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This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in s... See more...
Aliases for MUTYH Gene
Aliases for MUTYH Gene
External Ids for MUTYH Gene
- HGNC: 7527
- Entrez Gene: 4595
- Ensembl: ENSG00000132781
- OMIM: 604933
- UniProtKB: Q9UIF7
Previous GeneCards Identifiers for MUTYH Gene
- GC01M045522
- GC01M044795
- GC01M045224
- GC01M045208
- GC01M045464
- GC01M045567
- GC01M045794
- GC01M043906
Summaries for MUTYH Gene
-
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
GeneCards Summary for MUTYH Gene
MUTYH (MutY DNA Glycosylase) is a Protein Coding gene. Diseases associated with MUTYH include Familial Adenomatous Polyposis 2 and Gastric Cancer. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and DNA Damage. Gene Ontology (GO) annotations related to this gene include hydrolase activity and hydrolase activity, acting on glycosyl bonds. An important paralog of this gene is ENSG00000288208.
UniProtKB/Swiss-Prot Summary for MUTYH Gene
-
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
Additional gene information for MUTYH Gene
- Monarch Initiative
- Search for MUTYH at DataMed
- Search for MUTYH at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MUTYH Gene
Genomics for MUTYH Gene
GeneHancer (GH) Regulatory Elements for MUTYH Gene
Promoters and enhancers for MUTYH Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MUTYH on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MUTYH
- Top Transcription factor binding sites by QIAGEN in the MUTYH gene promoter:
-
- E2F-4
- E2F-5
- Evi-1
- FOXO4
- HEN1
Genomic Locations for MUTYH Gene
Genomic Locations for MUTYH Gene
- chr1:45,329,163-45,340,893
- (GRCh38/hg38)
- Size:
- 11,731 bases
- Orientation:
- Minus strand
- chr1:45,794,835-45,806,142
- (GRCh37/hg19)
- Size:
- 11,308 bases
- Orientation:
- Minus strand
Genomic View for MUTYH Gene
Genes around MUTYH on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p34.1 by HGNC
- 1p34.1 by Entrez Gene
- 1p34.1 by Ensembl
MUTYH Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MUTYH Gene
Proteins for MUTYH Gene
-
Protein details for MUTYH Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UIF7-MUTYH_HUMAN
- Recommended name:
- Adenine DNA glycosylase
- Protein Accession:
- Q9UIF7
- D3DPZ4
- Q15830
- Q9UBP2
- Q9UBS7
- Q9UIF4
- Q9UIF5
- Q9UIF6
Protein attributes for MUTYH Gene
- Size:
- 546 amino acids
- Molecular mass:
- 60069 Da
- Cofactor:
- Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA89339.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA89339.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA89345.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA89345.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
Protein Expression for MUTYH Gene
Selected DME Specific Peptides for MUTYH Gene
- Q9UIF7:
-
- MLQQTQV
- RPGDFNQA
Post-translational modifications for MUTYH Gene
Other Protein References for MUTYH Gene
- ENSEMBL proteins:
-
- ENSP00000436430
- ENSP00000361187
- ENSP00000361182
- ENSP00000500455
- ENSP00000436597
- ENSP00000500886
- ENSP00000347685
- ENSP00000409718
- ENSP00000500526
- ENSP00000500828
- ENSP00000500891
- ENSP00000432330
- ENSP00000433843
- ENSP00000437093
- ENSP00000407590
- ENSP00000346354
- ENSP00000431292
- ENSP00000361176
- ENSP00000361170
- ENSP00000432528
- ENSP00000403655
- ENSP00000433130
- ENSP00000431264
- ENSP00000431568
- ENSP00000410263
- ENSP00000436478
- ENSP00000408176
- ENSP00000500418
- ENSP00000437166
- ENSP00000436469
- ENSP00000435889
- ENSP00000434985
- REFSEQ proteins:
-
- NP_001041637.1
- XP_016856825.1
- NP_001121897.1
- XP_016856826.1
- XP_016856820.1
- XP_024303016.1
- NP_001280125.1
- XP_011539799.1
- NP_001041638.1
- XP_011539806.1
- XP_011539805.1
- NP_036354.1
- XP_011539800.1
- NP_001280124.1
- XP_016856822.1
- XP_016856821.1
- NP_001280121.1
- NP_001041636.2
- XP_024303013.1
- XP_011539808.1
- XP_011539807.1
- XP_024303019.1
- XP_011539802.1
- XP_016856823.1
- NP_001337580.1
- XP_011539801.1
- NP_001280120.1
- XP_016856824.1
- NP_001337579.1
- XP_024303012.1
- NP_001280119.1
- XP_024303018.1
- NP_001041639.1
- XP_024303017.1
- XP_011539804.1
- XP_011539803.1
Antibody Products
