Aliases for MTRNR2L8 Gene

Aliases for MTRNR2L8 Gene

  • MT-RNR2 Like 8 2 3 5
  • Humanin-Like 8 2 3 4
  • HN8 3 4
  • Humanin-Like Protein 8 3
  • MT-RNR2-Like Protein 8 4
  • MTRNR2-Like 8 3
  • MTRNR2L8 5

External Ids for MTRNR2L8 Gene

Previous GeneCards Identifiers for MTRNR2L8 Gene

  • GC11U901604
  • GC11M010202
  • GC11M010537
  • GC11M010538
  • GC11M010539
  • GC11M010540
  • GC11M010548
  • GC11M010515
  • GC11M010521
  • GC11M010597
  • GC11M010599
  • GC11M010604
  • GC11M010632
  • GC11M010526
  • GC11M010550
  • GC11M010558
  • GC11M010565
  • GC11M010570
  • GC11M010576
  • GC11M010583
  • GC11M010589

Summaries for MTRNR2L8 Gene

GeneCards Summary for MTRNR2L8 Gene

MTRNR2L8 (MT-RNR2 Like 8) is a Protein Coding gene. Diseases associated with MTRNR2L8 include Bare Lymphocyte Syndrome, Type Ii. An important paralog of this gene is MTRNR2L12.

UniProtKB/Swiss-Prot Summary for MTRNR2L8 Gene

Additional gene information for MTRNR2L8 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MTRNR2L8 Gene

Genomics for MTRNR2L8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MTRNR2L8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J010513 Promoter 0.3 Ensembl 600.7 -0.5 -515 0.2 6NU2_B EF153791 MF281474-001 MN297032 MTRNR2L8 MIR4485 RF02541-005 RF00177-003 piR-31637-001 piR-34871-001
GH11J010508 Enhancer 0.2 ENCODE 600.7 -0.2 -203 0.3 6NU2_B EF153791 MF281474-001 MN297032 MTRNR2L8 MIR4485 RF02541-005 RF00177-003 piR-31637-001 piR-34871-001
GH11J010509 Enhancer 0.2 ENCODE 600.7 -0.8 -843 0.2 6NU2_B EF153791 MF281474-001 MN297032 MTRNR2L8 MIR4485 RF02541-005 RF00177-003 piR-31637-001 piR-34871-001
GH11J010512 Enhancer 0.2 ENCODE 600.7 +1.0 977 0.2 6NU2_B MF281474-001 MN297032 MTRNR2L8 MIR4485 RF02541-005 piR-31637-001 piR-34871-001 piR-35548-001 piR-32376-001
GH11J010507 Enhancer 0.2 ENCODE 600.7 +1.2 1217 0.2 6NU2_B MF281474-001 MN297032 MTRNR2L8 MIR4485 RF02541-005 piR-34871-001 piR-35548-001 piR-32376-001 piR-44892-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MTRNR2L8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MTRNR2L8

Genomic Locations for MTRNR2L8 Gene

Genomic Locations for MTRNR2L8 Gene
chr11:10,507,894-10,509,186
(GRCh38/hg38)
Size:
1,293 bases
Orientation:
Minus strand
chr11:10,529,434-10,530,723
(GRCh37/hg19)
Size:
1,290 bases
Orientation:
Minus strand

Genomic View for MTRNR2L8 Gene

Genes around MTRNR2L8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTRNR2L8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTRNR2L8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L8 Gene

Proteins for MTRNR2L8 Gene

  • Protein details for MTRNR2L8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CJ75-HMN8_HUMAN
    Recommended name:
    Humanin-like 8
    Protein Accession:
    P0CJ75

    Protein attributes for MTRNR2L8 Gene

    Size:
    24 amino acids
    Molecular mass:
    2661 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L8 Gene

Post-translational modifications for MTRNR2L8 Gene

No Post-translational modifications

Other Protein References for MTRNR2L8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L8 Gene

Domains & Families for MTRNR2L8 Gene

Gene Families for MTRNR2L8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for MTRNR2L8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTRNR2L8 Gene

GenScript: Design optimal peptide antigens:
  • MT-RNR2-like protein 8 (HMN8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0CJ75

UniProtKB/Swiss-Prot:

HMN8_HUMAN :
  • Belongs to the humanin family.
Family:
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L8: view

Function for MTRNR2L8 Gene

Molecular function for MTRNR2L8 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.

