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This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat d... See more...
Aliases for MUC16 Gene
Aliases for MUC16 Gene
External Ids for MUC16 Gene
- HGNC: 15582
- Entrez Gene: 94025
- Ensembl: ENSG00000181143
- OMIM: 606154
- UniProtKB: Q8WXI7
Previous GeneCards Identifiers for MUC16 Gene
- GC19M009087
- GC19M009182
- GC19M008805
- GC19M008820
- GC19U900441
- GC19M008904
- GC19M008960
- GC19M008584
Summaries for MUC16 Gene
-
This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017]
GeneCards Summary for MUC16 Gene
MUC16 (Mucin 16, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC16 include Ovarian Cyst and Clear Cell Adenocarcinoma. Among its related pathways are Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) and Metabolism of proteins.
UniProtKB/Swiss-Prot Summary for MUC16 Gene
-
Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
Additional gene information for MUC16 Gene
- HGNC(15582)
- Entrez Gene(94025)
- Ensembl(ENSG00000181143)
- OMIM(606154)
- UniProtKB(Q8WXI7)
- Open Targets Platform(ENSG00000181143)
- Monarch Initiative
- Search for MUC16 at DataMed
- Search for MUC16 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MUC16 Gene
Genomics for MUC16 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MUC16 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH19J009009 | Enhancer | 0.3 | FANTOM5 | 611.9 | +0.4 | 350 | 0.2 | POLR2A | MUC16 HSALNG0123795 ZNF558 | |
| GH19J009008 | Enhancer | 0.3 | ENCODE | 600.7 | +1.5 | 1510 | 0.2 | ESR1 | MUC16 HSALNG0123795 ZNF558 | |
| GH19J009074 | Enhancer | 1.1 | ENCODE CraniofacialAtlas | 22.5 | -65.1 | -65147 | 1.7 | PRDM10 ZNF629 LEF1 IKZF1 ZNF692 JUND ZIC2 PKNOX1 PATZ1 REST | MUC16 ZNF414 LOC100419831 ZNF559 ZNF558 HNRNPM ZNF266 OR7G1 ZNF699 ZNF121 | |
| GH19J009052 | Enhancer | 0.8 | ENCODE | 26.4 | -44.1 | -44099 | 3.7 | PRDM10 KDM1A FOXA1 RFX1 ZIC2 REST ARNT SP1 SMARCC1 ATF3 | MUC16 ZNF177 ENSG00000267289 ENSG00000267273 ENSG00000200237 RF00017-2795 HG983750 TRQ-TTG8-1 OR1M1 | |
| GH19J009069 | Enhancer | 0.6 | Ensembl ENCODE | 29.6 | -60.0 | -59981 | 1.7 | TEAD4 ZNF341 SP1 EZH2 YY1 BACH1 | MUC16 OR7G1 OR7G3 OR1M4P RF00017-2795 lnc-OR7G2-1 OR1M1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MUC16 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MUC16
Genomic Locations for MUC16 Gene
Genomic Locations for MUC16 Gene
- chr19:8,848,840-9,010,390
- (GRCh38/hg38)
- Size:
- 161,551 bases
- Orientation:
- Minus strand
- chr19:8,959,520-9,092,018
- (GRCh37/hg19)
- Size:
- 132,499 bases
- Orientation:
- Minus strand
Genomic View for MUC16 Gene
Genes around MUC16 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
MUC16 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MUC16 Gene
Proteins for MUC16 Gene
-
Protein details for MUC16 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WXI7-MUC16_HUMAN
- Recommended name:
- Mucin-16
- Protein Accession:
- Q8WXI7
- B5ME49
- Q6ZQW5
- Q96RK2
Protein attributes for MUC16 Gene
- Size:
- 14507 amino acids
- Molecular mass:
- 1519175 Da
- Quaternary structure:
-
- Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN.
- SequenceCaution:
-
- Sequence=AAL65133.2; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAC87568.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- Antigen that is the basis for a widely used serum assay for the monitoring of patients with ovarian epithelial cancer. Due to lack of sensitivity for stage I disease and lack of specificity, it is of little value in the detection of early ovarian cancer. Due to its similarly elevated levels in some nonmalignant conditions, it is not specific enough to be used for population screening.
Protein Expression for MUC16 Gene
Post-translational modifications for MUC16 Gene
- Heavily O-glycosylated; expresses both type 1 and type 2 core glycans.
- Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans.
- May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.
