Aliases for MUCL3 Gene

Aliases for MUCL3 Gene

  • Mucin Like 3 2 3 5
  • C6orf37 2 3 4
  • PBLT 2 3 4
  • Diffuse Panbronchiolitis Critical Region Protein 1 3 4
  • Diffuse Panbronchiolitis Critical Region 1 2 3
  • Mucin-Like Protein 3 3 4
  • DPCR1 3 4
  • BCX105N19.6 2
  • MUCL3 5

External Ids for MUCL3 Gene

Previous HGNC Symbols for MUCL3 Gene

  • DPCR1

Previous GeneCards Identifiers for MUCL3 Gene

  • GC06P032355
  • GC06P032544
  • GC06P032757
  • GC06P033628
  • GC06P031444
  • GC06P032104

Summaries for MUCL3 Gene

GeneCards Summary for MUCL3 Gene

MUCL3 (Mucin Like 3) is a Protein Coding gene. Diseases associated with MUCL3 include Panbronchiolitis, Diffuse and Bjornstad Syndrome.

UniProtKB/Swiss-Prot Summary for MUCL3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MUCL3 Gene

Genomics for MUCL3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MUCL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J030931 Promoter/Enhancer 1.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 600.7 -1.4 -1422 2.6 ZNF341 BCOR ZNF768 ZMYM3 KDM1A ENSG00000252761 MUCL3 lnc-SFTA2-13 SFTA2 VARS2 CCHCR1 MICD ATP6V1G2 LY6G5B DDR1
GH06J030934 Enhancer 0.8 Ensembl ENCODE dbSUPER 600.7 +0.6 627 0.9 SCRT2 ZNF10 CEBPB NFIC CEBPG IKZF1 SREBF1 MUCL3 VARS2 HCG27 SFTA2 RF00017-5401
GH06J030879 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 -50.1 -50140 9.2 ARHGAP35 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 ZNF629 RFX1 SOX13 IKZF1 DDR1 lnc-GTF2H4-5 VARS2 PSORS1C1 HLA-C GNL1 PSORS1C3 SFTA2 HCG18 IER3
GH06J030777 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -153.7 -153726 6.9 CEBPG CREB1 GATAD2A ZBTB33 ATF7 PRDM10 REST ZNF629 TFE3 LEF1 HCG20 lnc-TUBB-17 IER3 GTF2H4 PPP1R10 VARS2 MDC1 DDX39B HCG18 LY6G5B
GH06J030826 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 -105.2 -105242 5.5 GATAD2A CTCF TEAD4 PRDM10 TFE3 LEF1 IKZF1 NFKBIZ BACH1 JUND LINC00243 DDR1 VARS2 IER3 HLA-C DDR1-DT FLOT1 MUCL3 ATP6V1G2 HCG21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MUCL3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MUCL3

Genomic Locations for MUCL3 Gene

Genomic Locations for MUCL3 Gene
chr6:30,934,523-30,954,221
(GRCh38/hg38)
Size:
19,699 bases
Orientation:
Plus strand
chr6:30,908,749-30,921,998
(GRCh37/hg19)
Size:
13,250 bases
Orientation:
Plus strand

Genomic View for MUCL3 Gene

Genes around MUCL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUCL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUCL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUCL3 Gene

Proteins for MUCL3 Gene

  • Protein details for MUCL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MIW9-MUCL3_HUMAN
    Recommended name:
    Mucin-like protein 3
    Protein Accession:
    Q3MIW9
    Secondary Accessions:
    • C9IZC0
    • Q658M7
    • Q8WYN2

    Protein attributes for MUCL3 Gene

    Size:
    517 amino acids
    Molecular mass:
    56347 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH56248.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for MUCL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MUCL3 Gene

Post-translational modifications for MUCL3 Gene

  • Glycosylation at Asn338, Asn88, and Asn124
  • Modification sites at PhosphoSitePlus

Other Protein References for MUCL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MUCL3 Gene

Domains & Families for MUCL3 Gene

Gene Families for MUCL3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MUCL3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MUCL3 Gene

GenScript: Design optimal peptide antigens:
  • Diffuse panbronchiolitis critical region protein 1 (DPCR1_HUMAN)
  • Diffuse panbronchiolitis critical region 1 (Q5SS95_HUMAN)
  • Diffuse panbronchiolitis critical region 1 (Q5ST29_HUMAN)
genes like me logo Genes that share domains with MUCL3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MUCL3 Gene

Function for MUCL3 Gene

Molecular function for MUCL3 Gene

UniProtKB/Swiss-Prot Function:
May modulate NF-kappaB signaling and play a role in cell growth.

