MVD Gene (Protein Coding)

Mevalonate Diphosphate Decarboxylase

GC16M088651
GIFtS:
45
The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008] See more...

Aliases for MVD Gene

Aliases for MVD Gene

  • Mevalonate Diphosphate Decarboxylase 2 3 5
  • Mevalonate Pyrophosphate Decarboxylase 2 3 4
  • Diphosphomevalonate Decarboxylase 2 3 4
  • MPD 2 3 4
  • Mevalonate (Diphospho) Decarboxylase 2 3
  • MDDase 3 4
  • Mevalonate (Diphospho)Decarboxylase 4
  • EC 4.1.1.33 4
  • FP17780 3
  • POROK7 3
  • MVD 5

External Ids for MVD Gene

Previous GeneCards Identifiers for MVD Gene

  • GC16M080154
  • GC16M089686
  • GC16M088421
  • GC16M088462
  • GC16M087245
  • GC16M088718
  • GC16M074412

Summaries for MVD Gene

Entrez Gene Summary for MVD Gene

  • The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]

GeneCards Summary for MVD Gene

MVD (Mevalonate Diphosphate Decarboxylase) is a Protein Coding gene. Diseases associated with MVD include Porokeratosis 7, Multiple Types and Porokeratosis. Among its related pathways are Transport to the Golgi and subsequent modification and Sterol Regulatory Element-Binding Proteins (SREBP) signalling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and Hsp70 protein binding.

UniProtKB/Swiss-Prot Summary for MVD Gene

  • Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

Additional gene information for MVD Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MVD Gene

Genomics for MVD Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MVD Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MVD on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MVD

Top Transcription factor binding sites by QIAGEN in the MVD gene promoter:
  • AhR
  • AP-1
  • Arnt
  • p53
  • Pax-5
  • PPAR-alpha
  • Sp1

Genomic Locations for MVD Gene

Genomic Locations for MVD Gene
chr16:88,651,935-88,663,161
(GRCh38/hg38)
Size:
11,227 bases
Orientation:
Minus strand
chr16:88,718,343-88,729,569
(GRCh37/hg19)
Size:
11,227 bases
Orientation:
Minus strand

Genomic View for MVD Gene

Genes around MVD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MVD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MVD Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MVD Gene

Proteins for MVD Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MVD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53602-MVD1_HUMAN
    Recommended name:
    Diphosphomevalonate decarboxylase
    Protein Accession:
    P53602
    Secondary Accessions:
    • Q53Y65

    Protein attributes for MVD Gene

    Size:
    400 amino acids
    Molecular mass:
    43405 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for MVD Gene

neXtProt entry for MVD Gene

Protein Expression for MVD Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MVD Gene

  • Ubiquitination at Lys22, Lys58, and Lys179
  • Modification sites at PhosphoSitePlus

Other Protein References for MVD Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MVD

No data available for DME Specific Peptides for MVD Gene

Domains & Families for MVD Gene

Gene Families for MVD Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MVD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MVD Gene

GenScript: Design optimal peptide antigens:
  • Mevalonate pyrophosphate decarboxylase (MVD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P53602

UniProtKB/Swiss-Prot:

MVD1_HUMAN :
  • Belongs to the diphosphomevalonate decarboxylase family.
Family:
  • Belongs to the diphosphomevalonate decarboxylase family.
genes like me logo Genes that share domains with MVD: view

Function for MVD Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MVD Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(R)-5-diphosphomevalonate + ATP = ADP + CO2 + isopentenyl diphosphate + phosphate; Xref=Rhea:RHEA:23732, ChEBI:CHEBI:16526, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57557, ChEBI:CHEBI:128769, ChEBI:CHEBI:456216; EC=4.1.1.33; Evidence={ECO:0000269|PubMed:18823933, ECO:0000269|PubMed:8626466, ECO:0000269|PubMed:9392419};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=7.4 uM for (R)-5-diphosphomevalonate {ECO:0000269|PubMed:9392419}; KM=28.9 uM for (S,R)-5-diphosphomevalonate {ECO:0000269|PubMed:18823933}; KM=0.69 mM for ATP {ECO:0000269|PubMed:18823933}; KM=0.32 mM for ATP {ECO:0000269|PubMed:9392419};

Enzyme Numbers (IUBMB) for MVD Gene

Phenotypes From GWAS Catalog for MVD Gene

Gene Ontology (GO) - Molecular Function for MVD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004163 diphosphomevalonate decarboxylase activity IBA,IDA 11792727
GO:0005524 ATP binding IEA --
GO:0016829 lyase activity IEA --
GO:0016831 carboxy-lyase activity IEA --
genes like me logo Genes that share ontologies with MVD: view
genes like me logo Genes that share phenotypes with MVD: view