- May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
-
Glycosylation at Asn139, Asn434, Ser472, Ser475, Ser477, Thr480, Ser620, Thr623, Thr624, Thr628, Ser708, Ser709, Thr718, Asn787, Ser908, Ser912, Ser913, Ser914, Ser918, Asn930, Asn957, Asn1375, Thr1512, Ser1514, Thr1515, Thr1516, Asn1633, Asn1840, Ser1864, Thr1867, Thr1870, Asn1877, Asn1890, Asn2345, Asn2375, Asn2737, Thr2982, Asn3085, Ser3146, Ser3147, Ser3149, Asn3178, Ser3210, Ser3211, Ser3215, Ser3217, Thr3390, Ser3395, Thr3396, Thr3397, Ser3401, Thr3402, Thr3415, Ser3416, Asn3501, Ser3795, Thr3799, Ser3801, Thr3806, Ser3807, Thr3813, Ser3814, Thr3815, Thr3819, Thr3820, Thr3821, Ser3822, Ser3831, Thr3834, Thr3835, Thr3842, Thr4007, Ser4011, Thr4014, Ser4058, Ser4059, Ser4065, Thr4130, Ser4132, Thr4135, Thr4136, Asn4220, Thr4250, Thr4255, Ser4256, Ser4260, Thr4266, Ser4269, Asn4498, Asn4606, Asn4613, Asn4624, Ser4660, Ser4663, Asn4861, Thr5091, Asn5096, Asn5131, Thr5185, Thr5189, Asn5228, Ser5234, Thr5235, Ser5241, Thr5242, Thr5247, Thr5249, Thr5257, Ser5258, Ser5259, Thr5262, Asn5320, Asn5394, Asn5470, Thr5553, Ser5554, Thr5558, Asn5689, Thr5774, Ser5776, Thr5777, Ser5778, Ser5779, Asn5863, Ser5900, Thr5903, Thr5904, Thr5905, Thr6071, Ser6072, Asn6088, Thr6263, Thr6273, Ser6358, Thr6360, Thr6361, Ser6363, Ser6381, Thr6383, Ser6384, Thr6385, Thr6392, Thr6395, Thr6396, Thr6429, Ser6432, Thr6433, Thr6438, Thr6444, Thr6447, Thr6449, Thr6575, Thr6576, Ser6577, Thr6583, Thr6682, Thr6683, Thr6686, Thr6688, Ser6689, Thr6691, Ser6695, Asn6732, Asn6859, Ser6945, Thr6946, Ser6948, Thr6950, Asn6961, Ser7069, Thr7072, Thr7073, Ser7076, Ser7240, Ser7242, Ser7243, Ser7365, Thr7368, Thr7369, Ser7372, Ser7534, Ser7538, Ser7539, Thr7541, Thr7542, Ser7608, Ser7610, Ser7611, Thr7614, Ser7616, Ser7674, Ser7677, Thr7823, Ser7827, Ser7828, Thr7830, Ser7958, Ser7961, Asn8029, Asn8055, Thr8113, Thr8116, Ser8117, Ser8118, Thr8120, Ser8237, Ser8239, Thr8242, Thr8243, Ser8246, Asn8324, Thr8411, Ser8412, Thr8415, Ser8416, Ser8534, Thr8537, Thr8538, Ser8541, Asn8618, Ser8642, Ser8643, Thr8645, Thr8652, Asn8684, Ser8714, Thr8715, Ser8716, Thr8719, Ser8720, Ser8721, Thr8723, Thr8791, Ser8797, Ser8798, Thr8803, Ser8807, Ser8808, Ser8811, Thr8815, Ser8817, Thr8820, Ser8840, Ser8843, Thr8884, Thr8888, Asn8913, Thr9007, Ser9008, Thr9009, Ser9010, Thr9017, Ser9020, Thr9021, Asn9202, Thr9363, Thr9368, Asn9493, Thr9551, Ser9552, Ser9714, Thr9716, Ser9717, Asn9785, Ser9809, Thr9812, Thr9869, Thr9872, Ser9874, Thr9876, Ser9994, Thr9997, Thr9998, Ser10001, Ser10003, Asn10075, Asn10173, Ser10299, Ser10301, Thr10424, Thr10426, Thr10434, Thr10445, Thr10454, Ser10455, Thr10456, Ser10457, Ser10460, Asn10510, Thr10679, Thr10681, Thr10682, Thr10685, Thr10690, Ser10691, Ser10692, Asn10700, Asn10749, Thr10794, Ser10795, Thr10798, Ser10799, Asn11053, Asn11224, Asn11263, Asn11367, Asn11594, Thr11608, Ser11609, Ser11