Phenotypes From GWAS Catalog for MTRNR2L8 Gene

Gene Ontology (GO) - Molecular Function for MTRNR2L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048019 receptor antagonist activity IBA 21873635
genes like me logo Genes that share ontologies with MTRNR2L8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTRNR2L8

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTRNR2L8 Gene

Localization for MTRNR2L8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L8 Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTRNR2L8 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for MTRNR2L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MTRNR2L8 Gene

Pathways & Interactions for MTRNR2L8 Gene

PathCards logo

SuperPathways for MTRNR2L8 Gene

No Data Available

Interacting Proteins for MTRNR2L8 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000439666 P0CJ75-HMN8_HUMAN for MTRNR2L8 Gene via STRING IID

Gene Ontology (GO) - Biological Process for MTRNR2L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1900118 negative regulation of execution phase of apoptosis IBA 21873635
GO:2000272 negative regulation of signaling receptor activity IEA --
genes like me logo Genes that share ontologies with MTRNR2L8: view

No data available for Pathways by source and SIGNOR curated interactions for MTRNR2L8 Gene

Drugs & Compounds for MTRNR2L8 Gene

No Compound Related Data Available

Transcripts for MTRNR2L8 Gene

mRNA/cDNA for MTRNR2L8 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTRNR2L8

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L8 Gene

No ASD Table

Relevant External Links for MTRNR2L8 Gene

GeneLoc Exon Structure for
MTRNR2L8

Expression for MTRNR2L8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MTRNR2L8 Gene

mRNA differential expression in normal tissues according to GTEx for MTRNR2L8 Gene

This gene is overexpressed in Brain - Amygdala (x7.2), Brain - Putamen (basal ganglia) (x5.9), Brain - Anterior cingulate cortex (BA24) (x4.7), Brain - Substantia nigra (x4.4), and Brain - Frontal Cortex (BA9) (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MTRNR2L8

SOURCE GeneReport for Unigene cluster for MTRNR2L8 Gene:

Hs.717003

mRNA Expression by UniProt/SwissProt for MTRNR2L8 Gene:

P0CJ75-HMN8_HUMAN
Tissue specificity: Highly expressed in the kidney, heart muscle and testis. Not expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with MTRNR2L8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTRNR2L8 Gene

Orthologs for MTRNR2L8 Gene

Evolution for MTRNR2L8 Gene

ENSEMBL:
Gene Tree for MTRNR2L8 (if available)
TreeFam:
Gene Tree for MTRNR2L8 (if available)

No data available for Orthologs for MTRNR2L8 Gene

Paralogs for MTRNR2L8 Gene

Paralogs for MTRNR2L8 Gene

(7) SIMAP similar genes for MTRNR2L8 Gene using alignment to 1 proteins:

  • HMN8_HUMAN
genes like me logo Genes that share paralogs with MTRNR2L8: view

Variants for MTRNR2L8 Gene

Additional dbSNP identifiers (rs#s) for MTRNR2L8 Gene

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L8 Gene

Variant ID Type Subtype PubMed ID
esv22967 CNV gain 19812545
esv3625358 CNV gain 21293372
nsv1044011 CNV gain 25217958
nsv972946 CNV duplication 23825009
nsv975881 CNV duplication 23825009

Variation tolerance for MTRNR2L8 Gene

Gene Damage Index Score: 0.06; 1.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTRNR2L8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTRNR2L8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MTRNR2L8 Gene

Disorders for MTRNR2L8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MTRNR2L8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bare lymphocyte syndrome, type ii
  • bls, type ii
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MTRNR2L8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTRNR2L8 Gene

Publications for MTRNR2L8 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M … Dembinska-Kiec A (Genomics 2009) 2 3 4
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4
  3. Epigenome-Wide Association Study Indicates Hypomethylation of MTRNR2L8 in Large-Artery Atherosclerosis Stroke. (PMID: 31084332) Shen Y … Chen X (Stroke 2019) 3
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3

Products for MTRNR2L8 Gene

Sources for MTRNR2L8 Gene