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Aliases for MTRNR2L6 Gene

Aliases for MTRNR2L6 Gene

  • MT-RNR2 Like 6 2 3
  • Humanin-Like 6 2 3
  • HN6 3 4
  • Humanin-Like Protein 6 3
  • MT-RNR2-Like Protein 6 4
  • MT-RNR2-Like 6 5
  • MTRNR2-Like 6 3

External Ids for MTRNR2L6 Gene

Previous GeneCards Identifiers for MTRNR2L6 Gene

  • GC07U902933
  • GC07P142375
  • GC07P142377
  • GC07P142393
  • GC07P142435
  • GC07P142482
  • GC07P142639
  • GC07P142709
  • GC07P142771
  • GC07P142817
  • GC07P142881
  • GC07P143012
  • GC07P143161
  • GC07P143360
  • GC07P143510
  • GC07P143640
  • GC07P143781

Summaries for MTRNR2L6 Gene

GeneCards Summary for MTRNR2L6 Gene

MTRNR2L6 (MT-RNR2 Like 6) is a Protein Coding gene. An important paralog of this gene is MTRNR2L1.

UniProtKB/Swiss-Prot for MTRNR2L6 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

Additional gene information for MTRNR2L6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTRNR2L6 Gene

Genomics for MTRNR2L6 Gene

GeneHancer (GH) Regulatory Elements for MTRNR2L6 Gene

Promoters and enhancers for MTRNR2L6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J142667 Enhancer 0.2 Ensembl 650.7 +1.2 1229 0.2 GC07P144038 MTRNR2L6 TRBV25-1 TRB
GH07J142666 Enhancer 0.2 Ensembl 650.7 -0.1 -72 0.4 GC07P144038 GC07P144040 MTRNR2L6 TRB
GH07J142669 Enhancer 0.5 ENCODE 0.7 +3.2 3222 0.2 CTCF TRIM22 REST RAD21 TRBV25-1 MTRNR2L6 TRB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MTRNR2L6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MTRNR2L6 Gene

Genomic Locations for MTRNR2L6 Gene
1,447 bases
Plus strand
1,447 bases
Plus strand

Genomic View for MTRNR2L6 Gene

Genes around MTRNR2L6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTRNR2L6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTRNR2L6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTRNR2L6 Gene

Proteins for MTRNR2L6 Gene

  • Protein details for MTRNR2L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Humanin-like 6
    Protein Accession:

    Protein attributes for MTRNR2L6 Gene

    24 amino acids
    Molecular mass:
    2719 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTRNR2L6 Gene

Post-translational modifications for MTRNR2L6 Gene

No Post-translational modifications

Other Protein References for MTRNR2L6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTRNR2L6 Gene

Domains & Families for MTRNR2L6 Gene

Gene Families for MTRNR2L6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MTRNR2L6 Gene


Suggested Antigen Peptide Sequences for MTRNR2L6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the humanin family.
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MTRNR2L6: view

Function for MTRNR2L6 Gene

Molecular function for MTRNR2L6 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.
UniProtKB/Swiss-Prot Induction:
Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTRNR2L6

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTRNR2L6 Gene

Localization for MTRNR2L6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTRNR2L6 Gene

Secreted. Cytoplasm.

Gene Ontology (GO) - Cellular Components for MTRNR2L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MTRNR2L6: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MTRNR2L6 Gene

Pathways & Interactions for MTRNR2L6 Gene

SuperPathways for MTRNR2L6 Gene

No Data Available

Interacting Proteins for MTRNR2L6 Gene

Gene Ontology (GO) - Biological Process for MTRNR2L6 Gene


No data available for Pathways by source and SIGNOR curated interactions for MTRNR2L6 Gene

Drugs & Compounds for MTRNR2L6 Gene

No Compound Related Data Available

Transcripts for MTRNR2L6 Gene

mRNA/cDNA for MTRNR2L6 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTRNR2L6 Gene

MT-RNR2-like 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MTRNR2L6

Alternative Splicing Database (ASD) splice patterns (SP) for MTRNR2L6 Gene

No ASD Table

Relevant External Links for MTRNR2L6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTRNR2L6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTRNR2L6 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTRNR2L6 Gene:


SOURCE GeneReport for Unigene cluster for MTRNR2L6 Gene:


mRNA Expression by UniProt/SwissProt for MTRNR2L6 Gene:

Tissue specificity: Expressed in skeletal muscle and testis.
genes like me logo Genes that share expression patterns with MTRNR2L6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTRNR2L6 Gene

Orthologs for MTRNR2L6 Gene

Evolution for MTRNR2L6 Gene

Gene Tree for MTRNR2L6 (if available)
Gene Tree for MTRNR2L6 (if available)

No data available for Orthologs for MTRNR2L6 Gene

Paralogs for MTRNR2L6 Gene

Paralogs for MTRNR2L6 Gene

(5) SIMAP similar genes for MTRNR2L6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTRNR2L6: view

Variants for MTRNR2L6 Gene

Sequence variations from dbSNP and Humsavar for MTRNR2L6 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000131168 -- 142,664,608(+) T/C upstream_transcript_variant
rs1000415820 -- 142,664,852(+) A/G upstream_transcript_variant
rs1000466121 -- 142,665,772(+) T/C upstream_transcript_variant
rs1001581615 -- 142,665,361(+) C/G upstream_transcript_variant
rs1002316992 -- 142,666,390(+) G/A 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for MTRNR2L6 Gene

Variant ID Type Subtype PubMed ID
dgv11644n54 CNV loss 21841781
dgv11652n54 CNV loss 21841781
dgv841n27 CNV loss 19166990
esv2759569 CNV loss 17122850
esv34617 CNV loss 17911159
esv3576450 CNV gain 25503493
esv3615286 CNV loss 21293372
nsv1018286 CNV gain 25217958
nsv1029719 CNV loss 25217958
nsv428187 CNV loss 18775914
nsv465148 CNV loss 19166990
nsv465170 CNV loss 19166990
nsv470396 CNV loss 18288195
nsv608630 CNV loss 21841781
nsv8223 CNV loss 18304495
nsv824336 CNV loss 20364138
nsv824337 CNV loss 20364138
nsv831165 CNV gain 17160897
nsv831166 CNV gain+loss 17160897
nsv971553 CNV duplication 23825009
nsv981597 CNV duplication 23825009

Variation tolerance for MTRNR2L6 Gene

Gene Damage Index Score: 0.18; 3.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MTRNR2L6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTRNR2L6 Gene

Disorders for MTRNR2L6 Gene

Additional Disease Information for MTRNR2L6

No disorders were found for MTRNR2L6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTRNR2L6 Gene

Publications for MTRNR2L6 Gene

  1. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M … Dembinska-Kiec A (Genomics 2009) 2 3 4 58
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  3. The human mitochondrial genome may code for more than 13 proteins. (PMID: 25630734) Capt C … Breton S (Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis 2016) 3 58
  4. Humanin: a harbinger of mitochondrial-derived peptides? (PMID: 23402768) Lee C … Cohen P (Trends in endocrinology and metabolism: TEM 2013) 3 58
  5. Immunolocalization of humanin in human sperm and testis. (PMID: 20542501) Moretti E … Collodel G (Fertility and sterility 2010) 3 58

Products for MTRNR2L6 Gene

Sources for MTRNR2L6 Gene

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