Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MUS81 Gene

Aliases for MUS81 Gene

  • MUS81 Structure-Specific Endonuclease Subunit 2 3 5
  • SLX3 Structure-Specific Endonuclease Subunit Homolog (S. Cerevisiae) 2
  • SLX3 Structure-Specific Endonuclease Subunit Homolog 3
  • MUS81 Endonuclease Homolog (S. Cerevisiae) 2
  • Crossover Junction Endonuclease MUS81 3
  • MUS81 Endonuclease Homolog (Yeast) 2
  • MUS81 Endonuclease Homolog 3
  • EC 3.1.22.- 4
  • EC 3.1.22 56
  • SLX3 3

External Ids for MUS81 Gene

Previous GeneCards Identifiers for MUS81 Gene

  • GC11P068162
  • GC11P067309
  • GC11P065403
  • GC11P065384
  • GC11P065627
  • GC11P061954

Summaries for MUS81 Gene

Entrez Gene Summary for MUS81 Gene

  • This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. [provided by RefSeq, Jun 2017]

GeneCards Summary for MUS81 Gene

MUS81 (MUS81 Structure-Specific Endonuclease Subunit) is a Protein Coding gene. Diseases associated with MUS81 include Xeroderma Pigmentosum, Complementation Group F and Fanconi Anemia, Complementation Group A. Among its related pathways are DNA Double-Strand Break Repair and Fanconi anemia pathway. Gene Ontology (GO) annotations related to this gene include nuclease activity and 3-flap endonuclease activity.

UniProtKB/Swiss-Prot for MUS81 Gene

  • Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5-end at the branch nick. Typical substrates include 3-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.

Gene Wiki entry for MUS81 Gene

Additional gene information for MUS81 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUS81 Gene

Genomics for MUS81 Gene

GeneHancer (GH) Regulatory Elements for MUS81 Gene

Promoters and enhancers for MUS81 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I065851 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 606.9 +0.4 358 12.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MUS81 CFL1 EIF1AD POLA2 PCNX3 SART1 ENSG00000258297 ZFPL1 RBM14 RBM4
GH11I065470 Promoter/Enhancer 2.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 123.6 -367.0 -367042 40 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 LOC105369346 SF1 PCNX3 POLA2 ZFPL1 EIF1AD SART1 MUS81 LOC105369352 KAT5
GH11I065414 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 79.9 -432.9 -432945 18.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 NEAT1 ENSG00000277599 ENSG00000278050 ENSG00000278144 GC11P065529 SF1 ZFPL1 EIF1AD POLA2 PCNX3
GH11I065886 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 57 +38.3 38332 18.4 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 FOSL1 FIBP CCDC85B SNX32 ENSG00000258297 EIF1AD RBM14 MUS81 SART1 POLA2
GH11I065910 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 43.9 +58.6 58601 11.4 CLOCK MLX ZFP64 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D SSRP1 DRAP1 C11orf68 RBM14 LOC105369352 ZFPL1 ENSG00000254461 MUS81 ENSG00000258297 EIF1AD PCNX3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MUS81 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MUS81 gene promoter:

Genomic Locations for MUS81 Gene

Genomic Locations for MUS81 Gene
chr11:65,857,126-65,867,653
(GRCh38/hg38)
Size:
10,528 bases
Orientation:
Plus strand
chr11:65,624,597-65,635,124
(GRCh37/hg19)

Genomic View for MUS81 Gene

Genes around MUS81 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUS81 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUS81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUS81 Gene

Proteins for MUS81 Gene

  • Protein details for MUS81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NY9-MUS81_HUMAN
    Recommended name:
    Crossover junction endonuclease MUS81
    Protein Accession:
    Q96NY9
    Secondary Accessions:
    • Q9H7D9

    Protein attributes for MUS81 Gene

    Size:
    551 amino acids
    Molecular mass:
    61173 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • May self-associate. Interacts with EME1, EME2 and CHEK2. Interacts with BLM, and this interaction may stimulate the endonuclease activity of MUS81. Interacts with SLX4/BTBD12; this interaction is direct and links the MUS81-EME1 complex to SLX4, which may coordinate the action of the structure-specific endonuclease during DNA repair. Interacts with DCLRE1B/Apollo.
    SequenceCaution:
    • Sequence=BAB14953.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MUS81 Gene

neXtProt entry for MUS81 Gene

Selected DME Specific Peptides for MUS81 Gene

Q96NY9:
  • EVFARQLMQ
  • GDFVWVA
  • DGRFREQK
  • WLTEWRD
  • ERKRLDDL
  • DGFFVKR
  • RNLGPALSRT

Post-translational modifications for MUS81 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MUS81 Gene

