MTUS1 Gene (Protein Coding)

Microtubule Associated Scaffold Protein 1

GC08M017643
GIFtS:
38
This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a t... See more...

Aliases for MTUS1 Gene

Aliases for MTUS1 Gene

  • Microtubule Associated Scaffold Protein 1 2 3 5
  • MTSG1 2 3 4
  • ATBP 2 3 4
  • Angiotensin-II Type 2 Receptor-Interacting Protein 3 4
  • Microtubule Associated Tumor Suppressor 1 2 3
  • Microtubule-Associated Tumor Suppressor 1 3 4
  • Mitochondrial Tumor Suppressor Gene 1 2 3
  • AT2 Receptor-Interacting Protein 2 3
  • Mitochondrial Tumor Suppressor 1 2 4
  • AT2 Receptor-Binding Protein 3 4
  • AT2R Binding Protein 2 3
  • KIAA1288 2 4
  • ATIP3 2 3
  • ATIP 3 4
  • ICIS 2 3
  • MP44 2 3
  • Erythroid Differentiation-Related 3
  • Transcription Factor MTSG1 3
  • DKFZp586D1519 2
  • FLJ14295 2
  • MTUS1 5
  • ATIP1 2
  • GK1 4

External Ids for MTUS1 Gene

Previous GeneCards Identifiers for MTUS1 Gene

  • GC08M017512
  • GC08M017545
  • GC08M016045
  • GC08M017501

Summaries for MTUS1 Gene

Entrez Gene Summary for MTUS1 Gene

  • This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008]

GeneCards Summary for MTUS1 Gene

MTUS1 (Microtubule Associated Scaffold Protein 1) is a Protein Coding gene. Diseases associated with MTUS1 include Hepatocellular Carcinoma and Diffuse Glomerulonephritis. An important paralog of this gene is MTUS2.

UniProtKB/Swiss-Prot Summary for MTUS1 Gene

  • Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.

Gene Wiki entry for MTUS1 Gene

Additional gene information for MTUS1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MTUS1 Gene

Genomics for MTUS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MTUS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MTUS1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MTUS1

Top Transcription factor binding sites by QIAGEN in the MTUS1 gene promoter:
  • aMEF-2
  • Lmo2
  • MEF-2
  • MEF-2A
  • POU2F1
  • POU2F1a
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for MTUS1 Gene

Latest Assembly
chr8:17,643,794-17,801,521
(GRCh38/hg38)
Size:
157,728 bases
Orientation:
Minus strand

Previous Assembly
chr8:17,501,311-17,659,030
(GRCh37/hg19 by Entrez Gene)
Size:
157,720 bases
Orientation:
Minus strand

chr8:17,501,304-17,658,426
(GRCh37/hg19 by Ensembl)
Size:
157,123 bases
Orientation:
Minus strand

Genomic View for MTUS1 Gene

Genes around MTUS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTUS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTUS1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MTUS1 Gene

Proteins for MTUS1 Gene

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  • Protein details for MTUS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULD2-MTUS1_HUMAN
    Recommended name:
    Microtubule-associated tumor suppressor 1
    Protein Accession:
    Q9ULD2
    Secondary Accessions:
    • A8K135
    • B2RBJ6
    • B3KWJ9
    • B4DH03
    • B9EGA1
    • D3DSP8
    • Q63HJ6
    • Q659F4
    • Q6PK49
    • Q6URW7
    • Q8N4M6
    • Q8WTT9
    • Q9H7T2

    Protein attributes for MTUS1 Gene

    Size:
    1270 amino acids
    Molecular mass:
    141397 Da
    Quaternary structure:
    • Homodimer. Interacts with AGTR2. Interacts with PTPN6 (By similarity). Isoform 1 associates with microtubules.
    SequenceCaution:
    • Sequence=AAH07328.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH33842.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14894.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 5]: Expressed at very low levels in most tissues.

    Alternative splice isoforms for MTUS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTUS1 Gene

Protein Expression for MTUS1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MTUS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTUS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTUS1 Gene

Domains & Families for MTUS1 Gene

Gene Families for MTUS1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MTUS1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTUS1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59507, highly similar to Homo sapiens mitochondrial tumor suppressor 1 (MTUS1), transcript variant 4, mRNA (B4DH03_HUMAN)
  • Mitochondrial tumor suppressor 1 (MTUS1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULD2

UniProtKB/Swiss-Prot:

MTUS1_HUMAN :
  • Belongs to the MTUS1 family.
Family:
  • Belongs to the MTUS1 family.
genes like me logo Genes that share domains with MTUS1: view

Function for MTUS1 Gene

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  6. Cell Lines for research

Molecular function for MTUS1 Gene

UniProtKB/Swiss-Prot Function:
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.
UniProtKB/Swiss-Prot Induction:
[Isoform 1]: Down-regulated in invasive breast carcinomas (at protein level).

