Free for academic non-profit institutions. Other users need a Commercial license
The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]
MVD (Mevalonate Diphosphate Decarboxylase) is a Protein Coding gene. Diseases associated with MVD include Porokeratosis 7, Multiple Types and Porokeratosis. Among its related pathways are Transport to the Golgi and subsequent modification and Sterol Regulatory Element-Binding Proteins (SREBP) signalling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and Hsp70 protein binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004163 | diphosphomevalonate decarboxylase activity | IBA,IDA | 11792727 |
GO:0005524 | ATP binding | IEA | -- |
GO:0016829 | lyase activity | IEA | -- |
GO:0016831 | carboxy-lyase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005777 | NOT peroxisome | IDA | 14972328 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Terpenoid backbone biosynthesis | ||
2 | Metabolism |
.40
|
|
3 | Synthesis of substrates in N-glycan biosythesis | ||
4 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | ||
5 | Metabolism of proteins |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006489 | dolichyl diphosphate biosynthetic process | TAS | -- |
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006694 | steroid biosynthetic process | IEA | -- |
GO:0006695 | cholesterol biosynthetic process | TAS | -- |
GO:0008202 | steroid metabolic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Scopolamine | Approved, Investigational | Pharma | Antagonist | 108 | ||
Carbon dioxide | Approved, Investigational, Vet_approved | Pharma | 0 | |||
Phosphoric acid | Approved | Pharma | 0 | |||
Isopentenyl pyrophosphate | Experimental | Pharma | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
(R)-Mevalonic acid-5-pyrophosphate |
|
1492-08-6 |
|
|||
(S)-5-Diphosphomevalonic acid |
|
|
||||
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
||
Phosphate |
|
14066-19-4, 14265-44-2 |
|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP15: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP16: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP17: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP18: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP19: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP20: | - |
ExUns: | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||
SP2: | - | ||||||||||||||||||||
SP3: | - | ||||||||||||||||||||
SP4: | - | ||||||||||||||||||||
SP5: | |||||||||||||||||||||
SP6: | |||||||||||||||||||||
SP7: | |||||||||||||||||||||
SP8: | - | ||||||||||||||||||||
SP9: | - | ||||||||||||||||||||
SP10: | - | - | |||||||||||||||||||
SP11: | - | ||||||||||||||||||||
SP12: | |||||||||||||||||||||
SP13: | |||||||||||||||||||||
SP14: | |||||||||||||||||||||
SP15: | |||||||||||||||||||||
SP16: | |||||||||||||||||||||
SP17: | - | ||||||||||||||||||||
SP18: | |||||||||||||||||||||
SP19: | |||||||||||||||||||||
SP20: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MVD 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MVD 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MVD 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mvd 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mvd 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MVD 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MVD 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MVD 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MVD 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mvd 30 |
|
||
LOC394871 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | mvda 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001611 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG8239 30 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | Y48B6A.13 31 |
|
OneToOne | |
Y48B6A.13b 32 |
|
|
|||
Y48B6A.13a 32 |
|
|
|||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGL232C 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F10285g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MVD1 30 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT3G54250 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.7599 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0109100 30 |
|
||
Os.10543 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.5909 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.14376 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU11381 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | mvd1 30 |
|
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
638465 | Uncertain Significance: Porokeratosis 7, multiple types | 88,658,663(-) | A/G | MISSENSE_VARIANT | |
790170 | Benign: not provided | 88,657,940(-) | C/T | SYNONYMOUS_VARIANT | |
790328 | Benign: not provided | 88,653,318(-) | T/C | SYNONYMOUS_VARIANT | |
rs144010349 | Porokeratosis 7, multiple types (POROK7) [MIM:614714] | p.Arg161Gln | |||
rs200033380 | Porokeratosis 7, multiple types (POROK7) [MIM:614714] | p.Pro101Arg |
Disorder | Aliases | PubMed IDs |
---|---|---|
porokeratosis 7, multiple types |
|
|
porokeratosis |
|
|
scirrhous adenocarcinoma |
|
|
punctate porokeratosis |
|
|
linear porokeratosis |
|
|