Aliases for MVD Gene
Aliases for MVD Gene
External Ids for MVD Gene
- HGNC: 7529
- Entrez Gene: 4597
- Ensembl: ENSG00000167508
- OMIM: 603236
- UniProtKB: P53602
Previous GeneCards Identifiers for MVD Gene
- GC16M080154
- GC16M089686
- GC16M088421
- GC16M088462
- GC16M087245
- GC16M088718
- GC16M074412
Summaries for MVD Gene
-
The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]
GeneCards Summary for MVD Gene
MVD (Mevalonate Diphosphate Decarboxylase) is a Protein Coding gene. Diseases associated with MVD include Porokeratosis 7, Multiple Types and Porokeratosis. Among its related pathways are Synthesis of substrates in N-glycan biosythesis and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and Hsp70 protein binding.
UniProtKB/Swiss-Prot for MVD Gene
-
Performs the first committed step in the biosynthesis of isoprenes.
Additional gene information for MVD Gene
- Monarch Initiative
- Search for MVD at DataMed
- Search for MVD at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MVD Gene
Genomics for MVD Gene
GeneHancer (GH) Regulatory Elements for MVD Gene
Promoters and enhancers for MVD Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MVD on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MVD gene promoter:
Regulatory Element Products
Genomic Locations for MVD Gene
Genomic Locations for MVD Gene
- chr16:88,651,935-88,663,161
- (GRCh38/hg38)
- Size:
- 11,227 bases
- Orientation:
- Minus strand
- chr16:88,718,343-88,729,569
- (GRCh37/hg19)
Genomic View for MVD Gene
Genes around MVD on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q24.2 by Ensembl
- 16q24.2 by Entrez Gene
- 16q24.2 by HGNC
MVD Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MVD Gene
Proteins for MVD Gene
-
Protein details for MVD Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P53602-MVD1_HUMAN
- Recommended name:
- Diphosphomevalonate decarboxylase
- Protein Accession:
- P53602
- Q53Y65
Protein attributes for MVD Gene
- Size:
- 400 amino acids
- Molecular mass:
- 43405 Da
- Quaternary structure:
-
- Homodimer.
Protein Expression for MVD Gene
Post-translational modifications for MVD Gene
Other Protein References for MVD Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MVD
- Novus Biologicals Antibodies for MVD
-
Abcam antibodies for MVD
- Invitrogen Antibodies for MVD
- GeneTex MVD antibody for MVD
-
Santa Cruz Biotechnology (SCBT) Antibodies for MVD
Protein Products
-
OriGene Purified Proteins for MVD
- Search Origene for MassSpec and Protein Over-expression Lysates for MVD
- Origene Custom Protein Services for MVD
- ProSpec Recombinant Proteins for MVD
- antibodies-online: Search results for 8 available MVD Proteins ranked by validation data
- Compare Top MVD Proteins
-
Quality Products:
- Search GeneTex for Proteins for MVD
-
Abcam proteins for MVD
Assay Products
-
Cloud-Clone Corp. Assay Kits for MVD
- antibodies-online: Search results for 5 available MVD Elisa Kits ranked by validation data
- Compare Top MVD Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for MVD Gene
Domains & Families for MVD Gene
Gene Families for MVD Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for MVD Gene
Suggested Antigen Peptide Sequences for MVD Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P53602- Family:
-
- Belongs to the diphosphomevalonate decarboxylase family.
Function for MVD Gene
Molecular function for MVD Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=7.4 uM for (R)-5-diphosphomevalonate {ECO:0000269 PubMed:9392419}; KM=0.32 mM for ATP {ECO:0000269 PubMed:9392419};
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2).
- UniProtKB/Swiss-Prot Function:
- Performs the first committed step in the biosynthesis of isoprenes.