836, Thr11838, Ser11840, Ser11844, Ser11963, Thr11965, Asn12079, Asn12100, Asn12116, Asn12168, Asn12235, Asn12272, Asn12393, Asn12414, Asn12430, Asn12549, Asn12570, Asn12586, Asn12704, Asn12725, Asn12741, Asn12824, Asn12860, Asn12881, Asn12897, Asn13016, Asn13037, Asn13053, Asn13172, Asn13193, Asn13328, Asn13349, Asn13365, Asn13484, Asn13505, Asn13521, Asn13640, Asn13661, Asn13733, Asn13744, Ser13774, Thr13776, Asn13796, Asn13816, Asn13832, Asn13929, Asn13950, Asn14080, Asn14100, Asn14195, Asn14212, Asn14254, Asn14287, Asn14326, Asn14363, Asn14417, and Asn14423
- NX_Q8WXI7 (NX_Q8WXI7-1)
- Modification sites at PhosphoSitePlus
Other Protein References for MUC16 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ MUC16 Antibody and Immunotag™ Mucin 16 Polyclonal Antibody
- NSJ Bioreagents MUC16 Antibody / CA125 (Recombinant Rabbit Monoclonal)
- GeneTex Anti-CA125 antibody [X75] and Anti-CA125 antibody [X325]
-
Custom Antibody ServicesOriGene Antibodies for MUC16
- AM09240PU-N
- AM09241PU-N
- AM09242PU-N
- AM09243PU-N
- AM09244PU-N
- AM10052SU-N
- CF801209
- CF801210
- CF801212
- CF801241
- CF801279
- CF801281
- CF801872
- CF801881
- TA315999
- TA322180
- TA590450
- TA801209
- TA801209S
- TA801210
- TA801210S
- TA801212
- TA801212S
- TA801241
- TA801241S
- TA801279
- TA801279S
- TA801281
- TA801281S
- TA801872
- TA801872S
- TA801881
- TA801881S
- Novus Biologicals Antibodies for MUC16
-
Abcam antibodies for MUC16
- Invitrogen Antibodies for MUC16 (AFLGC-MUC16)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MUC16
Protein Products
-
OriGene Purified Proteins for MUC16
- Search Origene for MassSpec and Protein Over-expression Lysates for MUC16
- Origene Custom Protein Services for MUC16
- Novus Biologicals proteins for MUC16
-
Signalway Proteins for MUC16
-
Abcam proteins for MUC16
No data available for DME Specific Peptides for MUC16 Gene
Domains & Families for MUC16 Gene
Gene Families for MUC16 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for MUC16 Gene
- InterPro:
- Blocks:
-
- SEA domain
- ProtoNet:
Suggested Antigen Peptide Sequences for MUC16 Gene
- GenScript: Design optimal peptide antigens:
-
- Ovarian carcinoma antigen CA125 (MUC16_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8WXI7UniProtKB/Swiss-Prot:
MUC16_HUMAN :- Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing between 12 and 60 partially conserved tandem repeats of 156 amino acids and a C-terminal transmembrane contain domain with a short cytoplasmic tail.
- Domain:
-
- Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing between 12 and 60 partially conserved tandem repeats of 156 amino acids and a C-terminal transmembrane contain domain with a short cytoplasmic tail.
Function for MUC16 Gene
Molecular function for MUC16 Gene
- UniProtKB/Swiss-Prot Function:
- Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in ovarian cancer cells.
