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Aliases for MTSS1 Gene

Aliases for MTSS1 Gene

  • MTSS1, I-BAR Domain Containing 2 3 5
  • Missing In Metastasis Protein 3 4
  • Metastasis Suppressor YGL-1 3 4
  • Metastasis Suppressor 1 2 3
  • MIM 3 4
  • Metastasis Suppressor Protein 1 3
  • Missing In Metastasis 2
  • KIAA0429 4
  • MIMA 3
  • MIMB 3

External Ids for MTSS1 Gene

Previous GeneCards Identifiers for MTSS1 Gene

  • GC08M125567
  • GC08M125231
  • GC08M125519
  • GC08M125632
  • GC08M125563
  • GC08M120888

Summaries for MTSS1 Gene

GeneCards Summary for MTSS1 Gene

MTSS1 (MTSS1, I-BAR Domain Containing) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Hedgehog Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and actin binding. An important paralog of this gene is MTSS1L.

UniProtKB/Swiss-Prot for MTSS1 Gene

  • May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.

Gene Wiki entry for MTSS1 Gene

Additional gene information for MTSS1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTSS1 Gene

Genomics for MTSS1 Gene

GeneHancer (GH) Regulatory Elements for MTSS1 Gene

Promoters and enhancers for MTSS1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J124724 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 659.1 +1.8 1809 5 FOXA2 ARID4B SIN3A ETS1 YY1 SLC30A9 GLIS2 ELK1 RXRA MXD4 MTSS1 LOC105375741 TATDN1 NSMCE2 GC08P124718
GH08J124846 Enhancer 1.4 Ensembl ENCODE dbSUPER 33 -119.6 -119586 3.1 PKNOX1 ATF1 ARNT YY1 TCF12 ZNF766 ATF7 RUNX3 RXRA CAVIN1 LINC00964 ZNF572 MTSS1 SQLE LOC105375744 LOC105375743 MIR4662B
GH08J124750 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 21.4 -23.3 -23298 2.6 PKNOX1 RAD21 RFX5 FOS SMARCA5 RXRA REST GATAD2B ELF1 SP1 MTSS1 NSMCE2 TATDN1 RNF139 ZNF572 WASHC5 LOC105375741 GC08P124786
GH08J124626 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14 +99.3 99322 6.1 HDGF PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 FOS JUNB MTSS1 LOC105375744 SQLE NSMCE2 TRMT12 RNF139 WASHC5 ZNF572 GC08P124592 GC08P124718
GH08J124761 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 21.1 -33.7 -33665 1.5 MEIS2 SRF EBF1 MEF2B BATF FOSL1 BCL11A POLR2A ZNF184 IKZF1 MTSS1 NSMCE2 WASHC5 RNF139 GC08P124786 LOC105375741
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MTSS1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MTSS1 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • AREB6
  • TGIF
  • AhR
  • C/EBPalpha
  • MyoD
  • S8
  • RORalpha2
  • c-Myb

Genomic Locations for MTSS1 Gene

Genomic Locations for MTSS1 Gene
177,738 bases
Minus strand
177,706 bases
Minus strand

Genomic View for MTSS1 Gene

Genes around MTSS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTSS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTSS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTSS1 Gene

Proteins for MTSS1 Gene

  • Protein details for MTSS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metastasis suppressor protein 1
    Protein Accession:
    Secondary Accessions:
    • J3KNK6
    • Q8TCA2
    • Q96RX2

    Protein attributes for MTSS1 Gene

    755 amino acids
    Molecular mass:
    82251 Da
    Quaternary structure:
    • Binds to actin. Binds to the cytoplasmic domain of receptor protein tyrosine phosphatase delta.

    Three dimensional structures from OCA and Proteopedia for MTSS1 Gene

    Alternative splice isoforms for MTSS1 Gene


neXtProt entry for MTSS1 Gene

Post-translational modifications for MTSS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MTSS1 Gene

Domains & Families for MTSS1 Gene

Gene Families for MTSS1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MTSS1 Gene

Graphical View of Domain Structure for InterPro Entry



  • The WH2 motif at the C-terminus binds to actin monomers.
  • Belongs to the MTSS1 family.
  • The WH2 motif at the C-terminus binds to actin monomers.
  • Belongs to the MTSS1 family.
genes like me logo Genes that share domains with MTSS1: view

Function for MTSS1 Gene

Molecular function for MTSS1 Gene

UniProtKB/Swiss-Prot Function:
May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.

Phenotypes From GWAS Catalog for MTSS1 Gene

Gene Ontology (GO) - Molecular Function for MTSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0003785 actin monomer binding IDA 12570871
GO:0005102 signaling receptor binding IPI 12570871
GO:0005515 protein binding IPI 15383276
GO:0042802 identical protein binding IPI 14752106
genes like me logo Genes that share ontologies with MTSS1: view
genes like me logo Genes that share phenotypes with MTSS1: view

Animal Models for MTSS1 Gene

MGI Knock Outs for MTSS1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTSS1 Gene

Localization for MTSS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTSS1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTSS1 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MTSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle NAS 12570871
GO:0005737 cytoplasm TAS 12570871
GO:0005856 cytoskeleton IEA --
GO:0015629 actin cytoskeleton IDA 12570871
GO:0030139 endocytic vesicle TAS 12570871
genes like me logo Genes that share ontologies with MTSS1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MTSS1 Gene

