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Aliases for MTURN Gene

Aliases for MTURN Gene

  • Maturin, Neural Progenitor Differentiation Regulator Homolog 2 3 5
  • Maturin Neural Progenitor Differentiation Regulator Protein Homolog 3 4
  • Protein Ells1 3 4
  • C7orf41 3 4
  • Maturin, Neural Progenitor Differentiation Regulator Homolog (Xenopus) 2
  • Chromosome 7 Open Reading Frame 41 2
  • UPF0452 Protein C7orf41 3
  • Maturin 3
  • Ells1 3

External Ids for MTURN Gene

Previous HGNC Symbols for MTURN Gene

  • C7orf41

Previous GeneCards Identifiers for MTURN Gene

  • GC07P030174

Summaries for MTURN Gene

GeneCards Summary for MTURN Gene

MTURN (Maturin, Neural Progenitor Differentiation Regulator Homolog) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MTURN Gene

  • May be involved in early neuronal development.

Additional gene information for MTURN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTURN Gene

Genomics for MTURN Gene

GeneHancer (GH) Regulatory Elements for MTURN Gene

Promoters and enhancers for MTURN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I030133 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 560.7 +0.6 559 2.9 ATF1 ARID4B SIN3A DMAP1 BRCA1 ZNF48 GLIS2 E2F8 FOS ATF7 MTURN LOC105375216 ENSG00000226874 DKFZP586I1420 ENSG00000263683 PLEKHA8 ENSG00000230751
GH07I029986 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.1 -146.0 -145967 3.7 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 LOC105375215 PIR35583 SCRN1 MTURN
GH07I030141 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.4 +8.2 8163 3 CLOCK NFIB INSM2 KLF17 MZF1 FEZF1 BATF ZNF2 ZNF213 ZNF366 MTURN ENSG00000230751 ENSG00000251660
GH07I030145 Enhancer 1.1 ENCODE dbSUPER 9.4 +11.8 11840 2.1 HDGF PKNOX1 SMAD1 ATF1 ARNT ZNF280A TCF12 ZNF766 GATA2 E2F8 RPS27P16 MTURN ENSG00000230751 ENSG00000251660
GH07I030161 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 6.4 +29.7 29746 5.4 PKNOX1 ARID4B FEZF1 YY1 TCF12 ZNF143 RUNX3 RXRA SP5 REST ZNRF2 MIR550A1 NOD1 MTURN LOC105375217 RPS27P16 ENSG00000251660
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MTURN on UCSC Golden Path with GeneCards custom track

Genomic Locations for MTURN Gene

Genomic Locations for MTURN Gene
chr7:30,134,810-30,162,765
(GRCh38/hg38)
Size:
27,956 bases
Orientation:
Plus strand
chr7:30,174,426-30,202,381
(GRCh37/hg19)

Genomic View for MTURN Gene

Genes around MTURN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTURN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTURN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTURN Gene

Proteins for MTURN Gene

  • Protein details for MTURN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3F0-MTURN_HUMAN
    Recommended name:
    Maturin
    Protein Accession:
    Q8N3F0
    Secondary Accessions:
    • B8ZZW9
    • Q8N791
    • Q8N8M4
    • Q8NEX2

    Protein attributes for MTURN Gene

    Size:
    131 amino acids
    Molecular mass:
    14925 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MTURN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTURN Gene

Post-translational modifications for MTURN Gene

  • Ubiquitination at Lys80 and Lys88

Other Protein References for MTURN Gene

No data available for DME Specific Peptides for MTURN Gene

Domains & Families for MTURN Gene

Gene Families for MTURN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MTURN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTURN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N3F0

UniProtKB/Swiss-Prot:

MTURN_HUMAN :
  • Belongs to the MTURN family.
Family:
  • Belongs to the MTURN family.
genes like me logo Genes that share domains with MTURN: view

Function for MTURN Gene

Molecular function for MTURN Gene

UniProtKB/Swiss-Prot Function:
May be involved in early neuronal development.
genes like me logo Genes that share phenotypes with MTURN: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTURN Gene