Enzyme Numbers (IUBMB) for MVD Gene
Phenotypes From GWAS Catalog for MVD Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004163 | diphosphomevalonate decarboxylase activity | TAS | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016829 | lyase activity | IEA | -- |
| GO:0016831 | carboxy-lyase activity | IEA | -- |
| GO:0030544 | Hsp70 protein binding | IPI | 12646231 |
Phenotypes for MVD Gene
- GenomeRNAi human phenotypes for MVD:
Animal Model Products
-
Taconic Biosciences Mouse Models for MVD
- Cyagen custom Knockout/knockin (KOKI) mouse models for MVD
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MVD gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MVD gene
- Search ViGene Biosciences for MVD
CRISPR Products
-
OriGene CRISPR knockouts for MVD
- genomics-online: gRNA clones - Search results for 127 available MVD gene related products
- Overview of 127 available MVD gene related products
- Applied Biological Materials CRISPR for MVD
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MVD
- GenScript: Design CRISPR guide RNA sequences for MVD
miRNA for MVD Gene
- miRTarBase miRNAs that target MVD
miRNA Products
- Search ViGene Biosciences for MVD
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MVD
- Browse OriGene Inhibitory RNA Products For MVD
- genomics-online: shRNA clones - Search results for 127 available MVD gene related products
- Overview of 127 available MVD gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MVD gene
Clone Products
- Sino Biological Human cDNA Clone for MVD
- VectorBuilder custom plasmid, inducible vectors for MVD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MVD
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MVD
- Applied Biological Materials Clones for MVD
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for MVD gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MVD gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MVD gene
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MVD Gene
Localization for MVD Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| peroxisome | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
- Cell Junctions (2)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005777 | NOT peroxisome | IDA | 14972328 |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for MVD Gene
Pathways & Interactions for MVD Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Terpenoid backbone biosynthesis | ||
| 2 | Metabolism |
.37
|
|
| 3 | Synthesis of substrates in N-glycan biosythesis | ||
| 4 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | ||
| 5 | Metabolism of proteins | ||
Pathways by source for MVD Gene
5 BioSystems pathways for MVD Gene
2 KEGG pathways for MVD Gene
UniProtKB/Swiss-Prot P53602-MVD1_HUMAN
- Pathway: Steroid biosynthesis; cholesterol biosynthesis.
Interacting Proteins for MVD Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006489 | dolichyl diphosphate biosynthetic process | TAS | -- |
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006694 | steroid biosynthetic process | IEA | -- |
| GO:0006695 | cholesterol biosynthetic process | TAS | -- |
| GO:0008202 | steroid metabolic process | IEA | -- |
No data available for SIGNOR curated interactions for MVD Gene
Drugs & Compounds for MVD Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Carbon dioxide | Approved, Investigational, Vet_approved | Pharma | 0 | |||
| Phosphoric acid | Approved | Pharma | 0 | |||
| Isopentenyl pyrophosphate | Experimental | Pharma | 0 | |||
| ATP | Investigational | Nutra | Agonist | 0 | ||
| 6-fluoromevalonate 5-diphosphate | Pharma | Competitive, Inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| P-geranyl 2-fluoromevalonate 5-diphosphate |
|
Competitive, Inhibitor |
|
|||
| (R)-Mevalonic acid-5-pyrophosphate |
|
1492-08-6 |
|
|||
| (S)-5-Diphosphomevalonic acid |
|
|
||||
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
| Phosphate |
|
14265-44-2 |
|
Transcripts for MVD Gene
mRNA/cDNA for MVD Gene
- (5) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (268) Selected AceView cDNA sequences:
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MVD Gene
CRISPR Products
-
OriGene CRISPR knockouts for MVD
- genomics-online: gRNA clones - Search results for 127 available MVD gene related products
- Overview of 127 available MVD gene related products
- Applied Biological Materials CRISPR for MVD
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MVD
- GenScript: Design CRISPR guide RNA sequences for MVD
miRNA Products
- Search ViGene Biosciences for MVD
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MVD
- Browse OriGene Inhibitory RNA Products For MVD
- genomics-online: shRNA clones - Search results for 127 available MVD gene related products
- Overview of 127 available MVD gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MVD gene
