Aliases for MTTP Gene
External Ids for MTTP Gene
Previous HGNC Symbols for MTTP Gene
Previous GeneCards Identifiers for MTTP Gene
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
GeneCards Summary for MTTP Gene
MTTP (Microsomal Triglyceride Transfer Protein) is a Protein Coding gene. Diseases associated with MTTP include Abetalipoproteinemia and Abdominal Obesity-Metabolic Syndrome 1. Among its related pathways are Lipoprotein metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and lipid transporter activity.
UniProtKB/Swiss-Prot for MTTP Gene
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406). Required for the secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:23475612, PubMed:8939939, PubMed:26224785).