Phenotypes From GWAS Catalog for MTUS1 Gene

Gene Ontology (GO) - Molecular Function for MTUS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
GO:0008017 microtubule binding IBA 21873635
genes like me logo Genes that share ontologies with MTUS1: view
genes like me logo Genes that share phenotypes with MTUS1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTUS1

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTUS1 Gene

Localization for MTUS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTUS1 Gene

Mitochondrion. Golgi apparatus. Cell membrane. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II. {ECO:0000250}.
[Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTUS1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 4
extracellular 4
mitochondrion 4
golgi apparatus 3
endoplasmic reticulum 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (4)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MTUS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 22664934
GO:0005634 nucleus IBA 21873635
GO:0005730 nucleolus IDA --
GO:0005737 colocalizes_with cytoplasm IBA 21873635
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with MTUS1: view

Pathways & Interactions for MTUS1 Gene

PathCards logo

SuperPathways for MTUS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTUS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010758 regulation of macrophage chemotaxis IBA 21873635
genes like me logo Genes that share ontologies with MTUS1: view

No data available for Pathways by source and SIGNOR curated interactions for MTUS1 Gene

Drugs & Compounds for MTUS1 Gene

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No Compound Related Data Available

Transcripts for MTUS1 Gene

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mRNA/cDNA for MTUS1 Gene

13 REFSEQ mRNAs :
42 NCBI additional mRNA sequence :
29 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTUS1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for MTUS1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ·
SP1: - - - - - - - - - - -
SP2: - - - -
SP3:
SP4: - - - - - - - - -
SP5:
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - -
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - - - - - - - - - -
SP14: - - -
SP15: - - - -
SP16:
SP17:
SP18:
SP19: - - - -
SP20:
SP21:
SP22: - - - - -
SP23:
SP24:
SP25: - -

ExUns: 20c · 20d · 20e ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b · 27c · 27d ^ 28a · 28b · 28c · 28d ^ 29 ^ 30 ^ 31a · 31b ^ 32a · 32b ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6:
SP7: - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - -
SP11: - - - - - -
SP12: - - -
SP13:
SP14:
SP15: - - - - - - - - - - - - -
SP16: -
SP17:
SP18: -
SP19:
SP20:
SP21:
SP22: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP23:
SP24:
SP25:

ExUns: 33a · 33b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for MTUS1 Gene

GeneLoc Exon Structure for
MTUS1

Expression for MTUS1 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MTUS1 Gene

mRNA expression in normal human tissues for MTUS1 Gene
mRNA expression by BioGPS for MTUS1 GenemRNA expression by GTEx for MTUS1 Gene

Protein differential expression in normal tissues from HIPED for MTUS1 Gene

This gene is overexpressed in Serum (34.0) and Pancreas (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MTUS1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MTUS1

SOURCE GeneReport for Unigene cluster for MTUS1 Gene:

Hs.7946

mRNA Expression by UniProt/SwissProt for MTUS1 Gene:

Q9ULD2-MTUS1_HUMAN
Tissue specificity: Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain.

Evidence on tissue expression from TISSUES for MTUS1 Gene

  • Nervous system(5)
  • Lung(4.5)
  • Liver(4.5)
  • Skin(4.5)
  • Heart(2.6)
  • Muscle(2.6)
  • Kidney(2.2)
  • Intestine(2.1)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with MTUS1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTUS1 Gene

Orthologs for MTUS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTUS1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MTUS1 31
  • 98 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MTUS1 30 31
  • 86.48 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MTUS1 30 31
  • 84.27 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Mtus1 30 17 31
  • 75.82 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia LOC100911065 30
  • 69.33 (n)
Oppossum
(Monodelphis domestica)
 Mammalia MTUS1 31
  • 57 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia MTUS1 31
  • 51 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves MTUS1 31
  • 67 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MTUS1 31
  • 60 (a)
 OneToOne
African clawed frog
(Xenopus laevis)
 Amphibia LOC398697 30
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia Str.13519 30
Zebrafish
(Danio rerio)
 Actinopterygii mtus1a 31
  • 26 (a)
 OneToMany
MTUS1 (1 of 2) 31
  • 18 (a)
 OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.6933 30
Species where no ortholog for MTUS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MTUS1 Gene

ENSEMBL:
Gene Tree for MTUS1 (if available)
TreeFam:
Gene Tree for MTUS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MTUS1: view image