Clone Products
- Sino Biological Human cDNA Clone for MVD
- VectorBuilder custom plasmid, inducible vectors for MVD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MVD
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MVD
- Applied Biological Materials Clones for MVD
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - |
| ExUns: | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||
| SP5: | |||||||||||||||||||||
| SP6: | |||||||||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||
| SP10: | - | - | |||||||||||||||||||
| SP11: | - | ||||||||||||||||||||
| SP12: | |||||||||||||||||||||
| SP13: | |||||||||||||||||||||
| SP14: | |||||||||||||||||||||
| SP15: | |||||||||||||||||||||
| SP16: | |||||||||||||||||||||
| SP17: | - | ||||||||||||||||||||
| SP18: | |||||||||||||||||||||
| SP19: | |||||||||||||||||||||
| SP20: |
Expression for MVD Gene
This gene is overexpressed in Fetal testis (32.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MVD Gene
NURSA nuclear receptor signaling pathways regulating expression of MVD Gene:
MVDSOURCE GeneReport for Unigene cluster for MVD Gene:
Hs.252457mRNA Expression by UniProt/SwissProt for MVD Gene:
P53602-MVD1_HUMAN
Tissue specificity:
Expressed in heart, skeletal muscle, lung, liver, brain, pancreas, kidney and placenta.
Evidence on tissue expression from TISSUES for MVD Gene
- Liver(4.4)
- Nervous system(3.7)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MVD Gene
Germ Layers:
- ectoderm
Systems:
- integumentary
Regions:
Limb:
- nail
General:
- hair
- skin
- sweat gland
Primer Products
-
OriGene qPCR primer pairs for MVD
-
OriGene qPCR primer pairs and template standards for MVD
- genomics-online: primer clones - Search results for 127 available MVD gene related products
- Overview of 127 available MVD gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MVD Gene
Orthologs for MVD Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MVD 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MVD 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MVD 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mvd 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Mvd 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MVD 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MVD 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MVD 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MVD 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mvd 33 |
|
||
| LOC394871 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | mvda 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001611 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG8239 35 33 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | Y48B6A.13b 35 |
|
|
|
| Y48B6A.13 34 |
|
OneToOne | |||
| Y48B6A.13a 35 |
|
|
|||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AGL232C 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F10285g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MVD1 33 34 36 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G54250 33 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.7599 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0109100 33 |
|
||
| Os.10543 33 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.5909 33 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.14376 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU11381 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | mvd1 33 |
|
- Species where no ortholog for MVD was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MVD Gene
No data available for Paralogs for MVD Gene
Variants for MVD Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs144010349 | Porokeratosis 7, multiple types (POROK7) [MIM:614714] | 88,656,226(-) | C/T | coding_sequence_variant, missense_variant | |
| rs200033380 | Porokeratosis 7, multiple types (POROK7) [MIM:614714] | 88,657,537(-) | G/A/C | 5_prime_UTR_variant, coding_sequence_variant, missense_variant | |
| rs546127665 | Porokeratosis 7, multiple types (POROK7) [MIM:614714] | 88,652,602(-) | C/G/T | coding_sequence_variant, missense_variant | |
| rs755948940 | pathogenic, Porokeratosis 7, multiple types, Porokeratosis 7, multiple types (POROK7) [MIM:614714] | 88,655,221(-) | T/C | coding_sequence_variant, missense_variant | |
| rs761991070 | pathogenic, Porokeratosis 7, multiple types, Porokeratosis 7, multiple types (POROK7) [MIM:614714] | 88,655,350(-) | A/G | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.34;
41.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MVD Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MVD Gene
Disorders for MVD Gene
(9) MalaCards diseases for MVD Gene - From: HGMD, OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| porokeratosis 7, multiple types |
|
|
| porokeratosis |
|
|
| linear porokeratosis |
|
|
| punctate porokeratosis |
|
|
