Aliases for MUC12 Gene
External Ids for MUC12 Gene
Previous HGNC Symbols for MUC12 Gene
Previous GeneCards Identifiers for MUC12 Gene
This gene encodes an integral membrane glycoprotein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces and have been implicated in epithelial renewal and differentiation. These glycoproteins also play a role in intracellular signaling. This protein is expressed on the apical membrane surface of epithelial cells that line the mucosal surfaces of many different tissues including the colon, pancreas, prostate, and uterus. The expression of this gene is downregulated in colorectal cancer tissue. [provided by RefSeq, Apr 2017]
GeneCards Summary for MUC12 Gene
MUC12 (Mucin 12, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC12 include Tn Polyagglutination Syndrome and Colorectal Cancer. Among its related pathways are Metabolism of proteins and CLEC7A (Dectin-1) signaling. An important paralog of this gene is SRRM2.
UniProtKB/Swiss-Prot Summary for MUC12 Gene
Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium.