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Aliases for MUC21 Gene

Aliases for MUC21 Gene

  • Mucin 21, Cell Surface Associated 2 3 5
  • Epiglycanin 2 3 4
  • C6orf205 3 4
  • MUC-21 3 4
  • Chromosome 6 Open Reading Frame 205 2
  • Mucin-21 3
  • KMQK697 3

External Ids for MUC21 Gene

Previous HGNC Symbols for MUC21 Gene

  • C6orf205

Previous GeneCards Identifiers for MUC21 Gene

  • GC06P031060
  • GC06P030951
  • GC06P030751
  • GC06P030985
  • GC06P030995
  • GC06P031119
  • GC06P031123
  • GC06P031227

Summaries for MUC21 Gene

Entrez Gene Summary for MUC21 Gene

  • This gene encodes a large membrane-bound glycoprotein which is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. The encoded protein contains an N-terminal signal sequence, an extracellular mucin domain, a stem domain, a transmembrane domain, and a C-terminal cytoplasmic tail domain. The mucin domain contains O-glycosylation sites and is polymorphic with isoforms containing a variable number of nonidentical proline-, threonine-, and serine-rich tandem repeats of 15 amino acids each. The aberrent expression of this gene is associated with lung adenocarcinoma. [provided by RefSeq, May 2017]

GeneCards Summary for MUC21 Gene

MUC21 (Mucin 21, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC21 include Colorectal Cancer 1 and Tn Polyagglutination Syndrome. Among its related pathways are O-linked glycosylation and Metabolism of proteins. An important paralog of this gene is MUC22.

Additional gene information for MUC21 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC21 Gene

Genomics for MUC21 Gene

GeneHancer (GH) Regulatory Elements for MUC21 Gene

Promoters and enhancers for MUC21 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J030981 Enhancer 0.9 Ensembl ENCODE 650.7 -1.4 -1431 0.7 CTCF ZBTB6 MZF1 ZNF2 ZNF335 ZFHX2 ZNF366 ZNF143 PRDM10 ZNF444 MUC21 HCG21 MUCL3 GTF2H4 VARS2 DDR1 NAPGP2
GH06J030983 Promoter 0.6 EPDnew 650.7 0.0 -9 0.1 SCRT2 MUC21 NAPGP2
GH06J030998 Promoter 0.7 EPDnew 0.4 +15.1 15128 0.1 CTBP1 GATA3 FOXA1 SFTA2 MUCL3 HCG21 MUC22 MUC21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MUC21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MUC21 gene promoter:
  • AML1a
  • STAT1
  • TBP
  • C/EBPalpha

Genomic Locations for MUC21 Gene

Genomic Locations for MUC21 Gene
6,196 bases
Plus strand
6,196 bases
Plus strand

Genomic View for MUC21 Gene

Genes around MUC21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUC21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUC21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MUC21 Gene

  • Protein details for MUC21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B0UZT7
    • B4DQ55
    • C9JMK2
    • D9N007
    • Q0VGF1
    • Q3B7T2
    • Q5SS94
    • Q6UXC5

    Protein attributes for MUC21 Gene

    566 amino acids
    Molecular mass:
    54228 Da
    Quaternary structure:
    No Data Available
    • Could be considered as a marker for lung carcinomas.
    • Sequence=AAI05737.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MUC21 Gene


neXtProt entry for MUC21 Gene

Post-translational modifications for MUC21 Gene

Other Protein References for MUC21 Gene

No data available for DME Specific Peptides for MUC21 Gene

Domains & Families for MUC21 Gene

Gene Families for MUC21 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MUC21 Gene

Suggested Antigen Peptide Sequences for MUC21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MUC21: view

No data available for UniProtKB/Swiss-Prot for MUC21 Gene

Function for MUC21 Gene

Phenotypes From GWAS Catalog for MUC21 Gene

genes like me logo Genes that share phenotypes with MUC21: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MUC21 Gene

Localization for MUC21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC21 Gene

Cell membrane; Single-pass type I membrane protein; Extracellular side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MUC21 gene
Compartment Confidence
extracellular 5
plasma membrane 4
golgi apparatus 4
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MUC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with MUC21: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MUC21 Gene