- Creative Diagnostics Anti-MUTYH (C-terminal) polyclonal antibody
- GeneTex Anti-MUTYH antibody [N3C3]
-
Custom Antibody ServicesOriGene Antibodies for MUTYH
- Novus Biologicals Antibodies for MUTYH
-
Abcam antibodies for MUTYH
- Invitrogen Antibodies for MUTYH (AFLGC-MUTYH)
- antibodies-online: Show 27 available MUTYH Antibodies ranked by validation data
- Compare Top MUTYH Antibodies
-
Recommended
- 97 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 44 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 35 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 1 IF Antibody (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Biorbyt antibodies for MUTYH
-
Santa Cruz Biotechnology (SCBT) Antibodies for MUTYH
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MUTYH
- Origene Custom Protein Services for MUTYH
-
Signalway Proteins for MUTYH
-
Abcam proteins for MUTYH
Assay Products
- Aviva Systems Biology MUTYH ELISA Kit (Human) (OKDD00409) and MUTYH ELISA Kit (Human) (OKCD00581)
- antibodies-online: Show 10 available MUTYH Elisa Kits ranked by validation data
- Compare Top MUTYH Elisa Kits
-
Quality Products:
Domains & Families for MUTYH Gene
Gene Families for MUTYH Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for MUTYH Gene
- Blocks:
-
- NUDIX hydrolase
- Endonuclease III, HhH
- DNA glycosylase
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MUTYH Gene
- GenScript: Design optimal peptide antigens:
-
- MutY homolog (E. coli), isoform CRA_f (D3DPZ6_HUMAN)
- MutY homolog (E. coli), isoform CRA_e (E5KP26_HUMAN)
- MutY homolog (E. coli), isoform CRA_d (E5KP27_HUMAN)
- MutY homolog (E. coli), isoform CRA_b (E5KP28_HUMAN)
- MutY homolog (MUTYH_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UIF7- Family:
-
- Belongs to the Nth/MutY family.
Function for MUTYH Gene
Molecular function for MUTYH Gene
- UniProtKB/Swiss-Prot Function:
- Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.; EC=3.2.2.31; Evidence=. ;.
- GENATLAS Biochemistry:
- mutY E coli homolog,involved in the repair of oxidative DNA damage
Enzyme Numbers (IUBMB) for MUTYH Gene
Phenotypes From GWAS Catalog for MUTYH Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000701 | purine-specific mismatch base pair DNA N-glycosylase activity | IMP | 20848659 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 11801590 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for MUTYH Gene
- MGI mutant phenotypes for MUTYH:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for MUTYH:
-
- Dynamic nuclei (hole, folded or small irregular)
- Reduced mammosphere formation
- Decreased viability
- no effect
- Increased shRNA abundance
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased hepcidin::fluc mRNA expression
- Increased transferrin (TF) endocytosis
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MUTYH - Select products 50% OFF >
- * MUTYH CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MUTYH
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MUTYH
- genomics-online: gRNA clones - Search results for available MUTYH gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for MUTYH
miRNA for MUTYH Gene
- miRTarBase miRNAs that target MUTYH
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MUTYH
- Browse OriGene Inhibitory RNA Products For MUTYH
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MUTYH
- genomics-online: shRNA clones - Search results for available MUTYH gene related products
Clone Products
- Applied Biological Materials (abm): Clones for MUTYH - Select products 50% OFF >
- * MUTYH as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG208268
- MG221374
- MR208268
- MR208268L3
- MR208268L4
- MR221374
- MR221374L3
- MR221374L4
- RC201376
- RC201376L3
- RC201376L4
- RC212561
- RC212561L3
- RC212561L4
- RC212609
- RC212609L3
- RC212609L4
- RC221402
- RC221402L3
- RC221402L4
- RC222842
- RC222842L3
- RC222842L4
- RC225939
- RC225939L3
- RC225939L4
- RC238177
- RC238178
- RC238703
- RC238746
- RC238781
- RG201376
- RG212561
- RG212609
- RG221402
- RG222842
- RG225939
- RR210408
- RR210408L3
- RR210408L4
- MR208268L3V
- MR208268L4V
- MR221374L3V
- MR221374L4V
- RC201376L3V
- RC201376L4V
- RC212561L3V
- RC212561L4V