Pathways & Interactions for MTSS1 Gene

genes like me logo Genes that share pathways with MTSS1: view

Pathways by source for MTSS1 Gene

1 BioSystems pathway for MTSS1 Gene
1 Cell Signaling Technology pathway for MTSS1 Gene

SIGNOR curated interactions for MTSS1 Gene


Gene Ontology (GO) - Biological Process for MTSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007009 plasma membrane organization IEA --
GO:0007155 cell adhesion NAS 12570871
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 12570871
GO:0030035 microspike assembly NAS 12570871
GO:0030036 actin cytoskeleton organization TAS,IEA 12082544
genes like me logo Genes that share ontologies with MTSS1: view

Drugs & Compounds for MTSS1 Gene

No Compound Related Data Available

Transcripts for MTSS1 Gene

Unigene Clusters for MTSS1 Gene

Metastasis suppressor 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTSS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^
SP1: - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: -
SP8: -

ExUns: 19a · 19b

Relevant External Links for MTSS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTSS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTSS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MTSS1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.6), Adrenal (7.4), Fetal Brain (6.9), and Platelet (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MTSS1 Gene

Protein tissue co-expression partners for MTSS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTSS1 Gene:


SOURCE GeneReport for Unigene cluster for MTSS1 Gene:


mRNA Expression by UniProt/SwissProt for MTSS1 Gene:

Tissue specificity: Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.

Evidence on tissue expression from TISSUES for MTSS1 Gene

  • Nervous system(4.9)
  • Blood(4.4)
  • Kidney(2.1)
  • Liver(2)
genes like me logo Genes that share expression patterns with MTSS1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTSS1 Gene

Orthologs for MTSS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTSS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MTSS1 34 33
  • 99.65 (n)
(Canis familiaris)
Mammalia MTSS1 34 33
  • 92.18 (n)
(Bos Taurus)
Mammalia MTSS1 34 33
  • 90.73 (n)
(Rattus norvegicus)
Mammalia Mtss1 33
  • 90.25 (n)
(Mus musculus)
Mammalia Mtss1 16 34 33
  • 89.99 (n)
(Monodelphis domestica)
Mammalia MTSS1 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia MTSS1 34
  • 87 (a)
(Gallus gallus)
Aves MTSS1 34 33
  • 80.31 (n)
(Anolis carolinensis)
Reptilia MTSS1 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mtss1.1 33
  • 75.29 (n)
(Danio rerio)
Actinopterygii si:dkey-46l15.1 34 33
  • 63.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta mim 34
  • 5 (a)
(Caenorhabditis elegans)
Secernentea M04F3.5 34
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
-- 34
  • 21 (a)
Species where no ortholog for MTSS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTSS1 Gene

Gene Tree for MTSS1 (if available)
Gene Tree for MTSS1 (if available)
Evolutionary constrained regions (ECRs) for MTSS1: view image

Paralogs for MTSS1 Gene

Paralogs for MTSS1 Gene

(1) SIMAP similar genes for MTSS1 Gene using alignment to 9 proteins:

  • A5YM41_HUMAN
  • B7Z3B6_HUMAN
  • H0YB53_HUMAN
genes like me logo Genes that share paralogs with MTSS1: view

Variants for MTSS1 Gene

Sequence variations from dbSNP and Humsavar for MTSS1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000007681 -- 124,698,148(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000010520 -- 124,660,522(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000015823 -- 124,583,129(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000097333 -- 124,579,076(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000115498 -- 124,705,314(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MTSS1 Gene

Variant ID Type Subtype PubMed ID
dgv1415e214 CNV gain 21293372
dgv7309n100 CNV gain 25217958
esv23776 CNV gain 19812545
esv2737533 CNV deletion 23290073
esv2737534 CNV deletion 23290073
esv2737535 CNV deletion 23290073
esv275001 CNV gain+loss 21479260
esv275526 CNV loss 21479260
esv5049 CNV loss 18987735
nsv1027585 CNV loss 25217958
nsv1117853 CNV deletion 24896259
nsv396843 CNV insertion 16902084
nsv465801 CNV loss 19166990
nsv465802 CNV loss 19166990
nsv472025 CNV novel sequence insertion 20440878
nsv472085 CNV novel sequence insertion 20440878
nsv507489 OTHER sequence alteration 20534489
nsv525649 CNV gain 19592680
nsv528287 CNV gain 19592680
nsv612145 CNV loss 21841781
nsv612146 CNV loss 21841781
nsv612147 CNV loss 21841781

Variation tolerance for MTSS1 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.53; 64.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTSS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTSS1 Gene

Disorders for MTSS1 Gene

Additional Disease Information for MTSS1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MTSS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTSS1 Gene

Publications for MTSS1 Gene

  1. MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta. (PMID: 12570871) Woodings JA … Machesky LM (The Biochemical journal 2003) 3 4 22 58
  2. Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain. (PMID: 12482861) Mattila PK … Lappalainen P (The Journal of biological chemistry 2003) 2 3 22 58
  3. MIM, a potential metastasis suppressor gene in bladder cancer. (PMID: 12082544) Lee YG … Pienta KJ (Neoplasia (New York, N.Y.) 2002) 2 3 4 58
  4. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 44 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for MTSS1 Gene

Sources for MTSS1 Gene

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