Phenotypes From GWAS Catalog for MUC16 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 14676194 |
Phenotypes for MUC16 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for MUC16
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MUC16 - Select products 50% OFF >
- * MUC16 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MUC16
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MUC16
-
Santa Cruz Biotechnology (SCBT) CRISPR for MUC16
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MUC16
- Browse OriGene Inhibitory RNA Products For MUC16
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MUC16
Clone Products
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MUC16
Cell Line Products
-
Horizon Cell Lines for MUC16
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MUC16 Gene
Localization for MUC16 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MUC16 Gene
- Cell membrane. Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| golgi apparatus | 4 |
| cytoskeleton | 3 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| endosome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005796 | Golgi lumen | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MUC16 Gene
Pathways & Interactions for MUC16 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) |
.62
|
|
| 2 | Diseases of glycosylation | ||
| 3 | Innate Immune System |
.61
|
|
| 4 | Metabolism of proteins | ||
| 5 | O-linked glycosylation | ||
Pathways by source for MUC16 Gene
Interacting Proteins for MUC16 Gene
GPS-Prot Interaction Network for MUC16
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0007155 | cell adhesion | NAS | 14676194 |
| GO:0016266 | O-glycan processing | TAS | -- |
No data available for SIGNOR curated interactions for MUC16 Gene
Drugs & Compounds for MUC16 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for MUC16 Gene
mRNA/cDNA for MUC16 Gene
- 1 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000397910 43816 nts (view in UCSC)
- ENST00000596768 2888 nts (view in UCSC)
- ENST00000596956 352 nts (view in UCSC)
- ENST00000599436 4079 nts (view in UCSC)
- ENST00000601404 4078 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MUC16 - Select products 50% OFF >
- * MUC16 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MUC16
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MUC16
-
Santa Cruz Biotechnology (SCBT) CRISPR for MUC16
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MUC16
- Browse OriGene Inhibitory RNA Products For MUC16
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MUC16
Clone Products
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MUC16
Relevant External Links for MUC16 Gene
- GeneLoc Exon Structure for
- MUC16
Expression for MUC16 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for MUC16 Gene
This gene is overexpressed in Cervix - Endocervix (x24.2), Minor Salivary Gland (x8.7), and Adipose - Visceral (Omentum) (x8.3).
This gene is overexpressed in Cervix (19.9), Breast (18.8), Liver (11.8), and Platelet (8.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MUC16 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MUC16
SOURCE GeneReport for Unigene cluster for MUC16 Gene:
Hs.432676mRNA Expression by UniProt/SwissProt for MUC16 Gene:
Q8WXI7-MUC16_HUMAN
Tissue specificity:
Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.
Evidence on tissue expression from TISSUES for MUC16 Gene
- Lung(2.9)
- Intestine(2.7)
- Eye(2.5)
- Blood(2.3)
- Liver(2.1)
Primer Products
-
OriGene qPCR primer pairs for MUC16
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MUC16 Gene
Orthologs for MUC16 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MUC16 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Muc16 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MUC16 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MUC16 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MUC16 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MUC16 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MUC16 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MUC16 31 |
|
OneToOne |
- Species where no ortholog for MUC16 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for MUC16 Gene
- ENSEMBL:
- Gene Tree for MUC16 (if available)
- TreeFam:
- Gene Tree for MUC16 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MUC16: view image
Paralogs for MUC16 Gene
No data available for Paralogs for MUC16 Gene
Variants for MUC16 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for MUC16 Gene
- MUC16_HUMAN-Q8WXI7
- The number of repeats is highly polymorphic and can be composed between 12 and 60 extracellular mucin repeats.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MUC16 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 718464 | Benign: not provided | 8,882,863(-) | C/T | SYNONYMOUS_VARIANT | |
| 720412 | Benign: not provided | 8,948,212(-) | C/T | MISSENSE_VARIANT | |
| 724122 | Benign: not provided | 8,963,211(-) | G/T | MISSENSE_VARIANT | |
| 726691 | Likely Benign: not provided | 8,956,342(-) | C/G | MISSENSE_VARIANT | |
| 726692 | Likely Benign: not provided | 8,958,627(-) | A/G | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv48n68 | CNV | gain | 17160897 |
| dgv621e199 | CNV | deletion | 23128226 |
| esv2117991 | CNV | deletion | 18987734 |
| esv2221846 | CNV | deletion | 18987734 |
| esv2664410 | CNV | deletion | 23128226 |
| esv2718141 | CNV | deletion | 23290073 |
| esv2718142 | CNV | deletion | 23290073 |
| esv2718143 | CNV | deletion | 23290073 |
| esv2718144 | CNV | deletion | 23290073 |
| esv2718145 | CNV | deletion | 23290073 |
| esv2718146 | CNV | deletion | 23290073 |
| esv2718147 | CNV | deletion | 23290073 |
| esv2758744 | CNV | gain+loss | 17122850 |
| esv2762024 | CNV | gain | 21179565 |