Paralogs for MTUS1 Gene

Paralogs for MTUS1 Gene

genes like me logo Genes that share paralogs with MTUS1: view

Variants for MTUS1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MTUS1 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
157106 Not Provided: Small for gestational age; Preeclampsia; Normal pregnancy 17,723,281(-) ATATTAGTCCTATTAC
NM_001001924.2(MTUS1):c.2288-795_2449+390del 		SPLICE_ACCEPTOR_VARIANT,SPLICE_DONOR_VARIANT,INTRON
rs1554507014 Not Provided: Large for gestational age; Normal pregnancy 17,723,280(-) TATATTAGTCCTATTA
NM_001001924.2(MTUS1):c.2288-111_2449+391del 		SPLICE_ACCEPTOR_VARIANT,SPLICE_DONOR_VARIANT,INTRON
rs1554507029 Not Provided: Normal pregnancy; Gestational diabetes mellitus uncontrolled 17,723,281(-) ATATTAGTCCTATTAC
NM_001001924.2(MTUS1):c.2288-358_2449+390del 		SPLICE_ACCEPTOR_VARIANT,SPLICE_DONOR_VARIANT,INTRON
rs17125115 Benign: not provided 17,684,551(-) C/T
NM_001001924.2(MTUS1):c.2624-9G>A 		INTRON
rs187103704 Hepatocellular carcinoma (HCC) [MIM:114550] p.Asn873His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MTUS1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MTUS1 Gene

Variant ID Type Subtype PubMed ID
dgv12040n54 CNV loss 21841781
dgv12041n54 CNV loss 21841781
dgv12042n54 CNV loss 21841781
dgv12043n54 CNV loss 21841781
dgv7120n100 CNV gain 25217958
dgv7121n100 CNV gain 25217958
esv23139 CNV gain 19812545
esv2421533 CNV deletion 20811451
esv2605243 CNV insertion 19546169
esv2659440 CNV deletion 23128226
esv2674241 CNV deletion 23128226
esv2759600 CNV loss 17122850
esv2761186 CNV loss 21179565
esv2762735 CNV gain 21179565
esv2764066 CNV gain+loss 21179565
esv3310470 CNV novel sequence insertion 20981092
esv3340868 CNV insertion 20981092
esv3378123 CNV duplication 20981092
esv3394562 CNV insertion 20981092
esv34867 CNV loss 17911159
esv3543157 CNV deletion 23714750
esv3543158 CNV deletion 23714750
esv3616489 CNV loss 21293372
esv3616492 CNV loss 21293372
esv3616495 CNV loss 21293372
esv3616497 CNV loss 21293372
esv3616498 CNV loss 21293372
esv3616499 CNV gain 21293372
esv3616500 CNV gain 21293372
esv3891363 CNV loss 25118596
esv3891364 CNV gain 25118596
nsv1029903 CNV loss 25217958
nsv1075540 CNV deletion 25765185
nsv1077024 CNV deletion 25765185
nsv1137350 CNV deletion 24896259
nsv1137351 CNV deletion 24896259
nsv1137352 CNV deletion 24896259
nsv471727 CNV loss 16327809
nsv510133 OTHER sequence alteration 20534489
nsv512032 CNV loss 21212237
nsv514481 CNV loss 21397061
nsv516696 CNV loss 19592680
nsv526978 CNV loss 19592680
nsv6098 CNV insertion 18451855
nsv610681 CNV loss 21841781
nsv610692 CNV loss 21841781
nsv610700 CNV gain 21841781
nsv610701 CNV gain 21841781
nsv818613 CNV loss 17921354
nsv819748 CNV gain 19587683
nsv821096 CNV deletion 20802225
nsv8307 CNV loss 18304495
nsv8308 CNV gain 18304495
nsv831247 CNV gain 17160897
nsv831249 CNV loss 17160897
nsv831250 CNV loss 17160897
nsv957083 CNV deletion 24416366

Variation tolerance for MTUS1 Gene

Residual Variation Intolerance Score: 99.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.10; 80.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTUS1 Gene

Human Gene Mutation Database (HGMD)
MTUS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTUS1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTUS1 Gene

Disorders for MTUS1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MTUS1 Gene - From: SWI, COP, and GCD

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
diffuse glomerulonephritis
  • glomerulonephritis diffuse
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search MTUS1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MTUS1_HUMAN
  • Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. {ECO:0000269 PubMed:16650523}. Note=The gene represented in this entry may be involved in disease pathogenesis.

Additional Disease Information for MTUS1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MTUS1: view

No data available for Genatlas for MTUS1 Gene

Publications for MTUS1 Gene

  1. Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma. (PMID: 16650523) Di Benedetto M … Nahmias C (Molecular and cellular endocrinology 2006) 3 4 23
  2. Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP. (PMID: 16887298) Di Benedetto M … Nahmias C (Gene 2006) 3 4 23
  3. Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP. (PMID: 15123706) Nouet S … Nahmias C (The Journal of biological chemistry 2004) 3 4 23
  4. Identification of a new tumor suppressor gene located at chromosome 8p21.3-22. (PMID: 12692079) Seibold S … Marx M (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003) 2 3 4
  5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4

ExternalLinks

View latest publications for MTUS1 gene in Mastermind

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