Aliases for MUC5AC Gene

Aliases for MUC5AC Gene

  • Mucin 5AC, Oligomeric Mucus/Gel-Forming 2 3 5
  • Mucin 5, Subtypes A And C, Tracheobronchial/Gastric 2 3
  • Mucin-5 Subtype AC, Tracheobronchial 3 4
  • Major Airway Glycoprotein 3 4
  • Tracheobronchial Mucin 3 4
  • Gastric Mucin 3 4
  • Mucin-5AC 3 4
  • MUC5 3 4
  • TBM 3 4
  • Mucin 5AC, Oligomeric Mucus/Gel-Forming Pseudogene 3
  • Lewis B Blood Group Antigen 3
  • MUC-5AC 4
  • Mucin 3
  • LeB 3

External Ids for MUC5AC Gene

Previous GeneCards Identifiers for MUC5AC Gene

  • GC11U990089
  • GC11P001169
  • GC11P000972

Summaries for MUC5AC Gene

GeneCards Summary for MUC5AC Gene

MUC5AC (Mucin 5AC, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC5AC include Barrett Esophagus and Biliary Papillomatosis. Among its related pathways are Metabolism of proteins and CLEC7A (Dectin-1) signaling. Gene Ontology (GO) annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is MUC5B.

UniProtKB/Swiss-Prot Summary for MUC5AC Gene

  • Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999).

Gene Wiki entry for MUC5AC Gene

Additional gene information for MUC5AC Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MUC5AC Gene

Genomics for MUC5AC Gene

GeneHancer (GH) Regulatory Elements for MUC5AC Gene

Promoters and enhancers for MUC5AC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J001157 Enhancer 0.4 ENCODE 500.7 +0.2 183 1.8 ZFX NFIC POLR2A TAF1 MUC5AC HSALNG0082081
GH11J001326 Enhancer 0.7 Ensembl ENCODE 11.3 +168.9 168917 1.3 NRF1 FOS FOXA2 TAL1 FOSL2 TFAP4 BHLHE40 TEAD3 JUND FOXA1 TOLLIP MUC5AC ENSG00000287935 TOLLIP-AS1
GH11J001317 Enhancer 0.7 FANTOM5 Ensembl ENCODE 11.3 +160.5 160547 4.2 SPI1 RAD21 MUC5AC TOLLIP KRTAP5-3 TOLLIP-AS1 KRTAP5-6 KRTAP5-5 KRTAP5-1 ENSG00000287935
GH11J001207 Enhancer 0.5 dbSUPER 12.8 +49.8 49834 0.9 KLF4 ESRRA NR2F1 MYC DPF2 NR2F6 ZNF687 NR2C1 CREB1 NR2C2 MUC5AC piR-54987-017 HSALNG0082081
GH11J001323 Enhancer 0.3 Ensembl 11.3 +165.8 165848 2.8 POLR2A ESRRA TOLLIP MUC5AC TOLLIP-AS1 BRSK2 ENSG00000287935
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MUC5AC on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MUC5AC

Top Transcription factor binding sites by QIAGEN in the MUC5AC gene promoter:
  • p53
  • Sp1

Genomic Locations for MUC5AC Gene

Genomic Locations for MUC5AC Gene
chr11:1,157,953-1,201,138
(GRCh38/hg38)
Size:
43,186 bases
Orientation:
Plus strand
chr11:1,142,474-1,222,364
(GRCh37/hg19)
Size:
79,891 bases
Orientation:
Plus strand

Genomic View for MUC5AC Gene

Genes around MUC5AC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUC5AC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUC5AC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC5AC Gene

Proteins for MUC5AC Gene

  • Protein details for MUC5AC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98088-MUC5A_HUMAN
    Recommended name:
    Mucin-5AC
    Protein Accession:
    P98088
    Secondary Accessions:
    • A0A096LPK4
    • O60460
    • O76065
    • Q13792
    • Q14425
    • Q658Q1
    • Q7M4S5
    • Q8N4M9
    • Q8WWQ3
    • Q8WWQ4
    • Q8WWQ5

