Aliases for MTRNR2L7 Gene

Aliases for MTRNR2L7 Gene

  • MT-RNR2 Like 7 2 3 5
  • Humanin-Like 7 2 3 4
  • HN7 3 4
  • Humanin-Like Protein 7 3
  • MT-RNR2-Like Protein 7 4
  • MTRNR2-Like 7 3

External Ids for MTRNR2L7 Gene

Previous GeneCards Identifiers for MTRNR2L7 Gene

  • GC10M037892
  • GC10M037893
  • GC10M037895

Summaries for MTRNR2L7 Gene

GeneCards Summary for MTRNR2L7 Gene

MTRNR2L7 (MT-RNR2 Like 7) is a Protein Coding gene. Diseases associated with MTRNR2L7 include Retinitis Pigmentosa 30 and Disuse Amblyopia.

UniProtKB/Swiss-Prot Summary for MTRNR2L7 Gene

Additional gene information for MTRNR2L7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MTRNR2L7 Gene

Genomics for MTRNR2L7 Gene

Genomic Locations for MTRNR2L7 Gene

Genomic Locations for MTRNR2L7 Gene
chr10:37,601,438-37,602,974
(GRCh38/hg38)
Size:
1,537 bases
Orientation:
Minus strand
chr10:37,890,366-37,891,859
(GRCh37/hg19)
Size:
1,494 bases
Orientation:
Minus strand

Genomic View for MTRNR2L7 Gene

Genes around MTRNR2L7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTRNR2L7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTRNR2L7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L7 Gene

No data available for GeneHancer (GH) Regulatory Elements for MTRNR2L7 Gene

Proteins for MTRNR2L7 Gene

  • Protein details for MTRNR2L7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CJ74-HMN7_HUMAN
    Recommended name:
    Humanin-like 7
    Protein Accession:
    P0CJ74

    Protein attributes for MTRNR2L7 Gene

    Size:
    24 amino acids
    Molecular mass:
    2647 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L7 Gene

Post-translational modifications for MTRNR2L7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTRNR2L7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L7 Gene

Domains & Families for MTRNR2L7 Gene

Gene Families for MTRNR2L7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for MTRNR2L7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTRNR2L7 Gene

GenScript: Design optimal peptide antigens:
  • MT-RNR2-like protein 7 (HMN7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0CJ74

UniProtKB/Swiss-Prot:

HMN7_HUMAN :
  • Belongs to the humanin family.
Family:
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L7: view

Function for MTRNR2L7 Gene

Molecular function for MTRNR2L7 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.

Phenotypes From GWAS Catalog for MTRNR2L7 Gene

Gene Ontology (GO) - Molecular Function for MTRNR2L7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048019 receptor antagonist activity IBA 21873635
genes like me logo Genes that share ontologies with MTRNR2L7: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTRNR2L7 Gene

Localization for MTRNR2L7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L7 Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTRNR2L7 gene
Compartment Confidence
extracellular 3
nucleus 1

Gene Ontology (GO) - Cellular Components for MTRNR2L7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MTRNR2L7 Gene

Pathways & Interactions for MTRNR2L7 Gene

PathCards logo

SuperPathways for MTRNR2L7 Gene

No Data Available

Interacting Proteins for MTRNR2L7 Gene

;

Gene Ontology (GO) - Biological Process for MTRNR2L7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1900118 negative regulation of execution phase of apoptosis IBA 21873635
GO:2000272 negative regulation of signaling receptor activity IEA --
genes like me logo Genes that share ontologies with MTRNR2L7: view

No data available for Pathways by source and SIGNOR curated interactions for MTRNR2L7 Gene

Drugs & Compounds for MTRNR2L7 Gene

No Compound Related Data Available

Transcripts for MTRNR2L7 Gene

mRNA/cDNA for MTRNR2L7 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L7 Gene

No ASD Table

Relevant External Links for MTRNR2L7 Gene

GeneLoc Exon Structure for
MTRNR2L7

Expression for MTRNR2L7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MTRNR2L7 Gene

SOURCE GeneReport for Unigene cluster for MTRNR2L7 Gene:

Hs.727092

mRNA Expression by UniProt/SwissProt for MTRNR2L7 Gene:

P0CJ74-HMN7_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with MTRNR2L7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTRNR2L7 Gene

Orthologs for MTRNR2L7 Gene

Evolution for MTRNR2L7 Gene

ENSEMBL:
Gene Tree for MTRNR2L7 (if available)
TreeFam:
Gene Tree for MTRNR2L7 (if available)

No data available for Orthologs for MTRNR2L7 Gene

Paralogs for MTRNR2L7 Gene

(1) SIMAP similar genes for MTRNR2L7 Gene using alignment to 1 proteins:

  • HMN7_HUMAN
genes like me logo Genes that share paralogs with MTRNR2L7: view

No data available for Paralogs for MTRNR2L7 Gene

Variants for MTRNR2L7 Gene

Additional dbSNP identifiers (rs#s) for MTRNR2L7 Gene

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L7 Gene

Variant ID Type Subtype PubMed ID
dgv112e214 CNV loss 21293372
esv3622960 CNV gain 21293372
nsv1041584 CNV gain 25217958
nsv947850 CNV duplication 23825009
nsv975797 CNV duplication 23825009

Variation tolerance for MTRNR2L7 Gene

Gene Damage Index Score: 0.28; 6.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTRNR2L7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTRNR2L7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MTRNR2L7 Gene

Disorders for MTRNR2L7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MTRNR2L7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 30
  • rp30
disuse amblyopia
  • deprivation amblyopia
tolosa-hunt syndrome
  • tolosa hunt syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MTRNR2L7

genes like me logo Genes that share disorders with MTRNR2L7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTRNR2L7 Gene

Publications for MTRNR2L7 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M … Dembinska-Kiec A (Genomics 2009) 2 3 4 54
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  3. The human mitochondrial genome may code for more than 13 proteins. (PMID: 25630734) Capt C … Breton S (Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis 2016) 3 54
  4. Humanin: a harbinger of mitochondrial-derived peptides? (PMID: 23402768) Lee C … Cohen P (Trends in endocrinology and metabolism: TEM 2013) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for MTRNR2L7 Gene

Sources for MTRNR2L7 Gene