Aliases for MUCL1 Gene

Aliases for MUCL1 Gene

  • Mucin Like 1 2 3 5
  • Small Breast Epithelial Mucin 2 3 4
  • SBEM 2 3 4
  • Mucin-Like Protein 1 3 4
  • Protein BS106 4
  • MUCL1 5

External Ids for MUCL1 Gene

Previous GeneCards Identifiers for MUCL1 Gene

  • GC12P053539
  • GC12P055248
  • GC12P052287

Summaries for MUCL1 Gene

GeneCards Summary for MUCL1 Gene

MUCL1 (Mucin Like 1) is a Protein Coding gene. Diseases associated with MUCL1 include Breast Cancer and Klebsiella Pneumonia. Among its related pathways are Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) and Metabolism of proteins.

UniProtKB/Swiss-Prot Summary for MUCL1 Gene

  • May play a role as marker for the diagnosis of metastatic breast cancer.

Gene Wiki entry for MUCL1 Gene

Additional gene information for MUCL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MUCL1 Gene

Genomics for MUCL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MUCL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J054854 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 605.6 +23.6 23646 0.7 CTCF ZNF143 REST RAD21 TRIM22 YY1 ZNF444 SMC3 ZNF217 GATA3 MUCL1 ENSG00000250654 HSALNG0091391 piR-39341-085 TESPA1
GH12J054829 Enhancer 0.2 Ensembl 605.4 +0.8 783 3.8 MUCL1 HSALNG0091391 ZNF385A HNRNPA1 piR-39341-085 TESPA1
GH12J054932 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 5 +104.8 104756 5.6 LEF1 BACH1 JUND FOXA1 ZNF143 REST CTCF SOX6 GATAD2B EP300 TESPA1 NEUROD4 MUCL1 NCKAP1L OR6C65 OR6C3 piR-54768-003 piR-30444-079 LOC105369778
GH12J054734 Enhancer 0.7 Ensembl ENCODE 7.7 -95.9 -95860 0.9 SP1 FOXA2 YY1 ZBTB33 JUND NR2F2 RAD21 HNF4A RXRA REST HSALNG0091386 MUCL1 HSALNG0091385 DCD
GH12J054749 Enhancer 0.7 Ensembl ENCODE 5.3 -80.6 -80648 1.5 CTCF ZNF143 REST RAD21 TRIM22 SMC3 ZNF217 NBN RFX5 ZNF654 MUCL1 piR-53029-025 piR-45726-012 DCD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MUCL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MUCL1

Top Transcription factor binding sites by QIAGEN in the MUCL1 gene promoter:
  • c-Rel
  • CBF-A
  • CBF-B
  • CBF-C
  • E47
  • FOXF2
  • Hand1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for MUCL1 Gene

Genomic Locations for MUCL1 Gene
65,491 bases
Plus strand
27,875 bases
Plus strand

Genomic View for MUCL1 Gene

Genes around MUCL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUCL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUCL1 Gene

Proteins for MUCL1 Gene

  • Protein details for MUCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mucin-like protein 1
    Protein Accession:
    Secondary Accessions:
    • Q0VG95
    • Q32ZB5

    Protein attributes for MUCL1 Gene

    90 amino acids
    Molecular mass:
    9039 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MUCL1 Gene

Post-translational modifications for MUCL1 Gene

  • O-glycosylated.
  • Glycosylation at Thr23, Thr24, Thr30, Thr34, Thr46, Thr47, Thr51, Thr52, Thr54, Thr55, Thr59, Thr60, Thr62, Thr63, Ser66, Thr67, and Thr68
  • Modification sites at PhosphoSitePlus

Other Protein References for MUCL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

  • Signalway Proteins for MUCL1
  • Abcam proteins for MUCL1

No data available for DME Specific Peptides for MUCL1 Gene

Domains & Families for MUCL1 Gene

Gene Families for MUCL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for MUCL1 Gene


Suggested Antigen Peptide Sequences for MUCL1 Gene

GenScript: Design optimal peptide antigens:
  • Small breast epithelial mucin (MUCL1_HUMAN)
genes like me logo Genes that share domains with MUCL1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MUCL1 Gene

Function for MUCL1 Gene

Molecular function for MUCL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role as marker for the diagnosis of metastatic breast cancer.