    Protein attributes for MUC5AC Gene

    Size:
    5654 amino acids
    Molecular mass:
    585570 Da
    Quaternary structure:
    • Multimeric.
    SequenceCaution:
    • Sequence=AAA18431.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=AAA18431.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAC15950.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAA88307.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAH56330.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MUC5AC Gene

neXtProt entry for MUC5AC Gene

Post-translational modifications for MUC5AC Gene

  • C-, O- and N-glycosylated (PubMed:14718370). O-glycosylated on the second and last Thr of the Thr-/Ser-rich tandem repeats TTPSPVPTTSTTSA (PubMed:25939779, PubMed:14718370). One form of glycosylation is also known as Lewis B (LeB) blood group antigen, a tetrasaccharide consisting of N-acetylglucosamine having a fucosyl residue attached (PubMed:14535999). It has a role as an epitope and antigen and functions as a receptor for H.pylori binding and facilitates infection (PubMed:14535999). C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis (PubMed:14718370).
  • Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.
  • Glycosylation at Asn205, Asn258, Asn415, Asn524, Asn1308, Trp1389, Trp1584, Trp1749, Trp1957, Trp2122, Trp3228, Trp3526, Asn3774, Trp3959, Trp4633, Asn4869, Asn4942, Asn5057, Asn5093, Asn5236, Asn5347, Asn5377, Asn5386, Asn5455, Asn5528, and Asn5591
  • Glycosylation from GlyConnect
    • MUC5A_HUMAN (375)

Other Protein References for MUC5AC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MUC5AC Gene

Domains & Families for MUC5AC Gene

Gene Families for MUC5AC Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for MUC5AC Gene

Blocks:
  • von Willebrand factor, type C
  • Trypsin inhibitor-like, cysteine-rich TIL region
  • Cystine knot, C-terminal
  • Von Willebrand factor, type D
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MUC5AC Gene

GenScript: Design optimal peptide antigens:
  • Mucin 5AC, oligomeric mucus/gel-forming (A7Y9J9_HUMAN)
  • Tracheobronchial mucin (MUC5A_HUMAN)
  • Gastric mucin (O75372_HUMAN)
  • Mucin (Q14851_HUMAN)
  • Mucin (Q14886_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P98088

UniProtKB/Swiss-Prot:

MUC5A_HUMAN :
  • The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.
Domain:
  • The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.
genes like me logo Genes that share domains with MUC5AC: view

Function for MUC5AC Gene

Molecular function for MUC5AC Gene

UniProtKB/Swiss-Prot Function:
Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999).
GENATLAS Biochemistry:
mucin 5A/C,tracheobronchial and gastric,with two distinct transcripts MUC5A,MUC5C,belonging to the secreted mucin cluster (MUC2,MUC5B and MUC6),involved in intestinal epithelial cell differentiation (aberrant expression in colorectal neoplasia),expressed in epithelial ovarian cancer

Phenotypes From GWAS Catalog for MUC5AC Gene

Gene Ontology (GO) - Molecular Function for MUC5AC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent TAS 7513696
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with MUC5AC: view
genes like me logo Genes that share phenotypes with MUC5AC: view

Animal Models for MUC5AC Gene

MGI Knock Outs for MUC5AC:

miRNA for MUC5AC Gene

miRTarBase miRNAs that target MUC5AC

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MUC5AC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MUC5AC Gene

Localization for MUC5AC Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC5AC Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MUC5AC gene
Compartment Confidence
extracellular 5
plasma membrane 4
golgi apparatus 4
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for MUC5AC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 25591774
GO:0005737 cytoplasm IDA 25591774
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with MUC5AC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MUC5AC Gene

Pathways & Interactions for MUC5AC Gene

genes like me logo Genes that share pathways with MUC5AC: view

Pathways by source for MUC5AC Gene

2 GeneGo (Thomson Reuters) pathways for MUC5AC Gene
  • Mucin expression in CF via IL-6, IL-17 signaling pathways
  • Mucin expression in CF via TLRs, EGFR signaling pathways

Gene Ontology (GO) - Biological Process for MUC5AC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0016266 O-glycan processing TAS --
GO:0048015 phosphatidylinositol-mediated signaling IDA 25591774
genes like me logo Genes that share ontologies with MUC5AC: view

No data available for SIGNOR curated interactions for MUC5AC Gene

Drugs & Compounds for MUC5AC Gene

(26) Drugs for MUC5AC Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fudosteine Pharma 0

(27) Additional Compounds for MUC5AC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for MUC5AC Gene

Compound Action Cas Number
Fudosteine 13189-98-5
genes like me logo Genes that share compounds with MUC5AC: view

Drug Products

Transcripts for MUC5AC Gene

mRNA/cDNA for MUC5AC Gene

2 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MUC5AC

Alternative Splicing Database (ASD) splice patterns (SP) for MUC5AC Gene

No ASD Table

Relevant External Links for MUC5AC Gene

GeneLoc Exon Structure for
MUC5AC

Expression for MUC5AC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MUC5AC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC5AC Gene

This gene is overexpressed in Stomach (x50.8).