Human Phenotype Ontology for MVD Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for MVD

CRISPR Products

miRNA for MVD Gene

miRTarBase miRNAs that target MVD

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MVD

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MVD Gene

Localization for MVD Gene

Subcellular locations from UniProtKB/Swiss-Prot for MVD Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MVD gene
Compartment Confidence
cytosol 5
extracellular 2
mitochondrion 2
peroxisome 2
nucleus 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MVD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 NOT peroxisome IDA 14972328
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MVD: view

Pathways & Interactions for MVD Gene

genes like me logo Genes that share pathways with MVD: view

UniProtKB/Swiss-Prot P53602-MVD1_HUMAN

  • Pathway: Steroid biosynthesis; cholesterol biosynthesis.

Gene Ontology (GO) - Biological Process for MVD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006489 dolichyl diphosphate biosynthetic process TAS --
GO:0006629 lipid metabolic process IEA --
GO:0006694 steroid biosynthetic process IEA --
GO:0006695 cholesterol biosynthetic process TAS --
GO:0008202 steroid metabolic process IEA --
genes like me logo Genes that share ontologies with MVD: view

No data available for SIGNOR curated interactions for MVD Gene

Drugs & Compounds for MVD Gene

Products:

  1. Drug

(22) Drugs for MVD Gene - From: ClinicalTrials, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Scopolamine Approved, Investigational Pharma Antagonist 108
Carbon dioxide Approved, Investigational, Vet_approved Pharma 0
Phosphoric acid Approved Pharma 0
Isopentenyl pyrophosphate Experimental Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(9) Additional Compounds for MVD Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(R)-Mevalonic acid-5-pyrophosphate
  • (R)-5-Diphosphomevalonic acid
  • 1,1,3,7-Tetrahydroxy-7-methyl-2,4-dioxa-1,3-diphosphanonan-9-Oate
  • 1,1,3,7-Tetrahydroxy-7-methyl-2,4-dioxa-1,3-diphosphanonan-9-Oic acid
  • 1,1,3,7-Tetrahydroxy-7-methyl-2,4-dioxa-1,3-diphosphanonan-9-Oic acid 1,3-dioxide
  • 5-Pyrophosphomevalonate
 1492-08-6
(S)-5-Diphosphomevalonic acid
  • (R)-5-Diphosphomevalonate
  • (R)-5-Diphosphomevalonic acid
  • (S)-5-Diphosphomevalonate
  • (S)-Mevalonic acid-5-pyrophosphate
  • 1,1,3,7-Tetrahydroxy-7-methyl-2,4-dioxa-1,3-diphosphanonan-9-Oate
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
 14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with MVD: view

Transcripts for MVD Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MVD Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MVD

Alternative Splicing Database (ASD) splice patterns (SP) for MVD Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - -
SP10:
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - -
SP16: - - - -
SP17: - - -
SP18: - - - -
SP19: - - -
SP20: -

ExUns: 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8: -
SP9: -
SP10: - -
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:

Relevant External Links for MVD Gene

GeneLoc Exon Structure for
MVD

Expression for MVD Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MVD Gene

mRNA expression in normal human tissues for MVD Gene
mRNA expression by BioGPS for MVD GenemRNA expression by GTEx for MVD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Lymph (Hematopoietic System)

Protein differential expression in normal tissues from HIPED for MVD Gene

This gene is overexpressed in Fetal testis (32.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MVD Gene



Protein tissue co-expression partners for MVD Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MVD

SOURCE GeneReport for Unigene cluster for MVD Gene:

Hs.252457

mRNA Expression by UniProt/SwissProt for MVD Gene:

P53602-MVD1_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, lung, liver, brain, pancreas, kidney and placenta.

Evidence on tissue expression from TISSUES for MVD Gene

  • Liver(4.5)
  • Nervous system(4.1)
  • Skin(2.7)
  • Blood(2.2)
  • Intestine(2.1)
  • Kidney(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MVD Gene

Germ Layers:
  • ectoderm
Systems:
  • integumentary
Regions:
Limb:
  • nail
General:
  • hair
  • skin
  • sweat gland
genes like me logo Genes that share expression patterns with MVD: view

No data available for mRNA differential expression in normal tissues for MVD Gene

