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Aliases for MUM1L1 Gene

Aliases for MUM1L1 Gene

  • MUM1 Like 1 2 3 5
  • Mutated Melanoma-Associated Antigen 1-Like Protein 1 4
  • Melanoma Associated Antigen (Mutated) 1-Like 1 2
  • MUM1-Like Protein 1 4

External Ids for MUM1L1 Gene

Previous GeneCards Identifiers for MUM1L1 Gene

  • GC0XP105218
  • GC0XP105412
  • GC0XP095038

Summaries for MUM1L1 Gene

Entrez Gene Summary for MUM1L1 Gene

  • This gene encodes a protein which contains a mutated melanoma-associated antigen 1 domain. Proteins which contain mutated antigens are expressed at high levels on certain types of cancers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]

GeneCards Summary for MUM1L1 Gene

MUM1L1 (MUM1 Like 1) is a Protein Coding gene. An important paralog of this gene is MUM1.

Additional gene information for MUM1L1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUM1L1 Gene

Genomics for MUM1L1 Gene

GeneHancer (GH) Regulatory Elements for MUM1L1 Gene

Promoters and enhancers for MUM1L1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI106168 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 550.8 +0.1 116 0.4 POLR2A L3MBTL2 ZNF449 MUM1L1 GC0XP106229
GH0XI105313 Enhancer 0.8 FANTOM5 ENCODE 4.4 -853.9 -853905 2.2 STAT1 JUN CEBPB EP300 JUND STAT3 FOS NFE2L2 TCF7L2 MUM1L1 GC0XM105265 GC0XP105365 IL1RAPL2
GH0XI106672 Enhancer 0.3 ENCODE 4.7 +504.4 504421 0.9 SCRT2 MUM1L1 PIR40777 GC0XP106640 CXorf57
GH0XI106170 Enhancer 0.4 ENCODE 0.8 +3.1 3091 1.8 CTCF RAD21 MUM1L1 GC0XP106229
GH0XI106176 Enhancer 0.6 Ensembl ENCODE 0.4 +9.2 9167 1.5 POLR2A TAF1 MUM1L1 GC0XP106229
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MUM1L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MUM1L1 gene promoter:

Genomic Locations for MUM1L1 Gene

Genomic Locations for MUM1L1 Gene
40,684 bases
Plus strand

Genomic View for MUM1L1 Gene

Genes around MUM1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUM1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUM1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUM1L1 Gene

Proteins for MUM1L1 Gene

  • Protein details for MUM1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PWWP domain-containing protein MUM1L1
    Protein Accession:
    Secondary Accessions:
    • D3DUX2
    • Q49AS5
    • Q8N2C0
    • Q96MT6

    Protein attributes for MUM1L1 Gene

    696 amino acids
    Molecular mass:
    79040 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH31229.1; Type=Frameshift; Positions=406; Evidence={ECO:0000305}; Sequence=BAB71194.1; Type=Erroneous termination; Positions=638; Note=Translated as Glu.; Evidence={ECO:0000305};

neXtProt entry for MUM1L1 Gene

Post-translational modifications for MUM1L1 Gene

No Post-translational modifications

Other Protein References for MUM1L1 Gene

No data available for DME Specific Peptides for MUM1L1 Gene

Domains & Families for MUM1L1 Gene

Gene Families for MUM1L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MUM1L1 Gene


Suggested Antigen Peptide Sequences for MUM1L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MUM1 family.
  • Belongs to the MUM1 family.
genes like me logo Genes that share domains with MUM1L1: view

Function for MUM1L1 Gene

Phenotypes From GWAS Catalog for MUM1L1 Gene

Phenotypes for MUM1L1 Gene

genes like me logo Genes that share phenotypes with MUM1L1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MUM1L1 Gene

Localization for MUM1L1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MUM1L1 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MUM1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with MUM1L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MUM1L1 Gene

Pathways & Interactions for MUM1L1 Gene

SuperPathways for MUM1L1 Gene

No Data Available

Interacting Proteins for MUM1L1 Gene

Gene Ontology (GO) - Biological Process for MUM1L1 Gene


No data available for Pathways by source and SIGNOR curated interactions for MUM1L1 Gene

Drugs & Compounds for MUM1L1 Gene

No Compound Related Data Available

Transcripts for MUM1L1 Gene

Unigene Clusters for MUM1L1 Gene

Melanoma associated antigen (mutated) 1-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MUM1L1 Gene

No ASD Table

Relevant External Links for MUM1L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MUM1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MUM1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUM1L1 Gene

This gene is overexpressed in Ovary (x20.0).

Protein differential expression in normal tissues from HIPED for MUM1L1 Gene

This gene is overexpressed in Ovary (54.4), Platelet (8.3), and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MUM1L1 Gene

Protein tissue co-expression partners for MUM1L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MUM1L1 Gene:


SOURCE GeneReport for Unigene cluster for MUM1L1 Gene:


Evidence on tissue expression from TISSUES for MUM1L1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with MUM1L1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MUM1L1 Gene

Orthologs for MUM1L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MUM1L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MUM1L1 33 34
  • 99.38 (n)
(Canis familiaris)
Mammalia MUM1L1 33 34
  • 85.14 (n)
(Bos Taurus)
Mammalia MUM1L1 33 34
  • 84.49 (n)
(Rattus norvegicus)
Mammalia Mum1l1 33
  • 76.16 (n)
(Mus musculus)
Mammalia Mum1l1 33 16 34
  • 75.36 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 34 (a)
(Gallus gallus)
Aves -- 34
  • 29 (a)
(Danio rerio)
Actinopterygii MUM1L1 34
  • 16 (a)
Species where no ortholog for MUM1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MUM1L1 Gene

Gene Tree for MUM1L1 (if available)
Gene Tree for MUM1L1 (if available)

Paralogs for MUM1L1 Gene

Paralogs for MUM1L1 Gene

(2) SIMAP similar genes for MUM1L1 Gene using alignment to 1 proteins: Pseudogenes for MUM1L1 Gene

genes like me logo Genes that share paralogs with MUM1L1: view

Variants for MUM1L1 Gene

Sequence variations from dbSNP and Humsavar for MUM1L1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000030856 -- 106,180,474(+) G/A intron_variant
rs1000175525 -- 106,181,100(+) A/C intron_variant
rs1000177418 -- 106,204,605(+) A/G intron_variant
rs1000206669 -- 106,180,672(+) G/C intron_variant
rs1000290549 -- 106,189,907(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MUM1L1 Gene

Variant ID Type Subtype PubMed ID
nsv521259 CNV gain 19592680
esv2752312 CNV gain 17911159

Variation tolerance for MUM1L1 Gene

Residual Variation Intolerance Score: 9.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MUM1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MUM1L1 Gene

Disorders for MUM1L1 Gene

Additional Disease Information for MUM1L1

No disorders were found for MUM1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MUM1L1 Gene

Publications for MUM1L1 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales PA … Knepper MA (Journal of the American Society of Nephrology : JASN 2009) 3 58
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58

Products for MUM1L1 Gene

Sources for MUM1L1 Gene

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