Phenotypes From GWAS Catalog for MUCL1 Gene

genes like me logo Genes that share phenotypes with MUCL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MUCL1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MUCL1 Gene

Localization for MUCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUCL1 Gene

Secreted. Membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MUCL1 gene
Compartment Confidence
plasma membrane 4
extracellular 4
golgi apparatus 4
mitochondrion 2
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MUCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MUCL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MUCL1 Gene

Pathways & Interactions for MUCL1 Gene

genes like me logo Genes that share pathways with MUCL1: view

Gene Ontology (GO) - Biological Process for MUCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0016266 O-glycan processing TAS --
genes like me logo Genes that share ontologies with MUCL1: view

No data available for SIGNOR curated interactions for MUCL1 Gene

Drugs & Compounds for MUCL1 Gene

No Compound Related Data Available

Transcripts for MUCL1 Gene

mRNA/cDNA for MUCL1 Gene

5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MUCL1

Alternative Splicing Database (ASD) splice patterns (SP) for MUCL1 Gene

No ASD Table

Relevant External Links for MUCL1 Gene

GeneLoc Exon Structure for

Expression for MUCL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MUCL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUCL1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x21.5), Skin - Not Sun Exposed (Suprapubic) (x18.6), and Breast - Mammary Tissue (x11.4).

Protein differential expression in normal tissues from HIPED for MUCL1 Gene

This gene is overexpressed in Urine (64.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MUCL1 Gene

Protein tissue co-expression partners for MUCL1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MUCL1

SOURCE GeneReport for Unigene cluster for MUCL1 Gene:


mRNA Expression by UniProt/SwissProt for MUCL1 Gene:

Tissue specificity: Expressed in mammary, salivary glands and prostate. Also detected in lung. Mainly expressed in cancer cell lines of breast origin. Highly expressed in lymph node-positive compared with node-negative tumors. Detected in all lymph node containing metastatic cells.

Evidence on tissue expression from TISSUES for MUCL1 Gene

  • Skin(2.5)
genes like me logo Genes that share expression patterns with MUCL1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MUCL1 Gene

Orthologs for MUCL1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MUCL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MUCL1 30 31
  • 95.19 (n)
Species where no ortholog for MUCL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MUCL1 Gene

Gene Tree for MUCL1 (if available)
Gene Tree for MUCL1 (if available)
Evolutionary constrained regions (ECRs) for MUCL1: view image

Paralogs for MUCL1 Gene

No data available for Paralogs for MUCL1 Gene

Variants for MUCL1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MUCL1 Gene

The number of repeats varies from 3 to 2 in one variant form which is equally present in breast cancer tumors.

Additional dbSNP identifiers (rs#s) for MUCL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MUCL1 Gene

Variant ID Type Subtype PubMed ID
nsv516882 CNV gain 19592680

Variation tolerance for MUCL1 Gene

Residual Variation Intolerance Score: 84.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MUCL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MUCL1 Gene

Disorders for MUCL1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MUCL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast lobular carcinoma
klebsiella pneumonia
  • pneumonia due to klebsiella pneumoniae
pleural empyema
  • abscess of pleural cavity
colorectal cancer 1
  • colorectal cancer, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search MUCL1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with MUCL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MUCL1 Gene

Publications for MUCL1 Gene

  1. Identification of a novel breast- and salivary gland-specific, mucin-like gene strongly expressed in normal and tumor human mammary epithelium. (PMID: 12019145) Miksicek RJ … Leygue E (Cancer research 2002) 2 3 4 23
  2. Serological identification of breast cancer-related antigens from a Saccharomyces cerevisiae surface display library. (PMID: 15880534) Wadle A … Renner C (International journal of cancer 2005) 3 4 23
  3. Identification of MGB1 as a marker in the differential diagnosis of lung tumors in patients with a history of breast cancer by analysis of publicly available SAGE data. (PMID: 15096563) Koga T … Yatabe Y (The Journal of molecular diagnostics : JMD 2004) 3 4 23
  4. Human small breast epithelial mucin: the promise of a new breast tumor biomarker. (PMID: 15684711) Hubé F … Myal Y (DNA and cell biology 2004) 3 4 23
  5. Small breast epithelial mucin (SBEM) has the potential to be a marker for predicting hematogenous micrometastasis and response to neoadjuvant chemotherapy in breast cancer. (PMID: 20364301) Liu ZZ … Wang YK (Clinical & experimental metastasis 2010) 3 23

Products for MUCL1 Gene

Sources for MUCL1 Gene