Aliases for MTSS1 Gene

Aliases for MTSS1 Gene

  • MTSS I-BAR Domain Containing 1 2 3 5
  • Metastasis Suppressor Protein 1 3 4
  • MTSS1, I-BAR Domain Containing 2 3
  • Missing In Metastasis Protein 3 4
  • Metastasis Suppressor YGL-1 3 4
  • Metastasis Suppressor 1 2 3
  • Protein MTSS 1 3 4
  • MIM 3 4
  • Missing In Metastasis 2
  • KIAA0429 4
  • MIMA 3
  • MIMB 3

External Ids for MTSS1 Gene

Previous GeneCards Identifiers for MTSS1 Gene

  • GC08M125567
  • GC08M125231
  • GC08M125519
  • GC08M125632
  • GC08M125563
  • GC08M120888

Summaries for MTSS1 Gene

GeneCards Summary for MTSS1 Gene

MTSS1 (MTSS I-BAR Domain Containing 1) is a Protein Coding gene. Diseases associated with MTSS1 include Bladder Urothelial Carcinoma. Among its related pathways are Cytoskeletal Signaling and Hedgehog signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include identical protein binding and actin binding. An important paralog of this gene is MTSS2.

UniProtKB/Swiss-Prot Summary for MTSS1 Gene

  • May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.

Gene Wiki entry for MTSS1 Gene

Additional gene information for MTSS1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MTSS1 Gene

Genomics for MTSS1 Gene

GeneHancer (GH) Regulatory Elements for MTSS1 Gene

Promoters and enhancers for MTSS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MTSS1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MTSS1 gene promoter:
  • AhR
  • AREB6
  • c-Myb
  • C/EBPalpha
  • MyoD
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha2
  • S8
  • TGIF

Genomic Locations for MTSS1 Gene

Genomic Locations for MTSS1 Gene
chr8:124,550,770-124,728,507
(GRCh38/hg38)
Size:
177,738 bases
Orientation:
Minus strand
chr8:125,563,025-125,740,730
(GRCh37/hg19)
Size:
177,706 bases
Orientation:
Minus strand

Genomic View for MTSS1 Gene

Genes around MTSS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTSS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTSS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTSS1 Gene

Proteins for MTSS1 Gene

  • Protein details for MTSS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43312-MTSS1_HUMAN
    Recommended name:
    Protein MTSS 1
    Protein Accession:
    O43312
    Secondary Accessions:
    • J3KNK6
    • Q8TCA2
    • Q96RX2

    Protein attributes for MTSS1 Gene

    Size:
    755 amino acids
    Molecular mass:
    82251 Da
    Quaternary structure:
    • Binds to actin. Binds to the cytoplasmic domain of receptor protein tyrosine phosphatase delta.

    Three dimensional structures from OCA and Proteopedia for MTSS1 Gene

    Alternative splice isoforms for MTSS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTSS1 Gene

Post-translational modifications for MTSS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MTSS1 Gene

Domains & Families for MTSS1 Gene

Gene Families for MTSS1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MTSS1 Gene

Suggested Antigen Peptide Sequences for MTSS1 Gene

GenScript: Design optimal peptide antigens:
  • MTSS1 protein (A5YM41_HUMAN)
  • cDNA FLJ55977, highly similar to Metastasis suppressor protein 1 (B7Z3B6_HUMAN)
  • Missing in metastasis protein (MTSS1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43312

UniProtKB/Swiss-Prot:

MTSS1_HUMAN :
  • The WH2 motif at the C-terminus binds to actin monomers.
  • Belongs to the MTSS family.
Domain:
  • The WH2 motif at the C-terminus binds to actin monomers.
Family:
  • Belongs to the MTSS family.
genes like me logo Genes that share domains with MTSS1: view

Function for MTSS1 Gene

Molecular function for MTSS1 Gene

UniProtKB/Swiss-Prot Function:
May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.

Phenotypes From GWAS Catalog for MTSS1 Gene

Gene Ontology (GO) - Molecular Function for MTSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0003785 actin monomer binding IDA 12570871
GO:0005102 signaling receptor binding IPI 12570871
GO:0005515 protein binding IPI 15383276
GO:0042802 identical protein binding IPI 14752106
genes like me logo Genes that share ontologies with MTSS1: view
genes like me logo Genes that share phenotypes with MTSS1: view

Animal Models for MTSS1 Gene

MGI Knock Outs for MTSS1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTSS1 Gene

Localization for MTSS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTSS1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTSS1 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 1
extracellular 1
endosome 1
cytosol 1
nucleus 0

Gene Ontology (GO) - Cellular Components for MTSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle NAS 12570871
GO:0005737 cytoplasm TAS 12570871
GO:0005856 cytoskeleton IEA --
GO:0015629 actin cytoskeleton IDA 12570871
GO:0030139 endocytic vesicle TAS 12570871
genes like me logo Genes that share ontologies with MTSS1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MTSS1 Gene