- RC212609L3V
- RC212609L4V
- RC221402L3V
- RC221402L4V
- RC222842L3V
- RC222842L4V
- RC225939L3V
- RC225939L4V
- RR210408L3V
- RR210408L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MUTYH
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MUTYH
- genomics-online: cdna clones - Search results for available MUTYH gene related products
- orf clones - Search results for available MUTYH gene related products
Cell Line Products
-
Horizon Cell Lines for MUTYH
No data available for Transcription Factor Targets and HOMER Transcription for MUTYH Gene
Localization for MUTYH Gene
Subcellular locations from UniProtKB/Swiss-Prot for MUTYH Gene
- Nucleus. Mitochondrion.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005739 | mitochondrion | IEA | -- |
Pathways & Interactions for MUTYH Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Telomere C-strand (Lagging Strand) Synthesis | ||
| 2 | Recognition and association of DNA glycosylase with site containing an affected purine |
.01
|
|
| 3 | DNA Damage | ||
| 4 | DNA Double-Strand Break Repair |
.53
|
|
Pathways by source for MUTYH Gene
8 Reactome pathways for MUTYH Gene
1 KEGG pathway for MUTYH Gene
1 Cell Signaling Technology pathway for MUTYH Gene
Interacting Proteins for MUTYH Gene
Selected Interacting proteins:
Q9UIF7-MUTYH_HUMAN
ENSP00000361170
for MUTYH Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for MUTYH
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006281 | DNA repair | IBA,IEA | 21873635 |
| GO:0006284 | base-excision repair | IEA,IBA | 21873635 |
| GO:0006298 | mismatch repair | IBA | 21873635 |
| GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
| GO:0008152 | metabolic process | IEA | -- |
Drugs & Compounds for MUTYH Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cisplatin | Approved | Pharma | Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum | 3311 | ||
| Cyclophosphamide | Approved, Investigational | Pharma | Nitrogen mustard alkylating agent and prodrug. | 3570 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for MUTYH Gene
mRNA/cDNA for MUTYH Gene
- 13 REFSEQ mRNAs :
- 21 NCBI additional mRNA sequence :
- 46 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000354383 1744 bps (ENST00000354383.10)
- ENST00000355498 1776 bps (ENST00000355498.6)
- ENST00000372098 1839 bps (ENST00000372098.7)
- ENST00000372104 1823 bps (ENST00000372104.5)
- ENST00000372110 1809 bps (ENST00000372110.7)
- 10 RNACentral transcripts :
- 1 LncBook transcripts :
- 9 LNCipedia transcripts :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MUTYH - Select products 50% OFF >
- * MUTYH CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MUTYH
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MUTYH
- genomics-online: gRNA clones - Search results for available MUTYH gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for MUTYH
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MUTYH
- Browse OriGene Inhibitory RNA Products For MUTYH
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MUTYH
- genomics-online: shRNA clones - Search results for available MUTYH gene related products
Clone Products
- Applied Biological Materials (abm): Clones for MUTYH - Select products 50% OFF >
- * MUTYH as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG208268
- MG221374
- MR208268
- MR208268L3
- MR208268L4
- MR221374
- MR221374L3
- MR221374L4
- RC201376
- RC201376L3
- RC201376L4
- RC212561
- RC212561L3
- RC212561L4
- RC212609
- RC212609L3
- RC212609L4
- RC221402
- RC221402L3
- RC221402L4
- RC222842
- RC222842L3
- RC222842L4
- RC225939
- RC225939L3
- RC225939L4
- RC238177
- RC238178
- RC238703
- RC238746
- RC238781
- RG201376
- RG212561
- RG212609
- RG221402
- RG222842
- RG225939
- RR210408
- RR210408L3
- RR210408L4
- MR208268L3V
- MR208268L4V
- MR221374L3V
- MR221374L4V
- RC201376L3V
- RC201376L4V
- RC212561L3V
- RC212561L4V
- RC212609L3V
- RC212609L4V
- RC221402L3V
- RC221402L4V
- RC222842L3V
- RC222842L4V
- RC225939L3V
- RC225939L4V
- RR210408L3V
- RR210408L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MUTYH
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MUTYH
- genomics-online: cdna clones - Search results for available MUTYH gene related products