Protein differential expression in normal tissues from HIPED for MUC5AC Gene

This gene is overexpressed in Stomach (16.3), Pancreatic juice (15.3), Nasal epithelium (14.2), and Cardia (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MUC5AC Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MUC5AC

SOURCE GeneReport for Unigene cluster for MUC5AC Gene:

Hs.534332

mRNA Expression by UniProt/SwissProt for MUC5AC Gene:

P98088-MUC5A_HUMAN
Tissue specificity: Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.

Evidence on tissue expression from TISSUES for MUC5AC Gene

  • Intestine(4.6)
  • Lung(4.6)
  • Stomach(4.6)
  • Blood(2)
genes like me logo Genes that share expression patterns with MUC5AC: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MUC5AC Gene

Orthologs for MUC5AC Gene

This gene was present in the common ancestor of animals.

Orthologs for MUC5AC Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MUC5AC 31 30
  • 76.45 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100847395 30
  • 76.16 (n)
-- 31
  • 3 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Muc5ac 17 30
  • 74.33 (n)
Sspo 31
  • 3 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Muc5ac 30
  • 74.32 (n)
oppossum
(Monodelphis domestica)
Mammalia MUC5AC 31
  • 31 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 9 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 31
  • 12 (a)
OneToMany
-- 31
  • 8 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MUC5AC 31
  • 12 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493937 30
  • 55.7 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100148804 30
  • 49.24 (n)
muc5ac 31
  • 5 (a)
OneToMany
MUC5AC (3 of 3) 31
  • 5 (a)
OneToMany
MUC5AC (1 of 3) 31
  • 3 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Hml 31
  • 4 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 11 (a)
ManyToMany
Species where no ortholog for MUC5AC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MUC5AC Gene

ENSEMBL:
Gene Tree for MUC5AC (if available)
TreeFam:
Gene Tree for MUC5AC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MUC5AC: view image

Paralogs for MUC5AC Gene

(6) SIMAP similar genes for MUC5AC Gene using alignment to 22 proteins:

  • MUC5A_HUMAN
  • A7Y9J9_HUMAN
  • E9PGF7_HUMAN
  • E9PJ98_HUMAN
  • H9XFC1_HUMAN
  • O75372_HUMAN
  • Q14851_HUMAN
  • Q14886_HUMAN
  • Q14887_HUMAN
  • Q14888_HUMAN
  • Q14889_HUMAN
  • Q14890_HUMAN
  • Q14891_HUMAN
  • Q14892_HUMAN
  • Q14893_HUMAN
  • Q96DU6_HUMAN
  • T1R7A8_HUMAN
  • T1R7M6_HUMAN
  • T1R7N1_HUMAN
  • T1R7N3_HUMAN
  • T1R7Q9_HUMAN
  • T1S9D5_HUMAN

Pseudogenes.org Pseudogenes for MUC5AC Gene

genes like me logo Genes that share paralogs with MUC5AC: view

Variants for MUC5AC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MUC5AC Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1132436 - p.Pro5521Leu

Additional dbSNP identifiers (rs#s) for MUC5AC Gene

Variation tolerance for MUC5AC Gene

Gene Damage Index Score: 6.07; 75.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MUC5AC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MUC5AC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MUC5AC Gene

Disorders for MUC5AC Gene

MalaCards: The human disease database

(107) MalaCards diseases for MUC5AC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
barrett esophagus
  • barrett metaplasia
biliary papillomatosis
  • bile duct papillomatosis
pseudomyxoma peritonei
  • mucinous ascites
otitis media
  • otitis media, susceptibility to
pancreatic ductal carcinoma
  • malignant neoplasm of duct of wirsung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MUC5AC

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MUC5AC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MUC5AC Gene

Publications for MUC5AC Gene

  1. A comprehensive analysis of common genetic variation in MUC1, MUC5AC, MUC6 genes and risk of stomach cancer. (PMID: 19924550) Jia Y … Ye W (Cancer causes & control : CCC 2010) 3 23 41 54
  2. Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif. (PMID: 9588204) van de Bovenkamp JH … Einerhand AW (Biochemical and biophysical research communications 1998) 2 3 23 54
  3. Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains. (PMID: 8948439) Klomp LW … Strous GJ (The Biochemical journal 1995) 3 4 23 54
  4. Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5). (PMID: 7513696) Meezaman D … Rose MC (The Journal of biological chemistry 1994) 3 4 23 54
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 41 54

Products for MUC5AC Gene

Sources for MUC5AC Gene