Aliases for MUC6 Gene
External Ids for MUC6 Gene
Previous GeneCards Identifiers for MUC6 Gene
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. [provided by RefSeq, Dec 2016]
GeneCards Summary for MUC6 Gene
MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC6 include Pancreatic Ductal Carcinoma and Tumor Of Exocrine Pancreas. Among its related pathways are CLEC7A (Dectin-1) signaling and Defective GALNT12 causes colorectal cancer 1 (CRCS1). Gene Ontology (GO) annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is MUC5B.
UniProtKB/Swiss-Prot Summary for MUC6 Gene
May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.