Orthologs for MVD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MVD Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MVD 30 31
  • 99.33 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MVD 30 31
  • 85.25 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MVD 30 31
  • 84.33 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Mvd 30
  • 83.38 (n)
Mouse
(Mus musculus)
 Mammalia Mvd 30 17 31
  • 82.7 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia MVD 31
  • 77 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia MVD 31
  • 77 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves MVD 30 31
  • 73.35 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MVD 31
  • 68 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia mvd 30
  • 65.22 (n)
LOC394871 30
Zebrafish
(Danio rerio)
 Actinopterygii mvda 30 31
  • 65.56 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP001611 30
  • 57.05 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta CG8239 30 31 32
  • 54.16 (n)
 OneToOne
Worm
(Caenorhabditis elegans)
 Secernentea Y48B6A.13 31
  • 40 (a)
 OneToOne
Y48B6A.13b 32
  • 40 (a)
Y48B6A.13a 32
  • 39 (a)
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_AGL232C 30
  • 58.09 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0F10285g 30
  • 50.13 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes MVD1 30 31 33
  • 49.09 (n)
 OneToOne
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT3G54250 30
  • 52.79 (n)
Soybean
(Glycine max)
 eudicotyledons Gma.7599 30
Rice
(Oryza sativa)
 Liliopsida Os02g0109100 30
  • 61.2 (n)
Os.10543 30
Barley
(Hordeum vulgare)
 Liliopsida Hv.5909 30
Corn
(Zea mays)
 Liliopsida Zm.14376 30
Bread mold
(Neurospora crassa)
 Ascomycetes NCU11381 30
  • 54.27 (n)
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes mvd1 30
  • 51.05 (n)
Species where no ortholog for MVD was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MVD Gene

ENSEMBL:
Gene Tree for MVD (if available)
TreeFam:
Gene Tree for MVD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MVD: view image

Paralogs for MVD Gene

No data available for Paralogs for MVD Gene

Variants for MVD Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MVD Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
638465 Uncertain Significance: Porokeratosis 7, multiple types 88,658,663(-) A/G MISSENSE_VARIANT
790170 Benign: not provided 88,657,940(-) C/T SYNONYMOUS_VARIANT
790328 Benign: not provided 88,653,318(-) T/C SYNONYMOUS_VARIANT
rs144010349 Porokeratosis 7, multiple types (POROK7) [MIM:614714] p.Arg161Gln
rs200033380 Porokeratosis 7, multiple types (POROK7) [MIM:614714] p.Pro101Arg

Additional dbSNP identifiers (rs#s) for MVD Gene

Structural Variations from Database of Genomic Variants (DGV) for MVD Gene

Variant ID Type Subtype PubMed ID
esv3639554 CNV loss 21293372
nsv1065973 CNV loss 25217958
nsv1926 CNV insertion 18451855
nsv471113 CNV loss 18288195
nsv482951 CNV loss 15286789
nsv833325 CNV loss 17160897
nsv952070 CNV deletion 24416366

Variation tolerance for MVD Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MVD Gene

Human Gene Mutation Database (HGMD)
MVD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MVD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MVD Gene

Disorders for MVD Gene

MalaCards: The human disease database

(9) MalaCards diseases for MVD Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
porokeratosis 7, multiple types
  • porok7
porokeratosis
  • porokeratosis of mibelli
scirrhous adenocarcinoma
  • adenocarcinoma with productive fibrosis
punctate porokeratosis
  • porokeratosis punctata palmaris et plantaris
linear porokeratosis
  • congenital facial linear porokeratosis
- elite association - COSMIC cancer census association via MalaCards
Search MVD in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MVD1_HUMAN
  • Porokeratosis 7, multiple types (POROK7) [MIM:614714]: A form of porokeratosis, a disorder of faulty keratinization characterized by one or more atrophic patches surrounded by a distinctive hyperkeratotic ridgelike border called the cornoid lamella. The keratotic lesions can progress to overt cutaneous neoplasms, typically squamous cell carcinomas. Multiple clinical variants of porokeratosis are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis. Different clinical presentations can be observed among members of the same family. Individuals expressing more than one variant have also been reported. {ECO:0000269 PubMed:18823933, ECO:0000269 PubMed:26202976}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for MVD

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MVD: view

No data available for Genatlas for MVD Gene

Publications for MVD Gene

  1. Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase. (PMID: 8626466) Toth MJ … Huwyler L (The Journal of biological chemistry 1996) 2 3 4 23
  2. Human mevalonate pyrophosphate decarboxylase is localized in the cytosol. (PMID: 14972328) Hogenboom S … Waterham HR (Molecular genetics and metabolism 2004) 3 4 23
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  4. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y … Boer JM (Journal of lipid research 2008) 3 41
  5. Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. (PMID: 18823933) Voynova NE … Miziorko HM (Archives of biochemistry and biophysics 2008) 3 4

ExternalLinks

View latest publications for MVD gene in Mastermind

Products for MVD Gene

  • Addgene plasmids for MVD
  • Signalway ELISA kits for MVD

Sources for MVD Gene