Gene Families for MUS81 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q96NY9

UniProtKB/Swiss-Prot:

MUS81_HUMAN :
  • Belongs to the XPF family.
Family:
  • Belongs to the XPF family.
genes like me logo Genes that share domains with MUS81: view

Function for MUS81 Gene

Molecular function for MUS81 Gene

UniProtKB/Swiss-Prot Function:
Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5-end at the branch nick. Typical substrates include 3-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
UniProtKB/Swiss-Prot Induction:
Up-regulated in cells treated with agents that damage DNA or block replication. This up-regulation seems to be independent of transcription.

Enzyme Numbers (IUBMB) for MUS81 Gene

Phenotypes From GWAS Catalog for MUS81 Gene

Gene Ontology (GO) - Molecular Function for MUS81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0004520 endodeoxyribonuclease activity TAS --
GO:0005515 protein binding IPI 12686547
genes like me logo Genes that share ontologies with MUS81: view
genes like me logo Genes that share phenotypes with MUS81: view

Animal Models for MUS81 Gene

MGI Knock Outs for MUS81:

Animal Model Products

  • Taconic Biosciences Mouse Models for MUS81

miRNA for MUS81 Gene

miRTarBase miRNAs that target MUS81

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MUS81 Gene

Localization for MUS81 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUS81 Gene

Nucleus, nucleolus. Note=Recruited to foci of DNA damage in S-phase cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MUS81 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MUS81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0048476 Holliday junction resolvase complex IBA --
genes like me logo Genes that share ontologies with MUS81: view

Pathways & Interactions for MUS81 Gene

genes like me logo Genes that share pathways with MUS81: view

Gene Ontology (GO) - Biological Process for MUS81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000712 resolution of meiotic recombination intermediates IBA --
GO:0000727 double-strand break repair via break-induced replication IBA --
GO:0000737 DNA catabolic process, endonucleolytic IMP 23361013
GO:0006281 DNA repair IMP 19596235
GO:0006310 DNA recombination IEA --
genes like me logo Genes that share ontologies with MUS81: view

No data available for SIGNOR curated interactions for MUS81 Gene

Drugs & Compounds for MUS81 Gene

(1) Drugs for MUS81 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
genes like me logo Genes that share compounds with MUS81: view

Transcripts for MUS81 Gene

Unigene Clusters for MUS81 Gene

MUS81 endonuclease homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MUS81 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a ·
SP1: - - - - -
SP2:
SP3: - - - -
SP4: - -
SP5:
SP6:
SP7:
SP8: - - - -
SP9:
SP10:

ExUns: 16b · 16c ^ 17 ^ 18a · 18b · 18c · 18d
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9: -
SP10: -

Relevant External Links for MUS81 Gene

GeneLoc Exon Structure for
MUS81
ECgene alternative splicing isoforms for
MUS81

Expression for MUS81 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MUS81 Gene

Protein differential expression in normal tissues from HIPED for MUS81 Gene

This gene is overexpressed in Lung (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MUS81 Gene



Protein tissue co-expression partners for MUS81 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MUS81 Gene:

MUS81

SOURCE GeneReport for Unigene cluster for MUS81 Gene:

Hs.288798

mRNA Expression by UniProt/SwissProt for MUS81 Gene:

Q96NY9-MUS81_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for MUS81 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with MUS81: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MUS81 Gene

Orthologs for MUS81 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MUS81 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MUS81 33 34
  • 98.91 (n)
dog
(Canis familiaris)
Mammalia MUS81 33 34
  • 86.45 (n)
cow
(Bos Taurus)
Mammalia MUS81 33 34
  • 83.76 (n)
mouse
(Mus musculus)
Mammalia Mus81 33 16 34
  • 82.79 (n)
rat
(Rattus norvegicus)
Mammalia Mus81 33
  • 82.33 (n)
oppossum
(Monodelphis domestica)
Mammalia MUS81 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MUS81 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mus81 33
  • 55.13 (n)
African clawed frog
(Xenopus laevis)
Amphibia