Localization for MTURN Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTURN gene
Compartment Confidence
extracellular 3
cytosol 3
nucleus 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MTURN Gene

Pathways & Interactions for MTURN Gene

SuperPathways for MTURN Gene

No Data Available

Interacting Proteins for MTURN Gene

Selected Interacting proteins: Q8N3F0-MTURN_HUMAN for MTURN Gene via IID UniProtKB

Gene Ontology (GO) - Biological Process for MTURN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with MTURN: view

No data available for Pathways by source and SIGNOR curated interactions for MTURN Gene

Drugs & Compounds for MTURN Gene

No Compound Related Data Available

Transcripts for MTURN Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTURN Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6
SP1: - - - - - -
SP2:
SP3:
SP4: - -
SP5: - - - -
SP6: -

Relevant External Links for MTURN Gene

GeneLoc Exon Structure for
MTURN
ECgene alternative splicing isoforms for
MTURN

Expression for MTURN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTURN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTURN Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x10.7), Brain - Substantia nigra (x6.4), Brain - Amygdala (x5.1), Brain - Hippocampus (x5.1), and Brain - Putamen (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for MTURN Gene

This gene is overexpressed in Spinal cord (28.7), Nasopharynx (6.5), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MTURN Gene



NURSA nuclear receptor signaling pathways regulating expression of MTURN Gene:

MTURN

Evidence on tissue expression from TISSUES for MTURN Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with MTURN: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTURN Gene

Orthologs for MTURN Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTURN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C4H7orf41 34
  • 100 (a)
OneToOne
MTURN 33
  • 95.67 (n)
chimpanzee
(Pan troglodytes)
Mammalia MTURN 33 34
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia MTURN 34
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTURN 34
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mturn 33
  • 90.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MTURN 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-1723 34
  • 85 (a)
OneToOne
MTURN 33
  • 82.7 (n)
lizard
(Anolis carolinensis)
Reptilia MTURN 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mturn 33
  • 83.46 (n)
Str.11166 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53931 33
zebrafish
(Danio rerio)
Actinopterygii mturn 33 34
  • 75.9 (n)
Species where no ortholog for MTURN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTURN Gene

ENSEMBL:
Gene Tree for MTURN (if available)
TreeFam:
Gene Tree for MTURN (if available)

Paralogs for MTURN Gene

No data available for Paralogs for MTURN Gene

Variants for MTURN Gene

Sequence variations from dbSNP and Humsavar for MTURN Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000085206 -- 30,141,990(+) G/C intron_variant
rs1000125907 -- 30,158,491(+) T/C 3_prime_UTR_variant, intron_variant
rs1000157190 -- 30,158,193(+) C/T 3_prime_UTR_variant, intron_variant
rs1000277213 -- 30,134,717(+) T/C upstream_transcript_variant
rs1000336494 -- 30,162,070(+) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for MTURN Gene

Variant ID Type Subtype PubMed ID
nsv1148830 OTHER inversion 26484159
nsv1133648 CNV deletion 24896259
nsv1074492 CNV deletion 25765185
nsv1068321 OTHER inversion 25765185
nsv1030571 CNV gain 25217958
nsv1019527 CNV gain 25217958

Variation tolerance for MTURN Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTURN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTURN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTURN Gene

Disorders for MTURN Gene

Additional Disease Information for MTURN

No disorders were found for MTURN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTURN Gene

Publications for MTURN Gene

  1. Maturin is a novel protein required for differentiation during primary neurogenesis. (PMID: 24095902) Martinez-De Luna RI … Zuber ME (Developmental biology 2013) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Novel function of the chromosome 7 open reading frame 41 gene to promote leukemic megakaryocyte differentiation by modulating TPA-induced signaling. (PMID: 24681962) Sun X … Huang Z (Blood cancer journal 2014) 3 58
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58

Products for MTURN Gene

Sources for MTURN Gene

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