Pathways & Interactions for MUC21 Gene

genes like me logo Genes that share pathways with MUC21: view

Interacting Proteins for MUC21 Gene

Gene Ontology (GO) - Biological Process for MUC21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0007162 negative regulation of cell adhesion IEA --
GO:0016266 O-glycan processing TAS --
GO:0022408 negative regulation of cell-cell adhesion IBA --
genes like me logo Genes that share ontologies with MUC21: view

No data available for SIGNOR curated interactions for MUC21 Gene

Drugs & Compounds for MUC21 Gene

No Compound Related Data Available

Transcripts for MUC21 Gene

mRNA/cDNA for MUC21 Gene

(3) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MUC21 Gene

Mucin 21, cell surface associated:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MUC21 Gene

No ASD Table

Relevant External Links for MUC21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MUC21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MUC21 Gene

mRNA differential expression in normal tissues according to GTEx for MUC21 Gene

This gene is overexpressed in Esophagus - Mucosa (x32.5), Vagina (x9.2), Cervix - Ectocervix (x6.3), and Minor Salivary Gland (x4.6).

Protein differential expression in normal tissues from HIPED for MUC21 Gene

This gene is overexpressed in Esophagus (31.8), Saliva (28.6), and Cervix (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MUC21 Gene

Protein tissue co-expression partners for MUC21 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MUC21 Gene:


SOURCE GeneReport for Unigene cluster for MUC21 Gene:


mRNA Expression by UniProt/SwissProt for MUC21 Gene:

Tissue specificity: Expressed in lung, large intestine, thymus, and testis. Expressed in normal and malignant bronchial epithelial cells.
genes like me logo Genes that share expression patterns with MUC21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MUC21 Gene

Orthologs for MUC21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MUC21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MUC21 34 33
  • 94.08 (n)
(Canis familiaris)
Mammalia MUC21 33
  • 70.51 (n)
Species where no ortholog for MUC21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC21 Gene

Gene Tree for MUC21 (if available)
Gene Tree for MUC21 (if available)
Evolutionary constrained regions (ECRs) for MUC21: view image

Paralogs for MUC21 Gene

Paralogs for MUC21 Gene

genes like me logo Genes that share paralogs with MUC21: view

Variants for MUC21 Gene

Sequence variations from dbSNP and Humsavar for MUC21 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs772843697 benign, not specified 30,986,840(+) C/ coding_sequence_variant, frameshift, non_coding_transcript_variant
rs1000583547 -- 30,988,759(+) C/T downstream_transcript_variant
rs1000765494 -- 30,981,975(+) C/T upstream_transcript_variant
rs1001478867 -- 30,985,188(+) C/T intron_variant
rs1001610464 -- 30,984,115(+) A/G intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MUC21 Gene

Variant ID Type Subtype PubMed ID
dgv10370n54 CNV loss 21841781
esv2670269 CNV deletion 23128226
esv2677358 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv2731799 CNV deletion 23290073
esv2731800 CNV deletion 23290073
esv3411275 CNV duplication 20981092
esv3608518 CNV gain 21293372
esv5663 CNV loss 19470904
nsv1023108 CNV gain 25217958
nsv1031677 CNV gain 25217958
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv462744 CNV loss 19166990
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv601483 CNV loss 21841781
nsv601484 CNV loss 21841781

Variation tolerance for MUC21 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.82; 83.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MUC21 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MUC21 Gene

Disorders for MUC21 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MUC21 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer 1
  • colorectal cancer, susceptibility to, 1
tn polyagglutination syndrome
  • tnps
- elite association - COSMIC cancer census association via MalaCards
Search MUC21 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MUC21

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MUC21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MUC21 Gene

Publications for MUC21 Gene

  1. Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin. (PMID: 17977904) Itoh Y … Irimura T (Glycobiology 2008) 2 3 4 58
  2. Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe. (PMID: 21801394) Génin E … Mockenhaupt M (Orphanet journal of rare diseases 2011) 3 44 58
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for MUC21 Gene

Sources for MUC21 Gene

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