Pathways & Interactions for MTSS1 Gene

genes like me logo Genes that share pathways with MTSS1: view

Pathways by source for MTSS1 Gene

1 BioSystems pathway for MTSS1 Gene
1 Cell Signaling Technology pathway for MTSS1 Gene

SIGNOR curated interactions for MTSS1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MTSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007009 plasma membrane organization IEA --
GO:0007155 cell adhesion NAS 12570871
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 12570871
GO:0030035 microspike assembly NAS 12570871
GO:0030036 actin cytoskeleton organization TAS,IEA 12082544
genes like me logo Genes that share ontologies with MTSS1: view

Drugs & Compounds for MTSS1 Gene

No Compound Related Data Available

Transcripts for MTSS1 Gene

mRNA/cDNA for MTSS1 Gene

(12) REFSEQ mRNAs :
(25) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(18) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTSS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^
SP1: - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: -
SP8: -
SP9:
SP10:

ExUns: 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for MTSS1 Gene

GeneLoc Exon Structure for
MTSS1
ECgene alternative splicing isoforms for
MTSS1

Expression for MTSS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTSS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MTSS1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.6), Adrenal (7.4), Fetal Brain (6.9), and Platelet (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MTSS1 Gene



Protein tissue co-expression partners for MTSS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTSS1 Gene:

MTSS1

SOURCE GeneReport for Unigene cluster for MTSS1 Gene:

Hs.336994

mRNA Expression by UniProt/SwissProt for MTSS1 Gene:

O43312-MTSS1_HUMAN
Tissue specificity: Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.

Evidence on tissue expression from TISSUES for MTSS1 Gene

  • Nervous system(4.9)
  • Blood(4.4)
  • Kidney(2.1)
  • Liver(2)
genes like me logo Genes that share expression patterns with MTSS1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTSS1 Gene

Orthologs for MTSS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTSS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTSS1 33 32
  • 99.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MTSS1 33 32
  • 92.18 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MTSS1 33 32
  • 90.73 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtss1 32
  • 90.25 (n)
mouse
(Mus musculus)
Mammalia Mtss1 17 33 32
  • 89.99 (n)
oppossum
(Monodelphis domestica)
Mammalia MTSS1 33
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTSS1 33
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTSS1 33 32
  • 80.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTSS1 33
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtss1.1 32
  • 75.29 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-46l15.1 33 32
  • 63.71 (n)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta mim 33
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M04F3.5 33
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 50 (a)
ManyToMany
-- 33
  • 21 (a)
ManyToMany
Species where no ortholog for MTSS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTSS1 Gene

ENSEMBL:
Gene Tree for MTSS1 (if available)
TreeFam:
Gene Tree for MTSS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MTSS1: view image

Paralogs for MTSS1 Gene

Paralogs for MTSS1 Gene

(1) SIMAP similar genes for MTSS1 Gene using alignment to 9 proteins:

  • MTSS1_HUMAN
  • A5YM41_HUMAN
  • B7Z3B6_HUMAN
  • E5RJX3_HUMAN
  • E7EWW5_HUMAN
  • H0YAZ8_HUMAN
  • H0YB53_HUMAN
  • H0YBL3_HUMAN
  • J3KNK6_HUMAN
genes like me logo Genes that share paralogs with MTSS1: view

Variants for MTSS1 Gene

Sequence variations from dbSNP and Humsavar for MTSS1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000007681 -- 124,698,148(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000010520 -- 124,660,522(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000015823 -- 124,583,129(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000097333 -- 124,579,076(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000115498 -- 124,705,314(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MTSS1 Gene

Variant ID Type Subtype PubMed ID
dgv1415e214 CNV gain 21293372
dgv7309n100 CNV gain 25217958
esv23776 CNV gain 19812545
esv2737533 CNV deletion 23290073
esv2737534 CNV deletion 23290073
esv2737535 CNV deletion 23290073
esv275001 CNV gain+loss 21479260
esv275526 CNV loss 21479260
esv5049 CNV loss 18987735
nsv1027585 CNV loss 25217958
nsv1117853 CNV deletion 24896259
nsv396843 CNV insertion 16902084
nsv465801 CNV loss 19166990
nsv465802 CNV loss 19166990
nsv472025 CNV novel sequence insertion 20440878
nsv472085 CNV novel sequence insertion 20440878
nsv507489 OTHER sequence alteration 20534489
nsv525649 CNV gain 19592680
nsv528287 CNV gain 19592680
nsv612145 CNV loss 21841781
nsv612146 CNV loss 21841781
nsv612147 CNV loss 21841781

Variation tolerance for MTSS1 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.53; 64.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTSS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTSS1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTSS1 Gene

Disorders for MTSS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MTSS1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bladder urothelial carcinoma
  • bladder transitional cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search MTSS1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MTSS1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MTSS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTSS1 Gene

Publications for MTSS1 Gene

  1. MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta. (PMID: 12570871) Woodings JA … Machesky LM (The Biochemical journal 2003) 3 4 23 56
  2. Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain. (PMID: 12482861) Mattila PK … Lappalainen P (The Journal of biological chemistry 2003) 2 3 23 56
  3. MIM, a potential metastasis suppressor gene in bladder cancer. (PMID: 12082544) Lee YG … Pienta KJ (Neoplasia (New York, N.Y.) 2002) 2 3 4 56
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 43 56

Products for MTSS1 Gene

Sources for MTSS1 Gene