GWAS Catalog for MVP Gene

Gene Ontology (GO) - Molecular Function for MVP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15133037
GO:0019901 protein kinase binding IPI 16441665
GO:0019903 protein phosphatase binding IDA 15133037
GO:0042802 identical protein binding IPI 21988832
genes like me logo Genes that share ontologies with MVP: view
genes like me logo Genes that share phenotypes with MVP: view

Animal Models for MVP Gene

MGI Knock Outs for MVP:
  • Mvp Mvp<tm1Wie>

Animal Model Products

CRISPR Products

miRNA for MVP Gene

miRTarBase miRNAs that target MVP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MVP

Clone Products

  • Addgene plasmids for MVP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MVP Gene

Localization for MVP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MVP Gene

Cytoplasm. Nucleus, nuclear pore complex. Cytoplasm, perinuclear region. Note=5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MVP gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 4
plasma membrane 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MVP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IBA,IDA 15133037
GO:0005643 nuclear pore IEA --
GO:0005737 cytoplasm IDA,IBA 16441665
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MVP: view

Pathways & Interactions for MVP Gene

PathCards logo

SuperPathways for MVP Gene

genes like me logo Genes that share pathways with MVP: view

Pathways by source for MVP Gene

Gene Ontology (GO) - Biological Process for MVP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0023057 negative regulation of signaling IDA 16441665
GO:0031953 negative regulation of protein autophosphorylation IDA 16441665
GO:0038127 ERBB signaling pathway IDA 15133037
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with MVP: view

No data available for SIGNOR curated interactions for MVP Gene

Drugs & Compounds for MVP Gene

(31) Drugs for MVP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(13) Additional Compounds for MVP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MVP: view

Transcripts for MVP Gene

mRNA/cDNA for MVP Gene

4 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MVP

Clone Products

  • Addgene plasmids for MVP

Alternative Splicing Database (ASD) splice patterns (SP) for MVP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - - - - - - - - - - - -
SP9:
SP10:
SP11: - - - - - - -
SP12:
SP13: - -
SP14: - -
SP15: - - -
SP16: -
SP17:

ExUns: 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21
SP1: -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8: - -
SP9: -
SP10: - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for MVP Gene

GeneLoc Exon Structure for
MVP

Expression for MVP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MVP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MVP Gene

This gene is overexpressed in Whole Blood (x5.7).

Protein differential expression in normal tissues from HIPED for MVP Gene

This gene is overexpressed in Bone marrow stromal cell (32.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MVP Gene



Protein tissue co-expression partners for MVP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MVP

SOURCE GeneReport for Unigene cluster for MVP Gene:

Hs.632177

mRNA Expression by UniProt/SwissProt for MVP Gene:

Q14764-MVP_HUMAN
Tissue specificity: Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.

Evidence on tissue expression from TISSUES for MVP Gene

  • Liver(4.5)
  • Eye(4.4)
  • Nervous system(4.4)
  • Kidney(4.1)
  • Intestine(4)
  • Skin(3.9)
  • Lung(3.5)
  • Spleen(3.1)
  • Gall bladder(2.4)
  • Blood(2.3)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with MVP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MVP Gene

Orthologs for MVP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MVP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MVP 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRP 31
  • 91 (a)
OneToOne
MVP 30
  • 87.98 (n)
cow
(Bos Taurus)
Mammalia MVP 31 30
  • 87.15 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mvp 17 31 30
  • 86.62 (n)
rat
(Rattus norvegicus)
Mammalia Mvp 30
  • 86.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MVP 31
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MVP 31
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves MVP 31 30
  • 70.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MVP 31
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mvp 30
  • 71.07 (n)
Str.15344 30
African clawed frog
(Xenopus laevis)
Amphibia MGC68839 30
zebrafish
(Danio rerio)
Actinopterygii mvp 31 30 30
  • 68.55 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11019 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 69 (a)
OneToOne
Cin.6610 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6610 30
Species where no ortholog for MVP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MVP Gene

ENSEMBL:
Gene Tree for MVP (if available)
TreeFam:
Gene Tree for MVP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MVP: view image

Paralogs for MVP Gene

No data available for Paralogs for MVP Gene

Variants for MVP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MVP Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
723775 Likely Benign: not provided 29,836,841(+) C/T SYNONYMOUS_VARIANT
727084 Likely Benign: not provided 29,836,833(+) G/C MISSENSE_VARIANT
728515 Likely Benign: not provided 29,844,715(+) G/A SYNONYMOUS_VARIANT
731123 Likely Benign: not provided 29,830,909(+) G/A MISSENSE_VARIANT
777004 Benign: not provided 29,840,237(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for MVP Gene

Structural Variations from Database of Genomic Variants (DGV) for MVP Gene

Variant ID Type Subtype PubMed ID
esv33498 CNV gain 17666407
esv3638373 CNV loss 21293372
nsv518568 CNV gain 19592680
nsv827611 CNV gain 20364138
nsv833186 CNV loss 17160897

Variation tolerance for MVP Gene

Residual Variation Intolerance Score: 8.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MVP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MVP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MVP Gene

Disorders for MVP Gene

MalaCards: The human disease database

(12) MalaCards diseases for MVP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mesial temporal lobe epilepsy with hippocampal sclerosis
  • mtle-hs
lung cancer
  • adenocarcinoma of lung
acute leukemia
  • stem cell leukaemia
leukemia, acute lymphoblastic
  • all
testicular cancer
  • childhood neoplasm of the testis
- elite association - COSMIC cancer census association via MalaCards
Search MVP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MVP

genes like me logo Genes that share disorders with MVP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MVP Gene

Publications for MVP Gene

  1. Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling. (PMID: 16441665) Kim E … Suh PG (The FEBS journal 2006) 3 4 23 54
  2. The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals. (PMID: 16418217) Steiner E … Berger W (Journal of cell science 2006) 3 4 23 54
  3. The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. (PMID: 15133037) Kolli S … Bennett AM (The Journal of biological chemistry 2004) 3 4 23 54
  4. PTEN associates with the vault particles in HeLa cells. (PMID: 12177006) Yu Z … Shen SH (The Journal of biological chemistry 2002) 3 4 23 54
  5. The drug resistance-related protein LRP is the human major vault protein. (PMID: 7585126) Scheffer GL … Scheper RJ (Nature medicine 1995) 2 3 4 54

Products for MVP Gene

Sources for MVP Gene