Phenotypes From GWAS Catalog for MUCL3 Gene

Gene Ontology (GO) - Molecular Function for MUCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MUCL3: view
genes like me logo Genes that share phenotypes with MUCL3: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MUCL3 Gene

Localization for MUCL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUCL3 Gene

Cell membrane. Single-pass type I membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MUCL3 gene
Compartment Confidence
plasma membrane 4
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MUCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MUCL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MUCL3 Gene

Pathways & Interactions for MUCL3 Gene

PathCards logo

SuperPathways for MUCL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MUCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MUCL3: view

No data available for Pathways by source and SIGNOR curated interactions for MUCL3 Gene

Drugs & Compounds for MUCL3 Gene

(2) Drugs for MUCL3 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 2588
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2451
genes like me logo Genes that share compounds with MUCL3: view

Transcripts for MUCL3 Gene

mRNA/cDNA for MUCL3 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MUCL3 Gene

No ASD Table

Relevant External Links for MUCL3 Gene

GeneLoc Exon Structure for
MUCL3

Expression for MUCL3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MUCL3

mRNA Expression by UniProt/SwissProt for MUCL3 Gene:

Q3MIW9-MUCL3_HUMAN
Tissue specificity: Detected in lung, esophagus, stomach, rectum, skin, cervix, testis, kidney, uterus and small intestine (PubMed:12185533). Expressed in pancreas (at protein level) (PubMed:29242154).

Evidence on tissue expression from TISSUES for MUCL3 Gene

  • Stomach(4.6)
  • Blood(4.3)
  • Intestine(4.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MUCL3 Gene

Germ Layers:
  • endoderm
Systems:
  • immune
  • nervous
  • respiratory
Regions:
Head and neck:
  • epiglottis
  • larynx
  • neck
Thorax:
  • bronchus
  • lung

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MUCL3 Gene

Orthologs for MUCL3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MUCL3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DPCR1 31
  • 87 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC102152456 30
  • 64.92 (n)
DPCR1 31
  • 37 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Dpcr1 30 31
  • 61.07 (n)
OneToOne
Mucl3 17
Rat
(Rattus norvegicus)
Mammalia Dpcr1 30
  • 59.5 (n)
Species where no ortholog for MUCL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MUCL3 Gene

ENSEMBL:
Gene Tree for MUCL3 (if available)
TreeFam:
Gene Tree for MUCL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MUCL3: view image

Paralogs for MUCL3 Gene

No data available for Paralogs for MUCL3 Gene

Variants for MUCL3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MUCL3 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
770548 Benign: not provided 30,948,868(+) G/A MISSENSE_VARIANT
770549 Benign: not provided 30,951,280(+) G/A MISSENSE_VARIANT
776122 Benign: not provided 30,952,069(+) C/A MISSENSE_VARIANT
rs11970154 - p.Gly337Arg
rs2240804 - p.Arg517Gln

Additional dbSNP identifiers (rs#s) for MUCL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for MUCL3 Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv3411275 CNV duplication 20981092
esv3608518 CNV gain 21293372
nsv1031677 CNV gain 25217958
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv462744 CNV loss 19166990
nsv525438 CNV gain 19592680
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv601483 CNV loss 21841781
nsv601484 CNV loss 21841781
nsv823473 CNV loss 20364138

Variation tolerance for MUCL3 Gene

Gene Damage Index Score: 8.39; 85.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MUCL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MUCL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MUCL3 Gene

Disorders for MUCL3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MUCL3 Gene - From: OMIM, Orphanet, and DISEASES

Disorder Aliases PubMed IDs
panbronchiolitis, diffuse
  • dpb
bjornstad syndrome
  • bjs
- elite association - COSMIC cancer census association via MalaCards
Search MUCL3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with MUCL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MUCL3 Gene

Publications for MUCL3 Gene

  1. Identification of novel candidate genes in the diffuse panbronchiolitis critical region of the class I human MHC. (PMID: 12185533) Matsuzaka Y … Inoko H (Immunogenetics 2002) 2 3 4
  2. High expression of diffuse panbronchiolitis critical region 1 gene promotes cell proliferation, migration and invasion in pancreatic ductal adenocarcinoma. (PMID: 29242154) Yan J … Miao F (Biochemical and biophysical research communications 2018) 3 4
  3. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. (PMID: 16702430) Shiina T … Bahram S (Genetics 2006) 3 4
  4. Fine localization of a major disease-susceptibility locus for diffuse panbronchiolitis. (PMID: 10677310) Keicho N … Kudoh S (American journal of human genetics 2000) 2 3
  5. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson SA … Youle RJ (Nature 2013) 3

Products for MUCL3 Gene

Sources for MUCL3 Gene