- orf clones - Search results for available MUTYH gene related products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
Relevant External Links for MUTYH Gene
- GeneLoc Exon Structure for
- MUTYH
Expression for MUTYH Gene
This gene is overexpressed in Urinary Bladder (23.8), Colon (19.7), Rectum (9.8), CD4 Tcells (8.7), and Prostate (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MUTYH Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MUTYH
SOURCE GeneReport for Unigene cluster for MUTYH Gene:
Hs.271353Evidence on tissue expression from TISSUES for MUTYH Gene
- Kidney(4.3)
- Intestine(3.1)
- Nervous system(2.8)
- Muscle(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MUTYH Gene
Germ Layers:
- ectoderm
- endoderm
Systems:
- digestive
- integumentary
Regions:
Abdomen:
- intestine
- large intestine
- stomach
General:
- hair
- skin
Primer Products
-
OriGene qPCR primer pairs for MUTYH
-
OriGene qPCR primer pairs and template standards for MUTYH
- genomics-online: primer clones - Search results for available MUTYH gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MUTYH Gene
Orthologs for MUTYH Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MUTYH 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MUTYH 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MUTYH 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mutyh 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mutyh 30 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MUTYH 31 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MUTYH 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MUTYH 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MUTYH 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mutyh 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mutyh 31 30 |
|
OneToOne | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G12740 30 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os12g0211400 30 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | myh1 30 |
|
- Species where no ortholog for MUTYH was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for MUTYH Gene
- ENSEMBL:
- Gene Tree for MUTYH (if available)
- TreeFam:
- Gene Tree for MUTYH (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MUTYH: view image
Paralogs for MUTYH Gene
Paralogs for MUTYH Gene
(2) SIMAP similar genes for MUTYH Gene using alignment to 22 proteins:
- MUTYH_HUMAN
- D3DPZ6_HUMAN
- E5KP25_HUMAN
- E5KP26_HUMAN
- E5KP27_HUMAN
- E5KP28_HUMAN
- E9PI11_HUMAN
- E9PIW5_HUMAN
- E9PKM9_HUMAN
- E9PLT4_HUMAN
- E9PM53_HUMAN
- E9PMH1_HUMAN
- E9PNY0_HUMAN
- E9PP30_HUMAN
- E9PP34_HUMAN
- G8JLP0_HUMAN
- H0YCA8_HUMAN
- H0YCY5_HUMAN
- H0YEI2_HUMAN
- H0YER6_HUMAN
- Q5T413_HUMAN
- Q5T418_HUMAN
Variants for MUTYH Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MUTYH Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 216871 | Uncertain Significance: Hereditary cancer-predisposing syndrome; MYH-associated polyposis | 45,330,532(-) | TGTTG/CAACA | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| 464717 | Pathogenic: MYH-associated polyposis | 45,332,596(-) | ATGGCCCCAGCTGTGT | SPLICE_ACCEPTOR_VARIANT,SPLICE_DONOR_VARIANT,INITIATIOR_CODON_VARIANT | |
| 631250 | Uncertain Significance: Hereditary cancer-predisposing syndrome | 45,332,026(-) | ACTC/A | NON_CODING_TRANSCRIPT_VARIANT,INFRAME_DELETION | |
| 639290 | Uncertain Significance: MYH-associated polyposis | 45,333,108(-) | C/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT | |
| 640844 | Uncertain Significance: MYH-associated polyposis | 45,332,224(-) | GGGGTACACA/G | NON_CODING_TRANSCRIPT_VARIANT,INFRAME_INDEL |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1314250 | CNV | insertion | 17803354 |
| esv2750837 | CNV | loss | 17911159 |
| nsv1133024 | OTHER | inversion | 24896259 |
Residual Variation Intolerance Score:
54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.69;
82.98% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MUTYH Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MUTYH Gene
Disorders for MUTYH Gene
(44) MalaCards diseases for MUTYH Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| familial adenomatous polyposis 2 |
|
|
| gastric cancer |
|
|