| esv3347927 | CNV | insertion | 20981092 |
| esv3377252 | CNV | insertion | 20981092 |
| esv3555996 | CNV | deletion | 23714750 |
| esv3574308 | CNV | gain | 25503493 |
| esv3643623 | CNV | gain | 21293372 |
| esv3643624 | CNV | loss | 21293372 |
| nsv1063481 | CNV | gain | 25217958 |
| nsv1066058 | CNV | gain | 25217958 |
| nsv1067291 | CNV | loss | 25217958 |
| nsv1067521 | CNV | loss | 25217958 |
| nsv1070217 | CNV | deletion | 25765185 |
| nsv1076464 | CNV | duplication | 25765185 |
| nsv1118613 | CNV | duplication | 24896259 |
| nsv1123217 | CNV | deletion | 24896259 |
| nsv1124777 | CNV | duplication | 24896259 |
| nsv1148080 | CNV | duplication | 26484159 |
| nsv2406 | CNV | insertion | 18451855 |
| nsv2407 | CNV | insertion | 18451855 |
| nsv428362 | CNV | gain+loss | 18775914 |
| nsv469648 | CNV | gain+loss | 16826518 |
| nsv470123 | CNV | loss | 18288195 |
| nsv473060 | CNV | novel sequence insertion | 20440878 |
| nsv473504 | CNV | novel sequence insertion | 20440878 |
| nsv475070 | CNV | novel sequence insertion | 20440878 |
| nsv475838 | CNV | novel sequence insertion | 20440878 |
| nsv476136 | CNV | novel sequence insertion | 20440878 |
| nsv476877 | CNV | novel sequence insertion | 20440878 |
| nsv479273 | CNV | novel sequence insertion | 20440878 |
| nsv479569 | CNV | novel sequence insertion | 20440878 |
| nsv479657 | CNV | novel sequence insertion | 20440878 |
| nsv481459 | CNV | novel sequence insertion | 20440878 |
| nsv483078 | CNV | gain+loss | 15286789 |
| nsv523652 | CNV | loss | 19592680 |
| nsv954645 | CNV | deletion | 24416366 |
| nsv962999 | CNV | duplication | 23825009 |
| nsv963000 | CNV | duplication | 23825009 |
| nsv978767 | CNV | duplication | 23825009 |
| nsv978768 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
100% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
31.77;
99.93% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MUC16 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for MUC16 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ovarian cyst |
|
|
| clear cell adenocarcinoma |
|
|
| serous cystadenocarcinoma |
|
|
| pleural cancer |
|
|
| cystadenocarcinoma |
|
Search MUC16 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MUC16
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MUC16 Gene
Publications for MUC16 Gene
- Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer. (PMID: 15788735) McLemore MR … Aouizerat B (Biological research for nursing 2005) 3 4 23
- Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. (PMID: 14676194) Rump A … Miyajima A (The Journal of biological chemistry 2004) 3 4 23
- Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125. (PMID: 12734200) Kui Wong N … Patankar MS (The Journal of biological chemistry 2003) 3 4 23
- Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. (PMID: 11369781) Yin BW … Lloyd KO (The Journal of biological chemistry 2001) 2 3 4
- MUC16 expression and risk of adenocarcinoma metastases to peritoneum, pleura, leptomeninges, and brain. (PMID: 20090516) Johnson MD … Xu H (Applied immunohistochemistry & molecular morphology : AIMM 2010) 3 23
ExternalLinks
Products for MUC16 Gene
- View all 25 R&D Systems MUC16 (CA125/MUC16) Products
- View all R&D Systems MUC16 (CA125/MUC16) Proteins and Enzymes
- View all 18 R&D Systems MUC16 (CA125/MUC16) Primary Antibodies
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- View all R&D Systems MUC16 (CA125/MUC16) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom MUC16 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for MUC16
- AM09240PU-N
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- Taconic Biosciences Mouse Models for MUC16
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- VectorBuilder Custom and pre-made DNA vectors for MUC16 (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder Virus packaging for MUC16 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MUC16
- antibodies-online: Show 99 available MUC16 Antibodies ranked by validation data
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- antibodies-online: Show 19 available MUC16 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for MUC16
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MUC16
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Sources for MUC16 Gene
- (1) GeneCards
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- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
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- (15) ProtoNet
- (16) Blocks
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- (22) IntAct
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- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
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- (48) IMGT
- (49) Leiden
- (50) miRBase
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- (52) OriGene
- (53) PubMed
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- (55) TGDB
- (56) Tocris
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
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- (83) Illumina
- (84) COMPARTMENTS
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- (88) Addgene
- (89) antibodies-online
- (90) CYP
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- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
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- (100) DGIdb
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- (104) diseasecard
- (105) NIH Rare Diseases
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- (156) Mastermind
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- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
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- (163) LncBase
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