| waterhouse-friderichsen syndrome |
|
|
Search MVD in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MVD1_HUMAN- Porokeratosis 7, multiple types (POROK7) [MIM:614714]: A form of porokeratosis, a disorder of faulty keratinization characterized by one or more atrophic patches surrounded by a distinctive hyperkeratotic ridgelike border called the cornoid lamella. The keratotic lesions can progress to overt cutaneous neoplasms, typically squamous cell carcinomas. Multiple clinical variants of porokeratosis are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis. Different clinical presentations can be observed among members of the same family. Individuals expressing more than one variant have also been reported. {ECO:0000269 PubMed:18823933, ECO:0000269 PubMed:26202976}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for MVD
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for MVD Gene
Publications for MVD Gene
- Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase. (PMID: 8626466) Toth MJ … Huwyler L (The Journal of biological chemistry 1996) 2 3 4 22 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y … Boer JM (Journal of lipid research 2008) 3 44 58
- Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. (PMID: 18823933) Voynova NE … Miziorko HM (Archives of biochemistry and biophysics 2008) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for MVD Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for MVD
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MVD
- Search Origene for MassSpec and Protein Over-expression Lysates for MVD
- Origene Custom Protein Services for MVD
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MVD
- Browse OriGene Inhibitory RNA Products For MVD
- OriGene qPCR primer pairs and template standards for MVD
- OriGene qPCR primer pairs for MVD
- OriGene CRISPR knockouts for MVD
- OriGene ORF clones in human for MVD
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MVD
- GenScript: Next-day shipping of latest version cDNA ORF clones for MVD in any vector
- GenScript Custom Purified and Recombinant Proteins Services for MVD
- GenScript Custom Assay Services for MVD
- GenScript Custom overexpressing Cell Line Services for MVD
- GenScript: Design CRISPR guide RNA sequences for MVD
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Sino Biological Human cDNA Clone for MVD
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- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for MVD
- Novus Biologicals lysates and proteins for MVD
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- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MVD
- Abcam proteins for MVD
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for MVD
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Cloud-Clone Corp. Assay Kits for MVD
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for MVD
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for MVD
- Cyagen custom Knockout/knockin (KOKI) mouse models for MVD
- VectorBuilder custom plasmid, inducible vectors for MVD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MVD
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MVD
- antibodies-online: Search results for 45 available MVD Antibodies ranked by validation data
- Compare Top MVD Antibodies
- Quality Products:
- antibodies-online: Search results for 5 available MVD Elisa Kits ranked by validation data
- Compare Top MVD Elisa Kits
- Quality Products:
- antibodies-online: Search results for 8 available MVD Proteins ranked by validation data
- Compare Top MVD Proteins
- Quality Products:
- GeneTex MVD antibody for MVD
- Search GeneTex for Proteins for MVD
- ViGene Biosciences adenoviral particle packaged cDNA for MVD gene
- ViGene Biosciences lentiviral particle packaged cDNA for MVD gene
- ViGene Biosciences ready-to-package AAV shRNAs for MVD gene
- Search ViGene Biosciences for MVD
- Santa Cruz Biotechnology (SCBT) Antibodies for MVD
- Search Santa Cruz Biotechnology (SCBT) for MVD siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MVD
- genomics-online: cdna clones - Search results for 127 available MVD gene related products
- Overview of 127 available MVD gene related products
- orf clones - Search results for 127 available MVD gene related products
- Overview of 127 available MVD gene related products
- genomics-online: gRNA clones - Search results for 127 available MVD gene related products
- Overview of 127 available MVD gene related products
- genomics-online: primer clones - Search results for 127 available MVD gene related products
- Overview of 127 available MVD gene related products
- genomics-online: shRNA clones - Search results for 127 available MVD gene related products
- Overview of 127 available MVD gene related products
Sources for MVD Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
